Gene

KWMTBOMO02108  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003171

Annotation

PREDICTED:_annulin_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr4(-):12333542-12348412      View in EpiBrowser

Full name

Annulin      

Alternative Name

Protein-glutamine gamma-glutamyltransferase
Transglutaminase

Location in the cell

Cytoplasmic   Reliability : 2.539

CDS

ATGGAAGCACTTAAGAACTGGTGGAGATATTACTTTGGGGGACGCCGTAAATATATTATGGTGCCATTTAAGCCAGATGTGATCGACGGAACGAGACAAGGTGTCTTATCGGTGCAAAACATTGATTTCTGCACCGACATCAATGGAGAACATCACCACACCAGCAGATACAATTTGATGACCAGGGATGAGAAAAAATGTTTAGTTGTCCGTAGAGGACAGCCCTTCACGCTTGATCTGTTGCTCAATAGGGCATATGATCCAGATAAAGACGCTATTTCATTCATCATCTATGTGTCTGATATTGAGAAGCGTGGCCCTTCAGATGGGACGTCCGCAGCTGTGCCTCTGTTGGAAAGAGGCTCTGAAACAGTTGGATTGTGGAGTGCGGTCTATGACAGTCAAGTGGACTCTCATCTCATGGTGTCGGTGACGGCGGCCGCTGACTGCATGGTTGCCGCTTGGAAAGTTGACATTGACACAAAGCTCATTGGAGGTAGCTCATTGAGTTACACTCACCCGTTGCCAATCTACGTATTGTTCAATCCTTGGTGTTTGAATGATTCTGTGTACATGCCAGGTGAGAGTCATAGAGACGAATATGTATTGGAACAAGGAGGACTTATGTTCAGAGGAGTGTACAACATAATTAAGCCGACACCGTGGAACTACGCGCAATTTGAAAAAGATGTCTTAGACTGTGCTCTTTATCTAGTCAGGGAAGTTGGGAAGGTCACAGGAAGCGGTAGAAGTAGCGCCATCCGGACTGCCCGAGCTCTTTCGGCAGCCGTGAACGTGCAAGACGACAACGGTGTGCTATTCGGAAATTGGGGCAAAGAGCTGAGTGATTACGACGGAGGAACGCATCCTTTGAAGTGGGTTGGCTCTCTAGCGATCCTACAGAGGTTTTACGAGAAGAAGAAGCCCGTTAAATACGCCCAATGTTGGGTATACGCCGGAATTTTAACGACAATTTGTCGGGCACTCGGAATTCCCTGCAGGCCGGTAACTGGTTACGATGCAGCTCACGACAGTCAAGGAAGCCTCACGATTGACATAATCATGGACGAGGAAGGAAATACGATGGACGAATTCACTCGAGACTCCGTATGGAACTACCACGTTTGGAATGAAGTATGGATGGAGCGGCCGGATCTGGGCCCCCAATACGGAGGCTGGCAAGCTCTGGATGCTACTCCACAAGAAACATCAGAAGATAAATTCAGGTGCGGGCCGGCTTCGTTGAAAGCCATTTTAGACGGGGAATTGCAGCGGCCATATGATGCTACATACGTATTCGCACAAGTAAACGCTGATAAAATTTTATGGAAATATTCTGGGGAAATTCAACCACTAAAGCTAATGGCACGTGACACCACCTCTATCGGGCAGAATATCTCAACTAAAGCGATTGGAAAAATGGAAAGAGAGGATATCACCGACACATACAAATACCCGGAACGAACGCGCGAAGAGAGAATGACAATGGAAAAAGCGTTGCGCAAATCAGAGAACATCTTCGCTCGGTACTATTTGAACGATGCCTTCAATGACGTCACCTTCGAGTTTGATCTCAGAGACGACATTAAGATCGGACAGGACTTCAGTGTGGTCTTGCATATGAAAAATCGTTCGACGATCAATGAACATCAAGTCAAAGGCACGTTGCGAGTGGACACAGTGACGTACGCCGGCGTCACCGGAGACGGCGTGAAGCGATATGAATTCGACATGAAACTCAAGCCAGAACAGAAAGAGAAAGTGCAGATGCTGGTCACCTTCGACGATTACTTTAAAAAGCTTATTGATCAGGCATCCTTCAACATCGCATGCCTAGTCACGATCGTAGATCGAAAATTCGACTACTTCGCACAGGACGACTTCCGGGTCCGGAATCCTGACATCAAAATAACGATTGACGGCAAACCGGTCTCCCGCCAAGAATTTACCGTTCACATCAAAGTGGAGAATCCCTTGCCTATTCCGTTGAAGAACGGCAAGTTTTATATTCAAGGTCCAGGTTTGGATGAGCAGCTCAGAATTGCATTAGACGAGAACGTGGCACCTGGTACCTTTGCGACTGCTAACTTCAAGCTTACTCCTCCGTGGGCAGGCAGACATCAGATCTCGGCTAAGTTCACATCCAAAGAAATACGGGATATTGACGGATTTCTATCTTTTATTGTGTCAATGCCAGAAACCAACGGAGTGTCTTCTGAAACTGTAGAAACGAGGCAAATCTAA

