Gene

KWMTBOMO02061  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011168

Annotation

S-adenosyl-L-homocysteine_hydrolase_[Bombyx_mori]

Location

Bomo_Chr4(+):11219647-11228569      View in EpiBrowser

Full name

Adenosylhomocysteinase      

Alternative Name

S-adenosyl-L-homocysteine hydrolase

Location in the cell

Cytoplasmic   Reliability : 3.987

CDS

ATGAAGCCTCCTTACAAAATCGCTGACGAGAAATTGGCTGAATGGGGCCGAAAAGAAATTATGTTAGCAGAGAAAGAAATGCCAGGCCTTATGGCATGTCGTCGGAAATATGCTCCAGCTAAAATACTCAAAGGTGCCAGAATAGCCGGCAGCTTACACATGACAGTACAAACAGCGGTTCTTATTGAGACTTTAATAGAATTGGGAGCAGAGGTACAATGGTCCAGCAGTAACATTTATAGTACACAAGACGAGGCCGCAGCTGCACTGGTTGCCGTAGGAATACCCATCTATGCCTGGAAGGGAGAAACTGATGACGAGTATATTTGGTGTATTGAACAAACATTGATCTTCCCTGATGGAAAGCCTCTCAATATGATCTTGGATGATGGGGGTGACTTAACAAACTTAGTCCACACTAAGTACCCCGATCTTTTAAAAGACGTAAAAGGTATCACTGAAGAAACTACAACCGGGGTACATAATTTGTATAAAATGTTCCGAGAAGGACTTTTAAAAGTTCCTGCAATCAACGTTAACGATTCAGTAACAAAAAGCAAATTCGACAACTTGTATGGATGTAGGGAGTCTTTGCTCGACGGAATCAAAAGGGCAACAGACATAATGATTGCCGGGAAAGTTTGTGTAGTGGCAGGTTATGGTGACGTTGGAAAAGGATGCGCCCAAGCGTTCAAAGGTTTTGGCGGTAGAGTGATCGTTACCGAAATCGATCCCATCAACGCACTTCAGGCCGCAATGGAAGGTTTTCAAGTGACTACTATGGAGGAAGCCGCTGAAGTGGGTCAAATCTTTGTCACCACGACGGGAAATATTGACATTATATGCAAAGAACATCTTCTTAGAATGAAGGACGATGCAATTGTGTGCAACATTGGTCACTTTGATTGCGAAATTGATGTTGCATGGCTAGATAACAACGCAAAAAAAGTTAACATCAAACAACATGTTGATCGTTATGAATTAGAAAATGGTAACCATATTATTGTTCTTGCTGCAGGAAGACTGGTTAATTTAGGTTGCGCAACCGGCCATTCCTCTTTTGTAATGTCTAATTCATTCACAAATCAAGTTCTAGCTCAGATAGAGCTGTGGACCAAAGCAGACACATATCCAATAGGTGTCCACACACTACCTAAGAAACTTGACGAGGAAGTAGCTGCCTTGCATTTGGATCACCTTGGTGTAAAACTGACGAAGTTAACACCTAAACAAGCCAAATACATTGGTGTCTCTCGAGAAGGACCTTACAAGCCAGATCATTACAGATATTAA

Protein

MKPPYKIADEKLAEWGRKEIMLAEKEMPGLMACRRKYAPAKILKGARIAGSLHMTVQTAVLIETLIELGAEVQWSSSNIYSTQDEAAAALVAVGIPIYAWKGETDDEYIWCIEQTLIFPDGKPLNMILDDGGDLTNLVHTKYPDLLKDVKGITEETTTGVHNLYKMFREGLLKVPAINVNDSVTKSKFDNLYGCRESLLDGIKRATDIMIAGKVCVVAGYGDVGKGCAQAFKGFGGRVIVTEIDPINALQAAMEGFQVTTMEEAAEVGQIFVTTTGNIDIICKEHLLRMKDDAIVCNIGHFDCEIDVAWLDNNAKKVNIKQHVDRYELENGNHIIVLAAGRLVNLGCATGHSSFVMSNSFTNQVLAQIELWTKADTYPIGVHTLPKKLDEEVAALHLDHLGVKLTKLTPKQAKYIGVSREGPYKPDHYRY

Description

Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.

