Gene

KWMTBOMO02107

Pre Gene Modal

BGIBMGA002996

Annotation

PREDICTED:_protein_tilB_homolog_[Amyelois_transitella]

Location

Bomo_Chr4(+):12331643-12333070      View in EpiBrowser

Full name

Protein tilB       + More
Protein tilB homolog      

Alternative Name

Touch insensitive larva B protein
Leucine-rich repeat-containing 6-like protein
Leucine-rich repeat-containing protein 6
Seahorse

Location in the cell

Nuclear   Reliability : 2.799

CDS

ATGGTGAGAATCACTGTTGAATTAGTACGAAAAAAAGCTGAGCATCACGACTGCCTGCTGGCACCATTAGAAGAAATTGCACTCCATCAAGAAAATATCGAGAAAATTGAATTTCTACAAGATTGGTGCCCTAAATTAAAAATACTGCTAATGCAGAGCAATCTCATAGCAAAAATAGAAAACTTGAACAAACTAAAGAATCTTGTGTACCTTAATTTAGCTTTGAACAACATCGAGGTCATAGAAAACTTAGAACGATGCGAATCGCTGCGTAAGTTAGACCTTACACTGAATTTTATTGGTGATATTGTGAGCGTTGAAACACTTATGGGCAACTATAGTCTTGAAAGTTTATATTTAACTGGCAACCCTTGCACCGATTACGATAACTACAAGAACTTCGTAATCGGAACCCTACCCCAGCTAACCAGCTTGGACGGCAAAGATATTGAAAGATCCGAGAGGATCATGGCCTTACAAAACCTTCCCTTCATACGCTCTGATATAGTATTCGAACAAGAAAATTATCGACAGCAACGTAGAAAACAAAAATCTCGATTGGAAAAAACTATCAAAGACAAATGGGAAAATGAATATAAAGACATGGACCCGGAGGAAAGAAACAAAAAATTCTGGGCCGAAAAATGTGAGCATGCTCCAGAAGTTCGTTACGAAATTGAAAAAATGCGTAAGCTGAAACTAAAGAGCTACGAAACGGAAACAGAACAAGAAGAAAAACGAACTTACAAACTATTCGCTCCAGACGGTAGACCGTTTAATATTAACCAAGCAAAGATCAATTTTGTTTTCGACGACTCTGGCCCAAGCTATGTCTTGGATTTAGCAGTTTACAAACACTTAGATACTAGTTTACTCGATGTTGATGTCCAAGCTCATTACGTGAGAGTCACTATAAAAAACAAAATATTCCAAATTCAACTCCCACAAGAAGTGGACATAACTAATTCTTCAGCTCAACGATCTGAAATCACCGGGCATTTGGTGATAACAATGCCAAAAAGTAACGCTTGCATTATAAGTAGAGCGAAAAAAAAGGAAACTGCCGAAAAAGCCCAAGCGAAGTCCAAATCGAAAGTAACTGAATACCTCCGATCGGGACAGACTAAAAGAGAATTTCTTGAAATTGGACCAGCTGACGATGTTTTAGATTTCACAAACATGACCCGACCGAAGTCGACACCGGCTGCCATTGATCCAAGATTGTATGCAAGTGAAAAGAAGCCATCAGCCGATTTTGTTGACAATCCTGAAGTACCACATCTCATTTAA

Protein

MVRITVELVRKKAEHHDCLLAPLEEIALHQENIEKIEFLQDWCPKLKILLMQSNLIAKIENLNKLKNLVYLNLALNNIEVIENLERCESLRKLDLTLNFIGDIVSVETLMGNYSLESLYLTGNPCTDYDNYKNFVIGTLPQLTSLDGKDIERSERIMALQNLPFIRSDIVFEQENYRQQRRKQKSRLEKTIKDKWENEYKDMDPEERNKKFWAEKCEHAPEVRYEIEKMRKLKLKSYETETEQEEKRTYKLFAPDGRPFNINQAKINFVFDDSGPSYVLDLAVYKHLDTSLLDVDVQAHYVRVTIKNKIFQIQLPQEVDITNSSAQRSEITGHLVITMPKSNACIISRAKKKETAEKAQAKSKSKVTEYLRSGQTKREFLEIGPADDVLDFTNMTRPKSTPAAIDPRLYASEKKPSADFVDNPEVPHLI

