Gene

KWMTBOMO02038  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003206

Annotation

PREDICTED:_probable_cysteine_desulfurase?_mitochondrial_[Bombyx_mori]

Location

Bomo_Chr4(-):10767125-10772529      View in EpiBrowser

Full name

Probable cysteine desulfurase, mitochondrial       + More
Cysteine desulfurase, mitochondrial      

Location in the cell

Cytoplasmic   Reliability : 1.632 Mitochondrial   Reliability : 1.986

CDS

ATGTTCCGTTTGACAAAAAACGTGATTTCGGTGGTTTGTAAATCCGCAATAAAACAGAAAACCCAATTAAATGGAAACGGCGTTGTTATATTTGAGCAAAGCAATTTTTTTTCCGATTCTGCAAATGACAAATTTTCATTAAAACATGAGGAAGTTGGCCGGCCTTTGTATTTCGATGCTCAAGCCACTACACCAATGGATCCTAGAGTTCTTGATGTAATGCTACCATACTTAGTAAGTTATCATGGCAATCCACATTCAAGAACTCATGCGTATGGATGGGAAAGTGAAGCTGCTGTTGAAAAAGCCAGAGAACAAGTGGCAAATTTAATAAATGCTGAACCAAAAGAAATTATATTTACTTCAGGAGCAACAGAATCAAATAACATATCTGTTAAAGGTGTGGGTCGATTTTATGCACCAAGAAAAAAGCATGTCATTACTACTCAAATTGAACACAAATGTGTTTTAGACTCATGTCGTGCTTTAGAAGGTGAAGGTTTCAGAATTACATATTTACCAGTCCAACAGAATGGAATTATAAATTTAAAGGATTTGGAAGATGCCATCACGCCAGAAACCAGTTTGGTATCTATAATGACTGTCAATAATGAAATAGGTGTTAGACAACCAATTGAAGCTATAGGAGCAATATGCAAAAGCAAGAAAGTATTTTTTCATACTGATGCTGCCCAAGCTGTTGGAAAGGTACCTTTGGATGTTAACACAATGAACATTGATTTGATGTCGATTTCTGGACACAAAGTTTATGGACCTAAAGGCGTGGGCGCACTATACATTAGGCGGAGGCCTCGAGTGCGCGTAGAGCCAATACAGAGTGGGGGTGGACAGGAGAGAGGCATGAGAAGTGGAACTGTACCCACACCACTTGTTGTGGGATTAGGAGCTGCATGTGAGTTGGCCGGACGTGAAATGGCATATGATCATTTATGGATGGAAAAATTATCTAAAAGGTTTTTAGAAAAGATTAATTCTAAGCTGACACATGTGATAAGAAATGGAGATGCTGAACAAACATATCCAGGCTGTGTAAACTTATCTTTTGCATTTGTTGAAGGTGAATCTTTGTTGATGGCTTTAAAGGATGTAGCCTTGTCGAGTGGTTCAGCATGTACTTCTGCATCATTGGAACCTTCGTATGTTTTAAGAGCAATAGGAACTGATGAAGACTTAGCCCATAGTTCAATAAGATTTGGTTTAGGTCGCTTCACAACAATCGAAGAAGTAGACTACACAGCTGAAAAGACGATAAGACATGTTGAACGATTAAGAGAAATGAGTCCACTCTGGGAGATGGTACAAGAAGGCATAGATATAAAGACAATTCAATGGTCGCAGCATTAA

Protein

MFRLTKNVISVVCKSAIKQKTQLNGNGVVIFEQSNFFSDSANDKFSLKHEEVGRPLYFDAQATTPMDPRVLDVMLPYLVSYHGNPHSRTHAYGWESEAAVEKAREQVANLINAEPKEIIFTSGATESNNISVKGVGRFYAPRKKHVITTQIEHKCVLDSCRALEGEGFRITYLPVQQNGIINLKDLEDAITPETSLVSIMTVNNEIGVRQPIEAIGAICKSKKVFFHTDAAQAVGKVPLDVNTMNIDLMSISGHKVYGPKGVGALYIRRRPRVRVEPIQSGGGQERGMRSGTVPTPLVVGLGAACELAGREMAYDHLWMEKLSKRFLEKINSKLTHVIRNGDAEQTYPGCVNLSFAFVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSSIRFGLGRFTTIEEVDYTAEKTIRHVERLREMSPLWEMVQEGIDIKTIQWSQH

Description

Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters (By similarity).
Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor (By similarity).

