Gene

KWMTBOMO02064  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003196

Annotation

VA0D_MANSE_RecName:_Full%3DV-type_proton_ATPase_subunit_d;_short=V-ATPase_subunit_d;_altname:_full=M40,V-ATPase_40_kDa_subunit,Vacuolar_proton_pump_subunit_d

Location

Bomo_Chr4(-):11239150-11241756      View in EpiBrowser

Full name

V-type proton ATPase subunit       + More
V-type proton ATPase subunit d      
V-type proton ATPase subunit d 1      

Alternative Name

M40
V-ATPase 40 kDa subunit
Vacuolar proton pump subunit d
V-ATPase 39 kDa subunit
Vacuolar H+ ATPase subunit AC39-1
Vacuolar proton pump subunit d 1

Location in the cell

Cytoplasmic   Reliability : 2.696

CDS

ATGAAGGGTTGCATATTTAATATTGATGCTGGGTATTTGGAGGGCTTGTGCCGTGGTTTCAAATGTGGTATTCTGAAACAATCTGACTACTTGAACTTGGTGCAGTGTGAGACACTTGAAGATCTAAAGCTCCATCTTCAGGGTACAGATTATGGCACTTTCCTTGCCAACGAGCCCAGCCCCCTGTCTGTATCTACTATTGATGACAAGCTTCGTGAAAAGCTTGTTATTGAATTCCAACATCTTCGGAATCACTCTGTAGAGCCTCTGTCAACATTTTTGGATTTCATTACCTACAGCTATATGATTGATAACATCATCTTGTTGATTACTGGTACATTGCACCAGAGACCTATCTCGGAGTTAATTCCAAAGTGCCATCCATTAGGCTCATTTGAGCAGATGGAAGCTATTCATGTAGCTGCAACACCAGCTGAACTTTACAATGCTGTGTTGGTGGACACACCATTGGCGCCATTCTTTGTGGATTGCATTAGCGAACAAGACTTGGATGAAATGAATATTGAGATTATCCGGAACACTCTATACAAGGCGTATTTGGAAGCTTTTTATGATTTCTGTAAGCAAATCGGAGGAACTACTGCTGATGTGATGTGCGAAATCTTAGCTTTTGAAGCCGATCGCCGTGCTATTATCATTACAATCAACTCATTTGGCACTGAACTGTCCAAGGATGACCGTGCTAAATTGTATCCCCGTTGTGGCAAACTCAACCCTGATGGTCTTGCCGCACTGGCTCGTGCTGATGATTATGAACAAGTGAAGGCTGTTGCTGAATACTATGCTGAGTATTCTGCTTTGTTTGAAGGAGCTGGCAATAATGTGGGAGACAAAACTTTGGAAGACAAATTCTTTGAACATGAGGTAAGCCTTAATGTTCATGCTTTCCTGCAACAATTCCATTTTGGAGTTTTCTATTCTTATCTGAAATTAAAGGAACAGGAGTGCCGTAACATTGTTTGGATCAGTGAATGCGTGGCCCAGAAACATCGTGCCAAAATCGACAACTACATTCCAATCTTCTAA

Protein

MKGCIFNIDAGYLEGLCRGFKCGILKQSDYLNLVQCETLEDLKLHLQGTDYGTFLANEPSPLSVSTIDDKLREKLVIEFQHLRNHSVEPLSTFLDFITYSYMIDNIILLITGTLHQRPISELIPKCHPLGSFEQMEAIHVAATPAELYNAVLVDTPLAPFFVDCISEQDLDEMNIEIIRNTLYKAYLEAFYDFCKQIGGTTADVMCEILAFEADRRAIIITINSFGTELSKDDRAKLYPRCGKLNPDGLAALARADDYEQVKAVAEYYAEYSALFEGAGNNVGDKTLEDKFFEHEVSLNVHAFLQQFHFGVFYSYLKLKEQECRNIVWISECVAQKHRAKIDNYIPIF

Description

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.
Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).

Subunit

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.
V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Similarity

Belongs to the V-ATPase V0D/AC39 subunit family.

Keywords

Hydrogen ion transport   Ion transport   Transport   Complete proteome   Reference proteome  

