Gene

KWMTBOMO02149

Pre Gene Modal

BGIBMGA003152

Annotation

PREDICTED:_protein_O-mannosyltransferase_1_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr4(-):12766348-12772786      View in EpiBrowser

Full name

Protein O-mannosyltransferase 1      

Alternative Name

Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Protein rotated abdomen

Location in the cell

PlasmaMembrane   Reliability : 4.053

CDS

ATGGACACAGGACGGTGTGTTAAAAATCGTAAAATAAACAAGATTCGTAAGGAGGTCACAGAACCTCAGGAGTACAGTTATTCGGAGAAAACATGTAATTCCCATCGAGAAGTGGGCGATGGTGCCCCAGCTGAAAATGAAACTGAAAAACCAGAATTAATGCTGACGAACAAAATGAATCATTCTCCTTCACGCATATATTTACAGCTCAAGATTGATGTAATCGCAATAGGACTTCTAATATTGGCATTATGCACTCGTTTATATAAACTAGATGAACCTCGCCATATTGTATTTGATGAATTACATTATGGAAGATATGTTTCATTATATACTAAGGGTGTCTTTTTTTTTGATGCTCATCCACCACTTGGCAAACAGTTGTTATATCTAGCTGGTAGTATTGCTGGATATGATGGAAACTTTACTTTTGACCGGATTGGTACTCCATATACTGACAATGTTCCTGTGAAGGCTCTCAGGCTAGTTCCAGCTGTGTCAGGAAGTTTTCTAGTTTTAATTACATATTTTTTGATGCTAGAACTATCTTTACATCAATGGACTGCCATACTTGCTGCTTTATTAGTGCTCCTTGAAAATTGTTTCTTAGCACAGTCAAGGTTCATGTTGCTGGAAAGCATTCAGATACTATTTGGCTTGTGCGGTGTGTATTGTATTATTAAAAGTACAAAGAGAATTGGACTCACAGCACTTGTTTGGCTATGTGCTGCTGCTGTTTTGCTTGGTTGTTGCTTCTCGGTGAAATACTCTGGGCTGTACACATACTATTTATCATTATTCTTAGTTGGAAGACACATATGGTTGCAACTAGACCAAATAAAATCAGGAACACGTTTATTATTTTCTGCCTTGTGGCGGTTTGCGGTCTTATTGATCATCCCGCTGGCTGTGTATGTGAGCGTGTTTTACATGCATTTGTCTATGTTGCCAAAGGCTGGACCGCATGACAGTGTTATGACGAGTGCATTCCAAGCCTCATTACAGGGCGGCCTTGCGAGCATAACGCACGGACAGCCATTGCATGTCGCTCACGGCTCTCAAATAACACTCAGGCACACCCACGGCAGGACCTGTTGGCTCCATTCACACGCACACGTATATCCAGTGCGTTATGCGGACGGACGTGGCTCCTCACACCAGCAGCAAGTGACTTGTTACAGCTTCAAAGATGTCAACAATTGGTGGATTGTAAAACGGCCGGACCAAGCGTCGCTGGCCGTTTCGCGACCTCCAGACGCTATAAGACACGGAGATATCGTACAACTGTTGCATGGAATAACGAGTCGCGCTTTGAATTCCCACGATGTGGCCGCAGCTGTTTCGCCTCAATCTCAAGAAGTGTCTTGCTACATCGACTACAATGTATCGATGCCAGCTCAGAATCTTTGGCGTGTGGATATTGTGAATCGTGATTCTGAAGAGTCAACCTGGGATAGCATACGCTCGTTAGTGAGACTTGTTCACGTTGACACGGGGTCGGGCTTGCGTTACAGTGGTCGCCAACTTCCGGCTTGGGGTTTCCATCAACATGAGATTGTTGCTGACAAGGTGTTATCCCATCAAGATACAATATGGAATGTTGAAGAGCATCGCTATACCAAAGCCGATGATCGAAAAGAACGGGAACGCGAGTTAGTCACGGCTGAAATGATACCGACTGCAGTGACCCAATTAACTTTTTGGGAAAAATTTACAGAATTACAATATAAAATGATAGCACACGCACCTGATGCCCCTCACGGGCACATGTTTGCCAGCGAACCAGCTGAATGGCCTCTGCTTGTTCGTTCAATTGCATATTGGCTCTCTCCTGACTCTAATGCTCAAATACATCTGATAGGCAACATTGTAACATGGTATACTGGGACAATATCGGTAGTAGTCTACAGTGCCCTCCTGGCTATTTACTCCGTTCGAAAACGTCGAGCTTGTGAAGACTTGCCTCCATTTGTTTTGAATAAGTTTTATGAAACTGGCTATACATTATTTCTAGGTTATTGTGTTCTGAACTATGGAAATGTTGATTTAAAGGAAAATGATCTAATGAGTCTTAGGTGGAAAGATACCTGGGACTTTATATTACATAAAAAGATATAA