Catalytic Activity

[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine

Cofactor

pyridoxal 5'-phosphate

Subunit

Binds ISCU/NIFUN. Forms a complex with LYRM4. Interacts with HSPA9.

Similarity

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

Keywords

Complete proteome   Iron   Iron-sulfur   Metal-binding   Mitochondrion   Nucleus   Pyridoxal phosphate   Reference proteome   Transferase   Transit peptide   Cytoplasm   Molybdenum cofactor biosynthesis   Alternative initiation  

Feature

chain  Probable cysteine desulfurase, mitochondrial
splice variant  In isoform Cytoplasmic.

Uniprot

A0A2A4K5F3   A0A2H1VZL4   A0A212EHV0   A0A194PKB0   A0A194QLU2   A0A2M4AKD3   + More
W5JBI3   A0A2M4AKP9   A0A182KBK5   A0A2M4BN46   A0A182X2X1   A0A182TKS8   Q7PW45   A0A182I4Y2   A0A182UMA9   A0A182KUR2   A0A2M3Z7G9   A0A2M3ZI17   A0A182NEW2   A0A182S9G5   A0A182R9Q9   A0A1Q3G3Q5   A0A182YFF4   A0A1Y1N1Z5   A0A182QRE4   D6WLY0   A0A3B0JGX9   A0A182PDE1   Q16S16   B3MLH9   A0A0A1WH04   A0A182WGY4   A0A2M4ALG4   A0A182GGX4   U5EHA0   A0A0L0C8X4   B4P1W4   A0A182LUG5   A0A1I8NHY9   A0A034VRU6   A0A023ERX8   A0A0K8W0X9   B4MTY1   Q9VKD3   A0A1W4UYR4   B4GQH8   B4IE43   B3N3Z3   Q29L91   A0A0J9R157   A0A1Y1MYA8   W8B6N9   A0A1B0CW22   A0A1I8PKF3   A0A0M4EDZ3   V5GU79   B4JQY2   A0A1L8E2D7   A0A182JAG8   A0A1B0DDD8   B4KJS4   A0A182F5H7   B4LQW5   A0A1B0AGU5   A0A1A9YFN6   A0A1A9VPE8   A0A1B0APW9   A0A023F5P0   A0A0P4VSF9   V3ZF91   A0A1S3EQ44   M3VZZ3   B5FW56   C3PT67   W5PZ31   A0A224XQW1   L8IDU0   A5PKG4   Q921V3   A0A2Y9GZD5   A0A212CBF7   A0A1U7R2Z2   A0A2K6GVB4   A0A2U3VES6   A0A2K6TJF2   A0A210QXR5   A0A1B6M7W6   Q9Z1J3   G5B845   Q3MHT2   B4G169   A0A1A9WMD5   G3HAR4   G3U7S1   B7NZJ3   G1TCX0   A0A250YIE4   G3T5I7   A0A0A9W6A9   Q99P39  

EC Number

2.8.1.7

Pubmed

22118469    26354079    20920257    23761445    12364791    14747013    + More
17210077    20966253    25244985    28004739    18362917    19820115    17510324    17994087    25830018    26483478    26108605    17550304    25315136    25348373    24945155    10731132    12537572    12537569    15632085    22936249    24495485    25474469    27129103    23254933    17975172    20809919    22751099    19393038    15489334    28812685    9738949    16141072    19468303    21183079    21993625    15057822    15632090    19936069    21804562    21993624    28087693    25401762   

