Gene

KWMTBOMO02069

Pre Gene Modal

BGIBMGA003194

Annotation

PREDICTED:_E3_ubiquitin-protein_ligase_MIB1_[Bombyx_mori]

Location

Bomo_Chr4(-):11281721-11287346      View in EpiBrowser

Full name

E3 ubiquitin-protein ligase mind-bomb      

Alternative Name

Mind bomb homolog
RING-type E3 ubiquitin transferase mind-bomb

Location in the cell

Extracellular   Reliability : 2.544

CDS

ATGCTGGGTAAGCTTCCGAGATCGTGGATAGTAGACGACGCCAAGGACGATGGCTACACAGCTTTGCATCTGGCTGCCCTGAACAACCACGCCGAGGTCGCGGAGCTACTGGTGCGCGCAGGAGCCCGTCCTGACCTACAAAACGCAAATTTACAGACAGCTCTTCACTTGGCTGTAGAGCGTCAACACACTCAAATAGTTCGGCTACTAGTAGCTCATGGAGCCAATCTTAATATTTGTGACAAGGATGGTGACACACCGTTACATGAAGCGCTCCGGCATCATACCCTGCAGCAGCTCCGTCGTCTACAAGATGCACGAGACTCTGCACTGCTCACAGGCCTCTCACATGCTCATGACAAAAAGTCGTCTGCGTCGATAGCTTGTTTCCTCGCGGCTCACGGTGCCGATCTAACCGTCAAGAATAAAAAAGGTCAAACACCTCTTGACCTCTGTCCGGACCCCAATCTCTGCAAGACGTTGACTTCGTGCCGCAAAGCTGGCGCGTCGGCCACCGACAGTACTCCAGAGAGTGAGCCAGGCTCCTCCGCTATCAGCACATCGGCGCCCGCTGCGGACTCTATATCGGCAGGAGACACGCAGCCGCAGTCAGACCCCACAGCCGATGAATGTCTCGTATGCTCCGATGCTAAGAGAGACACTCTGTTCCGTCCTTGCGGACATATCTGTTGCTGCAATGCTTGCGCCGCCAGGGTGAAGAAGTGTCTGGTGTGCCGCGCCGGCGTGTCGTCACGCGAGCGCGTGCCTGAATGCAGAGTGTGCTCGGAGGCGCCAGCCACGGTGCTGTTCCGTCCGTGCGGCGACGTGTGTGCGTGTGCGGCCTGCGCTCCGCTCATGCGAAAGTGCGTGGAGTGTCGCACGCCGCTACAGTCTGCACAACCCGCACAACCGGTCCCGCATCCCGTCACGCAACCCATCGCGCAACCCGCCGCGCAGCCTACCCCGCAGCCCGCCCTGCACCACAACAACAACAACAACAACGCTCTCAACATCGATCTTGAAAAGGACAGCAGTAGTAATTTAGCTCAGGTGCAAGTGAATAAAGGGCAGCCCGCGGCGACGCCGGCCGCGCCGCACTTCATGAACAACGGCTCGCGGTTCGCGCCCGCCCCCGCCCCCGCGCCCGCCTCCGCGCTCGCCCCCGCACCCGACGTGCAGAAACTGCAACAACAACTACAGGACATTAAGGAACAGACGATGTGCCCGATATGTTTGGACCGCCTCAAGAACATGATATTCCTGTGCGGCCACGGTATGTGCCAAATGTGCGGCGATCGCATTACCGTGTGTCCCATCTGTCGCAAACAAGTCGAGAAACGCATACTGCTCTACTGA

Protein

MLGKLPRSWIVDDAKDDGYTALHLAALNNHAEVAELLVRAGARPDLQNANLQTALHLAVERQHTQIVRLLVAHGANLNICDKDGDTPLHEALRHHTLQQLRRLQDARDSALLTGLSHAHDKKSSASIACFLAAHGADLTVKNKKGQTPLDLCPDPNLCKTLTSCRKAGASATDSTPESEPGSSAISTSAPAADSISAGDTQPQSDPTADECLVCSDAKRDTLFRPCGHICCCNACAARVKKCLVCRAGVSSRERVPECRVCSEAPATVLFRPCGDVCACAACAPLMRKCVECRTPLQSAQPAQPVPHPVTQPIAQPAAQPTPQPALHHNNNNNNALNIDLEKDSSSNLAQVQVNKGQPAATPAAPHFMNNGSRFAPAPAPAPASALAPAPDVQKLQQQLQDIKEQTMCPICLDRLKNMIFLCGHGMCQMCGDRITVCPICRKQVEKRILLY

Description

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta (Dl) and Serrate (Ser) receptors, which act as ligands of Notch proteins. Positively regulates the Notch signaling by ubiquitinating the intracellular domain of Dl and Ser, leading to endocytosis of Dl and Ser receptors. Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity. Also modulates lateral inhibition, a neur- and Dl-dependent signaling event, suggesting a distinct but partially complementary function with neur.

