Gene

KWMTBOMO02082  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002981

Annotation

profilin_[Bombyx_mori]

Location

Bomo_Chr4(+):11654598-11659276      View in EpiBrowser

Full name

Profilin      

Alternative Name

Protein chickadee

Location in the cell

Cytoplasmic   Reliability : 2.2

CDS

ATGAGCTGGCAAGATTATGTCGACAAACAGTTAATGGCATCTAGATGTGTCACAAAAGCTGCCATTGCCGGTCATGATGGCAATGTGTGGGCAAAGTCGGAAGGCTTCGAAATTTCAAAAGATGAAGTGGCGAAGATTGTGGCTGGCTTTGAGAATGAATCACTGCTAACGAGTGGCGGCGTGACGATAGCGGGCACGCGGTACATCTACCTCAGTGGCACAGACCATATCATCCGCGCGAAGCTTGGCAAGGTCGGCGTGCATTGCATGAAGACACAGCAAGCTGTGGTCATTTCTCTCTATGAAGAACCCATCCAACCTCAGCAGGCCGCATCTGTCGTGGAGAAGTTAGGAGAATATTTAATTACCTGTGGTTATTAG

Protein

MSWQDYVDKQLMASRCVTKAAIAGHDGNVWAKSEGFEISKDEVAKIVAGFENESLLTSGGVTIAGTRYIYLSGTDHIIRAKLGKVGVHCMKTQQAVVISLYEEPIQPQQAASVVEKLGEYLITCGY

Description

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).

Subunit

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Similarity

Belongs to the profilin family.

Keywords

Actin-binding   Complete proteome   Cytoplasm   Cytoskeleton   Reference proteome  

Feature

chain  Profilin

Uniprot

A1E8I8   Q68HB4   A0A0L7LKM4   I7G0X7   A0A1E1WDV7   A0A2A4JYL4   + More
I4DRG9   A0A222AJF8   A0A212FD41   S4P8I6   A0A067QYW4   A0A0A9WSP9   A0A0U4B5D9   A0A2R7WJM6   R4WQQ2   J3JTV4   A0A139WI06   J3JX68   A0A195AVA9   A0A195ETL5   A0A158NHK5   A0A1B6LUA2   A0A1B6GYU7   E2APZ9   A0A2P8YC67   A0A1B6ITY7   A0A195C3G6   A0A1Y1MU09   A0A026WB74   A0A1W4XKU8   A0A146KJP4   A0A2A3EQJ2   V9IGT1   A0A087ZNT2   A0A232EQC9   K7IQ05   V5GLW9   A0A224Y093   A0A0V0G4A7   A0A023F948   A0A069DNN0   A0A154PS72   A0A0L7RAG9   Q5TP19   A0A310SRH1   A0A1D1XF39   T1DFI4   A0A1Q3F8G0   B0W2U6   T1DQL5   A0A2M3Z0V6   A0A2M4A439   W5JBU9   A0A023EFI4   A0A0P4VU02   R4G508   Q6QEJ7   Q16JE9   A0A1B6DCQ5   A0A0T6AWK4   E0VF14   A0A1J1I5Z8   T1PA74   A0A0C9RAU5   A0A1L8EHM5   A0A1L8E5E0   U5EZ71   A0A0L0C5L6   A0A1D2NDF1   A0A1I8P5R4   W8CDG5   A0A0K8UUJ6   A0A0C9RGL0   A0A034VKC7   A0A0M3QT59   A0A1A9Y520   A0A1A9UYB4   A0A1A9Z9G4   D3TQD6   B4MUZ7   B3MMQ1   B4LR73   A0A3B0KI43   Q29PL9   B4JC19   B4KGG2   D3TKT4   A0A1W4UBW4   A0A0P6IHW6   B3N5A1   A0A1I9WLF3   T1H7C2   B4I1N3   Q3YMV5   B4NZS9   M9NEU5   P25843   A0A0K8TNS2   A0A151WGI7   A0A336KD15  

Pubmed

18633732    26227816    22651552    22118469    23622113    24845553    + More
25401762    26823975    26694822    23691247    22516182    18362917    19820115    23537049    21347285    20798317    29403074    28004739    24508170    30249741    28648823    20075255    25474469    26334808    12364791    14747013    17210077    24330624    20920257    23761445    24945155    26483478    27129103    17510324    20566863    25315136    26108605    27289101    24495485    25348373    20353571    17994087    18057021    15632085    23185243    27538518    15917496    22936249    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    1339308    12537569    26369729   

