Gene

KWMTBOMO02115  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007334

Annotation

putative_NEDD8_precursor_[Danaus_plexippus]

Location

Bomo_Chr4(-):12444413-12445212      View in EpiBrowser

Full name

NEDD8      

Alternative Name

Neddylin
Ubiquitin-like protein Nedd8

Location in the cell

Cytoplasmic   Reliability : 1.281 Mitochondrial   Reliability : 1.004 Nuclear   Reliability : 1.506

CDS

ATGTTGATTAAAGTCAAGACGCTTACTGGTAAAGAAATTGAAATAGATATAGAACCCACCGACAAAGTGGAAAGAATCAAAGAAAGAGTAGAAGAAAAGGAAGGCATTCCGCCGCAGCAACAGCGTCTCATATTTTCAGGAAAACAAATGAATGATGAGAAGACAGCTCAAGATTACAAAGTTCAGGGAGGTTCAGTACTTCATCTTGTTTTGGCTTTAAGGGGAGGCGAATGA

Protein

MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIFSGKQMNDEKTAQDYKVQGGSVLHLVLALRGGE

Description

Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme Ubc12. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

Subunit

Covalently attached to cullins.

Similarity

Belongs to the ubiquitin family.

Keywords

Complete proteome   Developmental protein   Isopeptide bond   Nucleus   Reference proteome   Ubl conjugation pathway  

Feature

chain  NEDD8

Uniprot

H9JCT7   A0A212ESW7   E0VU21   S4P857   R4V541   A0A2W1BQB3   + More
A0A2A4JK69   K7J7I0   A0A2A3E9N1   V9IF73   A0A088A321   D6WL56   A0A1W4WES4   J9K6H7   A0A0P4VHF5   A0A069DV91   R4FL16   A0A067RD15   A0A224Y317   A0A158NI45   A0A1B6LAP1   B4MZM8   T1DNZ5   A0A2M4C5A3   A0A182NXB5   A0A023EDB2   A0A2M4ARA0   W5J935   T1DFZ4   Q17NI5   U5ESY7   R4WQJ5   A0A2M3ZI70   B4LSJ8   A0A1J1INB9   A0A182QPK7   A0A1D2N0R3   Q7Q3J6   A0A182IG44   A0A182FWW9   B0W504   B0R023   A0A1L8EAK2   Q6DGU4   A0A1Q3FG27   A0A1S3SDT9   A0A182V579   A0A182L256   B5XE79   A0A3P8TSK8   H2RUL2   B4I5M6   A0A0E9WQ96   B5X5E6   G1FKL5   B4JBY3   A0A1W4VXW6   A0A1B0AUR8   C3KK26   A0A0K8TP95   Q29LT5   B4G7F7   A0A146NPN0   A0A146WH92   H3A9S2   A0A3B0JBK2   G3PMC3   A3KNF0   Q28E73   A0A1S3DU76   A0A0J9TQZ0   X2J935   Q9VJ33   Q4SNR7   H3CR82   A0A0B8RX15   A0A1W7RF99   A0A0K8RYZ5   J3S959   A0A3B1JL70   A0A3B1IJ25   A0A3B3YIE0   A0A087YFD0   A0A3B3UNR2   A0A3P9QEH4   C1BKR4   A0A1S3KDM3   A0A1I8Q3G4   A0A1L8DWV1   A0A1A8NK04   A0A1A8K215   A0A1A8QJR2   A0A1A8DUT5   A0A1A8UZK2   A0A3P9LXQ9   B5X7L9   A0A1A8H196   A0A3B3SAT8   B4PAD3   B3NL79  

Pubmed

19121390    22118469    20566863    23622113    28756777    20075255    + More
18362917    19820115    27129103    26334808    24845553    21347285    17994087    24945155    26483478    20920257    23761445    24330624    17510324    23691247    27289101    12364791    14747013    17210077    23594743    20966253    20433749    21551351    25613341    26369729    15632085    9215903    20431018    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12231629    15843622    16127432    15496914    25476704    26358130    25727380    23025625    25329095    17554307    29240929    17550304   

