Gene

KWMTBOMO02123  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003001

Annotation

PREDICTED:_nucleolar_complex_protein_2_homolog_[Papilio_polytes]

Location

Bomo_Chr4(+):12515703-12520307      View in EpiBrowser

Full name

Nucleolar complex protein 2 homolog       + More
Ubiquinone biosynthesis O-methyltransferase, mitochondrial      

Alternative Name

3-demethylubiquinol 3-O-methyltransferase
Polyprenyldihydroxybenzoate methyltransferase

Location in the cell

Nuclear   Reliability : 3.579

CDS

ATGAAAAAAGCAACTGTACAAATCAAATCCCAATCAATGCAGGTGCAGGATTCATCAGACTCTGATGAAGAGCCAAATCCTGAGAGTCATAAAAAATCTTTGGAAAAATTGAAGAAGACAGATCCAGACTTCTATAATTTTCTTGAAGAGAATGACGAGAATTTGCTGAACTTTGAAGCAGCCAGTGATGATCAGGAATCTGACAGACAGAGTGACAGTAATGAAGATGATGAGAAAATACACACACCAGGAGCCTTGCAGGCTGATAGTGATGACAGTGACTTCGAGAATGACAATTATAAATTGGACAATACTAAAGTCACTCTTAAAATGGTTTCGGAATGGCAAGCAGAGTTGCAAAGTGAAGGCAAGATTAAACTGTCCACATTAATCACGGTTATAAAAGCATTTAATGCAGCTATGCTTCGAGTTAGTAGTGATGATGGAACTTCACAAGGAGAAATGAAAGTGGAGGGATCATCTGTTTTCAATGCTGTCATTCAATTATGTGTTGTTAATCTACCCGGTGCAGTAAAAAAGTATTTGGGTGTAGAACAGTCAGGCAAGGAACCACAAAAATGCAAGCATTTCTCCAAAATCAGAGGTCCTCTGATGTCGTATTTAGTTGATCTGATGAAACTGCTCTTAAGTATTTCATCTGAGAATATTTTGGGAGTACTGCTAAAGCATTTGCACCAAATGTGCACTTTCATTGCTTGTTTCCCAAGAATTGCTAAAATGGCATTAAGAAAACTTATTTTACTGTGGAGCACTAGTGAAGAAACTGTGAGAGTGTTAGCTTTTCTCTGCATTTTAAGAATAACCAGGAACCAACAAGCACTTCTTCTAGATCCAGTTCTGAAAGTAATGTACATGACTTATGTAAAAAACTGCAAATTTGTGAGCCCATCAACATGGCCAGGAATAAACTTTATGAGGAGATCCCTTGTTGAAATGTACTCTTTAGATTTGGATGTTGCCTATCGACATGTCTTTCTTTATATCAGGCAACTAGCTATTCACTTGAGGAATGCTATAGTAGTACAGAAAATTGAGAACAGACAGGCTGTATACAACTGGCAATTTGTGAACTCTCTGCGCTTATGGGGAGATCTACTGGCCGTCAACAACAGGCCACCATTACATCCACTAATTTACCCACTTGTGATGGTAACTATAAACACAATCAAACTTGTGCCAACTCATCAATATTACCCACTGAGATTTCACTGTGTGGAGATACTGATGAACTTATCTAAGGAAACTGAAACTTTCATTCCTGTACTGCCGTTCTTAACAGAAATTCTGGCCTATGACTTCAATAAAAAACACAAAAAAGTTTCAATGAAACCTCTAGATTTTTCATGCATATTGAGATTGGCTAAGTCTCAACTGATGGAAAATGGATTCAAAGATGCTGTAATAGATAAACTGTATGCCCTCATGTTGGAGTACACAGCTAATGAATCTCATACATTTGCTTTTCCTGATACCATTTTACTAGCAGTTATTCAGCTGAAACAGTTCTTAAAATCATGCTCAGTTGCCAATTACACAAAGAGATTCCGTCAGCTATTGGAAAAAATTGAAGAAAACGCAAGATTCATTGAGCAAGAACGTATAAAGTCAACCGTTGCCTTGGACGACGAAAGCTCAATAATGGCGTGGGAGACGAGCATGAAGGCAAAGGGAACACCCCTAAAATTATTCTTCGAGAACTGGAACAGGATTAATCAGTTACAGAAACGTAAGAAGGTAACGAACAATGATGAAATAGCTGGACAGATGCCGGTCATCAAACGACGTAAAATCACCGAACAACAAGTACAGCGGCCGGAGAGCAAGGGACCTCTCGTTTTGTTCCCCTCAGACAGTGAAGACGATGAGAGACCAAACTTTGAGGCGGACGAAGATGAGGAACCACCACGCGCTCCCAAAGTCAAGAAGCAAAAGAAGAAGAAGACGCAAAGGAAAATCGCAAAAAGAAATTCACCTCCAGAAGAAAGAGATACCATTGATAAAGGCGATATTGTTCAAGATCTCAGTGTAGGAGATTGGTAA