Protein

MDTGRCVKNRKINKIRKEVTEPQEYSYSEKTCNSHREVGDGAPAENETEKPELMLTNKMNHSPSRIYLQLKIDVIAIGLLILALCTRLYKLDEPRHIVFDELHYGRYVSLYTKGVFFFDAHPPLGKQLLYLAGSIAGYDGNFTFDRIGTPYTDNVPVKALRLVPAVSGSFLVLITYFLMLELSLHQWTAILAALLVLLENCFLAQSRFMLLESIQILFGLCGVYCIIKSTKRIGLTALVWLCAAAVLLGCCFSVKYSGLYTYYLSLFLVGRHIWLQLDQIKSGTRLLFSALWRFAVLLIIPLAVYVSVFYMHLSMLPKAGPHDSVMTSAFQASLQGGLASITHGQPLHVAHGSQITLRHTHGRTCWLHSHAHVYPVRYADGRGSSHQQQVTCYSFKDVNNWWIVKRPDQASLAVSRPPDAIRHGDIVQLLHGITSRALNSHDVAAAVSPQSQEVSCYIDYNVSMPAQNLWRVDIVNRDSEESTWDSIRSLVRLVHVDTGSGLRYSGRQLPAWGFHQHEIVADKVLSHQDTIWNVEEHRYTKADDRKERERELVTAEMIPTAVTQLTFWEKFTELQYKMIAHAPDAPHGHMFASEPAEWPLLVRSIAYWLSPDSNAQIHLIGNIVTWYTGTISVVVYSALLAIYSVRKRRACEDLPPFVLNKFYETGYTLFLGYCVLNYGNVDLKENDLMSLRWKDTWDFILHKKI

Description

Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development.

Catalytic Activity

dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)
dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+)

Subunit

Interacts with tw/POMT2.

Similarity

Belongs to the glycosyltransferase 39 family.

Keywords

Complete proteome   Developmental protein   Endoplasmic reticulum   Glycoprotein   Glycosyltransferase   Membrane   Reference proteome   Repeat   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Protein O-mannosyltransferase 1

Uniprot

A0A2H1WVF1   A0A212EJ94   A0A2A4J5U6   A0A2A3EGW3   A0A088ATG7   A0A0T6BBD0   + More
A0A2J7Q1P0   F4WIC4   A0A151XBF5   D6WKM8   A0A158NZU9   A0A023F3C7   A0A026WRA1   A0A195CM25   E2B7B0   A0A195F241   K7INM0   A0A154NX72   A0A151J2J5   J3JUS3   N6UCU0   A0A232ELW1   U4U6M1   A0A1Y1LCU5   E0VJ18   A0A0C9Q470   A0A131XGA6   A0A1B6DQK1   A0A1B6KKG3   A0A0L0CS09   L7M7K2   A0A146KPU2   A0A224YXG8   A0A131YZ60   B4KUQ5   A0A0J9RTB0   B4QQ77   B4HEG6   A0A0A1WD25   A0A3B0JUQ1   Q9VTK2   J9JYV6   A0A1E1XKQ7   A0A067RVV3   B4GZH3   B4PF70   A0A1A9UPF5   A0A1A9WGH5   B4LCN8   V5HMB9   A0A1E1X503   B7PZ28   A0A0L7R9R8   Q2LZ62   A0A2R7VYT2   A0A1B0G158   B3NGX3   A0A0M4F0N3   V5HA07   B3M490   T1JMV6   A0A2R5L9K6   B4MKP4   W8C4P4   A0A0K8UAP7   A0A1J1I054   A0A1I8NS44   A0A1I8NS45   B4J2K3   A0A1B6EE73   A0A336MDJ3   A0A336L2C7   A0A310SJW1   A0A034VD69   A0A195BMH9   A0A182K5A9   A0A182I5S5   A0A1W4W798   A0A182REJ6   A0A182V2U2   A0A182YIW7   A0A0P4VZT5   A0A182MN00   A0A182X0I8   A0A0P4WQZ7   Q7Q222   A0A182UJ28   A0A182W9K5   A0A182S7S1   B0WG88   A0A182NV70   A0A182P9V2   A0A0P4WVR7   A0A182QJ90   T1K338   A0A1S4EX29   A0A0P5MSZ4   A0A0C9R7N7  

