Gene

KWMTBOMO02111

Annotation

Transmembrane_protein_231_[Papilio_xuthus]

Location

Bomo_Chr4(+):12380113-12382214      View in EpiBrowser

Full name

Transmembrane protein 231      

Location in the cell

Extracellular   Reliability : 1.429

CDS

ATGCAGGTTCAAGAAAATGATTTCACTGGAGATGGCAAAAAGGATGAGCTGTATATTAAATTTCACCTAAATATACCACCAGACAGAACTGTGTCTTCTATTTTATTAATTTTATCTCTTGATTTTCAGCTGAAGACAATATGCCCTTTACAAATGCAGAGCTTGGCATTGATTACCAAAGAGTTTGTAATACCACCATCAGAATTAATTTTTCATGGAGATCTAAATTTTTATCAAACCACCCACTTACCTTGTGAATGGTTTAATCAAGATACGAAATATAACAGATCTTTATTTGAAATTGAAAAATGGGAAAGTTACATGTCTATTGATCATTATCTGTCTGATTATTTTCATAGAGAAGTTACCACAGAAGTCAGAACGATAAATTCTAGAACCTACAATGGCCAGACAGATTCTATGACTGTTCAAGTTCATCTAAGAATTCCAGAGATGCAAATAAGATACACTCCTAGTATACTAGAAGAGTTTAAGTGGGCTTGGCCTCAATATCTCTCTTTTGTAGTGATATTCCATTGGTTCTTCAATAAAGTTAAGGAATTTATATTTACCAATCGACTTCTCATGTCATGGAAAGTACAATCTTGGAAAACATTTGAATGA

Protein

MQVQENDFTGDGKKDELYIKFHLNIPPDRTVSSILLILSLDFQLKTICPLQMQSLALITKEFVIPPSELIFHGDLNFYQTTHLPCEWFNQDTKYNRSLFEIEKWESYMSIDHYLSDYFHREVTTEVRTINSRTYNGQTDSMTVQVHLRIPEMQIRYTPSILEEFKWAWPQYLSFVVIFHWFFNKVKEFIFTNRLLMSWKVQSWKTFE

Description

Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).

Subunit

Part of the tectonic-like complex (also named B9 complex) (PubMed:22179047). Interacts with TMEM107 (By similarity).
Part of the tectonic-like complex (also named B9 complex).
Part of the tectonic-like complex (also named B9 complex). Interacts with TMEM107.

Similarity

Belongs to the TMEM231 family.

Keywords

Cell membrane   Cell projection   Cilium   Complete proteome   Glycoprotein   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Alternative splicing   Ciliopathy   Disease mutation   Joubert syndrome   Meckel syndrome   Polymorphism  

Feature

chain  Transmembrane protein 231
splice variant  In isoform 3.
sequence variant  In dbSNP:rs3743601.

Uniprot

A0A2H1V3D2   A0A2W1BZL1   A0A2A4JJQ7   A0A194PUB6   Q3U284   I3MLP7   + More
F7B645   H2NRI6   A0A1S3A0Y6   A0A2K5LX09   K7FVD6   A0A2K5IXH4   A0A0D9QUK7   G7Q1N6   A0A2K5WVY5   H9EWK5   G7NR28   Q5FVM1   A0A2I2ZLG0   A0A2K6CDA5   A0A1U7UJS3   G5B5Y2   A0A2K5LWZ8   G3R9B3   G1RRG1   A0A2Y9K268   A0A2K5IWU2   A0A1D5RHD2   A0A2K5WVV2   A0A2K6L761   F1S455   Q5RBT8   A0A2K6CDA2   A0A2U3WUV9   A0A3B4E5K2   Q9H6L2   A0A2U3YI50   A0A2R9BYB0   K7ABC8   Q9H6L2-2   A0A384A637   A0A384BZI8   J9JSC6   G3U6D9   A0A2R9BYA1   H2RAT2   M3WT08   A0A2K6L718   A0A2Y9F8X1   G1LFT6   G3I4N6   G3VBH6   A0A2K6R7L8   A0A1U7QRF4   A0A340XS07   G1PMS9   A0A1S3MMS7   E2BKM4   A0A2Y9E7S7   G1SVQ5   A0A341ANX5   A0A2Y9P0S4   A7MB75   A0A2U3V088   A0A3B4ZCQ5   A0A2K6UTG7   W5PA73   A0A1B6CZK0   A0A2R8MMG1   A0A1A8EIP5   A0A1A8KWZ9   A0A1A8VDA7   A0A1A8QW84   A0A1A8MZ35   F1NNL1   A0A3P9A030   A0A3B5KIZ9   W5K2I9   A0A2Y9I8H6   A0A1A8GAT5   A0A1E1XGG4   A0A091CQ42   A0A1A8C765   Q7T316   A0A2J7QXK1   A0A0C9RRA0   A0A099ZY94   A0A2S2P2P6   A0A2I0M2E3   A0A2C9K0K3   A0A3P8NV07   A0A2H8TMR8   F4WIK3   H2ZUF6   H0ZDQ3   W5M5C6   K1QNN7   A0A286XGR8   A0A195F497  

