Gene

KWMTBOMO02057

Pre Gene Modal

BGIBMGA002970

Annotation

PREDICTED:_organic_cation_transporter_protein_[Bombyx_mori]

Location

Bomo_Chr4(+):11180417-11186878      View in EpiBrowser

Full name

Carcinine transporter      

Location in the cell

PlasmaMembrane   Reliability : 4.858

CDS

ATGAAGAAAAATAACAATTCTGAAAACTATGGAACCCAAAATCAACAAAAGACGGATTCCGTTCTGGACCATGAAAGTGATTCGATTGACTTGGATGACTTGTTGCCTAAGATCGGCGAATTTGGTATCTATCAGAAGCTCCTCCTTTGGCTCGTGTGCCTGCCGGCATGCCTGCCTTGCGGATTTTGTGCGTTCAACCAATTATTTATGACAGATGTGCCTGACCATTGGTGTAAAGTGCCCGAACTGCAAATGCTAAATATAACACAATACGAACGTAAACTGTTATCGATCCCAACAAAGGATAATGTCAGTTTTGAGAAATGCTTTAGATATGCAATGGATTGGTCTGACATAAGGAGTGTATCAGAAATTCAATTAAATAAAAACTTAACCGTGGAACCTTGCTATGACGGATATGAGTTTAATATAACAGAAGTATCCTCATCTATAGTAATAGACTTTAATTTAGTATGCGAGTATGATGTCTACCCTACACTTGGATTGGTCGCTTTAAACGTTGGAGGACCCATTGGCGTTTATTCTTTTGGTTATTTAAATGACCGGATAGGTCGAAAGAAGTCCTTCTTTATCTGCTTAACTACACTGCTTATCGGAAGTATAATGACATCATACGCTCACGAATATTGGCTTTGGGTACTCGCCAGAGCTATCGTTGGCTTAACTATTCCAGCTGTTTACCAAATTCCTTTTATAATATAAATTCATATGTCATTTTATGTTTCAGCCTTAGAACTTGCCGGACCCAATTACCGATCTTTCGTGACAGTCATGACATGTATATTTTATACGTTGGGCTTGATATTACTATCAGTAGTGACCTATCTTCTACGAGATTGGAGATCTCTGGCATTAGCTACTTCAGTTCCCTTTACTGTGTATTACTTATATTGGTTTGTTTTACCTGAATCGCCACGATGGCTTTTGATGCGAGGACGACTAGAAGAAGCTAATGATATTCTACAAACTATAGCAAGAGTAAACAAAAAGGAATTACCCGATGAATATATGATTAAACTGCAAAAGTTAATTTTAGAATTAAAAGAGGATACACAACAAAAAAACAAACAGCAAGAAAGTGTGTTTACTCTATGTCGTACACCAAATATGCGACTCAAGACGTTTTTGATCACATTAAATTGGTGCGCATCTGAAATGGTATACGTTGGCCTAAGTTACTACGGCCCGGCTATTGGCGACAATCAGTATATGAGTTTCTTTCTGTCATCCGCCGTTGAAATACCGAGCTACCTTATATGTTGGATGCTCATGGATCGTATTGGCAGAAGATGGCCTCTATGTTTATCGATGGTTATTAGCGGCATTTTTTGTATCGTAACCGTTTTACTACCGAAAGATGCCATCACAGAAACGCTCATACTTTACCTTATTTCAAAATTATTTATCTCAGCATCTTTCTTAATAATATATCCTTACGCTGGTGAGCTCTATCCTACGGCATTACGAGGAGTGGGAATAGGTACTTCAGCGTATATTGGTGGCTTGGGTTTGATCATAATCCCATTTATTAATTACCTGGGTTCCAACAACTTAGTTCTACCTCTTGTAGTCATGGGAGCAGTATCAGTTGTCGGGGGTTTAAGCGCCCTTCGACTGCCGGAAACACTACATTGTCCGCTACCACAAACAGCCGAGGAAGGAGAAGAGTTCGGCAAGGACTGGACGTACAAAGATTGTTTTACATGCGGAGCAAAAACAGAAGCAACAACCAACGATTCTTATGAAAATCTGGACCAGTTAGAACTAACACAAGCACCACTCGTAGAAGTTGACGAAGCGGCAGGAATTGCACCCAAACGACGTAGCTCTATGCGGAAGTTGCTCCGGCAAACCAGCGTCGTTGAAACCCAACGGGATGTAGACGGAAACATTAAAATGACCTATTGGTTTTAG