EMBL

BABH01027782    AGBW02012723    OWR44544.1    DS235778    EEB16877.1    GAIX01006091    + More
JAA86469.1    KC741179    AGM33003.1    KZ149933    PZC77259.1    NWSH01001291    PCG71823.1    KZ288322    PBC28184.1    JR040879    AEY59322.1    KQ971343    EFA04065.1    ABLF02031544    GDKW01002705    JAI53890.1    GBGD01003665    JAC85224.1    ACPB03004743    ACPB03004744    GAHY01002279    JAA75231.1    KK852541    KDR21761.1    GFTR01000964    JAW15462.1    ADTU01016271    GEBQ01019195    JAT20782.1    CH963920    EDW77813.1    GAMD01002425    JAA99165.1    GGFJ01011274    MBW60415.1    JXUM01035313    GAPW01006763    GAPW01006762    KQ561054    JAC06836.1    KXJ79855.1    GGFK01009979    MBW43300.1    ADMH02002093    ETN59309.1    GALA01000372    JAA94480.1    CH477199    EAT48231.1    GANO01003008    JAB56863.1    AK417956    BAN21171.1    GGFM01007458    MBW28209.1    CH940649    EDW64820.1    CVRI01000055    CRL01250.1    AXCN02000870    LJIJ01000314    ODM98876.1    AAAB01008964    EAA12768.3    APCN01002503    DS231840    EDS34570.1    FP017218    EF178472    AL772295    ABO92967.1    CAQ14646.1    GFDG01003163    JAV15636.1    BC076245    AAH76245.1    GFDL01008541    JAV26504.1    BT049348    BT149995    ACI69149.1    AGH92599.1    CH480822    EDW55682.1    GBXM01016131    JAH92446.1    BT046265    ACI66066.1    JN216973    AEM37718.1    CH916368    EDW04086.1    JXJN01003720    BT083291    ACQ58998.1    GDAI01001637    JAI15966.1    CH379060    EAL33960.2    CH479180    EDW29290.1    GCES01152937    JAQ33385.1    GCES01058008    JAR28315.1    AFYH01191437    AFYH01191438    OUUW01000004    SPP79415.1    BC133805    AAI33806.1    AAMC01087944    BC122002    CR848418    AAI22003.1    CAJ82981.1    CM002910    KMY90900.1    AE014134    AHN54584.1    BT024445    CAAE01014542    CAF97715.1    GBSH01001779    JAG67247.1    GDAY02001611    JAV49816.1    GBKD01001422    JAG46196.1    JU175219    AFJ50743.1    AYCK01004988    BT075193    ACO09617.1    GFDF01003137    JAV10947.1    HAEG01003423    SBR69204.1    HAEE01006261    SBR26281.1    HAEI01005446    SBR93339.1    HADZ01010556    HAEA01009625    SBQ38105.1    HADY01008820    HAEJ01013058    SBS53515.1    BT047038    ACI66839.1    HAEB01002941    HAEC01008856    SBQ77072.1    CM000158    EDW90341.1    CH954179    EDV54729.1   

Proteomes

UP000005204    UP000007151    UP000009046    UP000218220    UP000002358    UP000242457    + More
UP000005203    UP000007266    UP000192223    UP000007819    UP000015103    UP000027135    UP000005205    UP000007798    UP000075884    UP000069940    UP000249989    UP000000673    UP000008820    UP000008792    UP000183832    UP000075886    UP000094527    UP000007062    UP000075840    UP000069272    UP000002320    UP000000437    UP000087266    UP000075903    UP000075882    UP000265080    UP000005226    UP000001292    UP000001070    UP000192221    UP000092460    UP000001819    UP000008744    UP000008672    UP000268350    UP000007635    UP000008143    UP000079169    UP000000803    UP000007303    UP000018467    UP000261480    UP000028760    UP000261500    UP000242638    UP000085678    UP000095300    UP000265180    UP000265200    UP000261540    UP000002282    UP000008711   