Pubmed

28756777    26354079    16141072    15489334    22179047    20431018    + More
17381049    22002653    17431167    25319552    21993625    12975309    14702039    15616553    26595381    23012439    23349226    26477546    22722832    16136131    17975172    20010809    21804562    21709235    25362486    21993624    20798317    20809919    15592404    25069045    21551351    25329095    28503490    23594743    26131772    23371554    15562597    21719571    9215903    20360741    22992520   

EMBL

ODYU01000329    SOQ34882.1    KZ149933    PZC77263.1    NWSH01001190    PCG72201.1    + More
KQ459598    KPI94730.1    AK155425    BC100402    BC132428    BC132430    AGTP01010138    AAMC01039122    BC158962    ABGA01058223    AGCU01073933    AQIB01129775    AQIB01129776    CM001295    EHH60574.1    AQIA01043659    AQIA01043660    AQIA01043661    JSUE03026652    JSUE03026653    JSUE03026654    JU323008    JU477197    AFE66764.1    AFH34001.1    CM001272    EHH31859.1    BC089891    CABD030102203    CABD030102204    JH168604    EHB04693.1    ADFV01188582    ADFV01188583    AEMK02000039    CR858545    AY358612    AK025820    AK096650    AK290483    AC009163    AC025287    CH471114    BC010609    BC016401    BC063677    AJFE02103966    AJFE02103967    AACZ04039447    GABC01007755    GABF01007009    GABD01005457    JAA03583.1    JAA15136.1    JAA27643.1    ABLF02034922    AANG04002512    ACTA01003555    JH001261    EGW12978.1    AEFK01034667    AAPE02014532    GL448819    EFN83722.1    AAGW02055349    BC151375    AMGL01026904    AMGL01026905    GEDC01018565    JAS18733.1    HAEA01016474    SBQ44955.1    HAED01019730    HAEE01016119    SBR36169.1    HADY01018715    HAEJ01016726    SBS57183.1    HAEH01013590    HAEI01013651    SBR97782.1    HAEF01020687    HAEG01007902    SBR61846.1    AADN02054203    HAEB01019333    HAEC01000220    SBQ68297.1    GFAC01000860    JAT98328.1    KN124425    KFO21224.1    HADZ01010619    SBP74560.1    BX890570    BC053293    NEVH01009379    PNF33317.1    GBZX01003019    JAG89721.1    KL870252    KGL87249.1    GGMR01011118    MBY23737.1    AKCR02000046    PKK23847.1    GFXV01003658    MBW15463.1    GL888176    EGI65939.1    AFYH01235257    AFYH01235258    AFYH01235259    AFYH01235260    AFYH01235261    AFYH01235262    AFYH01235263    AFYH01235264    AFYH01235265    ABQF01034962    AHAT01010580    AHAT01010581    AHAT01010582    AHAT01010583    AHAT01010584    JH816014    EKC23161.1    AAKN02026360    KQ981820    KYN35288.1   