EC Number

2.4.1.109

Pubmed

22118469    21719571    18362917    19820115    21347285    25474469    + More
24508170    30249741    20798317    20075255    22516182    23537049    28648823    28004739    20566863    28049606    26108605    25576852    26823975    28797301    26830274    17994087    22936249    25830018    8650217    15271988    10731132    12537572    12537569    16219785    29209593    24845553    17550304    18057021    25765539    28503490    15632085    24495485    25348373    25244985    12364791    14747013    17210077   

EMBL

ODYU01011353    SOQ57045.1    AGBW02014506    OWR41554.1    NWSH01003201    PCG66793.1    + More
KZ288253    PBC30948.1    LJIG01002331    KRT84609.1    NEVH01019395    PNF22479.1    GL888175    EGI66055.1    KQ982330    KYQ57674.1    KQ971342    EFA03006.2    ADTU01005005    ADTU01005006    GBBI01002782    JAC15930.1    KK107144    QOIP01000003    EZA57599.1    RLU24315.1    KQ977580    KYN01760.1    GL446154    EFN88395.1    KQ981856    KYN34645.1    KQ434777    KZC04285.1    KQ980404    KYN16198.1    BT126988    AEE61950.1    APGK01034125    KB740904    ENN78451.1    NNAY01003486    OXU19345.1    KB632006    ERL87963.1    GEZM01059416    JAV71489.1    DS235219    EEB13374.1    GBYB01008836    GBYB01008838    JAG78603.1    JAG78605.1    GEFH01002408    JAP66173.1    GEDC01016863    GEDC01009346    JAS20435.1    JAS27952.1    GEBQ01028051    GEBQ01003489    JAT11926.1    JAT36488.1    JRES01000005    KNC34982.1    GACK01005177    JAA59857.1    GDHC01020914    JAP97714.1    GFPF01007376    MAA18522.1    GEDV01004782    JAP83775.1    CH933809    EDW19311.1    CM002912    KMY99011.1    CM000363    EDX10095.1    CH480815    EDW41120.1    GBXI01017423    JAC96868.1    OUUW01000002    SPP77086.1    X95956    AB176550    AE014296    AY071270    AAF50046.2    AAL48892.1    BAD54754.1    CAA65194.1    ABLF02031480    GFAA01003514    JAT99920.1    KK852432    KDR24004.1    CH479199    EDW29400.1    CM000159    EDW94152.1    CH940647    EDW70930.1    KRF85195.1    GANP01007871    JAB76597.1    GFAC01005082    JAT94106.1    ABJB010465798    ABJB010495453    ABJB010952312    ABJB010978496    DS823764    EEC11850.1    KQ414621    KOC67579.1    CH379069    KK854178    PTY12654.1    CCAG010020780    CH954178    EDV51430.1    CP012525    ALC44725.1    GANP01012886    JAB71582.1    CH902618    EDV39360.1    JH430339    GGLE01002047    MBY06173.1    CH963847    EDW72750.2    GAMC01009462    GAMC01009460    GAMC01009458    GAMC01009456    GAMC01009454    GAMC01009452    JAB97099.1    GDHF01028653    JAI23661.1    CVRI01000037    CRK93645.1    CH916366    EDV97088.1    GEDC01001062    JAS36236.1    UFQT01000995    SSX28355.1    UFQS01001598    UFQT01001598    SSX11541.1    SSX31108.1    KQ761797    OAD56791.1    GAKP01018885    GAKP01018884    JAC40067.1    KQ976440    KYM86491.1    APCN01003494    GDRN01100275    GDRN01100274    GDRN01100273    GDRN01100271    JAI58605.1    AXCM01003724    GDIP01251960    JAI71441.1    AAAB01008979    EAA13728.4    DS231923    EDS26784.1    GDIP01251916    JAI71485.1    AXCN02001805    CAEY01001374    GDIQ01152320    JAK99405.1    GBYB01008837    JAG78604.1   

Proteomes

UP000007151    UP000218220    UP000242457    UP000005203    UP000235965    UP000007755    + More
UP000075809    UP000007266    UP000005205    UP000053097    UP000279307    UP000078542    UP000008237    UP000078541    UP000002358    UP000076502    UP000078492    UP000019118    UP000215335    UP000030742    UP000009046    UP000037069    UP000009192    UP000000304    UP000001292    UP000268350    UP000000803    UP000007819    UP000027135    UP000008744    UP000002282    UP000078200    UP000091820    UP000008792    UP000001555    UP000053825    UP000001819    UP000092444    UP000008711    UP000092553    UP000007801    UP000007798    UP000183832    UP000095300    UP000001070    UP000078540    UP000075881    UP000075840    UP000192221    UP000075900    UP000075903    UP000076408    UP000075883    UP000076407    UP000007062    UP000075902    UP000075920    UP000075901    UP000002320    UP000075884    UP000075885    UP000075886    UP000015104   

