Gene

KWMTBOMO02052  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003199

Annotation

PREDICTED:_aromatic-L-amino-acid_decarboxylase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr4(-):11088955-11095686      View in EpiBrowser

Full name

Aromatic-L-amino-acid decarboxylase      

Alternative Name

DOPA decarboxylase

Location in the cell

Cytoplasmic   Reliability : 2.831

CDS

ATGGAGGCCCCTGACTTCAAAGAATTTGCAAAAGCAATGACTGATTACATTGCTGAGTACTTGGAAAATATTCGTGACAGACAAGTTGTTCCGTCAGTAAAACCTGGCTACCTTCGACCATTAGTTCCGGAACAAGCACCGCAACAACCGGAGCCTTGGACTGCTGTGATGGCGGATATCGAGCGCGTGGTTATGTCCGGGGTCACCCACTGGCACTCGCCTCGGTTCCACGCCTACTTCCCAACCGCTAACTCGTATCCCGCTATAGTAGCAGACATGCTCAGCGGCGCCATCGCTTGCATTGGTTTTACTTGGATTGCTAGCCCGGCATGTACAGAGTTGGAAGTGGTTATGTTGGATTGGTTGGGTCAAATGCTTGGCCTGCCAGAAGAGTTCTTGGCGCGATCAGGTGGCGAGGCCGGCGGTGTAATCCAGGGCACGGCTAGCGAAGCTACTCTTGTCGCACTGCTAGGAGCCAAGTCTCGCATGATGCAAAGAGTCAAGGAACAACACCCTGAATGGAGTGACACCGATATATTATCCAAGCTCGTCGGCTATTGTAATAAACAAGCCCATTCTTCGGTGGAGCGAGCTGGACTCCTCGGCGGTGTTAGGCTAAAATCACTACAGCCAGACGGTCAACGTCGTCTTCGCGGAGACACTCTTCGTGACGCTATTGATGAAGACATCCGCAACGGTCTCATTCCATTCTATGTTGTTGCTACATTGGGTACAACTTCATCCTGCACATTCGACGCTCTTGACGAAATTGGAGATGTCTGTCTCTCACATGGAATTTGGCTTCACGTCGATGCCGCCTACGCTGGATCTGCTTTCATCTGCCCTGAGTATCGATACCTTATGAAAGGCGTTGAGAAAGCGGATTCATTTAATTTCAATCCTCACAAATGGATGCTGGTCAATTTTGATTGTTCAGCAATGTGGTTGAAACAGCCACGATGGATCGTCGATGCTTTCAACGTTGATCCTCTTTACTTGAAACACGACCAGCAAGGCTCAGCGCCAGATTACCGTCATTGGCAAATACCGTTGGGCCGCAGATTCAGAGCGCTGAAGTTGTGGTTCGTTTTGCGATTATACGGTGTTGAGAACTTACAAAAACACATCAGAAAACAGATCGCATTGGCCCATCTGTTCGAGAAGCTTTGCACTTCAGATGATAGATTCGAGTTGTTTGAAGAAGTCACTATGGGTTTAGTGTGTTTCAAACTGAAAGGAAGCAATGAAATCAATGAAGAACTATTACGCCGTATAAACGGACGTGGAAAAATTCATCTTGTCCCATCTAAGATCGATGATGTCTATTTCTTGAGATTGGCTATTTGCTCGCGTTTCTCCGAAGAAAGCGATATACATATTTCTTGGGAAGAAATAAAATCGAGTGCTGACGAAGTTCTTAAAAGCCAAAAGAAGTAA

Protein

MEAPDFKEFAKAMTDYIAEYLENIRDRQVVPSVKPGYLRPLVPEQAPQQPEPWTAVMADIERVVMSGVTHWHSPRFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMLDWLGQMLGLPEEFLARSGGEAGGVIQGTASEATLVALLGAKSRMMQRVKEQHPEWSDTDILSKLVGYCNKQAHSSVERAGLLGGVRLKSLQPDGQRRLRGDTLRDAIDEDIRNGLIPFYVVATLGTTSSCTFDALDEIGDVCLSHGIWLHVDAAYAGSAFICPEYRYLMKGVEKADSFNFNPHKWMLVNFDCSAMWLKQPRWIVDAFNVDPLYLKHDQQGSAPDYRHWQIPLGRRFRALKLWFVLRLYGVENLQKHIRKQIALAHLFEKLCTSDDRFELFEEVTMGLVCFKLKGSNEINEELLRRINGRGKIHLVPSKIDDVYFLRLAICSRFSEESDIHISWEEIKSSADEVLKSQKK

Catalytic Activity

H(+) + L-dopa = CO2 + dopamine
5-hydroxy-L-tryptophan + H(+) = CO2 + serotonin

Cofactor

pyridoxal 5'-phosphate

Subunit

Homodimer.