EMBL

EF112402    ABK97428.1    AY690617    JTDY01000719    KOB76103.1    JX087453    + More
ODYU01008012    AFP36379.1    SOQ51264.1    GDQN01005896    JAT85158.1    NWSH01000373    PCG76866.1    AK405112    BAM20509.1    KY609793    ASO76491.1    AGBW02009105    OWR51666.1    GAIX01005911    JAA86649.1    KK852820    KDR15557.1    GBHO01035730    GBHO01035729    GBRD01001259    GBRD01001258    GDHC01001113    JAG07874.1    JAG07875.1    JAG64562.1    JAQ17516.1    KU218676    ALX00056.1    KK854931    PTY19758.1    AK417007    BAN20222.1    BT126663    AEE61626.1    KQ971342    KYB27628.1    APGK01037935    BT127836    KB740949    AEE62798.1    ENN77193.1    KQ976737    KYM75960.1    KQ981975    KYN31595.1    ADTU01015912    ADTU01015913    ADTU01015914    ADTU01015915    GEBQ01012719    JAT27258.1    GECZ01002182    JAS67587.1    GL441645    EFN64486.1    PYGN01000712    PSN41836.1    GECU01017324    JAS90382.1    KQ978350    KYM94731.1    GEZM01021258    JAV89049.1    KK107293    QOIP01000005    EZA53310.1    RLU22461.1    GDHC01021826    JAP96802.1    KZ288204    PBC33311.1    JR042933    AEY59691.1    NNAY01002818    OXU20506.1    GALX01003402    JAB65064.1    GFTR01002124    JAW14302.1    GECL01003333    JAP02791.1    GBBI01000701    JAC18011.1    GBGD01003474    JAC85415.1    KQ435090    KZC14597.1    KQ414619    KOC67761.1    AAAB01008980    EAL39221.3    KQ761343    OAD57879.1    GDJX01026916    JAT41020.1    GALA01000582    JAA94270.1    GFDL01011185    JAV23860.1    DS231829    EDS30305.1    GAMD01002409    JAA99181.1    GGFM01001399    MBW22150.1    GGFK01002190    MBW35511.1    ADMH02001847    GGFL01004245    ETN60893.1    MBW68423.1    JXUM01054759    JXUM01054760    JXUM01054761    JXUM01054762    GAPW01006018    GAPW01006017    JAC07581.1    GDKW01000568    JAI56027.1    ACPB03021270    GAHY01000905    JAA76605.1    AY545000    CH478012    EAT34394.1    GEDC01013866    GEDC01008505    JAS23432.1    JAS28793.1    LJIG01022646    KRT79464.1    DS235100    EEB11988.1    CVRI01000038    CRK94366.1    KA645040    KA649095    KA649185    AFP59669.1    GBYB01013604    JAG83371.1    GFDG01000706    JAV18093.1    GFDF01000117    JAV13967.1    GANO01001322    JAB58549.1    JRES01000864    KNC27688.1    LJIJ01000079    ODN03284.1    GAMC01001986    JAC04570.1    GDHF01025877    GDHF01022954    GDHF01022078    GDHF01011740    GDHF01004181    GDHF01000053    JAI26437.1    JAI29360.1    JAI30236.1    JAI40574.1    JAI48133.1    JAI52261.1    GBYB01006166    GBYB01006168    JAG75933.1    JAG75935.1    GAKP01016003    GAKP01016002    JAC42949.1    CP012523    ALC38343.1    CCAG010020379    EZ423638    ADD19914.1    CH963857    EDW76342.1    CH902620    EDV31942.2    KPU73710.1    CH940649    EDW63537.1    OUUW01000010    SPP86079.1    CH379058    EAL34274.1    KRT03334.1    CH916368    EDW03032.1    CH933807    EDW12158.1    KRG03107.1    EZ422021    ADD18444.1    GDIQ01004307    JAN90430.1    CH954177    EDV57931.1    KU932337    APA33973.1    CH480820    EDW54440.1    DQ062771    CM002910    AAY56644.1    KMY88420.1    CM000157    EDW88863.1    AE014134    KX531778    AFH03579.1    ANY27588.1    M84528    M84529    DQ062770    AY069444    AY128443    GDAI01001589    JAI16014.1    KQ983167    KYQ46950.1    UFQS01000281    UFQT01000281    SSX02379.1    SSX22754.1   

