Gene

KWMTBOMO02088  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002984

Annotation

lysyl-tRNA_synthetase_[Antheraea_pernyi]

Location

Bomo_Chr4(+):11866798-11872395      View in EpiBrowser

Full name

Lysine--tRNA ligase      

Alternative Name

Lysyl-tRNA synthetase

Location in the cell

Cytoplasmic   Reliability : 3.491

CDS

ATGGCAGAAAGTTCCACTGAAAAAATTTCGAAAAACGAACTGAAACGAAGGTTGAAAGCTGAAGAAAAGTTAAGGGAGAAGGCCGAAAAAGCTTCACAACAGCCGGTCGTTGCCGCTGAAAAGAAACCATCTAAACAAGAAGAAGAAATTAGTCCTAATGAATATTATAAATTACGATCTGGAGCTGTAGCTGCCCTAAAAAATGGACTCAAAGAAGATCATCCATATCCTCATAAATTCAATGTTAGCATTTCCTTGGAGGAATTCATAGAAAAGTATCAGAACTTGAACAACGGAGATGTTTTGGAAAACGTCACTTTGTCAGTGGCTGGTAGAGTTCACTCCATTAGAGAATCAGGAGCGAAACTAATATTCTATGATTTAAGAGCTGAAGGGGCTAAAATCCAGGTAATGGCTAATGCAAAACTATATGAAACAGAAGATAAGTTTTTTAAAGATACTGATAAATTACGCAGAGGTGATATCATTGGTTGTGTGGGCCATCCAGGTAAAACTAAGAAAGGAGAACTTTCTATTATCCCGAAAAATATAAAATTGCTTGCACCATGCCTTCATATGTTGCCGCATTTACATTTCGGTCTCAAAGACAAAGAAACCCGCTTTAGAAAAAGGTATCTGGACCTTATTTTGAATGATAAGGTTCGACAAATCTTTTATACAAGAGCTAAAATCATAGCGTATGTTCGGCGATTCTTGGACAATATGGGCTTCCTAGAAGTGGAAACCCCACTTATGAATATGGTTCCCGGTGGCGCCACTGCCAAACCATTCATTACTCATCATAATGAATTAAACATGGACTTGTACATGCGAATAGCTCCTGAGCTTTATCACAAAATGCTTGTTGTGGGTGGACTCGATAGGGTATATGAAATTGGAAGACAGTTCCGAAATGAAGGTATCGACTTAACACATAACCCTGAGTTCACGACTTGTGAATTTTACATGGCATATGCGGATTATAATGACCTGATGACCATTACTGAATCAATCTTGTCTGGTATGGTACAGAGCATTCATGGATCCTACAAGGTCAAATATCATCCAGAAGGACCAGAGGGTAAGGAAATAGAAATCGATTTCACACCACCCTTTGCTAGAGTACCGATGATGGCAACATTGGAACGTGTTCTTAACGTGAAACTCCCAGCACCCGATAAACTTGATACACCTGAAGCTAATGATTTCCTTAACAACCTATGCAACACTCATCAGATTGAGTGCTCGCCACCGAGGACCACCGCGAGGCTCTTGGATAAATTGGTTTCTGTATTTCTGGAGGAGGAGTGTATAAATCCGACATTTATATTGGATCATCCTCAGATTATGAGTCCCCTCTCTAAGTACCATCGAGATGTTCCAGGACTTACAGAGAGGTTTGAAGTTTATGTTGCTAAGAAAGAAATCTGTAATGCCTACACCGAATTAAATGACCCGGCGACACAACGCGAAAGATTCGAAGAGCAAGCCAAGAATCGTGCTGCTGGTGACGATGAAACTCCCCCAACCGATGAAGCGTTTTGTACAGCTCTAGAATATGGCCTGCCGCCGACCGGCGGGTGGGGCCTCGGTGTAGACCGTTTGACTATGTTCCTTACCGATTCAAATAATATCAAGGAGGTGTTGTTGTTCCCTGCAATGAAGCCTGATGACCCAAACAAAAACAATACAGAAGAAGAGAATGTGGGTGTACAAACATCAGTTCCGAACGGAGCTAACTAA