Catalytic Activity

H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine

Cofactor

NAD(+)

Subunit

Interacts with AhcyL1; the interaction may negatively regulate Ahcy catalytic activity.

Similarity

Belongs to the adenosylhomocysteinase family.

Keywords

Complete proteome   Hydrolase   NAD   One-carbon metabolism   Reference proteome  

Feature

chain  Adenosylhomocysteinase

Uniprot

Q1HPU7   A0A212EK57   A0A2A4K6D7   A0A2H1VCY7   S4PFC2   A0A194QSI2   + More
A0JCJ9   I4DJ26   A0A220K8Q1   A0A2A4K821   A0A0L7LPR8   A0A222AJ25   H9JNR4   A0A182QB80   A0A0J7L559   A0A2M4BNW7   A0A0H4J5A1   A0A182N1X4   D6WMI3   A0A2M3ZH49   A0A182FH88   A0A182PPC4   A0A232F0W8   V5GRK7   E2A3R3   A0A2M4A5U0   J3JZ28   T1DMZ8   A0A1B6G340   A0A182W4B6   A0A182T5F0   A0A182MEY8   A0A182Y7K2   A0A182IJX3   A0A1B6MRU4   Q1HQR0   A0A023ES51   A0A182MZP9   A0A084VT28   T1PCH0   A0A182L6A9   O76757   A0A182X572   A0A182VBX5   A0A182I9R4   A0A182U980   A0A2A3EM47   A0A1L8EDS3   A0A1I8NVD1   A0A026WTZ2   A0A0L0C832   A0A088A1B6   A0A1Q3FVZ4   A0A182R3G7   A0A2M4CTK5   A0A158NKA3   U5EZ85   F4W8K2   A0A1J1HTJ9   A0A182IW45   A0A2M4CUT3   A0A310SGQ7   A0A084VVR9   B3MR98   A0A1L8DZN4   B4MSP6   B3NTL4   A0A1W4VH79   B4M6U8   B4L1T2   B4PWM7   E2BIK4   E9IBV6   A0A3B0J841   Q29G51   A0A0A1XL48   B4GVX7   A0A1Y1MK78   A0A0M5JDP9   B4JLP1   A0A1W4XAP6   X2JF40   Q27580   B4R576   A0A034VRE6   B4ILS9   A0A182R4F8   A0A2J7Q4G0   A0A1B6D2V7   A0A151WIQ5   A0A0K8U908   A0A067QR94   A0A336K2G9   A0A195BAW4   A0A195EHN6   W8CD81   A0A0L7R5T9   A0A069DUL7   A0A224XQH0   A0A161ME74  

EC Number

3.3.1.1

Pubmed

22118469    23622113    26354079    22651552    28630352    26227816    + More
19121390    18362917    19820115    28648823    20798317    22516182    25244985    17204158    17510324    24945155    26483478    24438588    25315136    20966253    12364791    24508170    30249741    26108605    21347285    21719571    17994087    17550304    21282665    15632085    25830018    28004739    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    9037110    12537569    27313316    25348373    24845553    24495485    26334808   