PRIDE

H9JCT7    Q9VJ33   

Pfam

PF00240   ubiquitin

Interpro

IPR029071   Ubiquitin-like_domsf        + More
IPR038738   Nedd8-like       
IPR019954   Ubiquitin_CS       
IPR000626   Ubiquitin_dom       
IPR019956   Ubiquitin       

SUPFAM

SSF54236   SSF54236       

CDD

cd01806  Nedd8

ProteinModelPortal

H9JCT7   A0A212ESW7   E0VU21   S4P857   R4V541   A0A2W1BQB3   + More
A0A2A4JK69   K7J7I0   A0A2A3E9N1   V9IF73   A0A088A321   D6WL56   A0A1W4WES4   J9K6H7   A0A0P4VHF5   A0A069DV91   R4FL16   A0A067RD15   A0A224Y317   A0A158NI45   A0A1B6LAP1   B4MZM8   T1DNZ5   A0A2M4C5A3   A0A182NXB5   A0A023EDB2   A0A2M4ARA0   W5J935   T1DFZ4   Q17NI5   U5ESY7   R4WQJ5   A0A2M3ZI70   B4LSJ8   A0A1J1INB9   A0A182QPK7   A0A1D2N0R3   Q7Q3J6   A0A182IG44   A0A182FWW9   B0W504   B0R023   A0A1L8EAK2   Q6DGU4   A0A1Q3FG27   A0A1S3SDT9   A0A182V579   A0A182L256   B5XE79   A0A3P8TSK8   H2RUL2   B4I5M6   A0A0E9WQ96   B5X5E6   G1FKL5   B4JBY3   A0A1W4VXW6   A0A1B0AUR8   C3KK26   A0A0K8TP95   Q29LT5   B4G7F7   A0A146NPN0   A0A146WH92   H3A9S2   A0A3B0JBK2   G3PMC3   A3KNF0   Q28E73   A0A1S3DU76   A0A0J9TQZ0   X2J935   Q9VJ33   Q4SNR7   H3CR82   A0A0B8RX15   A0A1W7RF99   A0A0K8RYZ5   J3S959   A0A3B1JL70   A0A3B1IJ25   A0A3B3YIE0   A0A087YFD0   A0A3B3UNR2   A0A3P9QEH4   C1BKR4   A0A1S3KDM3   A0A1I8Q3G4   A0A1L8DWV1   A0A1A8NK04   A0A1A8K215   A0A1A8QJR2   A0A1A8DUT5   A0A1A8UZK2   A0A3P9LXQ9   B5X7L9   A0A1A8H196   A0A3B3SAT8   B4PAD3   B3NL79  

PDB

4HCP     E-value=9.15054e-23,     Score=257

KEGG

101744114    K12158 ubiquitin-like protein Nedd8 | (RefSeq) NEDD8

GO

GO:0030162   GO:0045116   GO:0031625   GO:0005634   GO:0005737   GO:0031386   GO:0019941   GO:0030431   GO:2000736   GO:0036099   GO:0008283   GO:0031647   GO:0008589   GO:0051438   GO:0007275   GO:0005515   GO:0030150   GO:0006355   GO:0009072   GO:0003824   GO:0006520   GO:0008483   GO:0006418   GO:0016507   GO:0048384  

Subcellular location

Nucleus   Mainly nuclear.   With evidence from 1 publications.

Length:

77

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00245

Exp number, first 60 AAs:

0.0003

Total prob of N-in:

0.29002

outside

1  -  77

 

 

Pi

19.072047

Theta

57.505536

Tajima's D

-1.65361

CLR

880.945327

CSRT

0.0438978051097445

Interpretation

Possibly Positive selection