Protein

MAESSTEKISKNELKRRLKAEEKLREKAEKASQQPVVAAEKKPSKQEEEISPNEYYKLRSGAVAALKNGLKEDHPYPHKFNVSISLEEFIEKYQNLNNGDVLENVTLSVAGRVHSIRESGAKLIFYDLRAEGAKIQVMANAKLYETEDKFFKDTDKLRRGDIIGCVGHPGKTKKGELSIIPKNIKLLAPCLHMLPHLHFGLKDKETRFRKRYLDLILNDKVRQIFYTRAKIIAYVRRFLDNMGFLEVETPLMNMVPGGATAKPFITHHNELNMDLYMRIAPELYHKMLVVGGLDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYNDLMTITESILSGMVQSIHGSYKVKYHPEGPEGKEIEIDFTPPFARVPMMATLERVLNVKLPAPDKLDTPEANDFLNNLCNTHQIECSPPRTTARLLDKLVSVFLEEECINPTFILDHPQIMSPLSKYHRDVPGLTERFEVYVAKKEICNAYTELNDPATQRERFEEQAKNRAAGDDETPPTDEAFCTALEYGLPPTGGWGLGVDRLTMFLTDSNNIKEVLLFPAMKPDDPNKNNTEEENVGVQTSVPNGAN

Catalytic Activity

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)

Similarity

Belongs to the mitochondrial carrier (TC 2.A.29) family.

Feature

chain  Lysine--tRNA ligase

Uniprot

H9J0E7   G1CCJ6   S4PBV1   A0A212EN61   A0A2H1W0Z1   A0A194QLM7   + More
A0A2W1BX78   I4DMU1   A0A194PZF4   A0A2A4JIW3   A0A2A4JJQ8   A0A1Q3EZX7   B0XD88   A0A2J7RAY5   A0A2J7RAY4   A0A1B6LSI2   U5EUE8   A0A1B6M3H9   A0A1B6C8Y9   A0A1B6DR92   A0A1B6BZ67   A0A0K8TNB3   A0A067R9F2   A0A1Y1M9L9   A0A1L8DFT3   A0A336LR68   E9ISA6   A0A1L8DFK5   A0A1J1J949   A0A0T6B5Q0   A0A146L0Q6   A0A0A9W9C9   A0A182IR32   A0A0A9WHR8   A0A1B0DJU4   A0A182GJR0   A0A1L8DFR8   T1PAJ7   A0A1I8NEP2   A0A1J1J545   A0A182XBT6   A0A023EU24   A0A0Q9WJB8   A0A182UNN1   A0A182HMW8   A0A1Y1M4Q9   A0A023EU42   B4M385   A0A3F2Z1H5   F5HJL3   A0A0R3P1Y1   Q29G05   A0A182RM45   Q16FM7   B4JWR1   A0A182UAR3   Q7QF68   A0A2M4A759   F4W683   A0A2M4A814   A0A154PJF8   W5JCK4   A0A2M4A763   A0A158P209   A0A158P210   A0A2M4A7C8   A0A0L7QYY4   A0A088ACI9   A0A182W563   A0A2M4BHI7   A0A195DMH9   A0A0M3QZQ5   A0A2M4CVZ3   A0A182W1X6   A0A1A9WIN5   A0A3B0JZ42   A0A1A9VS04   A0A2M4CG32   A0A182P8J5   A0A3B0JRA6   B4NCI1   A0A1W4VGF9   A0A1W4VGP9   A0A151IKK5   A0A1B0G3H6   A0A2M3ZGZ7   Q8SXM8   B4IDH9   A0A2M3Z3P7   A0A0L0BZK1   A0A182FQR6   A0A182MV78   A0A1B0GBL2   Q9W327   A0A026X0R7   B4R752   A0A232F8V2   K7IQ24   A0A1A9ZIJ0   D3TPQ1  

EC Number

6.1.1.6

Pubmed

19121390    23622113    22118469    26354079    28756777    22651552    + More
26369729    24845553    28004739    21282665    26823975    25401762    26483478    25315136    24945155    17994087    12364791    14747013    17210077    15632085    17510324    21719571    20920257    23761445    21347285    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    26108605    24508170    30249741    28648823    20075255    20353571   