Similarity

Belongs to the group II decarboxylase family.

Keywords

Catecholamine biosynthesis   Decarboxylase   Lyase   Pyridoxal phosphate  

Feature

chain  Aromatic-L-amino-acid decarboxylase

Uniprot

Q6SA69   H9J112   Q967Q9   Q6SA70   Q95YG8   A0A2A4IYP3   + More
A0A194QSJ2   M4GVV8   D5MRK6   Q402L7   A0A2H1WW81   D5MRL2   A0A0L7LM89   A0A194PRI9   Q95YG9   B3TE27   B3TE26   A0A0G3VHZ3   P48861   V5R1B6   A0A212EHU9   A0A0S2E725   A0A220K8N1   D5LPS7   F2VLL8   F1T174   B3TEB6   L7QTW4   B3TE44   B3TE90   B3TE82   B3TE17   B3TE66   B3TE69   B3TE28   B3TE95   B3TE85   D7NUE8   L7QRN0   L7QTR5   B3TEA6   L7QX36   L7QRQ1   B3TE73   B3TE77   L7QS27   L7QSV8   L7QRE9   L7QSN9   D2WIZ6   L7QX01   B3TEB1   B3TE12   B3TE71   D2WIZ3   L7QRS1   L7QT77   B9U723   L7QSE1   L7QRB6   B3TE47   D2WJ28   L7QRR1   L7QTQ0   D2WJ33   L7QS08   L7QS32   L7QSY7   L7QTV7   L7QRL3   D2WIZ7   L7QSX0   L7QST5   L7QR19   D2WIX4   L7QRN2   B9U786   D2WJ44   L7QRP4   L7QT33   D2WIY6   L7QX15   L7QWC0   D2WJ25   L7QRY3   L7QWA0   L7QR05   L7QRD3   L7QS75   D2WJ42   B3TE51   B9U798   B3TEA4   D2WIZ8   B9U7B2   B9U7B8   B3TE96   B9U782   L7QX93   L7QQX1  

EC Number

4.1.1.28

Pubmed

19121390    26354079    16133568    26227816    7750638    22118469    + More
28630352    19954545    19492095   

EMBL

AY461438    AAR23825.1    BABH01010549    BABH01010550    BABH01010551    AF372836    + More
AAK48988.1    AY461437    AAR23824.1    AB072300    BAB68549.1    NWSH01005338    PCG64282.1    KQ461196    KPJ06511.1    JF795469    JF795470    AFG25780.1    AFG25781.1    AB525738    BAJ07588.1    AB178007    BAE43825.2    ODYU01011530    SOQ57325.1    AB525744    BAJ07594.1    JTDY01000586    KOB76562.1    KQ459601    KPI93750.1    AB072191    BAB68545.1    EU032793    ABW39060.1    EU032792    ABW39059.1    KP657625    AKL78850.1    U03909    KF620492    AHB23865.1    AGBW02014799    OWR41040.1    KT428965    ALN66634.2    MF319734    ASJ26448.1    GU953217    ADF43201.1    GU386338    ADU32894.1    AB605615    BAK09608.1    EU032882    ABW39149.1    JQ786184    AGB87994.1    EU032810    ABW39077.1    EU032856    ABW39123.1    EU032848    ABW39115.1    EU032783    ABW39050.1    EU032832    ABW39099.1    EU032835    ABW39102.1    EU032794    ABW39061.1    EU032861    ABW39128.1    EU032851    ABW39118.1    GQ292795    ADH04300.1    JQ785943    AGB87753.1    JQ786119    AGB87929.1    EU032872    ABW39139.1    JQ786061    AGB87871.1    JQ785682    AGB87492.1    EU032839    ABW39106.1    EU032843    ABW39110.1    JQ785832    AGB87642.1    JQ786077    AGB87887.1    JQ785920    AGB87730.1    JQ785789    AGB87599.1    GQ283615    ACT87681.1    JQ786026    AGB87836.1    EU032877    ABW39144.1    EU032778    ABW39045.1    EU032837    ABW39104.1    GQ283612    ACT87678.1    JQ785988    AGB87798.1    JQ785969    AGB87779.1    EU479128    ACD01558.1    JQ785674    AGB87484.1    JQ785890    AGB87700.1    EU032813    ABW39080.1    GQ283647    ACT87713.1    JQ786030    AGB87840.1    JQ786104    AGB87914.1    GQ283652    ACT87718.1    JQ786120    AGB87930.1    JQ786150    AGB87960.1    JQ785894    AGB87704.1    JQ786174    AGB87984.1    JQ785928    AGB87738.1    GQ283616    ACT87682.1    JQ785879    AGB87689.1    JQ785839    AGB87649.1    JQ785770    AGB87580.1    GQ283593    ACT87659.1    JQ786005    AGB87815.1    EU479191    ACD01621.1    GQ283663    ACT87729.1    JQ785958    AGB87768.1    JQ786172    AGB87982.1    GQ283605    ACT87671.1    JQ786041    AGB87851.1    JQ785801    AGB87611.1    GQ283644    ACT87710.1    JQ786090    AGB87900.1    JQ785771    AGB87581.1    JQ785755    AGB87565.1    JQ785848    AGB87658.1    JQ786133    AGB87943.1    GQ283661    ACT87727.1    EU032817    ABW39084.1    EU479203    ACD01633.1    EU032870    ABW39137.1    GQ283617    ACT87683.1    EU479217    ACD01647.1    EU479223    ACD01653.1    EU032862    ABW39129.1    EU479187    ACD01617.1    JQ786126    AGB87936.1    JQ785653    AGB87463.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000037510    UP000053268    UP000007151    + More