EMBL

DQ443305    ABF51394.1    AGBW02014319    OWR41879.1    NWSH01000081    PCG79801.1    + More
ODYU01001874    SOQ38687.1    GAIX01004082    JAA88478.1    KQ461196    KPJ06501.1    AB282637    BAF36817.1    AK401294    BAM17916.1    MF319733    ASJ26447.1    PCG79800.1    JTDY01000385    KOB77432.1    KY563910    ASO76366.1    BABH01042252    AXCN02000974    LBMM01000555    KMQ98067.1    GGFJ01005522    MBW54663.1    KP689345    AKO63327.1    KQ971343    EFA04274.1    GGFM01007039    MBW27790.1    NNAY01001377    OXU24183.1    GALX01004209    JAB64257.1    GL436457    EFN71955.1    GGFK01002761    MBW36082.1    BT128509    AEE63466.1    GAMD01003295    JAA98295.1    GECZ01012911    JAS56858.1    AXCM01002930    GEBQ01001310    JAT38667.1    DQ440384    CH477503    ABF18417.1    EAT39891.1    JXUM01075535    GAPW01001551    KQ562892    JAC12047.1    KXJ74898.1    ATLV01016154    KE525057    KFB41122.1    KA645830    AFP60459.1    AF080546    AAAB01008847    APCN01001029    KZ288215    PBC32760.1    GFDG01001931    JAV16868.1    KK107105    QOIP01000011    EZA59535.1    RLU17141.1    JRES01000777    KNC28405.1    GFDL01003265    JAV31780.1    GGFL01004472    MBW68650.1    ADTU01018755    GANO01001248    JAB58623.1    GL887908    EGI69493.1    CVRI01000020    CRK90708.1    GGFL01004420    MBW68598.1    KQ764881    OAD54323.1    ATLV01017216    KE525157    KFB42063.1    CH902622    EDV34303.1    GFDF01002188    JAV11896.1    CH963851    EDW75135.1    CH954180    EDV47018.1    CH940653    EDW62515.1    CH933810    EDW06735.2    CM000162    EDX01773.1    GL448516    EFN84451.1    GL762137    EFZ21986.1    OUUW01000003    SPP78317.1    CH379064    EAL32259.1    GBXI01003029    JAD11263.1    CH479193    EDW26822.1    GEZM01032229    JAV84755.1    CP012528    ALC49118.1    CH916371    EDV91652.1    AE014298    AHN59738.1    X95636    AY102668    CM000366    EDX17977.1    GAKP01014829    GAKP01014826    JAC44123.1    CH480888    EDW55379.1    NEVH01018383    PNF23459.1    GEDC01017322    JAS19976.1    KQ983082    KYQ47728.1    GDHF01029504    GDHF01009913    JAI22810.1    JAI42401.1    KK853038    KDR12193.1    UFQS01000063    UFQT01000063    SSW98879.1    SSX19265.1    KQ976537    KYM81334.1    KQ978881    KYN27773.1    GAMC01002406    JAC04150.1    KQ414652    KOC66131.1    GBGD01001527    JAC87362.1    GFTR01006185    JAW10241.1    GEMB01000308    JAS02811.1   

Proteomes

UP000007151    UP000218220    UP000053240    UP000037510    UP000005204    UP000075886    + More
UP000036403    UP000075884    UP000007266    UP000069272    UP000075885    UP000215335    UP000000311    UP000075920    UP000075901    UP000075883    UP000076408    UP000075880    UP000008820    UP000069940    UP000249989    UP000030765    UP000095301    UP000075882    UP000007062    UP000076407    UP000075903    UP000075840    UP000075902    UP000242457    UP000095300    UP000053097    UP000279307    UP000037069    UP000005203    UP000075900    UP000005205    UP000007755    UP000183832    UP000007801    UP000007798    UP000008711    UP000192221    UP000008792    UP000009192    UP000002282    UP000008237    UP000268350    UP000001819    UP000008744    UP000092553    UP000001070    UP000192223    UP000000803    UP000000304    UP000001292    UP000235965    UP000075809    UP000027135    UP000078540    UP000078492    UP000053825   

PRIDE

Q1HPU7    A0JCJ9    H9JNR4    O76757    A0A088A1B6    X2JF40    + More
Q27580   

Pfam

PF05221   AdoHcyase        + More
PF00670   AdoHcyase_NAD
PF13855   LRR_8
PF01040   UbiA