Protein

MKKATVQIKSQSMQVQDSSDSDEEPNPESHKKSLEKLKKTDPDFYNFLEENDENLLNFEAASDDQESDRQSDSNEDDEKIHTPGALQADSDDSDFENDNYKLDNTKVTLKMVSEWQAELQSEGKIKLSTLITVIKAFNAAMLRVSSDDGTSQGEMKVEGSSVFNAVIQLCVVNLPGAVKKYLGVEQSGKEPQKCKHFSKIRGPLMSYLVDLMKLLLSISSENILGVLLKHLHQMCTFIACFPRIAKMALRKLILLWSTSEETVRVLAFLCILRITRNQQALLLDPVLKVMYMTYVKNCKFVSPSTWPGINFMRRSLVEMYSLDLDVAYRHVFLYIRQLAIHLRNAIVVQKIENRQAVYNWQFVNSLRLWGDLLAVNNRPPLHPLIYPLVMVTINTIKLVPTHQYYPLRFHCVEILMNLSKETETFIPVLPFLTEILAYDFNKKHKKVSMKPLDFSCILRLAKSQLMENGFKDAVIDKLYALMLEYTANESHTFAFPDTILLAVIQLKQFLKSCSVANYTKRFRQLLEKIEENARFIEQERIKSTVALDDESSIMAWETSMKAKGTPLKLFFENWNRINQLQKRKKVTNNDEIAGQMPVIKRRKITEQQVQRPESKGPLVLFPSDSEDDERPNFEADEDEEPPRAPKVKKQKKKKTQRKIAKRNSPPEERDTIDKGDIVQDLSVGDW

Description

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

Catalytic Activity

3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine

Subunit

Component of a multi-subunit COQ enzyme complex.

Similarity

Belongs to the NOC2 family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.

Keywords

Complete proteome   Nucleus   Phosphoprotein   Reference proteome  

Feature

chain  Nucleolar complex protein 2 homolog

Uniprot

H9J0G4   A0A194PPQ9   A0A194QLL6   A0A2A4JID9   S4PE09   A0A2W1BQA6   + More
A0A212FA69   A0A1W4X2F6   D6WYX1   A0A0L7LJV0   A0A2J7QW64   A0A0T6AYN1   A0A1B6FG04   N6TJA4   A0A034WDR2   W8CEJ4   B4N7C6   U4U5R0   A0A1B6HKR6   A0A3B0JIG7   Q29NS9   B4P6Y8   Q9VIF0   B4LU00   A0A0J9R5A0   B4GJJ3   B4Q3Z7   A0A0L0C693   B4IFL5   A0A1A9WKS9   T1P9I6   B4KF49   A0A0A1WMA8   B3MN75   A0A1B6LVX7   A0A067R2Z6   A0A1W4UXJ3   A0A1A9ZDC8   A0A1B0B7Q4   B3NKT7   A0A1I8N2K9   A0A1Y1KSY0   B4JDW1   A0A0K8WHN5   A0A1B6DZR8   A0A0M4E6T1   A0A087ZZ77   A0A2A3EGM1   A0A154P4I2   A0A1I8PBQ6   A0A1L8DHM6   A0A336K657   U5EZK1   Q17BU6   A0A1B0F9N3   A0A1S4F8Q3   A0A1J1I4V7   A0A1B0DCP5   F4WAT4   A0A0J7L419   A0A0N0BGL2   A0A182H3X9   A0A158P3K1   A0A195BX33   A0A151XDN5   E9IEA4   E2ABS5   E0VL97   A0A195F149   A0A146M3S9   A0A3Q0J126   A0A151IV87   A0A232EQ69   A0A151IHL7   K7J2K8   A0A2H8TJS9   E2BPN6   A0A2S2PET5   J9JNJ9   A0A2M3Z3Z3   A0A2M4ADP9   A0A2M3Z417   A0A2M4AD27   A0A2M4BDC0   A0A2M4AD67   A0A2M4BDW7   A0A182M437   A0A2M4BD76   W5JDK2   A0A1S3JII8   A0A1Q3EXK3   A0A1Q3EXM8   A0A182FUH3   A0A182T3V7   A0A182J5F3   A0A1B0CXE3   A0A2M4BEM9  