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Subunit

Interacts with intracellular domain of Dl and Ser.

Keywords

ANK repeat   Coiled coil   Complete proteome   Cytoplasm   Metal-binding   Notch signaling pathway   Reference proteome   Repeat   Transferase   Ubl conjugation pathway   Zinc   Zinc-finger  

Feature

chain  E3 ubiquitin-protein ligase mind-bomb

Uniprot

H9J107   A0A2H1WML4   A0A194QLR0   A0A212EK29   A0A2A3EA99   A0A088A8B8   + More
A0A194PLX0   A0A195CFE0   F4WIJ4   A0A195F3X4   A0A0L7RIH0   A0A151XE45   A0A195BIV4   A0A195DZN0   A0A0T6B2W7   A0A154PRD7   A0A158NJZ7   N6TAJ2   U4UGT0   A0A0M9A144   E9JCD0   D6WM13   A0A2J7RDR8   E2A0Z9   A0A067QXN1   A0A3L8DNK5   A0A026WCI6   E0W273   A0A0C9RRG6   A0A165A7R7   E9FS90   A0A1W4X289   A0A1B6C9A4   A0A1Y1KUT7   A0A0P4ZJB9   A0A0P6HXA4   A0A0P5RS99   A0A0P5DHR8   A0A0P5G0C5   A0A0P5QQ02   A0A0P5NJF4   A0A0P5Q991   A0A0P6A951   A0A0P5DUB9   A0A2P6L022   A0A0K2V134   A0A0P4W1M4   A0A147BPD1   A0A1L8DSG8   Q16NN6   A0A1L8DSE2   A0A131YG45   A0A224YXG4   T1JJB8   A0A0P5RD33   A0A0P5JK59   A0A0P5LCI5   A0A0N8C9Q3   A0A0P6H0L9   V4AMK5   B4QLS7   A0A0J9UM16   B4ITV2   B3NDQ4   B4HIM6   M9PI73   Q9VUX2   A0A0P8XUH9   B3M9T6   A0A1W4VAP8  

EC Number

2.3.2.27

Pubmed

19121390    26354079    22118469    21719571    21347285    23537049    + More
21282665    18362917    19820115    20798317    24845553    30249741    24508170    20566863    21292972    28004739    29652888    17510324    26830274    28797301    23254933    17994087    22936249    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    15829515    15760269   

EMBL

BABH01010529    ODYU01009616    SOQ54172.1    KQ461196    KPJ06493.1    AGBW02014319    + More
OWR41872.1    KZ288325    PBC27991.1    KQ459601    KPI93734.1    KQ977827    KYM99492.1    GL888176    EGI65930.1    KQ981820    KYN35280.1    KQ414584    KOC70665.1    KQ982254    KYQ58654.1    KQ976465    KYM84269.1    KQ980031    KYN18162.1    LJIG01016070    KRT81705.1    KQ435022    KZC13914.1    ADTU01018488    APGK01037323    APGK01037324    KB740948    ENN77294.1    KB632288    ERL91558.1    KQ435768    KOX75210.1    GL771786    EFZ09510.1    KQ971343    EFA04203.1    NEVH01005285    PNF38968.1    GL435626    EFN73052.1    KK852840    KDR15205.1    QOIP01000006    RLU22025.1    KK107276    EZA53633.1    DS235874    EEB19729.1    GBYB01009931    JAG79698.1    LRGB01000642    KZS17274.1    GL732523    EFX89996.1    GEDC01027220    JAS10078.1    GEZM01075200    JAV64211.1    GDIP01225166    JAI98235.1    GDIQ01020721    JAN74016.1    GDIQ01115225    JAL36501.1    GDIP01156022    JAJ67380.1    GDIQ01253080    JAJ98644.1    GDIQ01121032    GDIQ01080234    GDIQ01030329    JAL30694.1    GDIQ01151706    JAL00020.1    GDIQ01138969    JAL12757.1    GDIP01045650    JAM58065.1    GDIP01157523    JAJ65879.1    MWRG01003060    PRD31921.1    HACA01026664    CDW44025.1    GDRN01079950    JAI62310.1    GEGO01002788    JAR92616.1    GFDF01004695    JAV09389.1    CH477816    EAT35949.1    GFDF01004688    JAV09396.1    GEDV01010273    JAP78284.1    GFPF01007498    MAA18644.1    JH431092    GDIQ01102669    JAL49057.1    GDIQ01201904    JAK49821.1    GDIQ01171703    JAK80022.1    GDIQ01101035    JAL50691.1    GDIQ01036547    JAN58190.1    KB199650    ESP05409.1    CM000363    EDX10626.1    CM002912    KMY99895.1    CH891734    EDW99815.1    CH954178    EDV52187.1    CH480815    EDW41656.1    AE014296    AGB94606.1    AY118647    CH902618    KPU78383.1    EDV40127.1   

