Gene

KWMTBOMO02042  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003205

Annotation

COP9_[Helicoverpa_zea]

Location

Bomo_Chr4(-):10878653-10882439      View in EpiBrowser

Full name

COP9 signalosome complex subunit 8      

Alternative Name

COP9 homolog
JAB1-containing signalosome subunit 8

Location in the cell

Cytoplasmic   Reliability : 1.255 Nuclear   Reliability : 1.653

CDS

ATGATTACGAATTTCGATAAACTTTGTGCTGATTTGGAAAGGCAAGAACTTGAGACACCAAATGGAATAGCCAGTCCCTCGACTTACGCTCAGCTATTAGCTATTTATTTGTATCAAAATGATCTGTGTAATGCAAAATTTTTATGGAAGAGAATACCACAAAATGTAATGAGTAGCTCCCCTGAAATAGTTGCAATATGGGCTATTGGACAGAAACTGTGGAAAAAAGATTTACCTGGTACATATGAGGCATTAGCAGCTTACTCTTGGACAGAACCAGTTTCCAACATTATAAGAGCTTTGGAAGAAAATGTTCGAGAAAGGACTCTAAACCTTATCGGAAGATCGTACAGTTCCATAAAAATAGATAAACTGATCTCAATGATTGGTCTCAGCAGGGAAGCCACATTACAAGTCTGTCAAGATCGCAGGTGGACTCTACATGATGATGGCATGACAGTGAATCCCTTACCCCCAGCACAACCAGCCCCATTGCATACTTCTAGTGAAGATCAACTTTTCAAACTAACAGAATTTGTGTCATTCTTAGAAAATTAA

Protein

MITNFDKLCADLERQELETPNGIASPSTYAQLLAIYLYQNDLCNAKFLWKRIPQNVMSSSPEIVAIWAIGQKLWKKDLPGTYEALAAYSWTEPVSNIIRALEENVRERTLNLIGRSYSSIKIDKLISMIGLSREATLQVCQDRRWTLHDDGMTVNPLPPAQPAPLHTSSEDQLFKLTEFVSFLEN

Description

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).

Subunit

Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B) (By similarity).

Similarity

Belongs to the CSN8 family.

Keywords

Complete proteome   Cytoplasm   Nucleus   Reference proteome   Signalosome   Phosphoprotein  

Feature

chain  COP9 signalosome complex subunit 8

Uniprot

H9J118   A0A2H1WFL5   A0A2A4K5E2   H2BDN5   A0A1E1W0Y4   A0A212EHT9   + More
S4P3L2   A0A194PKA5   A0A0L7L253   A0A194QLW4   A0A1Y1JYA5   D6WLE0   A0A1W4WR20   N6T9I7   A0A067QUY4   A0A0L7R6L8   A0A0M8ZTK8   A0A0P4VLZ3   R4G565   A0A2A3E8S2   V9IIH1   A0A087ZMX7   A0A2R7WHT4   A0A224XZB0   A0A069DWP3   A0A1B6CHB9   A0A0V0GC99   A0A0C9RWH6   A0A023F8D2   A0A2U9CCX2   W5MBW0   A0A1W4XR95   C1BK87   A0A3B3YRX6   A0A0P4VWY7   A0A2D0QI16   A0A2P8YEK9   A0A1S3NVB6   H2T2E4   K7IXY0   A0A3B5R691   E0VBW8   Q7ZUZ0   A0A3B4D8F3   C3Z0B0   A0A1Z5LAB0   F0JAE3   V4CFG1   A0A3B1KG27   A0A0A9W9W4   A0A2T7Q059   H3DKF3   A0A1B6GIB6   A0A023FV03   A0A1E1X1X8   S4RIE0   A0A0T6B310   A0A1E1XU43   A0A023FGJ4   R7TP68   A0A131XBQ2   A0A023GJ03   G3MR26   A0A2R5LFM5   A0A1S3H720   A0A3B4TQY5   A0A3B4WVZ1   A0A224YUT7   A0A131Z3X6   L7M424   I3JLX5   A0A2P6L7A5   A0A0K8RH84   G3MRD5   A0A093ILK3   A0A3B4GIQ7   A0A3P9D3V1   K9IHB3   A0A3P8N7Y1   A0A226N379   A0A226NWQ6   U5EKJ7   A0A091QUI0   H3B5M5   A0A3B4D9R2   A0A218UJY4   A0A293L5B0   A0A3P8RUS1   A0A1D5P6D2   K4GG99   H0YZN4   A0A210Q6K6   A0A293MYG5   T1J5K3   A0A3B5B033   A0A3B5MDL3   G1MV70   A0A1A6HWD5   A0A1V4K789   Q8VBV7  