Description

Cilium-specific protein required for cilia structures in Johnston's sensory organ. Plays a role in motility of cilia and flagella.
Plays a crucial role in regulating cilia motility in pronephric tubules, cloaca and neural tube. Required for establishing left-right asymmetry of the body plan; controls cell fate and convergent extension (CE) movements during gastrulation, respectively, via the Wnt and the planar cell polarity (PCP) signaling pathways. Required for the proper development of renal glomeruli and tubules.

Subunit

Interacts with dvl2 (PubMed:18539122, PubMed:19395640). Interacts with kur (PubMed:26904945).

Miscellaneous

Mutants show development of polycystic kidney disease and left-right (LR) asymmetry defects.

Similarity

Belongs to the tilB family.

Keywords

Cell projection   Cilium   Coiled coil   Complete proteome   Cytoplasm   Flagellum   Leucine-rich repeat   Reference proteome   Repeat  

Feature

chain  Protein tilB

Uniprot

H9J0F9   A0A2H1WF24   A0A2A4JJG6   A0A2W1BX60   A0A194QSC2   A0A0L7KSG8   + More
A0A194PP24   A0A212ESX5   A0A1B6MIK3   A0A067R9R3   A0A2T7NP80   A0A0A1XI82   W8BK96   A0A2C9M8H7   A0A0K8TWF8   A0A0K8WBD2   A0A0K8W6T6   N6SVA6   A0A1B0GJ85   B4PZ66   A0A0M4EUL4   A0A3B0JWQ4   A0A146M7U7   A0A3B0J7K0   A0A1W4VWN3   A0A182JCE8   A0A1W4W8L3   B3NY64   A0A146LCK8   A0A1S4GZN0   Q9VR52   B5DKI7   B4H399   A0A1B0DDS5   A0A336MHC9   A0A0Q9WCM8   B4M381   A0A182LMS6   A0A3M7RD39   A0A182UUB6   A0A1J1I100   E9I8F1   A0A182QFW7   A0A1B0G2P7   A0A0J7P591   B4NUV6   A0A182SGZ7   A0A1A9VRL4   W5J7S8   B4JWR5   Q7PWL0   A0A182TH17   B4N232   A0A1A9X8S9   Q17C36   B0W4S4   A0A182K1X2   A0A267FIT2   A0A151X2J1   B3DH20   A0A1A9WCC2   A0A1I8GGT6   A0A182RI66   A0A336MWB3   A7RJB1   A0A2R7WGY7   A0A0R3W4V8   A0A267E0M1   A0A195EZK2   A0A1Q3FTA2   B4L2V3   A0A182GAD9   C4QU59   D6WHE0   F1Q7C0   A0A2M4CQN3   A0A3Q0KKB4   A0A1W4XTJ2   A0A182LTD3   A0A1I8MFE6   A0A1V4KV39   A0A2P8Y373   A0A3L8TAC0   A0A195DFC7   A0A026X3H5   A0A1D5PLA5   A0A0A9W704   A0A0X3PCN4   R7V356   H2Z730   A0A1L8G016   A0A182I7D0   A0A0A9ZJS2   A0A182XNS4   A0A182FNC7   A0A182Y0D5   V3ZR69   A0A232FLT1   A0A154PM45   A0A1V4KVB7  

Pubmed

19121390    28756777    26354079    26227816    22118469    24845553    + More
25830018    24495485    15562597    23537049    17994087    17550304    26823975    12364791    10731132    12537572    20215474    15632085    20966253    30375419    21282665    20920257    23761445    17510324    15269167    17606911    18539122    19395640    26904945    26392545    17615350    26483478    22253936    18362917    19820115    23594743    25315136    29403074    30282656    24508170    30249741    15592404    25401762    23254933    27762356    25244985    28648823   