Protein

MEALKNWWRYYFGGRRKYIMVPFKPDVIDGTRQGVLSVQNIDFCTDINGEHHHTSRYNLMTRDEKKCLVVRRGQPFTLDLLLNRAYDPDKDAISFIIYVSDIEKRGPSDGTSAAVPLLERGSETVGLWSAVYDSQVDSHLMVSVTAAADCMVAAWKVDIDTKLIGGSSLSYTHPLPIYVLFNPWCLNDSVYMPGESHRDEYVLEQGGLMFRGVYNIIKPTPWNYAQFEKDVLDCALYLVREVGKVTGSGRSSAIRTARALSAAVNVQDDNGVLFGNWGKELSDYDGGTHPLKWVGSLAILQRFYEKKKPVKYAQCWVYAGILTTICRALGIPCRPVTGYDAAHDSQGSLTIDIIMDEEGNTMDEFTRDSVWNYHVWNEVWMERPDLGPQYGGWQALDATPQETSEDKFRCGPASLKAILDGELQRPYDATYVFAQVNADKILWKYSGEIQPLKLMARDTTSIGQNISTKAIGKMEREDITDTYKYPERTREERMTMEKALRKSENIFARYYLNDAFNDVTFEFDLRDDIKIGQDFSVVLHMKNRSTINEHQVKGTLRVDTVTYAGVTGDGVKRYEFDMKLKPEQKEKVQMLVTFDDYFKKLIDQASFNIACLVTIVDRKFDYFAQDDFRVRNPDIKITIDGKPVSRQEFTVHIKVENPLPIPLKNGKFYIQGPGLDEQLRIALDENVAPGTFATANFKLTPPWAGRHQISAKFTSKEIRDIDGFLSFIVSMPETNGVSSETVETRQI

Catalytic Activity

L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)

Cofactor

Ca(2+)

Similarity

Belongs to the transglutaminase superfamily. Transglutaminase family.

Keywords

Acyltransferase   Calcium   Cell membrane   Lipoprotein   Membrane   Metal-binding   Palmitate   Transferase  

Feature

chain  Annulin

Uniprot

H9J0Y4   A0A2A4JL80   A0A2A4JKT2   A0A194PN40   A0A2A4JKA1   A0A2W1BUC9   + More
A0A2A4JJD8   A0A0L7KSC2   A0A194QN88   A0A212EST5   A0A2H1VSA9   P52183   A0A067RCU8   A0A2J7QXK3   A0A1B6DQA6   A0A1B6CI98   D6WL51   A0A2P8YFS9   K7J8Z6   A0A1B6M799   A0A182KUQ7   Q7PW40   A0A1B6M4N6   A0A182X2W6   A0A182I4Y7   A0A182TY12   A0A182K7S5   A0A182PDD6   A0A182UNC4   A0A182YFF0   A0A182LWH2   A0A084VCS4   A0A0M9A9S7   A0A182WGZ0   A0A0C9RYG8   A0A182QZR5   A0A0C9RIG5   A0A182NEW6   A0A158NI49   A0A154P4Y1   F4WGC8   A0A195B662   A0A2M4ACY7   A0A195CNX6   E2AVG0   A0A195F074   A0A2M4AD71   A0A195EGS5   A0A182IJX8   A0A1Y1KBJ8   A0A0L7QXF2   W5JD55   A0A182F5H4   A0A1B6HIY8   A0A182R9Q5   A0A3L8D9Q4   A0A151WJI7   W8B3P9   A0A026WTI4   Q173Z9   W8C204   A0A1Q3FPS5   A0A0A1XKR6   A0A310SS45   A0A0K8U871   B0W8U9   A0A0T6BAH3   A0A0K8WE79   A0A034WQ72   A0A034WR17   A0A0J7KXA7   A0A1A9V6X9   A0A0L0CI74   A0A336MX03   A0A1A9WAJ9   A0A336LKB0   A0A1I8MF41   A0A0M4EB93   A0A1I8NU25   A0A0P4WTV7   A0A0P5W5M8   A0A0P4WPG6   Q8IPH0   A0A0P5UIH6   A0A0P4ZPC3   A0A0N8DE14   Q9VLU2   A0A1B0G6K5   A0A1I8MF31   B4KEB5   D0IQ93   A0A1W4VWJ9   B4LSK9   A0A0J9QY62   A0A0P5C4R2   A0A1D2NF26   A0A0P5KEW0   A0A0J9QXR5   A0A1W4W7J7   A0A0Q9WNF6  