PRIDE

H9J112    Q967Q9    B3TE27    P48861   

Pfam

PF00282   Pyridoxal_deC        + More
PF01593   Amino_oxidase

Interpro

IPR002129   PyrdxlP-dep_de-COase        + More
IPR015421   PyrdxlP-dep_Trfase_major       
IPR021115   Pyridoxal-P_BS       
IPR015424   PyrdxlP-dep_Trfase       
IPR010977   Aromatic_deC       
IPR015422   PyrdxlP-dep_Trfase_dom1       
IPR002937   Amino_oxidase       
IPR036188   FAD/NAD-bd_sf       

SUPFAM

SSF53383   SSF53383        + More
SSF51905   SSF51905       

Gene 3D

3.40.640.10     3.90.1150.10     3.50.50.60    

ProteinModelPortal

Q6SA69   H9J112   Q967Q9   Q6SA70   Q95YG8   A0A2A4IYP3   + More
A0A194QSJ2   M4GVV8   D5MRK6   Q402L7   A0A2H1WW81   D5MRL2   A0A0L7LM89   A0A194PRI9   Q95YG9   B3TE27   B3TE26   A0A0G3VHZ3   P48861   V5R1B6   A0A212EHU9   A0A0S2E725   A0A220K8N1   D5LPS7   F2VLL8   F1T174   B3TEB6   L7QTW4   B3TE44   B3TE90   B3TE82   B3TE17   B3TE66   B3TE69   B3TE28   B3TE95   B3TE85   D7NUE8   L7QRN0   L7QTR5   B3TEA6   L7QX36   L7QRQ1   B3TE73   B3TE77   L7QS27   L7QSV8   L7QRE9   L7QSN9   D2WIZ6   L7QX01   B3TEB1   B3TE12   B3TE71   D2WIZ3   L7QRS1   L7QT77   B9U723   L7QSE1   L7QRB6   B3TE47   D2WJ28   L7QRR1   L7QTQ0   D2WJ33   L7QS08   L7QS32   L7QSY7   L7QTV7   L7QRL3   D2WIZ7   L7QSX0   L7QST5   L7QR19   D2WIX4   L7QRN2   B9U786   D2WJ44   L7QRP4   L7QT33   D2WIY6   L7QX15   L7QWC0   D2WJ25   L7QRY3   L7QWA0   L7QR05   L7QRD3   L7QS75   D2WJ42   B3TE51   B9U798   B3TEA4   D2WIZ8   B9U7B2   B9U7B8   B3TE96   B9U782   L7QX93   L7QQX1  

PDB

3K40     E-value=0,     Score=1970

KEGG

692675    K01593 aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105] | (RefSeq) dopa deca

PATHWAY

00350    Tyrosine metabolism - Bombyx mori (domestic silkworm)
00360    Phenylalanine metabolism - Bombyx mori (domestic silkworm)
00380    Tryptophan metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006520   GO:0030170   GO:0016831   GO:0016491   GO:0004058   GO:0042423   GO:0019752   GO:0003824   GO:0043565   GO:0003677   GO:0003707   GO:0003708   GO:0048384  

Length:

478

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.33659

Exp number, first 60 AAs:

8e-05

Total prob of N-in:

0.05143

outside

1  -  478

 

 

Pi

203.580724

Theta

181.69458

Tajima's D

0.198578

CLR

0.7315

CSRT

0.427728613569322

Interpretation

Uncertain