EMBL

NWSH01000140    PCG79148.1    ODYU01005437    SOQ46280.1    AGBW02014799    OWR41054.1    + More
KQ459601    KPI93762.1    KQ461196    KPJ06523.1    GGFK01007896    MBW41217.1    ADMH02001866    ETN60758.1    GGFK01008039    MBW41360.1    GGFJ01005334    MBW54475.1    AAAB01008984    EAA14741.3    APCN01003737    GGFM01003703    MBW24454.1    GGFM01007327    MBW28078.1    GFDL01000624    JAV34421.1    GEZM01017441    JAV90675.1    AXCN02000839    KQ971343    EFA04185.1    OUUW01000006    SPP81425.1    CH477689    EAT37252.1    CH902620    EDV31728.1    GBXI01016604    JAC97687.1    GGFK01008127    MBW41448.1    JXUM01062622    KQ562208    KXJ76410.1    GANO01003116    JAB56755.1    JRES01000753    KNC28705.1    CM000157    EDW88135.1    AXCM01011510    GAKP01013778    JAC45174.1    GAPW01001621    JAC11977.1    GDHF01007585    GDHF01006401    JAI44729.1    JAI45913.1    CH963852    EDW75570.1    AE014134    AY113363    CH479187    EDW39850.1    CH480831    EDW45870.1    CH954177    EDV58845.1    CH379060    EAL34154.1    CM002910    KMY89853.1    GEZM01017444    JAV90671.1    GAMC01012273    JAB94282.1    AJWK01031590    CP012523    ALC40160.1    GALX01000742    JAB67724.1    CH916372    EDV99312.1    GFDF01001206    JAV12878.1    AJVK01031886    CH933807    EDW11519.1    CH940649    EDW64504.1    JXJN01001600    GBBI01002229    JAC16483.1    GDKW01002656    JAI53939.1    KB203854    ESO82787.1    AANG04003379    DP000893    ACH53037.1    DP001108    ACQ63011.1    AMGL01025929    GFTR01005893    JAW10533.1    JH881604    ELR53297.1    BC142478    AAI42479.1    BC010586    AAH10586.1    MKHE01000023    OWK03331.1    NEDP02001335    OWF53511.1    GEBQ01007958    JAT32019.1    AJ222660    AK075575    AK132838    AK148527    AK159828    AL833786    BX649640    CH466551    JH168905    EHB05456.1    AABR07054397    AC118414    BC104699    CH474050    AAI04700.1    EDL85866.1    BT043107    ACF88112.1    JH000254    EGW02782.1    DP001043    ACJ76630.1    AAGW02060160    AAGW02060161    AAGW02060162    GFFW01001391    JAV43397.1    GBHO01039629    GBHO01039627    GBRD01017014    GBRD01010924    JAG03975.1    JAG03977.1    JAG48813.1    AF336041   

Proteomes

UP000218220    UP000007151    UP000053268    UP000053240    UP000000673    UP000075881    + More
UP000076407    UP000075902    UP000007062    UP000075840    UP000075903    UP000075882    UP000075884    UP000075901    UP000075900    UP000076408    UP000075886    UP000007266    UP000268350    UP000075885    UP000008820    UP000007801    UP000075920    UP000069940    UP000249989    UP000037069    UP000002282    UP000075883    UP000095301    UP000007798    UP000000803    UP000192221    UP000008744    UP000001292    UP000008711    UP000001819    UP000092461    UP000095300    UP000092553    UP000001070    UP000075880    UP000092462    UP000009192    UP000069272    UP000008792    UP000092445    UP000092443    UP000078200    UP000092460    UP000030746    UP000081671    UP000011712    UP000002356    UP000009136    UP000248481    UP000189706    UP000233160    UP000245340    UP000233220    UP000242188    UP000000589    UP000006813    UP000002494    UP000091820    UP000001075    UP000007646    UP000001811   

PRIDE

Q9VKD3    Q9Z1J3    G3HAR4    Q99P39   

Pfam

PF00266   Aminotran_5        + More
PF00270   DEAD
PF00282   Pyridoxal_deC
PF04408   HA2
PF00271   Helicase_C