Pubmed

19121390    22118469    23622113    26354079    26227816    28004739    + More
18362917    19820115    23537049    24845553    27129103    26334808    25474469    29403074    21551351    20075255    23542700    20566863    18563158    28528879    21362191    23254933    25329095    25401762    26823975    15496914    28503490    29209593    28049606    22216098    28797301    26830274    25576852    25186727    24621616    9215903    15592404    23056606    20360741    28812685    20838655    14636993    16141072    15489334    9707402    21183079   

EMBL

BABH01010566    ODYU01008242    SOQ51662.1    NWSH01000140    PCG79138.1    HQ840515    + More
ADX66430.1    GDQN01010397    JAT80657.1    AGBW02014799    OWR41048.1    GAIX01006394    JAA86166.1    KQ459601    KPI93757.1    JTDY01003468    KOB69510.1    KQ461196    KPJ06517.1    GEZM01102088    JAV51986.1    KQ971343    EFA04765.1    APGK01046715    KB741067    KB631663    ENN74403.1    ERL85125.1    KK853366    KDR08114.1    KQ414646    KOC66396.1    KQ435896    KOX69259.1    GDKW01000465    JAI56130.1    ACPB03009038    GAHY01000770    JAA76740.1    KZ288335    PBC27864.1    JR045954    AEY60094.1    KK854770    PTY18560.1    GFTR01003025    JAW13401.1    GBGD01003140    JAC85749.1    GEDC01024527    JAS12771.1    GECL01000646    JAP05478.1    GBYB01013350    JAG83117.1    GBBI01001150    JAC17562.1    CP026256    AWP12722.1    AHAT01011311    BT075016    ACO09440.1    GDRN01136910    JAI56661.1    PYGN01000658    PSN42702.1    DS235042    EEB10874.1    BC046071    BC071487    GG666568    EEN53958.1    GFJQ02002760    JAW04210.1    BK007844    DAA34781.1    KB200682    ESP00760.1    GBHO01041994    GBRD01005069    GDHC01012418    JAG01610.1    JAG60752.1    JAQ06211.1    PZQS01000001    PVD39051.1    GECZ01007716    JAS62053.1    GBBL01002001    JAC25319.1    GFAC01005970    JAT93218.1    LJIG01016041    KRT81792.1    GFAA01000642    JAU02793.1    GBBK01003830    JAC20652.1    AMQN01011861    KB309148    ELT95352.1    GEFH01004008    JAP64573.1    GBBM01002663    JAC32755.1    JO844327    AEO35944.1    GGLE01004190    MBY08316.1    GFPF01006907    MAA18053.1    GEDV01002448    JAP86109.1    GACK01007126    JAA57908.1    AERX01027305    MWRG01001240    PRD34473.1    GADI01003605    JAA70203.1    JO844436    AEO36053.1    KL215991    KFV67631.1    GABZ01007922    JAA45603.1    MCFN01000262    OXB61689.1    AWGT02000333    OXB71914.1    GANO01001786    JAB58085.1    KK682175    KFQ13049.1    AFYH01083954    AFYH01083955    AFYH01083956    AFYH01083957    AFYH01083958    MUZQ01000267    OWK53740.1    GFWV01001887    MAA26617.1    AADN05000347    JX053068    JX210869    AFK11296.1    AFM89183.1    ABQF01047938    NEDP02004821    OWF44351.1    GFWV01020451    MAA45179.1    JH431865    LZPO01008025    OBS82556.1    LSYS01004331    OPJ80255.1    AF482000    AF502144    AK079111    AK079522    AK088323    AK090013    AK145899    AK162502    BC017690    BC021488    BC024421   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000037510    UP000053240    + More
UP000007266    UP000192223    UP000019118    UP000030742    UP000027135    UP000053825    UP000053105    UP000015103    UP000242457    UP000005203    UP000246464    UP000018468    UP000192224    UP000261480    UP000221080    UP000245037    UP000087266    UP000005226    UP000002358    UP000002852    UP000009046    UP000000437    UP000261440    UP000001554    UP000030746    UP000018467    UP000245119    UP000007303    UP000245300    UP000014760    UP000085678    UP000261420    UP000261360    UP000005207    UP000053875    UP000261460    UP000265160    UP000265100    UP000198323    UP000198419    UP000008672    UP000197619    UP000265080    UP000000539    UP000007754    UP000242188    UP000261400    UP000261380    UP000001645    UP000092124    UP000190648    UP000000589   