Protein

MKKNNNSENYGTQNQQKTDSVLDHESDSIDLDDLLPKIGEFGIYQKLLLWLVCLPACLPCGFCAFNQLFMTDVPDHWCKVPELQMLNITQYERKLLSIPTKDNVSFEKCFRYAMDWSDIRSVSEIQLNKNLTVEPCYDGYEFNITEVSSSIVIDFNLVCEYDVYPTLGLVALNVGGPIGVYSFGYLNDRIGRKKSFFICLTTLLIGSIMTSYAHEYWLWVLARAIVGLTIPAVYQIPFIIXIHMSFYVSALELAGPNYRSFVTVMTCIFYTLGLILLSVVTYLLRDWRSLALATSVPFTVYYLYWFVLPESPRWLLMRGRLEEANDILQTIARVNKKELPDEYMIKLQKLILELKEDTQQKNKQQESVFTLCRTPNMRLKTFLITLNWCASEMVYVGLSYYGPAIGDNQYMSFFLSSAVEIPSYLICWMLMDRIGRRWPLCLSMVISGIFCIVTVLLPKDAITETLILYLISKLFISASFLIIYPYAGELYPTALRGVGIGTSAYIGGLGLIIIPFINYLGSNNLVLPLVVMGAVSVVGGLSALRLPETLHCPLPQTAEEGEEFGKDWTYKDCFTCGAKTEATTNDSYENLDQLELTQAPLVEVDEAAGIAPKRRSSMRKLLRQTSVVETQRDVDGNIKMTYWF

Description

Carcinine transporter which is required for recycling of the neurotransmitter histamine in photoreceptor neurons of the compound eye. Following histamine release from photoreceptors and its uptake by glia where it is converted to carcinine, required for the uptake of carcinine from glia into photoreceptor cells where it can be hydrolyzed by tan to form histamine and beta-alanine.

Similarity

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

Keywords

Cell membrane   Cell projection   Complete proteome   Glycoprotein   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Carcinine transporter

Uniprot

H9J0D4   A0A194QNF5   A0A194PRI5   A0A212FFN8   A0A182RMA0   A0A2A3E7Z2   + More
A0A087ZMY0   A0A182JHQ2   A0A0L7R6C6   A0A084W5R2   A0A182QQV7   A0A182XLB1   B0WBR2   A0A182VMF3   A0A182L0Q2   A0A0L0CC65   A0A182ICB2   A0A1S4GXZ9   A0A182UBB2   E2A047   Q7Q4C7   Q0IE90   A0A182NTV3   A0A182JZG1   A0A1W4XAG3   A0A0L7LPR6   A0A182F2J7   D6WNI6   A0A182P8L9   A0A182W6K2   J9JW50   W5JPR9   A0A1A9WLX5   A0A2H8TJJ3   E2BR29   A0A154P5C7   A0A1I8PHT8   A0A195D0L4   A0A1Q3FRQ8   A0A182Y3B5   E0VS39   A0A1B6DAL9   A0A1Y1MSY1   B4KJ01   A0A0A9Y7Z4   F4X0L0   A0A0M4EHD2   A0A026WGX9   A0A195B829   A0A2S2PVC3   A0A1A9ZEW6   B3MK17   Q29LW6   T1IDN4   A0A1W4UWC4   B3NLY6   A0A0Q9WK90   A0A151WYK2   B4P6K9   B4MVJ4   Q9VIK2   B4LV91   B4JAJ5   A0A0J9R5B2   W8BB72   A0A3B0JH67   B4IFF0   A0A0K8VPL8   A0A195D8P8   A0A195F707   A0A158ND10   A0A0A1XPC6   A0A1B6C0H0   A0A1B6C6H3   A0A1B6JUL4   A0A0A9YFN6   A0A182G8S6   A0A1I8N894   A0A1B0DPS5   A0A2S2NMF3   A0A336LNX3   A0A0C9RBQ7   A0A0P6ETD0   A0A0P5VAX3   A0A0N8EHR9   A0A0N0BCN3   A0A0P6BG71   D6W4U2   E9G0N5   A0A1W4WZY3   N6TNM1   A0A182M534   A0A2P8YUW3   A0A1B0BDQ4   A0A1J1HLR9   B4Q3H0   W8BP68   A0A0P4Y124  

Pubmed

19121390    26354079    22118469    24438588    20966253    26108605    + More
12364791    20798317    17510324    26227816    18362917    19820115    20920257    23761445    25244985    20566863    28004739    17994087    25401762    21719571    24508170    15632085    17550304    10731132    12537572    12537569    26653853    26713872    22936249    24495485    21347285    25830018    26483478    25315136    21292972    23537049    29403074   