Pubmed

19121390    26354079    28756777    26227816    22118469    1358727    + More
24845553    18362917    19820115    29403074    20075255    20966253    12364791    25244985    24438588    21347285    21719571    20798317    28004739    20920257    23761445    30249741    24495485    24508170    17510324    25830018    25348373    26108605    25315136    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17994087    22936249    27289101   

EMBL

BABH01010460    NWSH01001190    PCG72203.1    PCG72204.1    KQ459598    KPI94732.1    + More
PCG72206.1    KZ149933    PZC77265.1    PCG72205.1    JTDY01006433    KOB66015.1    KQ461196    KPJ06440.1    AGBW02012723    OWR44550.1    ODYU01004158    SOQ43725.1    M92291    KK852720    KDR17765.1    NEVH01009379    PNF33323.1    GEDC01009505    JAS27793.1    GEDC01024129    JAS13169.1    KQ971343    EFA03507.1    PYGN01000636    PSN43044.1    GEBQ01008196    JAT31781.1    AAAB01008984    EAA14718.2    GEBQ01009091    JAT30886.1    APCN01003737    AXCM01003519    ATLV01010846    KE524620    KFB35768.1    KQ435719    KOX78769.1    GBYB01013016    JAG82783.1    AXCN02000839    GBYB01013017    JAG82784.1    ADTU01016274    ADTU01016275    KQ434809    KZC06374.1    GL888128    EGI66895.1    KQ976579    KYM79996.1    GGFK01005318    MBW38639.1    KQ977481    KYN02438.1    GL443093    EFN62579.1    KQ981897    KYN33756.1    GGFK01005379    MBW38700.1    KQ978957    KYN27084.1    GEZM01088908    JAV57838.1    KQ414704    KOC63297.1    ADMH02001866    ETN60754.1    GECU01033042    JAS74664.1    QOIP01000011    RLU17074.1    KQ983039    KYQ48006.1    GAMC01010800    JAB95755.1    KK107111    EZA58976.1    CH477415    EAT41371.1    GAMC01010801    GAMC01010799    JAB95754.1    GFDL01005569    JAV29476.1    GBXI01002696    JAD11596.1    KQ761039    OAD58352.1    GDHF01029541    JAI22773.1    DS231860    EDS39328.1    LJIG01002619    KRT84321.1    GDHF01003154    JAI49160.1    GAKP01002183    JAC56769.1    GAKP01002185    JAC56767.1    LBMM01002376    KMQ94909.1    JRES01000438    KNC31199.1    UFQT01003367    SSX34922.1    UFQT01000037    SSX18380.1    CP012523    ALC38660.1    GDIP01253212    JAI70189.1    GDIP01090886    JAM12829.1    GDIP01254458    JAI68943.1    AE014134    AAN10650.1    GDIP01116572    JAL87142.1    GDIP01213724    JAJ09678.1    GDIP01202012    GDIP01042935    LRGB01000868    JAM60780.1    KZS15584.1    BT010024    AAF52590.2    AAQ22493.1    CCAG010018450    CH933807    EDW12883.1    BT100131    ACX94156.1    CH940649    EDW64831.1    CM002910    KMY88898.1    GDIP01179826    JAJ43576.1    LJIJ01000061    ODN03854.1    GDIQ01191689    GDIQ01191688    JAK60037.1    KMY88897.1    KRF81888.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000037510    UP000053240    UP000007151    + More
UP000027135    UP000235965    UP000007266    UP000245037    UP000002358    UP000075882    UP000007062    UP000076407    UP000075840    UP000075902    UP000075881    UP000075885    UP000075903    UP000076408    UP000075883    UP000030765    UP000053105    UP000075920    UP000075886    UP000075884    UP000005205    UP000076502    UP000007755    UP000078540    UP000078542    UP000000311    UP000078541    UP000078492    UP000075880    UP000053825    UP000000673    UP000069272    UP000075900    UP000279307    UP000075809    UP000053097    UP000008820    UP000002320    UP000036403    UP000078200    UP000037069    UP000091820    UP000095301    UP000092553    UP000095300    UP000000803    UP000076858    UP000092444    UP000009192    UP000192221    UP000008792    UP000094527   

