Gene

KWMTBOMO02147  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003153

Annotation

DnaJ_(Hsp40)_homolog_3_[Bombyx_mori]

Location

Bomo_Chr4(-):12758615-12760686      View in EpiBrowser

Full name

DnaJ homolog shv      

Alternative Name

Protein shriveled

Location in the cell

Cytoplasmic   Reliability : 2.512

CDS

ATGCTAGTTAACGCAATTAATGTGTGTTTAATTTATTTATTGTCAGCTCTAGTCATCACCCTCGCTGGTCGTGATTTCTACCAGATACTTGGTGTATCTCGGTCCGCGAATACAAATGAAATTAAAAAGGCTTACAGAAAATTAGCAAAAGCATTGCATCCTGATAAAAATCAAGATGATCCCGATGCTGCTCAAAAGTTTCAAGATTTAGGGGCGGCTTATGAGGCATTATCAGACCCCGAAAAACGCGAACTGTACGATCGTTGCGGCGAAGACTGTTTGAAGAAAGATGGAATGATGAACAATAATGACCCTTTTGCAAGCTTCTTTGGTGATTTTGGATTCCATTTTGGTGGTGAACCGCAACATCACGAAACACCACGAGGGGCGGACATTGTTATGGAGCTCACAGTTTCACTTGAAGAACTTTACAATGGAAATTTTATAGAGATAACTAGGAATAAACCCGTAATCAAACCAGCTCCAGGGACCCGCAAGTGTAACTGTAGACAAGAGATGGTAACAAGAAACTTGGGTCCAGGAAGATTCCAGATGATGCAGCAAACAGTGTGTGATGAATGTCCTAATGTAAAATTTGTTAATGAAGAAAGGCTACTAGAAATTGAGGTAGAAGTTGGTGCTCCGGATGGACACAAATCTAGGTTGCGTGGAGAAGGTGAACCCCATGTAGATGGTGAACCAGGTGATCTCATTGTAATACTCAAAACGGAAAGACACCCACAATTTACTCGCAAAGCTGATGACTTATACACCAATGTGACAATTTCACTACAGGATGCTCTGACTGGTTTTACTCTTGAACTTGAACATTTAGATGGTCATAAAGTGTCAGTGTCTAGAGACAAGGTAACATGGGCTGGTGCAAGAGTTCGTAAGAAGGGAGAAGGCATGCCAAATTTTGAAAATAACAACCTCCATGGAAATCTTTATGTAACTTTTGATATAGAATTTCCCAAGCAAGACTTCACAGATGCTGAGAAAGAGGCTTTGCGAAAAATACTGAACCAGCCACCAAATAATAAAATATACAATGGACTATAG

Protein

MLVNAINVCLIYLLSALVITLAGRDFYQILGVSRSANTNEIKKAYRKLAKALHPDKNQDDPDAAQKFQDLGAAYEALSDPEKRELYDRCGEDCLKKDGMMNNNDPFASFFGDFGFHFGGEPQHHETPRGADIVMELTVSLEELYNGNFIEITRNKPVIKPAPGTRKCNCRQEMVTRNLGPGRFQMMQQTVCDECPNVKFVNEERLLEIEVEVGAPDGHKSRLRGEGEPHVDGEPGDLIVILKTERHPQFTRKADDLYTNVTISLQDALTGFTLELEHLDGHKVSVSRDKVTWAGARVRKKGEGMPNFENNNLHGNLYVTFDIEFPKQDFTDAEKEALRKILNQPPNNKIYNGL

Description

Maintains stem cell niche architecture in the testes. Activates an extracellular integrin beta-PS pathway which regulates DE-cadherin (shg) levels in somatic hub cells, and is essential for maintaining the number of germline stem cells and the structure and localization of hub cells.

Miscellaneous

The name 'shriveled' derives from the shrinking testes phenotype of mutants.

Similarity

Belongs to the CD36 family.

Keywords

Cell adhesion   Cell membrane   Complete proteome   Glycoprotein   Membrane   Nucleus   Reference proteome   Secreted   Signal  