PRIDE

Q9VTK2    Q2LZ62   

Pfam

PF02366   PMT        + More
PF16192   PMT_4TMC
PF02815   MIR
PF01770   Folate_carrier
PF06080   DUF938

Interpro

IPR036300   MIR_dom_sf        + More
IPR027005   GlyclTrfase_39-like       
IPR032421   PMT_4TMC       
IPR003342   Glyco_trans_39/83       
IPR016093   MIR_motif       
IPR020846   MFS_dom       
IPR002666   Folate_carrier       
IPR036259   MFS_trans_sf       
IPR010342   DUF938       
IPR029063   SAM-dependent_MTases       

SUPFAM

SSF82109   SSF82109        + More
SSF103473   SSF103473       
SSF53335   SSF53335       

CDD

cd06174  MFS

ProteinModelPortal

A0A2H1WVF1   A0A212EJ94   A0A2A4J5U6   A0A2A3EGW3   A0A088ATG7   A0A0T6BBD0   + More
A0A2J7Q1P0   F4WIC4   A0A151XBF5   D6WKM8   A0A158NZU9   A0A023F3C7   A0A026WRA1   A0A195CM25   E2B7B0   A0A195F241   K7INM0   A0A154NX72   A0A151J2J5   J3JUS3   N6UCU0   A0A232ELW1   U4U6M1   A0A1Y1LCU5   E0VJ18   A0A0C9Q470   A0A131XGA6   A0A1B6DQK1   A0A1B6KKG3   A0A0L0CS09   L7M7K2   A0A146KPU2   A0A224YXG8   A0A131YZ60   B4KUQ5   A0A0J9RTB0   B4QQ77   B4HEG6   A0A0A1WD25   A0A3B0JUQ1   Q9VTK2   J9JYV6   A0A1E1XKQ7   A0A067RVV3   B4GZH3   B4PF70   A0A1A9UPF5   A0A1A9WGH5   B4LCN8   V5HMB9   A0A1E1X503   B7PZ28   A0A0L7R9R8   Q2LZ62   A0A2R7VYT2   A0A1B0G158   B3NGX3   A0A0M4F0N3   V5HA07   B3M490   T1JMV6   A0A2R5L9K6   B4MKP4   W8C4P4   A0A0K8UAP7   A0A1J1I054   A0A1I8NS44   A0A1I8NS45   B4J2K3   A0A1B6EE73   A0A336MDJ3   A0A336L2C7   A0A310SJW1   A0A034VD69   A0A195BMH9   A0A182K5A9   A0A182I5S5   A0A1W4W798   A0A182REJ6   A0A182V2U2   A0A182YIW7   A0A0P4VZT5   A0A182MN00   A0A182X0I8   A0A0P4WQZ7   Q7Q222   A0A182UJ28   A0A182W9K5   A0A182S7S1   B0WG88   A0A182NV70   A0A182P9V2   A0A0P4WVR7   A0A182QJ90   T1K338   A0A1S4EX29   A0A0P5MSZ4   A0A0C9R7N7  

PDB

3MAL     E-value=2.58569e-07,     Score=134

KEGG

101747223    K00728 dolichyl-phosphate-mannose-protein mannosyltransferase [EC:2.4.1.109] | (RefSeq) protein O-ma

PATHWAY

00514    Other types of O-glycan biosynthesis - Bombyx mori (domestic silkworm)
00515    Mannose type O-glycan biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006493   GO:0000030   GO:0016021   GO:0004169   GO:0005789   GO:0035269   GO:0090482   GO:0016020   GO:0030259   GO:0045214   GO:0060025   GO:0005783   GO:0007525   GO:0016203   GO:0007385   GO:0007517   GO:0004298   GO:0003824   GO:0006520   GO:0008483   GO:0006418   GO:0016507   GO:0048384  

PANTHER

PTHR10050  

Subcellular location

Endoplasmic reticulum membrane  

Length:

705

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

156.67352

Exp number, first 60 AAs:

6e-05

Total prob of N-in:

0.78967

inside

1  -  156

TMhelix

157  -  179

outside

180  -  183

TMhelix

184  -  203

inside

204  -  207

TMhelix

208  -  227

outside

228  -  236

TMhelix

237  -  259

inside

260  -  288

TMhelix

289  -  311

outside

312  -  622

TMhelix

623  -  645

inside

646  -  705

 

 

Pi

178.613657

Theta

178.388492

Tajima's D

0.279474

CLR

1.850559

CSRT

0.454977251137443

Interpretation

Uncertain