EMBL

BABH01010540    KQ461196    KPJ06505.1    KQ459601    KPI93745.1    AGBW02008803    + More
OWR52533.1    KZ288335    PBC27867.1    KQ414646    KOC66393.1    ATLV01020688    KE525305    KFB45556.1    AXCN02000807    DS231881    EDS42683.1    JRES01000714    KNC29034.1    APCN01000791    AAAB01008964    GL435551    EFN73180.1    EAA12223.2    CH478001    EAT34487.1    JTDY01000385    KOB77435.1    KQ971343    EFA04375.1    ABLF02033212    ADMH02000888    ETN64759.1    GFXV01002491    MBW14296.1    GL449898    EFN81835.1    KQ434822    KZC07145.1    KQ977012    KYN06396.1    GFDL01004754    JAV30291.1    DS235742    EEB16195.1    GEDC01014559    JAS22739.1    GEZM01028152    JAV86427.1    CH933807    EDW13514.1    GBHO01015300    GBHO01002531    JAG28304.1    JAG41073.1    GL888498    EGI60002.1    CP012523    ALC40317.1    KK107213    EZA55290.1    KQ976558    KYM80671.1    GGMS01000208    MBY69411.1    CH902620    EDV31435.1    CH379060    EAL33929.1    ACPB03012769    CH954179    EDV54522.1    CH940649    KRF81572.1    KQ982650    KYQ52866.1    CM000158    EDW90961.1    CH963857    EDW75714.1    AE014134    AY047547    AAK77279.1    EDW64351.1    CH916368    EDW02781.1    CM002910    KMY91196.1    GAMC01008085    JAB98470.1    OUUW01000004    SPP79622.1    CH480833    EDW46372.1    GDHF01011485    JAI40829.1    KQ981135    KYN09242.1    KQ981744    KYN36385.1    ADTU01012158    GBXI01001879    JAD12413.1    GEDC01030287    JAS07011.1    GEDC01028192    JAS09106.1    GECU01004827    JAT02880.1    GBHO01015857    GBHO01015284    GBHO01015269    GBHO01002527    JAG27747.1    JAG28320.1    JAG28335.1    JAG41077.1    JXUM01048149    JXUM01048150    JXUM01048151    KQ561549    KXJ78195.1    AJVK01008218    GGMR01005688    MBY18307.1    UFQS01000026    UFQT01000026    SSW97671.1    SSX18057.1    GBYB01013984    JAG83751.1    GDIP01069132    GDIQ01071591    LRGB01001581    JAM34583.1    JAN23146.1    KZS11223.1    GDIP01102481    JAM01234.1    GDIQ01025516    JAN69221.1    KQ435896    KOX69254.1    GDIP01015077    JAM88638.1    BT124992    ADI44150.1    GL732528    EFX87372.1    APGK01028357    KB740686    ENN79568.1    AXCM01010206    PYGN01000346    PSN48030.1    JXJN01012599    CVRI01000010    CRK89008.1    CM000361    EDX05651.1    GAMC01008082    JAB98473.1    GDIP01234013    JAI89388.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000075900    UP000242457    + More
UP000005203    UP000075880    UP000053825    UP000030765    UP000075886    UP000076407    UP000002320    UP000075903    UP000075882    UP000037069    UP000075840    UP000075902    UP000000311    UP000007062    UP000008820    UP000075884    UP000075881    UP000192223    UP000037510    UP000069272    UP000007266    UP000075885    UP000075920    UP000007819    UP000000673    UP000091820    UP000008237    UP000076502    UP000095300    UP000078542    UP000076408    UP000009046    UP000009192    UP000007755    UP000092553    UP000053097    UP000078540    UP000092445    UP000007801    UP000001819    UP000015103    UP000192221    UP000008711    UP000008792    UP000075809    UP000002282    UP000007798    UP000000803    UP000001070    UP000268350    UP000001292    UP000078492    UP000078541    UP000005205    UP000069940    UP000249989    UP000095301    UP000092462    UP000076858    UP000053105    UP000000305    UP000019118    UP000075883    UP000245037    UP000092460    UP000183832    UP000000304   

PRIDE

H9J0D4    Q9VIK2    D6W4U2   

Pfam

PF00083   Sugar_tr        + More
PF02535   Zip
PF03810   IBN_N
PF02493   MORN

Interpro

IPR005828   MFS_sugar_transport-like        + More
IPR020846   MFS_dom       
IPR036259   MFS_trans_sf       
IPR003689   ZIP       
IPR016024   ARM-type_fold       
IPR021133   HEAT_type_2       
IPR011989   ARM-like       
IPR003409   MORN       
IPR001494   Importin-beta_N       
IPR040122   Importin_beta       
IPR005829   Sugar_transporter_CS       