Interpro

IPR000043   Adenosylhomocysteinase-like        + More
IPR015878   Ado_hCys_hydrolase_NAD-bd       
IPR034373   Adenosylhomocysteinase       
IPR042172   Adenosylhomocyst_ase-like_sf       
IPR036291   NAD(P)-bd_dom_sf       
IPR020082   S-Ado-L-homoCys_hydrolase_CS       
IPR032675   LRR_dom_sf       
IPR001611   Leu-rich_rpt       
IPR030470   UbiA_prenylTrfase_CS       
IPR000537   UbiA_prenyltransferase       
IPR006369   Protohaem_IX_farnesylTrfase       

SUPFAM

SSF51735   SSF51735       

Gene 3D

3.40.50.1480     3.80.10.10    

CDD

cd00401  SAHH
cd13957  PT_UbiA_Cox10

ProteinModelPortal

Q1HPU7   A0A212EK57   A0A2A4K6D7   A0A2H1VCY7   S4PFC2   A0A194QSI2   + More
A0JCJ9   I4DJ26   A0A220K8Q1   A0A2A4K821   A0A0L7LPR8   A0A222AJ25   H9JNR4   A0A182QB80   A0A0J7L559   A0A2M4BNW7   A0A0H4J5A1   A0A182N1X4   D6WMI3   A0A2M3ZH49   A0A182FH88   A0A182PPC4   A0A232F0W8   V5GRK7   E2A3R3   A0A2M4A5U0   J3JZ28   T1DMZ8   A0A1B6G340   A0A182W4B6   A0A182T5F0   A0A182MEY8   A0A182Y7K2   A0A182IJX3   A0A1B6MRU4   Q1HQR0   A0A023ES51   A0A182MZP9   A0A084VT28   T1PCH0   A0A182L6A9   O76757   A0A182X572   A0A182VBX5   A0A182I9R4   A0A182U980   A0A2A3EM47   A0A1L8EDS3   A0A1I8NVD1   A0A026WTZ2   A0A0L0C832   A0A088A1B6   A0A1Q3FVZ4   A0A182R3G7   A0A2M4CTK5   A0A158NKA3   U5EZ85   F4W8K2   A0A1J1HTJ9   A0A182IW45   A0A2M4CUT3   A0A310SGQ7   A0A084VVR9   B3MR98   A0A1L8DZN4   B4MSP6   B3NTL4   A0A1W4VH79   B4M6U8   B4L1T2   B4PWM7   E2BIK4   E9IBV6   A0A3B0J841   Q29G51   A0A0A1XL48   B4GVX7   A0A1Y1MK78   A0A0M5JDP9   B4JLP1   A0A1W4XAP6   X2JF40   Q27580   B4R576   A0A034VRE6   B4ILS9   A0A182R4F8   A0A2J7Q4G0   A0A1B6D2V7   A0A151WIQ5   A0A0K8U908   A0A067QR94   A0A336K2G9   A0A195BAW4   A0A195EHN6   W8CD81   A0A0L7R5T9   A0A069DUL7   A0A224XQH0   A0A161ME74  

PDB

5W4B     E-value=0,     Score=1748

KEGG

100101173    K01251 adenosylhomocysteinase [EC:3.3.1.1] | (RefSeq) S-adenosyl-L-homocysteine hydrolase

PATHWAY

00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0051287   GO:0006730   GO:0004013   GO:0019510   GO:0033353   GO:0005829   GO:0016021   GO:0008495   GO:0048034   GO:0006412   GO:0003676   GO:0005739   GO:0006635   GO:0016507   GO:0048384  

PANTHER

PTHR23420  

Length:

430

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0768100000000001

Exp number, first 60 AAs:

0.03202

Total prob of N-in:

0.01034

outside

1  -  430

 

 

Pi

173.558112

Theta

171.997036

Tajima's D

0.187725

CLR

0.393889

CSRT

0.425778711064447

Interpretation

Uncertain