EMBL

BABH01010460    ODYU01008125    SOQ51462.1    NWSH01001190    PCG72207.1    KZ149933    + More
PZC77266.1    KQ461196    KPJ06441.1    JTDY01006433    KOB66016.1    KQ459598    KPI94733.1    AGBW02012723    OWR44551.1    GEBQ01004234    JAT35743.1    KK852833    KDR15302.1    PZQS01000010    PVD22974.1    GBXI01004094    JAD10198.1    GAMC01007393    JAB99162.1    GDHF01033686    JAI18628.1    GDHF01003848    JAI48466.1    GDHF01005401    JAI46913.1    APGK01055242    KB741261    KB632413    ENN71629.1    ERL95258.1    AJWK01019571    CM000162    EDX03127.1    CP012528    ALC49464.1    OUUW01000003    SPP77786.1    GDHC01002778    JAQ15851.1    SPP77785.1    CH954180    EDV47649.1    GDHC01012621    JAQ06008.1    AAAB01008984    AE014298    CH379063    EDY72036.1    CH479205    EDW30792.1    AJVK01014612    UFQT01000575    SSX25428.1    CH940651    KRF82146.1    EDW65256.1    REGN01003656    RNA21483.1    CVRI01000038    CRK94023.1    GL761538    EFZ23173.1    AXCN02002066    CCAG010005003    LBMM01000070    KMR05079.1    CH984300    EDX16391.1    ADMH02001918    ETN60517.1    CH916376    EDV95191.1    EAA14831.3    CH963925    EDW78421.1    CH477313    EAT43866.1    DS231839    EDS34262.1    NIVC01001051    PAA72939.1    KQ982576    KYQ54655.1    AY618925    BC162607    UFQS01002049    UFQT01002049    SSX13097.1    SSX32537.1    DS469513    EDO48550.1    KK854807    PTY18913.1    UYRS01018393    VDK34529.1    NIVC01002811    PAA55103.1    KQ981905    KYN33342.1    GFDL01004363    JAV30682.1    CH933810    EDW06920.2    JXUM01008873    KQ560270    KXJ83425.1    CABG01000244    CAZ38996.1    KQ971321    EFA00650.1    BX511268    CR848710    GGFL01003464    MBW67642.1    AXCM01010706    LSYS01001531    OPJ88383.1    PYGN01000982    PSN38717.1    QUSF01000001    RLW13041.1    KQ980903    KYN11605.1    KK107015    QOIP01000002    EZA62860.1    RLU25373.1    AADN05000663    GBHO01039372    GBHO01039368    JAG04232.1    JAG04236.1    GEEE01024524    GEEE01013757    JAP49468.1    AMQN01005174    AMQN01005175    KB295343    ELU13273.1    CM004476    OCT77178.1    APCN01003380    GBRD01007501    JAG58320.1    KB203711    ESO83361.1    NNAY01000050    OXU31543.1    KQ434977    KZC12922.1    OPJ88384.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000037510    UP000053268    UP000007151    + More
UP000027135    UP000245119    UP000076420    UP000019118    UP000030742    UP000092461    UP000002282    UP000092553    UP000268350    UP000192221    UP000075880    UP000008711    UP000000803    UP000001819    UP000008744    UP000092462    UP000008792    UP000075882    UP000276133    UP000075903    UP000183832    UP000075886    UP000092444    UP000036403    UP000000304    UP000075901    UP000078200    UP000000673    UP000001070    UP000007062    UP000075902    UP000007798    UP000092443    UP000008820    UP000002320    UP000075881    UP000215902    UP000075809    UP000000437    UP000091820    UP000095280    UP000075900    UP000001593    UP000046400    UP000282613    UP000078541    UP000009192    UP000069940    UP000249989    UP000008854    UP000007266    UP000192223    UP000075883    UP000095301    UP000190648    UP000245037    UP000276834    UP000078492    UP000053097    UP000279307    UP000000539    UP000014760    UP000007875    UP000186698    UP000075840    UP000076407    UP000069272    UP000076408    UP000030746    UP000215335    UP000076502   