Pubmed

19121390    26354079    23622113    28756777    22118469    18362917    + More
19820115    26227816    23537049    25348373    24495485    17994087    15632085    17550304    10731132    12537572    12537569    18327897    22936249    26108605    25830018    24845553    25315136    28004739    17510324    21719571    26483478    21347285    21282665    20798317    20566863    26823975    28648823    20075255    20920257    23761445   

EMBL

BABH01010446    KQ459598    KPI94719.1    KQ461196    KPJ06427.1    NWSH01001291    + More
PCG71827.1    GAIX01003401    JAA89159.1    KZ149933    PZC77252.1    AGBW02009514    OWR50631.1    KQ971363    EFA07851.1    JTDY01000796    KOB75843.1    NEVH01009768    PNF32812.1    LJIG01022525    KRT80116.1    GECZ01020631    JAS49138.1    APGK01035767    KB740928    ENN77953.1    GAKP01005271    JAC53681.1    GAMC01000091    JAC06465.1    CH964182    EDW80267.2    KB631763    ERL85936.1    GECU01032433    JAS75273.1    OUUW01000006    SPP82157.1    CH379058    EAL34565.1    CM000158    EDW89957.1    AE014134    AY061505    CH940649    EDW65053.1    CM002910    KMY91293.1    CH479184    EDW36809.1    CM000361    EDX05713.1    JRES01000842    KNC27805.1    CH480833    EDW46437.1    KA644825    AFP59454.1    CH933807    EDW13032.1    GBXI01014516    JAC99775.1    CH902620    EDV31032.1    GEBQ01012153    JAT27824.1    KK852794    KDR16437.1    JXJN01009697    CH954179    EDV54460.1    GEZM01074650    JAV64509.1    CH916368    EDW03481.1    GDHF01001712    JAI50602.1    GEDC01006125    JAS31173.1    CP012523    ALC40108.1    KZ288262    PBC30369.1    KQ434813    KZC06791.1    GFDF01008115    JAV05969.1    UFQS01000095    UFQT01000095    SSW99352.1    SSX19732.1    GANO01000648    JAB59223.1    CH477316    EAT43766.1    CCAG010005373    CVRI01000040    CRK94794.1    AJVK01031030    GL888053    EGI68690.1    LBMM01000723    KMQ97627.1    KQ435775    KOX74962.1    JXUM01025151    KQ560713    KXJ81191.1    ADTU01008167    KQ976394    KYM93137.1    KQ982268    KYQ58475.1    GL762576    EFZ21076.1    GL438356    EFN69102.1    DS235271    EEB14153.1    KQ981880    KYN33897.1    GDHC01004205    JAQ14424.1    KQ980924    KYN11411.1    NNAY01002834    OXU20472.1    KQ977636    KYN01142.1    GFXV01002579    MBW14384.1    GL449633    EFN82440.1    GGMR01015293    MBY27912.1    ABLF02027798    GGFM01002488    MBW23239.1    GGFK01005594    MBW38915.1    GGFM01002506    MBW23257.1    GGFK01005358    MBW38679.1    GGFJ01001866    MBW51007.1    GGFK01005398    MBW38719.1    GGFJ01001867    MBW51008.1    AXCM01000355    GGFJ01001868    MBW51009.1    ADMH02001479    ETN62432.1    GFDL01015000    JAV20045.1    GFDL01014978    JAV20067.1    AJWK01033652    AJWK01033653    GGFJ01002369    MBW51510.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000007151    UP000192223    + More
UP000007266    UP000037510    UP000235965    UP000019118    UP000007798    UP000030742    UP000268350    UP000001819    UP000002282    UP000000803    UP000008792    UP000008744    UP000000304    UP000037069    UP000001292    UP000091820    UP000009192    UP000007801    UP000027135    UP000192221    UP000092445    UP000092460    UP000008711    UP000095301    UP000001070    UP000092553    UP000005203    UP000242457    UP000076502    UP000095300    UP000008820    UP000092444    UP000183832    UP000092462    UP000007755    UP000036403    UP000053105    UP000069940    UP000249989    UP000005205    UP000078540    UP000075809    UP000000311    UP000009046    UP000078541    UP000079169    UP000078492    UP000215335    UP000078542    UP000002358    UP000008237    UP000007819    UP000075883    UP000000673    UP000085678    UP000069272    UP000075901    UP000075880    UP000092461   