EMBL

BABH01010489    JF773568    AEB77710.1    GAIX01004431    JAA88129.1    AGBW02013744    + More
OWR42891.1    ODYU01005642    SOQ46697.1    KQ461196    KPJ06463.1    KZ149933    PZC77286.1    AK402609    BAM19231.1    KQ459583    KPI98701.1    NWSH01001239    PCG72007.1    PCG72006.1    GFDL01014180    JAV20865.1    DS232745    EDS45342.1    NEVH01006564    PNF37991.1    PNF37990.1    GEBQ01013418    GEBQ01013221    JAT26559.1    JAT26756.1    GANO01002353    JAB57518.1    GEBQ01009529    GEBQ01007795    JAT30448.1    JAT32182.1    GEDC01027404    JAS09894.1    GEDC01009101    JAS28197.1    GEDC01030750    GEDC01030094    JAS06548.1    JAS07204.1    GDAI01001985    JAI15618.1    KK852804    KDR16239.1    GEZM01042242    JAV80027.1    GFDF01008864    JAV05220.1    UFQT01000123    SSX20460.1    GL765324    EFZ16544.1    GFDF01008858    JAV05226.1    CVRI01000072    CRL07529.1    LJIG01009614    KRT82728.1    GDHC01016458    JAQ02171.1    GBHO01039195    GBRD01011442    GDHC01007156    JAG04409.1    JAG54382.1    JAQ11473.1    GBHO01039194    GBRD01011441    JAG04410.1    JAG54383.1    AJVK01001081    AJVK01001082    AJVK01001083    JXUM01068669    KQ562512    KXJ75746.1    GFDF01008859    JAV05225.1    KA645796    AFP60425.1    CRL07531.1    GAPW01000735    JAC12863.1    CH940651    KRF82151.1    APCN01004922    GEZM01042241    JAV80028.1    GAPW01000668    JAC12930.1    EDW65260.1    AAAB01008846    EGK96474.1    CH379065    KRT07148.1    EAL31424.2    CH478408    EAT33042.1    CH916376    EDV95187.1    EAA06178.5    GGFK01003316    MBW36637.1    GL887707    EGI70218.1    GGFK01003457    MBW36778.1    KQ434936    KZC11962.1    ADMH02001802    ETN61063.1    GGFK01003249    MBW36570.1    ADTU01006930    GGFK01003330    MBW36651.1    KQ414685    KOC63798.1    GGFJ01003280    MBW52421.1    KQ980724    KYN14105.1    CP012528    ALC49789.1    GGFL01005261    MBW69439.1    OUUW01000003    SPP77991.1    GGFL01000096    MBW64274.1    SPP77990.1    CH964239    EDW82540.1    KQ977199    KYN05009.1    CCAG010011010    GGFM01007004    MBW27755.1    AY089547    AE014298    AAL90285.1    AAN09255.1    CH480830    EDW45637.1    GGFM01002391    MBW23142.1    JRES01001107    KNC25507.1    AXCM01002316    CCAG010001819    BT133498    AAF46510.2    AFI71928.1    KK107051    QOIP01000010    EZA61653.1    RLU17684.1    CM000366    EDX17521.1    NNAY01000707    OXU26873.1    EZ423403    ADD19679.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000053268    UP000218220    UP000002320    + More
UP000235965    UP000027135    UP000183832    UP000075880    UP000092462    UP000069940    UP000249989    UP000095301    UP000076407    UP000008792    UP000075903    UP000075840    UP000007062    UP000001819    UP000075900    UP000008820    UP000001070    UP000075902    UP000007755    UP000076502    UP000000673    UP000005205    UP000053825    UP000005203    UP000075920    UP000078492    UP000092553    UP000091820    UP000268350    UP000078200    UP000075885    UP000007798    UP000192221    UP000078542    UP000092444    UP000000803    UP000001292    UP000037069    UP000069272    UP000075883    UP000053097    UP000279307    UP000000304    UP000215335    UP000002358    UP000092445   

PRIDE

H9J0E7   

Pfam

PF00152   tRNA-synt_2        + More
PF01336   tRNA_anti-codon
PF00153   Mito_carr
PF17907   AWS
PF03360   Glyco_transf_43