PRIDE

H9J118    L7M424    Q8VBV7   

Pfam

PF10075   CSN8_PSD8_EIF3K        + More
PF00069   Pkinase

Interpro

IPR033464   CSN8_PSD8_EIF3K        + More
IPR033205   COP9_CSN8       
IPR000717   PCI_dom       
IPR036390   WH_DNA-bd_sf       
IPR000719   Prot_kinase_dom       
IPR000961   AGC-kinase_C       
IPR017441   Protein_kinase_ATP_BS       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       

SUPFAM

SSF46785   SSF46785        + More
SSF56112   SSF56112       

ProteinModelPortal

H9J118   A0A2H1WFL5   A0A2A4K5E2   H2BDN5   A0A1E1W0Y4   A0A212EHT9   + More
S4P3L2   A0A194PKA5   A0A0L7L253   A0A194QLW4   A0A1Y1JYA5   D6WLE0   A0A1W4WR20   N6T9I7   A0A067QUY4   A0A0L7R6L8   A0A0M8ZTK8   A0A0P4VLZ3   R4G565   A0A2A3E8S2   V9IIH1   A0A087ZMX7   A0A2R7WHT4   A0A224XZB0   A0A069DWP3   A0A1B6CHB9   A0A0V0GC99   A0A0C9RWH6   A0A023F8D2   A0A2U9CCX2   W5MBW0   A0A1W4XR95   C1BK87   A0A3B3YRX6   A0A0P4VWY7   A0A2D0QI16   A0A2P8YEK9   A0A1S3NVB6   H2T2E4   K7IXY0   A0A3B5R691   E0VBW8   Q7ZUZ0   A0A3B4D8F3   C3Z0B0   A0A1Z5LAB0   F0JAE3   V4CFG1   A0A3B1KG27   A0A0A9W9W4   A0A2T7Q059   H3DKF3   A0A1B6GIB6   A0A023FV03   A0A1E1X1X8   S4RIE0   A0A0T6B310   A0A1E1XU43   A0A023FGJ4   R7TP68   A0A131XBQ2   A0A023GJ03   G3MR26   A0A2R5LFM5   A0A1S3H720   A0A3B4TQY5   A0A3B4WVZ1   A0A224YUT7   A0A131Z3X6   L7M424   I3JLX5   A0A2P6L7A5   A0A0K8RH84   G3MRD5   A0A093ILK3   A0A3B4GIQ7   A0A3P9D3V1   K9IHB3   A0A3P8N7Y1   A0A226N379   A0A226NWQ6   U5EKJ7   A0A091QUI0   H3B5M5   A0A3B4D9R2   A0A218UJY4   A0A293L5B0   A0A3P8RUS1   A0A1D5P6D2   K4GG99   H0YZN4   A0A210Q6K6   A0A293MYG5   T1J5K3   A0A3B5B033   A0A3B5MDL3   G1MV70   A0A1A6HWD5   A0A1V4K789   Q8VBV7  

PDB

4D10     E-value=3.2083e-36,     Score=376

KEGG

101744476    K12181 COP9 signalosome complex subunit 8 | (RefSeq) COP9 signalosome complex subunit 8

GO

GO:0005737   GO:0010387   GO:0008180   GO:0000338   GO:0005524   GO:0004674   GO:0005654   GO:0007250   GO:0006468   GO:0008285   GO:0005829   GO:0048471   GO:0005634  

PANTHER

PTHR13339  

Subcellular location

Cytoplasm  
Nucleus  

Length:

185

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05407

Exp number, first 60 AAs:

0.04978

Total prob of N-in:

0.12609

outside

1  -  185

 

 

Pi

298.496292

Theta

212.998096

Tajima's D

1.345729

CLR

0.179696

CSRT

0.753762311884406

Interpretation

Uncertain