Proteomes

UP000005204    UP000053240    UP000007151    UP000242457    UP000005203    UP000053268    + More
UP000078542    UP000007755    UP000078541    UP000053825    UP000075809    UP000078540    UP000078492    UP000076502    UP000005205    UP000019118    UP000030742    UP000053105    UP000007266    UP000235965    UP000000311    UP000027135    UP000279307    UP000053097    UP000009046    UP000076858    UP000000305    UP000192223    UP000008820    UP000030746    UP000000304    UP000002282    UP000008711    UP000001292    UP000000803    UP000007801    UP000192221   

PRIDE

H9J107    M9PI73    Q9VUX2   

Pfam

PF12796   Ank_2        + More
PF13606   Ank_3
PF00023   Ank
PF06701   MIB_HERC2
PF18346   SH3_15
PF00569   ZZ

Interpro

IPR002110   Ankyrin_rpt        + More
IPR001841   Znf_RING       
IPR017066   E3ligase_BOI-like       
IPR013083   Znf_RING/FYVE/PHD       
IPR036770   Ankyrin_rpt-contain_sf       
IPR020683   Ankyrin_rpt-contain_dom       
IPR000433   Znf_ZZ       
IPR010606   Mib_Herc2       
IPR037252   Mib_Herc2_sf       
IPR040847   SH3_15       
IPR042056   MIB1/2_ZZ       

SUPFAM

SSF48403   SSF48403        + More
SSF159034   SSF159034       

Gene 3D

1.25.40.20     3.30.40.10     2.30.30.920    

CDD

cd00204  ANK
cd02339  ZZ_Mind_bomb

ProteinModelPortal

H9J107   A0A2H1WML4   A0A194QLR0   A0A212EK29   A0A2A3EA99   A0A088A8B8   + More
A0A194PLX0   A0A195CFE0   F4WIJ4   A0A195F3X4   A0A0L7RIH0   A0A151XE45   A0A195BIV4   A0A195DZN0   A0A0T6B2W7   A0A154PRD7   A0A158NJZ7   N6TAJ2   U4UGT0   A0A0M9A144   E9JCD0   D6WM13   A0A2J7RDR8   E2A0Z9   A0A067QXN1   A0A3L8DNK5   A0A026WCI6   E0W273   A0A0C9RRG6   A0A165A7R7   E9FS90   A0A1W4X289   A0A1B6C9A4   A0A1Y1KUT7   A0A0P4ZJB9   A0A0P6HXA4   A0A0P5RS99   A0A0P5DHR8   A0A0P5G0C5   A0A0P5QQ02   A0A0P5NJF4   A0A0P5Q991   A0A0P6A951   A0A0P5DUB9   A0A2P6L022   A0A0K2V134   A0A0P4W1M4   A0A147BPD1   A0A1L8DSG8   Q16NN6   A0A1L8DSE2   A0A131YG45   A0A224YXG4   T1JJB8   A0A0P5RD33   A0A0P5JK59   A0A0P5LCI5   A0A0N8C9Q3   A0A0P6H0L9   V4AMK5   B4QLS7   A0A0J9UM16   B4ITV2   B3NDQ4   B4HIM6   M9PI73   Q9VUX2   A0A0P8XUH9   B3M9T6   A0A1W4VAP8  

PDB

4GPM     E-value=4.02693e-10,     Score=156

KEGG

101743326    K10645 E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27] | (RefSeq) E3 ubiquitin-protein ligase MI

GO

GO:0016874   GO:0004842   GO:0005737   GO:0016567   GO:0016021   GO:0008270   GO:0046872   GO:0000209   GO:0045179   GO:0045807   GO:0006897   GO:0045747   GO:0008104   GO:0061630   GO:0046331   GO:0007423   GO:0008593   GO:0005829   GO:0007219   GO:0005515   GO:0004386   GO:0008026   GO:0006412   GO:0003676   GO:0005739   GO:0006635   GO:0016507   GO:0048384  

Subcellular location

  

Length:

451

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00289

Exp number, first 60 AAs:

0.00023

Total prob of N-in:

0.00176

outside

1  -  451

 

 

Pi

240.099787

Theta

173.490906

Tajima's D

1.45463

CLR

0.125242

CSRT

0.781410929453527

Interpretation

Uncertain