SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO02115  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA007334
Annotation
putative_NEDD8_precursor_[Danaus_plexippus]
Full name
NEDD8      
Alternative Name
Neddylin
Ubiquitin-like protein Nedd8
Location in the cell
Cytoplasmic   Reliability : 1.281 Mitochondrial   Reliability : 1.004 Nuclear   Reliability : 1.506
 

Sequence

CDS
ATGTTGATTAAAGTCAAGACGCTTACTGGTAAAGAAATTGAAATAGATATAGAACCCACCGACAAAGTGGAAAGAATCAAAGAAAGAGTAGAAGAAAAGGAAGGCATTCCGCCGCAGCAACAGCGTCTCATATTTTCAGGAAAACAAATGAATGATGAGAAGACAGCTCAAGATTACAAAGTTCAGGGAGGTTCAGTACTTCATCTTGTTTTGGCTTTAAGGGGAGGCGAATGA
Protein
MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIFSGKQMNDEKTAQDYKVQGGSVLHLVLALRGGE

Summary

Description
Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme Ubc12. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
Subunit
Covalently attached to cullins.
Similarity
Belongs to the ubiquitin family.
Keywords
Complete proteome   Developmental protein   Isopeptide bond   Nucleus   Reference proteome   Ubl conjugation pathway  
Feature
chain  NEDD8
EMBL
BABH01027782    AGBW02012723    OWR44544.1    DS235778    EEB16877.1    GAIX01006091    + More
JAA86469.1    KC741179    AGM33003.1    KZ149933    PZC77259.1    NWSH01001291    PCG71823.1    KZ288322    PBC28184.1    JR040879    AEY59322.1    KQ971343    EFA04065.1    ABLF02031544    GDKW01002705    JAI53890.1    GBGD01003665    JAC85224.1    ACPB03004743    ACPB03004744    GAHY01002279    JAA75231.1    KK852541    KDR21761.1    GFTR01000964    JAW15462.1    ADTU01016271    GEBQ01019195    JAT20782.1    CH963920    EDW77813.1    GAMD01002425    JAA99165.1    GGFJ01011274    MBW60415.1    JXUM01035313    GAPW01006763    GAPW01006762    KQ561054    JAC06836.1    KXJ79855.1    GGFK01009979    MBW43300.1    ADMH02002093    ETN59309.1    GALA01000372    JAA94480.1    CH477199    EAT48231.1    GANO01003008    JAB56863.1    AK417956    BAN21171.1    GGFM01007458    MBW28209.1    CH940649    EDW64820.1    CVRI01000055    CRL01250.1    AXCN02000870    LJIJ01000314    ODM98876.1    AAAB01008964    EAA12768.3    APCN01002503    DS231840    EDS34570.1    FP017218    EF178472    AL772295    ABO92967.1    CAQ14646.1    GFDG01003163    JAV15636.1    BC076245    AAH76245.1    GFDL01008541    JAV26504.1    BT049348    BT149995    ACI69149.1    AGH92599.1    CH480822    EDW55682.1    GBXM01016131    JAH92446.1    BT046265    ACI66066.1    JN216973    AEM37718.1    CH916368    EDW04086.1    JXJN01003720    BT083291    ACQ58998.1    GDAI01001637    JAI15966.1    CH379060    EAL33960.2    CH479180    EDW29290.1    GCES01152937    JAQ33385.1    GCES01058008    JAR28315.1    AFYH01191437    AFYH01191438    OUUW01000004    SPP79415.1    BC133805    AAI33806.1    AAMC01087944    BC122002    CR848418    AAI22003.1    CAJ82981.1    CM002910    KMY90900.1    AE014134    AHN54584.1    BT024445    CAAE01014542    CAF97715.1    GBSH01001779    JAG67247.1    GDAY02001611    JAV49816.1    GBKD01001422    JAG46196.1    JU175219    AFJ50743.1    AYCK01004988    BT075193    ACO09617.1    GFDF01003137    JAV10947.1    HAEG01003423    SBR69204.1    HAEE01006261    SBR26281.1    HAEI01005446    SBR93339.1    HADZ01010556    HAEA01009625    SBQ38105.1    HADY01008820    HAEJ01013058    SBS53515.1    BT047038    ACI66839.1    HAEB01002941    HAEC01008856    SBQ77072.1    CM000158    EDW90341.1    CH954179    EDV54729.1   
Pfam
PF00240   ubiquitin
Interpro
IPR029071   Ubiquitin-like_domsf        + More
IPR038738   Nedd8-like       
IPR019954   Ubiquitin_CS       
IPR000626   Ubiquitin_dom       
IPR019956   Ubiquitin       
SUPFAM
SSF54236   SSF54236       
PDB
4HCP     E-value=9.15054e-23,     Score=257

Ontologies

Topology

Subcellular location
Nucleus   Mainly nuclear.   With evidence from 1 publications.
Length:
77
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00245
Exp number, first 60 AAs:
0.0003
Total prob of N-in:
0.29002
outside
1  -  77
 
 

Population Genetic Test Statistics

Pi
19.072047
Theta
57.505536
Tajima's D
-1.65361
CLR
880.945327
CSRT
0.0438978051097445
Interpretation
Possibly Positive selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
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