Feature

chain  V-type proton ATPase subunit d

Uniprot

H9J109   Q25531   Q1HPX1   A0A2A4K6C5   I4DJR0   S4NX88   + More
A0A194QLU4   A0A2H1VEI1   A0A212EK84   A0A0L7LPI7   A0A2R8G1V9   A0A1Y1LI32   A0A1E1WIR1   A0A2A3E9S2   V9IGC1   A0A088A285   E2BFH2   A0A026WL89   A0A0N0U3U8   A0A0C9RWV7   A0A1B0DKW9   A0A1B0C852   A0A2J7Q4F3   A0A151IM95   A0A151WV68   D6WM16   A0A1L8DFH0   A0A1B6D0F1   Q1HQS1   A0A023ERH1   K9M063   A0A1Q3FK41   A0A182K744   A0A2M3ZFP2   A0A2M4A3B9   A0A2M4BSY5   W5JQU6   A0A182Y7J9   A0A182MB12   A0A182SNI7   A0A182VBW7   A0A182W4B4   B0WSX7   A0A084VVR6   A0A182KY13   A0A182IU71   A0A182X574   Q7PRN7   A0A182R3G5   A0A182I9R2   A0A195B7F4   A0A182PPC6   A0A232FD38   K7IWG7   A0A1A9WVC7   A0A0L0C8U6   A0A1I8NZZ2   A0A336LI54   U5EUP4   E0VS26   A0A151J7H2   A0A0A1XGK0   A0A1L8EES3   T1PAZ3   A0A0K8V165   A0A034WJ70   A0A1A9YP13   A0A1A9V6L9   A0A1B0AXR7   A0A1B0A5I2   D3TMM3   A0A1J1HQJ3   A0A182NN14   A0A1W4V1L8   W8C2B5   B4Q0H4   B3MQZ0   B4NDF5   B3NSS5   A0A3B0J7G0   Q29G85   B4GW26   A0A182QXA2   A0A1L8EHA9   A0A0A9WIC5   B4MB16   B4L743   A0A0M4ELE2   B4I142   A0A0K8TPI8   Q9W4P5   A0A069DSL2   R4G8R2   A0A224XSZ4   A0A2Z1YXZ9   B4JX96   N6UJ40   A0A161M474   B4NPU6   Q5UEM9  

Pubmed

19121390    9271213    22651552    26354079    23622113    22118469    + More
26227816    28004739    20798317    24508170    30249741    18362917    19820115    17204158    17510324    24945155    26483478    20920257    23761445    25244985    24438588    20966253    12364791    14747013    17210077    28648823    20075255    26108605    20566863    25830018    25315136    25348373    20353571    24495485    17994087    17550304    15632085    25401762    26369729    10731132    12537572    12537569    26334808    27558665    23537049   

EMBL

BABH01010534    X98825    DQ443281    ABF51370.1    NWSH01000081    PCG79815.1    + More
AK401528    KQ459601    BAM18150.1    KPI93738.1    GAIX01009169    JAA83391.1    KQ461196    KPJ06497.1    ODYU01001874    SOQ38684.1    AGBW02014319    OWR41875.1    JTDY01000385    KOB77433.1    KY921847    AVP73919.1    GEZM01056946    JAV72551.1    GDQN01004151    JAT86903.1    KZ288311    PBC28477.1    JR043001    AEY59707.1    GL448037    EFN85494.1    KK107154    QOIP01000001    EZA56805.1    RLU27159.1    KQ435881    KOX69852.1    GBYB01012335    GBYB01012336    JAG82102.1    JAG82103.1    AJVK01006516    AJVK01006517    AJWK01000173    NEVH01018383    PNF23460.1    KQ977063    KYN05993.1    KQ982706    KYQ51830.1    KQ971343    EFA03371.1    GFDF01008974    JAV05110.1    GEDC01018161    JAS19137.1    DQ440373    CH477719    ABF18406.1    EAT36933.1    JXUM01016045    JXUM01108598    GAPW01002337    KQ565246    KQ560448    JAC11261.1    KXJ71185.1    KXJ82372.1    JN676087    AFQ00928.1    GFDL01007098    JAV27947.1    GGFM01006550    MBW27301.1    GGFK01001920    MBW35241.1    GGFJ01006962    MBW56103.1    ADMH02000604    ETN65678.1    AXCM01004867    DS232077    EDS34105.1    ATLV01017216    KE525157    KFB42060.1    AXCP01004934    AAAB01008847    EAA06911.5    APCN01001027    KQ976565    KYM80441.1    NNAY01000440    OXU28379.1    JRES01000755    KNC28657.1    UFQS01000015    UFQT01000015    SSW97348.1    SSX17734.1    GANO01001377    JAB58494.1    DS235742    EEB16182.1    KQ979679    KYN19851.1    GBXI01004664    JAD09628.1    GFDG01001601    JAV17198.1    KA645902    AFP60531.1    GDHF01019718    JAI32596.1    GAKP01005124    JAC53828.1    JXJN01005350    CCAG010014759    EZ422675    ADD18951.1    CVRI01000014    CRK89802.1    GAMC01003197    JAC03359.1    CM000162    EDX01258.1    CH902622    EDV34195.1    CH964239    EDW82861.1    CH954180    EDV45755.1    OUUW01000003    SPP78184.1    CH379064    EAL32225.1    CH479193    EDW26871.1    AXCN02001590    GFDG01000755    JAV18044.1    GBHO01036458    GBRD01016805    JAG07146.1    JAG49022.1    CH940655    EDW66425.1    CH933812    EDW06189.1    CP012528    ALC48234.1    CH480819    EDW53223.1    GDAI01001540    JAI16063.1    AE014298    AY069530    GBGD01001994    JAC86895.1    ACPB03001482    GAHY01000527    JAA76983.1    GFTR01005337    JAW11089.1    KU665627    AOM63315.1    CH916376    EDV95372.1    APGK01018036    KB740064    KB632132    ENN81765.1    ERL89014.1    GEMB01004298    JAR98974.1    CH964291    EDW86171.1    AY750873    AAV31420.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000037510    + More
UP000242457    UP000005203    UP000008237    UP000053097    UP000279307    UP000053105    UP000092462    UP000092461    UP000235965    UP000078542    UP000075809    UP000007266    UP000008820    UP000069940    UP000249989    UP000075881    UP000000673    UP000076408    UP000075883    UP000075901    UP000075903    UP000075920    UP000002320    UP000030765    UP000075882    UP000075880    UP000076407    UP000007062    UP000075900    UP000075840    UP000078540    UP000075885    UP000215335    UP000002358    UP000091820    UP000037069    UP000095300    UP000009046    UP000078492    UP000095301    UP000092443    UP000078200    UP000092460    UP000092445    UP000092444    UP000183832    UP000075884    UP000192221    UP000002282    UP000007801    UP000007798    UP000008711    UP000268350    UP000001819    UP000008744    UP000075886    UP000008792    UP000009192    UP000092553    UP000001292    UP000000803    UP000015103    UP000001070    UP000019118    UP000030742   