PRIDE

H9J0Y4    P52183    Q8IPH0    Q9VLU2    D0IQ93   

Pfam

PF00868   Transglut_N        + More
PF01841   Transglut_core
PF00927   Transglut_C

Interpro

IPR036985   Transglutaminase-like_sf        + More
IPR001102   Transglutaminase_N       
IPR008958   Transglutaminase_C       
IPR036238   Transglutaminase_C_sf       
IPR002931   Transglutaminase-like       
IPR038765   Papain-like_cys_pep_sf       
IPR013783   Ig-like_fold       
IPR023608   Transglutaminase_animal       
IPR014756   Ig_E-set       
IPR013808   Transglutaminase_AS       
IPR028565   MHD       

SUPFAM

SSF49309   SSF49309        + More
SSF81296   SSF81296       
SSF54001   SSF54001       

Gene 3D

2.60.40.10     3.90.260.10    

ProteinModelPortal

H9J0Y4   A0A2A4JL80   A0A2A4JKT2   A0A194PN40   A0A2A4JKA1   A0A2W1BUC9   + More
A0A2A4JJD8   A0A0L7KSC2   A0A194QN88   A0A212EST5   A0A2H1VSA9   P52183   A0A067RCU8   A0A2J7QXK3   A0A1B6DQA6   A0A1B6CI98   D6WL51   A0A2P8YFS9   K7J8Z6   A0A1B6M799   A0A182KUQ7   Q7PW40   A0A1B6M4N6   A0A182X2W6   A0A182I4Y7   A0A182TY12   A0A182K7S5   A0A182PDD6   A0A182UNC4   A0A182YFF0   A0A182LWH2   A0A084VCS4   A0A0M9A9S7   A0A182WGZ0   A0A0C9RYG8   A0A182QZR5   A0A0C9RIG5   A0A182NEW6   A0A158NI49   A0A154P4Y1   F4WGC8   A0A195B662   A0A2M4ACY7   A0A195CNX6   E2AVG0   A0A195F074   A0A2M4AD71   A0A195EGS5   A0A182IJX8   A0A1Y1KBJ8   A0A0L7QXF2   W5JD55   A0A182F5H4   A0A1B6HIY8   A0A182R9Q5   A0A3L8D9Q4   A0A151WJI7   W8B3P9   A0A026WTI4   Q173Z9   W8C204   A0A1Q3FPS5   A0A0A1XKR6   A0A310SS45   A0A0K8U871   B0W8U9   A0A0T6BAH3   A0A0K8WE79   A0A034WQ72   A0A034WR17   A0A0J7KXA7   A0A1A9V6X9   A0A0L0CI74   A0A336MX03   A0A1A9WAJ9   A0A336LKB0   A0A1I8MF41   A0A0M4EB93   A0A1I8NU25   A0A0P4WTV7   A0A0P5W5M8   A0A0P4WPG6   Q8IPH0   A0A0P5UIH6   A0A0P4ZPC3   A0A0N8DE14   Q9VLU2   A0A1B0G6K5   A0A1I8MF31   B4KEB5   D0IQ93   A0A1W4VWJ9   B4LSK9   A0A0J9QY62   A0A0P5C4R2   A0A1D2NF26   A0A0P5KEW0   A0A0J9QXR5   A0A1W4W7J7   A0A0Q9WNF6  

PDB

3S3S     E-value=4.39672e-109,     Score=1011

KEGG

101738407    K05619 transglutaminase 1 [EC:2.3.2.13] | (RefSeq) annulin

GO

GO:0046872   GO:0003810   GO:0018149   GO:0005886   GO:0008233   GO:0045087   GO:0042381   GO:0006355   GO:0009072   GO:0003824   GO:0006520   GO:0008483   GO:0006418   GO:0016507   GO:0048384  

Subcellular location

Cell membrane  

Length:

747

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.21713

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01083

outside

1  -  747

 

 

Pi

176.803089

Theta

164.150695

Tajima's D

0.220402

CLR

0.900319

CSRT

0.429978501074946

Interpretation

Uncertain