Feature

chain  DnaJ homolog shv

Uniprot

C7AQZ1   H9J0W6   A0A2H1WVF2   A0A2A4J4I4   I4DK37   A0A1L2ECC5   + More
A0A212EJ93   A0A0L7L457   S4PML4   D6WL83   A0A0T6AVD1   A0A1B0EWR5   A0A1L8DTS7   U5EV74   A0A2J7RL45   E0VF38   A0A1W4WH14   B4KFI3   B4LTL8   T1PG77   A0A067RJF9   A0A1I8M720   Q9VPQ2   A0A0K8UEU8   B4ICX4   A0A0J9QT97   B3N7Q8   A0A034WNL9   A0A0C9QA70   T1GQC5   B4JDP9   B3MUH1   B4P2E8   A0A1L8EDJ2   A0A1Y1KBG6   A0A182J8D6   A0A1W4UPT7   A0A182NTU3   A0A1I8QAQ9   A0A2A3E8D9   A0A2M3Z766   A0A2M3Z6U9   A0A088AJE9   A0A151JMH5   A0A026WVY8   B4N0W9   A0A3B0K852   A0A2M4A611   A0A158P3J5   A0A2M4A669   T1DKK0   A0A195BWX2   A0A2M4BS45   A0A2M4BS56   A0A182W6L0   N6UC17   W5J5R6   A0A182RMA8   A0A1J1IMT3   A0A195F0K3   A0A0M4EP24   A0A182Y3C4   A0A182P8L0   E2BBA0   A0A182L0R0   A0A182VJ47   A0A182U2U1   A0A182XLA2   Q7Q4B9   B4G896   A0A182MKI3   A0A182Q8X2   A0A151IEL4   A0A182F1E7   Q29N47   W8CDD0   A0A2J7RL50   A0A0L0CAT2   A0A336LKK2   A0A232EU23   D3TLP6   K7J8X8   A0A224XJ42   A0A1Q3FF70   A0A1A9UR71   A0A1S4FP86   R4G8F2   A0A023EPG0   T1IYX8   A0A0C9QP73   B0WE51   A0A0N0PC20   A0A1D2MKG8   Q1HR07   A0A182GLJ3   A0A023EQJ1   A0A182ICC2   A0A226F0P8   R4WD81   A0A084VEC5  

Pubmed

26434795    19121390    22651552    26354079    22118469    26227816    + More
23622113    18362917    19820115    20566863    17994087    24845553    25315136    10731132    12537572    12537569    27191715    22936249    25348373    17550304    28004739    24508170    30249741    21347285    23537049    20920257    23761445    25244985    20798317    20966253    12364791    14747013    17210077    15632085    24495485    26108605    28648823    20353571    20075255    24945155    27289101    17204158    26483478    23691247    24438588   

EMBL

FJ592076    JN872878    ACT34037.1    AFC01217.1    BABH01010419    ODYU01011353    + More
SOQ57043.1    NWSH01003201    PCG66789.1    AK401655    KQ459598    BAM18277.1    KPI94698.1    KT003961    ANJ86401.1    AGBW02014506    OWR41556.1    JTDY01003048    KOB70252.1    GAIX01000116    JAA92444.1    KQ971343    EFA03492.2    LJIG01022778    KRT78766.1    AJWK01028794    GFDF01004215    JAV09869.1    GANO01002007    JAB57864.1    NEVH01002699    PNF41565.1    DS235100    EEB11927.1    CH933807    EDW13098.1    CH940649    EDW64991.1    KA647766    AFP62395.1    KK852595    KDR20633.1    AE014134    AY051778    AAF51493.1    AAK93202.1    GDHF01027201    JAI25113.1    CH480829    EDW45400.1    CM002910    KMY87318.1    CH954177    EDV57234.1    GAKP01002733    JAC56219.1    GBYB01011313    JAG81080.1    CAQQ02042346    CH916368    EDW03419.1    CH902624    EDV33500.1    CM000157    EDW87144.1    GFDG01002008    JAV16791.1    GEZM01087282    JAV58799.1    KZ288349    PBC27449.1    GGFM01003537    MBW24288.1    GGFM01003496    MBW24247.1    KQ978910    KYN27534.1    KK107109    QOIP01000008    EZA59269.1    RLU19928.1    CH963920    EDW77732.1    OUUW01000004    SPP79708.1    GGFK01002923    MBW36244.1    ADTU01008162    GGFK01002909    MBW36230.1    GAMD01000911    JAB00680.1    KQ976394    KYM93129.1    GGFJ01006738    MBW55879.1    GGFJ01006739    MBW55880.1    APGK01040621    KB740984    KB630727    KB632357    ENN76197.1    ERL83826.1    ERL93436.1    ADMH02002157    ETN58210.1    CVRI01000053    CRK99785.1    KQ981880    KYN33891.1    CP012523    ALC38525.1    GL446957    EFN87028.1    EFN87030.1    AAAB01008964    EAA12426.4    CH479180    EDW28576.1    AXCM01001485    AXCN02000805    KQ977866    KYM99246.1    CH379060    EAL33496.1    GAMC01002161    JAC04395.1    PNF41564.1    JRES01000673    KNC29356.1    UFQT01000039    SSX18490.1    NNAY01002204    OXU21817.1    EZ422348    ADD18624.1    GFTR01005362    JAW11064.1    GFDL01008851    JAV26194.1    ACPB03022605    GAHY01001077    JAA76433.1    GAPW01002226    JAC11372.1    JH431701    GBYB01002477    JAG72244.1    DS231904    EDS45227.1    KQ460709    KPJ12710.1    LJIJ01000977    ODM93470.1    DQ440287    ABF18320.1    JXUM01072609    KQ562729    KXJ75241.1    GAPW01002225    JAC11373.1    APCN01000793    LNIX01000001    OXA62781.1    AK417304    BAN20519.1    ATLV01012268    KE524777    KFB36319.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000037510    UP000007266    + More
UP000092461    UP000235965    UP000009046    UP000192223    UP000009192    UP000008792    UP000027135    UP000095301    UP000000803    UP000001292    UP000008711    UP000015102    UP000001070    UP000007801    UP000002282    UP000075880    UP000192221    UP000075884    UP000095300    UP000242457    UP000005203    UP000078492    UP000053097    UP000279307    UP000007798    UP000268350    UP000005205    UP000078540    UP000075920    UP000019118    UP000030742    UP000000673    UP000075900    UP000183832    UP000078541    UP000092553    UP000076408    UP000075885    UP000008237    UP000075882    UP000075903    UP000075902    UP000076407    UP000007062    UP000008744    UP000075883    UP000075886    UP000078542    UP000069272    UP000001819    UP000037069    UP000215335    UP000002358    UP000078200    UP000015103    UP000002320    UP000053240    UP000094527    UP000069940    UP000249989    UP000075840    UP000198287    UP000030765   