PRIDE

H9J0F9    Q9VR52   

Pfam

PF14360   PAP2_C

Interpro

IPR032675   LRR_dom_sf        + More
IPR001611   Leu-rich_rpt       
IPR008978   HSP20-like_chaperone       
IPR007052   CS_dom       
IPR003603   U2A'_phosphoprotein32A_C       
IPR025749   Sphingomyelin_synth-like_dom       

SUPFAM

SSF49764   SSF49764       

Gene 3D

3.80.10.10    

ProteinModelPortal

H9J0F9   A0A2H1WF24   A0A2A4JJG6   A0A2W1BX60   A0A194QSC2   A0A0L7KSG8   + More
A0A194PP24   A0A212ESX5   A0A1B6MIK3   A0A067R9R3   A0A2T7NP80   A0A0A1XI82   W8BK96   A0A2C9M8H7   A0A0K8TWF8   A0A0K8WBD2   A0A0K8W6T6   N6SVA6   A0A1B0GJ85   B4PZ66   A0A0M4EUL4   A0A3B0JWQ4   A0A146M7U7   A0A3B0J7K0   A0A1W4VWN3   A0A182JCE8   A0A1W4W8L3   B3NY64   A0A146LCK8   A0A1S4GZN0   Q9VR52   B5DKI7   B4H399   A0A1B0DDS5   A0A336MHC9   A0A0Q9WCM8   B4M381   A0A182LMS6   A0A3M7RD39   A0A182UUB6   A0A1J1I100   E9I8F1   A0A182QFW7   A0A1B0G2P7   A0A0J7P591   B4NUV6   A0A182SGZ7   A0A1A9VRL4   W5J7S8   B4JWR5   Q7PWL0   A0A182TH17   B4N232   A0A1A9X8S9   Q17C36   B0W4S4   A0A182K1X2   A0A267FIT2   A0A151X2J1   B3DH20   A0A1A9WCC2   A0A1I8GGT6   A0A182RI66   A0A336MWB3   A7RJB1   A0A2R7WGY7   A0A0R3W4V8   A0A267E0M1   A0A195EZK2   A0A1Q3FTA2   B4L2V3   A0A182GAD9   C4QU59   D6WHE0   F1Q7C0   A0A2M4CQN3   A0A3Q0KKB4   A0A1W4XTJ2   A0A182LTD3   A0A1I8MFE6   A0A1V4KV39   A0A2P8Y373   A0A3L8TAC0   A0A195DFC7   A0A026X3H5   A0A1D5PLA5   A0A0A9W704   A0A0X3PCN4   R7V356   H2Z730   A0A1L8G016   A0A182I7D0   A0A0A9ZJS2   A0A182XNS4   A0A182FNC7   A0A182Y0D5   V3ZR69   A0A232FLT1   A0A154PM45   A0A1V4KVB7  

PDB

5YXM     E-value=0.000172512,     Score=107

KEGG

101738270    K19753 protein TilB | (RefSeq) protein tilB

GO

GO:0035082   GO:0005737   GO:0060285   GO:0007605   GO:0030425   GO:0045433   GO:0031514   GO:0010378   GO:0044458   GO:0003146   GO:0060027   GO:0007368   GO:0060271   GO:0009953   GO:0003143   GO:0048793   GO:0003351   GO:0001947   GO:0060294   GO:0016021   GO:0036158   GO:0036159   GO:0008584   GO:0030317   GO:0060287   GO:0005515   GO:0005634   GO:0006355   GO:0009072   GO:0003824   GO:0006520   GO:0008483   GO:0006418   GO:0016507   GO:0048384  

Subcellular location

Cytoplasm  
Cell projection  
Dendrite  
Cilium  
Flagellum  

Length:

429

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00619

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00883

outside

1  -  429

 

 

Pi

25.400192

Theta

17.591459

Tajima's D

1.34752

CLR

0

CSRT

0.761061946902655

Interpretation

Uncertain