Proteomes

UP000218220    UP000053268    UP000000589    UP000005215    UP000008143    UP000001595    + More
UP000079721    UP000233060    UP000007267    UP000233080    UP000029965    UP000009130    UP000233100    UP000006718    UP000002494    UP000001519    UP000233120    UP000189704    UP000006813    UP000001073    UP000248482    UP000233180    UP000008227    UP000245340    UP000261440    UP000005640    UP000245341    UP000240080    UP000002277    UP000261680    UP000007819    UP000007646    UP000011712    UP000248484    UP000008912    UP000001075    UP000007648    UP000233200    UP000189706    UP000265300    UP000001074    UP000087266    UP000008237    UP000248480    UP000001811    UP000252040    UP000248483    UP000009136    UP000245320    UP000261400    UP000233220    UP000002356    UP000008225    UP000000539    UP000265140    UP000005226    UP000018467    UP000248481    UP000028990    UP000000437    UP000235965    UP000053858    UP000053872    UP000076420    UP000265100    UP000007755    UP000008672    UP000007754    UP000018468    UP000005408    UP000005447    UP000078541   

PRIDE

Q3U284    Q5FVM1    Q9H6L2    G3I4N6    A7MB75    F1NNL1    + More
Q7T316   

Pfam

PF10149   TM231        + More
PF00179   UQ_con

Interpro

IPR019306   TMEM231        + More
IPR000608   UBQ-conjugat_E2       
IPR016135   UBQ-conjugating_enzyme/RWD       

SUPFAM

SSF54495   SSF54495       

Gene 3D

3.10.110.10    

ProteinModelPortal

A0A2H1V3D2   A0A2W1BZL1   A0A2A4JJQ7   A0A194PUB6   Q3U284   I3MLP7   + More
F7B645   H2NRI6   A0A1S3A0Y6   A0A2K5LX09   K7FVD6   A0A2K5IXH4   A0A0D9QUK7   G7Q1N6   A0A2K5WVY5   H9EWK5   G7NR28   Q5FVM1   A0A2I2ZLG0   A0A2K6CDA5   A0A1U7UJS3   G5B5Y2   A0A2K5LWZ8   G3R9B3   G1RRG1   A0A2Y9K268   A0A2K5IWU2   A0A1D5RHD2   A0A2K5WVV2   A0A2K6L761   F1S455   Q5RBT8   A0A2K6CDA2   A0A2U3WUV9   A0A3B4E5K2   Q9H6L2   A0A2U3YI50   A0A2R9BYB0   K7ABC8   Q9H6L2-2   A0A384A637   A0A384BZI8   J9JSC6   G3U6D9   A0A2R9BYA1   H2RAT2   M3WT08   A0A2K6L718   A0A2Y9F8X1   G1LFT6   G3I4N6   G3VBH6   A0A2K6R7L8   A0A1U7QRF4   A0A340XS07   G1PMS9   A0A1S3MMS7   E2BKM4   A0A2Y9E7S7   G1SVQ5   A0A341ANX5   A0A2Y9P0S4   A7MB75   A0A2U3V088   A0A3B4ZCQ5   A0A2K6UTG7   W5PA73   A0A1B6CZK0   A0A2R8MMG1   A0A1A8EIP5   A0A1A8KWZ9   A0A1A8VDA7   A0A1A8QW84   A0A1A8MZ35   F1NNL1   A0A3P9A030   A0A3B5KIZ9   W5K2I9   A0A2Y9I8H6   A0A1A8GAT5   A0A1E1XGG4   A0A091CQ42   A0A1A8C765   Q7T316   A0A2J7QXK1   A0A0C9RRA0   A0A099ZY94   A0A2S2P2P6   A0A2I0M2E3   A0A2C9K0K3   A0A3P8NV07   A0A2H8TMR8   F4WIK3   H2ZUF6   H0ZDQ3   W5M5C6   K1QNN7   A0A286XGR8   A0A195F497  

KEGG

105842308    K19362 transmembrane protein 231 | (RefSeq) transmembrane protein 231

GO

GO:0016021   GO:0001701   GO:0042733   GO:0060271   GO:0036038   GO:0001944   GO:0060170   GO:0043010   GO:0016020   GO:0035869   GO:0032880   GO:0007224   GO:0060563  

PANTHER

PTHR14605  

Subcellular location

  

Length:

207

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

6.55114

Exp number, first 60 AAs:

0.04124

Total prob of N-in:

0.08479

outside

1  -  207

 

 

Pi

341.29305

Theta

231.185862

Tajima's D

1.421403

CLR

0

CSRT

0.766811659417029

Interpretation

Uncertain