PRIDE

C7AQZ1    H9J0W6    Q9VPQ2   

Pfam

PF01556   DnaJ_C        + More
PF00226   DnaJ
PF01130   CD36

Interpro

IPR002939   DnaJ_C        + More
IPR018253   DnaJ_domain_CS       
IPR036869   J_dom_sf       
IPR001623   DnaJ_domain       
IPR008971   HSP40/DnaJ_pept-bd       
IPR002159   CD36_fam       

SUPFAM

SSF46565   SSF46565        + More
SSF49493   SSF49493       

Gene 3D

1.10.287.110    

CDD

cd06257  DnaJ

ProteinModelPortal

C7AQZ1   H9J0W6   A0A2H1WVF2   A0A2A4J4I4   I4DK37   A0A1L2ECC5   + More
A0A212EJ93   A0A0L7L457   S4PML4   D6WL83   A0A0T6AVD1   A0A1B0EWR5   A0A1L8DTS7   U5EV74   A0A2J7RL45   E0VF38   A0A1W4WH14   B4KFI3   B4LTL8   T1PG77   A0A067RJF9   A0A1I8M720   Q9VPQ2   A0A0K8UEU8   B4ICX4   A0A0J9QT97   B3N7Q8   A0A034WNL9   A0A0C9QA70   T1GQC5   B4JDP9   B3MUH1   B4P2E8   A0A1L8EDJ2   A0A1Y1KBG6   A0A182J8D6   A0A1W4UPT7   A0A182NTU3   A0A1I8QAQ9   A0A2A3E8D9   A0A2M3Z766   A0A2M3Z6U9   A0A088AJE9   A0A151JMH5   A0A026WVY8   B4N0W9   A0A3B0K852   A0A2M4A611   A0A158P3J5   A0A2M4A669   T1DKK0   A0A195BWX2   A0A2M4BS45   A0A2M4BS56   A0A182W6L0   N6UC17   W5J5R6   A0A182RMA8   A0A1J1IMT3   A0A195F0K3   A0A0M4EP24   A0A182Y3C4   A0A182P8L0   E2BBA0   A0A182L0R0   A0A182VJ47   A0A182U2U1   A0A182XLA2   Q7Q4B9   B4G896   A0A182MKI3   A0A182Q8X2   A0A151IEL4   A0A182F1E7   Q29N47   W8CDD0   A0A2J7RL50   A0A0L0CAT2   A0A336LKK2   A0A232EU23   D3TLP6   K7J8X8   A0A224XJ42   A0A1Q3FF70   A0A1A9UR71   A0A1S4FP86   R4G8F2   A0A023EPG0   T1IYX8   A0A0C9QP73   B0WE51   A0A0N0PC20   A0A1D2MKG8   Q1HR07   A0A182GLJ3   A0A023EQJ1   A0A182ICC2   A0A226F0P8   R4WD81   A0A084VEC5  

PDB

1NLT     E-value=1.50149e-21,     Score=253

KEGG

100302617    K09517 DnaJ homolog subfamily B member 11 | (RefSeq) DnaJ-3; DnaJ (Hsp40) homolog 3

PATHWAY

04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0051082   GO:0006457   GO:0016021   GO:2001046   GO:0060250   GO:0005178   GO:0036098   GO:0031594   GO:0090129   GO:0005615   GO:0007155   GO:0005634   GO:0005886   GO:0005840   GO:0006412   GO:0003824   GO:0006520   GO:0008483   GO:0006418   GO:0016507   GO:0048384  

PANTHER

PTHR11923  

Subcellular location

Nucleus   Secreted by somatic cells of the testes. Detected at the cell borders between the hub and germline stem cells, and between the germ and cyst stem cells.   With evidence from 4 publications.
Cell membrane   Secreted by somatic cells of the testes. Detected at the cell borders between the hub and germline stem cells, and between the germ and cyst stem cells.   With evidence from 4 publications.
Secreted   Secreted by somatic cells of the testes. Detected at the cell borders between the hub and germline stem cells, and between the germ and cyst stem cells.   With evidence from 4 publications.

Length:

353

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

19.78391

Exp number, first 60 AAs:

19.78358

Total prob of N-in:

0.95078

POSSIBLE N-term signal

sequence

inside

1  -  1

TMhelix

2  -  24

outside

25  -  353

 

 

Pi

214.610805

Theta

200.778131

Tajima's D

0.182567

CLR

0.345779

CSRT

0.423828808559572

Interpretation

Uncertain