Proteomes

UP000005204    UP000037510    UP000218220    UP000007151    UP000027135    UP000007266    + More
UP000019118    UP000078540    UP000078541    UP000005205    UP000000311    UP000245037    UP000078542    UP000053097    UP000279307    UP000192223    UP000242457    UP000005203    UP000215335    UP000002358    UP000076502    UP000053825    UP000007062    UP000002320    UP000000673    UP000069940    UP000015103    UP000008820    UP000009046    UP000183832    UP000095301    UP000037069    UP000094527    UP000095300    UP000092553    UP000092443    UP000078200    UP000092445    UP000092444    UP000007798    UP000007801    UP000008792    UP000268350    UP000001819    UP000001070    UP000009192    UP000192221    UP000008711    UP000015102    UP000001292    UP000002282    UP000000803    UP000075809   

PRIDE

Q68HB4    A0A087ZNT2    M9NEU5    P25843   

Pfam

PF00235   Profilin

Interpro

IPR036140   PFN_sf        + More
IPR005455   PFN       
IPR027310   Profilin_CS       

SUPFAM

SSF55770   SSF55770       

CDD

cd00148  PROF

ProteinModelPortal

A1E8I8   Q68HB4   A0A0L7LKM4   I7G0X7   A0A1E1WDV7   A0A2A4JYL4   + More
I4DRG9   A0A222AJF8   A0A212FD41   S4P8I6   A0A067QYW4   A0A0A9WSP9   A0A0U4B5D9   A0A2R7WJM6   R4WQQ2   J3JTV4   A0A139WI06   J3JX68   A0A195AVA9   A0A195ETL5   A0A158NHK5   A0A1B6LUA2   A0A1B6GYU7   E2APZ9   A0A2P8YC67   A0A1B6ITY7   A0A195C3G6   A0A1Y1MU09   A0A026WB74   A0A1W4XKU8   A0A146KJP4   A0A2A3EQJ2   V9IGT1   A0A087ZNT2   A0A232EQC9   K7IQ05   V5GLW9   A0A224Y093   A0A0V0G4A7   A0A023F948   A0A069DNN0   A0A154PS72   A0A0L7RAG9   Q5TP19   A0A310SRH1   A0A1D1XF39   T1DFI4   A0A1Q3F8G0   B0W2U6   T1DQL5   A0A2M3Z0V6   A0A2M4A439   W5JBU9   A0A023EFI4   A0A0P4VU02   R4G508   Q6QEJ7   Q16JE9   A0A1B6DCQ5   A0A0T6AWK4   E0VF14   A0A1J1I5Z8   T1PA74   A0A0C9RAU5   A0A1L8EHM5   A0A1L8E5E0   U5EZ71   A0A0L0C5L6   A0A1D2NDF1   A0A1I8P5R4   W8CDG5   A0A0K8UUJ6   A0A0C9RGL0   A0A034VKC7   A0A0M3QT59   A0A1A9Y520   A0A1A9UYB4   A0A1A9Z9G4   D3TQD6   B4MUZ7   B3MMQ1   B4LR73   A0A3B0KI43   Q29PL9   B4JC19   B4KGG2   D3TKT4   A0A1W4UBW4   A0A0P6IHW6   B3N5A1   A0A1I9WLF3   T1H7C2   B4I1N3   Q3YMV5   B4NZS9   M9NEU5   P25843   A0A0K8TNS2   A0A151WGI7   A0A336KD15  

PDB

2ACG     E-value=4.76859e-25,     Score=277

KEGG

692652    K05759 profilin | (RefSeq) PFN; profilin

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0005856   GO:0003779   GO:0005737   GO:0042989   GO:0003785   GO:0005938   GO:0035019   GO:0007488   GO:0032507   GO:0007015   GO:0007436   GO:0007420   GO:0048842   GO:0016322   GO:0048471   GO:0000281   GO:0042060   GO:0048680   GO:0007411   GO:0043005   GO:0030717   GO:0035193   GO:0051491   GO:0036098   GO:0045451   GO:0000915   GO:0000902   GO:0007300   GO:0030041   GO:0007391   GO:0005524   GO:0004842   GO:0016567   GO:0046872   GO:0003676   GO:0005739   GO:0006635   GO:0016507   GO:0048384  

PANTHER

PTHR11604  

Subcellular location

  

Length:

126

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.44543

Exp number, first 60 AAs:

0.17511

Total prob of N-in:

0.46832

outside

1  -  126

 

 

Pi

254.900596

Theta

196.810306

Tajima's D

0.922549

CLR

0

CSRT

0.639118044097795

Interpretation

Uncertain