Interpro

IPR002313   Lys-tRNA-ligase_II        + More
IPR034762   Lys-tRNA-ligase_II_bac/euk       
IPR006195   aa-tRNA-synth_II       
IPR018149   Lys-tRNA-synth_II_C       
IPR004364   aa-tRNA-synt_II       
IPR004365   NA-bd_OB_tRNA       
IPR012340   NA-bd_OB-fold       
IPR018108   Mitochondrial_sb/sol_carrier       
IPR023395   Mt_carrier_dom_sf       
IPR008949   Isoprenoid_synthase_dom_sf       
IPR003616   Post-SET_dom       
IPR006560   AWS_dom       
IPR005027   Glyco_trans_43       
IPR029044   Nucleotide-diphossugar_trans       

SUPFAM

SSF50249   SSF50249        + More
SSF103506   SSF103506       
SSF48576   SSF48576       
SSF53448   SSF53448       

Gene 3D

1.50.40.10     1.10.600.10     3.90.550.10    

CDD

cd00775  LysRS_core
cd00218  GlcAT-I

ProteinModelPortal

H9J0E7   G1CCJ6   S4PBV1   A0A212EN61   A0A2H1W0Z1   A0A194QLM7   + More
A0A2W1BX78   I4DMU1   A0A194PZF4   A0A2A4JIW3   A0A2A4JJQ8   A0A1Q3EZX7   B0XD88   A0A2J7RAY5   A0A2J7RAY4   A0A1B6LSI2   U5EUE8   A0A1B6M3H9   A0A1B6C8Y9   A0A1B6DR92   A0A1B6BZ67   A0A0K8TNB3   A0A067R9F2   A0A1Y1M9L9   A0A1L8DFT3   A0A336LR68   E9ISA6   A0A1L8DFK5   A0A1J1J949   A0A0T6B5Q0   A0A146L0Q6   A0A0A9W9C9   A0A182IR32   A0A0A9WHR8   A0A1B0DJU4   A0A182GJR0   A0A1L8DFR8   T1PAJ7   A0A1I8NEP2   A0A1J1J545   A0A182XBT6   A0A023EU24   A0A0Q9WJB8   A0A182UNN1   A0A182HMW8   A0A1Y1M4Q9   A0A023EU42   B4M385   A0A3F2Z1H5   F5HJL3   A0A0R3P1Y1   Q29G05   A0A182RM45   Q16FM7   B4JWR1   A0A182UAR3   Q7QF68   A0A2M4A759   F4W683   A0A2M4A814   A0A154PJF8   W5JCK4   A0A2M4A763   A0A158P209   A0A158P210   A0A2M4A7C8   A0A0L7QYY4   A0A088ACI9   A0A182W563   A0A2M4BHI7   A0A195DMH9   A0A0M3QZQ5   A0A2M4CVZ3   A0A182W1X6   A0A1A9WIN5   A0A3B0JZ42   A0A1A9VS04   A0A2M4CG32   A0A182P8J5   A0A3B0JRA6   B4NCI1   A0A1W4VGF9   A0A1W4VGP9   A0A151IKK5   A0A1B0G3H6   A0A2M3ZGZ7   Q8SXM8   B4IDH9   A0A2M3Z3P7   A0A0L0BZK1   A0A182FQR6   A0A182MV78   A0A1B0GBL2   Q9W327   A0A026X0R7   B4R752   A0A232F8V2   K7IQ24   A0A1A9ZIJ0   D3TPQ1  

PDB

6CHD     E-value=0,     Score=1960

KEGG

101740883    K04567 lysyl-tRNA synthetase, class II [EC:6.1.1.6] | (RefSeq) lysine--tRNA ligase

PATHWAY

00970    Aminoacyl-tRNA biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0006430   GO:0004824   GO:0003676   GO:0005737   GO:0005524   GO:0016021   GO:0005829   GO:0005739   GO:0000049   GO:0017101   GO:0018024   GO:0005634   GO:0016020   GO:0015018   GO:0000166   GO:0004812   GO:0006418   GO:0016507   GO:0048384  

Length:

580

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.003

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00121

outside

1  -  580

 

 

Pi

285.594886

Theta

212.340672

Tajima's D

0.935429

CLR

0.208409

CSRT

0.644817759112044

Interpretation

Possibly Positive selection