PRIDE

H9J109    Q1HPX1    Q9W4P5   

Pfam

PF01992   vATP-synt_AC39

Interpro

IPR002843   ATPase_V0-cplx_csu/dsu        + More
IPR016727   ATPase_V0-cplx_dsu       
IPR036079   ATPase_su_C-like       
IPR035067   V-type_ATPase_suC       

SUPFAM

SSF103486   SSF103486       

Gene 3D

1.20.1690.10    

ProteinModelPortal

H9J109   Q25531   Q1HPX1   A0A2A4K6C5   I4DJR0   S4NX88   + More
A0A194QLU4   A0A2H1VEI1   A0A212EK84   A0A0L7LPI7   A0A2R8G1V9   A0A1Y1LI32   A0A1E1WIR1   A0A2A3E9S2   V9IGC1   A0A088A285   E2BFH2   A0A026WL89   A0A0N0U3U8   A0A0C9RWV7   A0A1B0DKW9   A0A1B0C852   A0A2J7Q4F3   A0A151IM95   A0A151WV68   D6WM16   A0A1L8DFH0   A0A1B6D0F1   Q1HQS1   A0A023ERH1   K9M063   A0A1Q3FK41   A0A182K744   A0A2M3ZFP2   A0A2M4A3B9   A0A2M4BSY5   W5JQU6   A0A182Y7J9   A0A182MB12   A0A182SNI7   A0A182VBW7   A0A182W4B4   B0WSX7   A0A084VVR6   A0A182KY13   A0A182IU71   A0A182X574   Q7PRN7   A0A182R3G5   A0A182I9R2   A0A195B7F4   A0A182PPC6   A0A232FD38   K7IWG7   A0A1A9WVC7   A0A0L0C8U6   A0A1I8NZZ2   A0A336LI54   U5EUP4   E0VS26   A0A151J7H2   A0A0A1XGK0   A0A1L8EES3   T1PAZ3   A0A0K8V165   A0A034WJ70   A0A1A9YP13   A0A1A9V6L9   A0A1B0AXR7   A0A1B0A5I2   D3TMM3   A0A1J1HQJ3   A0A182NN14   A0A1W4V1L8   W8C2B5   B4Q0H4   B3MQZ0   B4NDF5   B3NSS5   A0A3B0J7G0   Q29G85   B4GW26   A0A182QXA2   A0A1L8EHA9   A0A0A9WIC5   B4MB16   B4L743   A0A0M4ELE2   B4I142   A0A0K8TPI8   Q9W4P5   A0A069DSL2   R4G8R2   A0A224XSZ4   A0A2Z1YXZ9   B4JX96   N6UJ40   A0A161M474   B4NPU6   Q5UEM9  

PDB

6O7X     E-value=8.82683e-85,     Score=798

KEGG

732966    K02146 V-type H+-transporting ATPase subunit d | (RefSeq) H+ transporting ATPase V0 subunit D

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)
04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0033179   GO:0015078   GO:0015991   GO:0016471   GO:0007034   GO:0005769   GO:0008553   GO:0005765   GO:0046961   GO:0033181   GO:0007035   GO:0016787   GO:0007430   GO:0006879   GO:0036295   GO:0005886   GO:0000220   GO:0006730   GO:0006412   GO:0003676   GO:0005739   GO:0006635   GO:0016507   GO:0048384  

PANTHER

PTHR11028  

Length:

348

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.357740000000001

Exp number, first 60 AAs:

7e-05

Total prob of N-in:

0.02975

outside

1  -  348

 

 

Pi

188.901717

Theta

160.816885

Tajima's D

0.549177

CLR

1.188842

CSRT

0.529923503824809

Interpretation

Uncertain