SUPFAM

SSF103473   SSF103473        + More
SSF48371   SSF48371       

Gene 3D

1.25.10.10    

CDD

cd06174  MFS

ProteinModelPortal

H9J0D4   A0A194QNF5   A0A194PRI5   A0A212FFN8   A0A182RMA0   A0A2A3E7Z2   + More
A0A087ZMY0   A0A182JHQ2   A0A0L7R6C6   A0A084W5R2   A0A182QQV7   A0A182XLB1   B0WBR2   A0A182VMF3   A0A182L0Q2   A0A0L0CC65   A0A182ICB2   A0A1S4GXZ9   A0A182UBB2   E2A047   Q7Q4C7   Q0IE90   A0A182NTV3   A0A182JZG1   A0A1W4XAG3   A0A0L7LPR6   A0A182F2J7   D6WNI6   A0A182P8L9   A0A182W6K2   J9JW50   W5JPR9   A0A1A9WLX5   A0A2H8TJJ3   E2BR29   A0A154P5C7   A0A1I8PHT8   A0A195D0L4   A0A1Q3FRQ8   A0A182Y3B5   E0VS39   A0A1B6DAL9   A0A1Y1MSY1   B4KJ01   A0A0A9Y7Z4   F4X0L0   A0A0M4EHD2   A0A026WGX9   A0A195B829   A0A2S2PVC3   A0A1A9ZEW6   B3MK17   Q29LW6   T1IDN4   A0A1W4UWC4   B3NLY6   A0A0Q9WK90   A0A151WYK2   B4P6K9   B4MVJ4   Q9VIK2   B4LV91   B4JAJ5   A0A0J9R5B2   W8BB72   A0A3B0JH67   B4IFF0   A0A0K8VPL8   A0A195D8P8   A0A195F707   A0A158ND10   A0A0A1XPC6   A0A1B6C0H0   A0A1B6C6H3   A0A1B6JUL4   A0A0A9YFN6   A0A182G8S6   A0A1I8N894   A0A1B0DPS5   A0A2S2NMF3   A0A336LNX3   A0A0C9RBQ7   A0A0P6ETD0   A0A0P5VAX3   A0A0N8EHR9   A0A0N0BCN3   A0A0P6BG71   D6W4U2   E9G0N5   A0A1W4WZY3   N6TNM1   A0A182M534   A0A2P8YUW3   A0A1B0BDQ4   A0A1J1HLR9   B4Q3H0   W8BP68   A0A0P4Y124  

PDB

4LDS     E-value=1.84965e-09,     Score=152

KEGG

101743468    no KO assigned | (RefSeq) organic cation transporter protein

GO

GO:0022857   GO:0016021   GO:0046873   GO:0008643   GO:0005623   GO:0008536   GO:0006606   GO:1905131   GO:0043679   GO:0001504   GO:0046956   GO:0050908   GO:1905130   GO:0005326   GO:0007601   GO:0005886   GO:0006631   GO:0003824   GO:0008152   GO:0004300   GO:0005739   GO:0006635   GO:0016507   GO:0048384   GO:0055085  

PANTHER

PTHR10527  

Subcellular location

Cell membrane   Expressed predominantly in photoreceptor axon termini.   With evidence from 3 publications.
Cell projection   Expressed predominantly in photoreceptor axon termini.   With evidence from 3 publications.
Axon   Expressed predominantly in photoreceptor axon termini.   With evidence from 3 publications.

Length:

644

Number of predicted TMHs:

11

Exp number of AAs in TMHs:

247.10121

Exp number, first 60 AAs:

13.78023

Total prob of N-in:

0.99389

POSSIBLE N-term signal

sequence

inside

1  -  46

TMhelix

47  -  69

outside

70  -  162

TMhelix

163  -  185

inside

186  -  195

TMhelix

196  -  218

outside

219  -  232

TMhelix

233  -  255

inside

256  -  261

TMhelix

262  -  284

outside

285  -  288

TMhelix

289  -  308

inside

309  -  382

TMhelix

383  -  405

outside

406  -  437

TMhelix

438  -  457

inside

458  -  465

TMhelix

466  -  488

outside

489  -  497

TMhelix

498  -  520

inside

521  -  524

TMhelix

525  -  544

outside

545  -  644

 

 

Pi

248.379721

Theta

212.179982

Tajima's D

0.45815

CLR

0.351852

CSRT

0.503874806259687

Interpretation

Uncertain