PRIDE

H9J0G4    Q9VIF0   

Pfam

PF03715   Noc2        + More
PF00017   SH2
PF16454   PI3K_P85_iSH2
PF00096   zf-C2H2

Interpro

IPR005343   Noc2        + More
IPR016024   ARM-type_fold       
IPR000980   SH2       
IPR032498   PI3K_P85_iSH2       
IPR036860   SH2_dom_sf       
IPR010233   UbiG_MeTrfase       
IPR029063   SAM-dependent_MTases       
IPR013087   Znf_C2H2_type       
IPR036236   Znf_C2H2_sf       

SUPFAM

SSF48371   SSF48371        + More
SSF55550   SSF55550       
SSF53335   SSF53335       
SSF57667   SSF57667       

Gene 3D

3.30.505.10    

ProteinModelPortal

H9J0G4   A0A194PPQ9   A0A194QLL6   A0A2A4JID9   S4PE09   A0A2W1BQA6   + More
A0A212FA69   A0A1W4X2F6   D6WYX1   A0A0L7LJV0   A0A2J7QW64   A0A0T6AYN1   A0A1B6FG04   N6TJA4   A0A034WDR2   W8CEJ4   B4N7C6   U4U5R0   A0A1B6HKR6   A0A3B0JIG7   Q29NS9   B4P6Y8   Q9VIF0   B4LU00   A0A0J9R5A0   B4GJJ3   B4Q3Z7   A0A0L0C693   B4IFL5   A0A1A9WKS9   T1P9I6   B4KF49   A0A0A1WMA8   B3MN75   A0A1B6LVX7   A0A067R2Z6   A0A1W4UXJ3   A0A1A9ZDC8   A0A1B0B7Q4   B3NKT7   A0A1I8N2K9   A0A1Y1KSY0   B4JDW1   A0A0K8WHN5   A0A1B6DZR8   A0A0M4E6T1   A0A087ZZ77   A0A2A3EGM1   A0A154P4I2   A0A1I8PBQ6   A0A1L8DHM6   A0A336K657   U5EZK1   Q17BU6   A0A1B0F9N3   A0A1S4F8Q3   A0A1J1I4V7   A0A1B0DCP5   F4WAT4   A0A0J7L419   A0A0N0BGL2   A0A182H3X9   A0A158P3K1   A0A195BX33   A0A151XDN5   E9IEA4   E2ABS5   E0VL97   A0A195F149   A0A146M3S9   A0A3Q0J126   A0A151IV87   A0A232EQ69   A0A151IHL7   K7J2K8   A0A2H8TJS9   E2BPN6   A0A2S2PET5   J9JNJ9   A0A2M3Z3Z3   A0A2M4ADP9   A0A2M3Z417   A0A2M4AD27   A0A2M4BDC0   A0A2M4AD67   A0A2M4BDW7   A0A182M437   A0A2M4BD76   W5JDK2   A0A1S3JII8   A0A1Q3EXK3   A0A1Q3EXM8   A0A182FUH3   A0A182T3V7   A0A182J5F3   A0A1B0CXE3   A0A2M4BEM9  

KEGG

101737371    K14833 nucleolar complex protein 2 | (RefSeq) nucleolar complex protein 2 homolog

GO

GO:0030691   GO:0000122   GO:0042273   GO:0003714   GO:0035067   GO:0030690   GO:0005654   GO:0070491   GO:0042393   GO:0005730   GO:0016021   GO:0008689   GO:0031314   GO:0008425   GO:0004395   GO:0006744   GO:1990886   GO:0003676   GO:0005488   GO:0006367   GO:0005674   GO:0006366   GO:0003824   GO:0006520   GO:0008483   GO:0006418   GO:0016507   GO:0048384  

PANTHER

PTHR12687  

Subcellular location

Nucleus  
Mitochondrion inner membrane  

Length:

686

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.39227

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01749

outside

1  -  686

 

 

Pi

169.151822

Theta

195.927978

Tajima's D

-0.58724

CLR

0

CSRT

0.222588870556472

Interpretation

Possibly Positive selection