Interpro

IPR015422   PyrdxlP-dep_Trfase_dom1        + More
IPR020578   Aminotrans_V_PyrdxlP_BS       
IPR015421   PyrdxlP-dep_Trfase_major       
IPR016454   Cysteine_dSase       
IPR000192   Aminotrans_V_dom       
IPR015424   PyrdxlP-dep_Trfase       
IPR010240   Cys_deSase_IscS       
IPR011545   DEAD/DEAH_box_helicase_dom       
IPR001650   Helicase_C       
IPR021115   Pyridoxal-P_BS       
IPR002129   PyrdxlP-dep_de-COase       
IPR014001   Helicase_ATP-bd       
IPR007502   Helicase-assoc_dom       
IPR027417   P-loop_NTPase       
IPR002464   DNA/RNA_helicase_DEAH_CS       
IPR010977   Aromatic_deC       

SUPFAM

SSF53383   SSF53383        + More
SSF52540   SSF52540       

Gene 3D

3.40.640.10     3.90.1150.10    

CDD

cd00079  HELICc

ProteinModelPortal

A0A2A4K5F3   A0A2H1VZL4   A0A212EHV0   A0A194PKB0   A0A194QLU2   A0A2M4AKD3   + More
W5JBI3   A0A2M4AKP9   A0A182KBK5   A0A2M4BN46   A0A182X2X1   A0A182TKS8   Q7PW45   A0A182I4Y2   A0A182UMA9   A0A182KUR2   A0A2M3Z7G9   A0A2M3ZI17   A0A182NEW2   A0A182S9G5   A0A182R9Q9   A0A1Q3G3Q5   A0A182YFF4   A0A1Y1N1Z5   A0A182QRE4   D6WLY0   A0A3B0JGX9   A0A182PDE1   Q16S16   B3MLH9   A0A0A1WH04   A0A182WGY4   A0A2M4ALG4   A0A182GGX4   U5EHA0   A0A0L0C8X4   B4P1W4   A0A182LUG5   A0A1I8NHY9   A0A034VRU6   A0A023ERX8   A0A0K8W0X9   B4MTY1   Q9VKD3   A0A1W4UYR4   B4GQH8   B4IE43   B3N3Z3   Q29L91   A0A0J9R157   A0A1Y1MYA8   W8B6N9   A0A1B0CW22   A0A1I8PKF3   A0A0M4EDZ3   V5GU79   B4JQY2   A0A1L8E2D7   A0A182JAG8   A0A1B0DDD8   B4KJS4   A0A182F5H7   B4LQW5   A0A1B0AGU5   A0A1A9YFN6   A0A1A9VPE8   A0A1B0APW9   A0A023F5P0   A0A0P4VSF9   V3ZF91   A0A1S3EQ44   M3VZZ3   B5FW56   C3PT67   W5PZ31   A0A224XQW1   L8IDU0   A5PKG4   Q921V3   A0A2Y9GZD5   A0A212CBF7   A0A1U7R2Z2   A0A2K6GVB4   A0A2U3VES6   A0A2K6TJF2   A0A210QXR5   A0A1B6M7W6   Q9Z1J3   G5B845   Q3MHT2   B4G169   A0A1A9WMD5   G3HAR4   G3U7S1   B7NZJ3   G1TCX0   A0A250YIE4   G3T5I7   A0A0A9W6A9   Q99P39  

PDB

5WGB     E-value=0,     Score=1700

KEGG

101745395    K04487 cysteine desulfurase [EC:2.8.1.7] | (RefSeq) probable cysteine desulfurase, mitochondrial

PATHWAY

00730    Thiamine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04122    Sulfur relay system - Bombyx mori (domestic silkworm)

GO

GO:0031071   GO:0030170   GO:0044571   GO:0005634   GO:0005739   GO:0005829   GO:0016226   GO:1990221   GO:0070903   GO:0051536   GO:0046872   GO:0016831   GO:0006520   GO:0003676   GO:0004386   GO:0005524   GO:0005759   GO:0018283   GO:0005654   GO:0042803   GO:0006777   GO:0008270   GO:0003824   GO:0019752   GO:0005515   GO:0016876   GO:0043039   GO:0004651  

PANTHER

PTHR11601:SF34  

Subcellular location

Mitochondrion  
Nucleus  
Cytoplasm  

Length:

454

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01001

Exp number, first 60 AAs:

0.00034

Total prob of N-in:

0.00568

outside

1  -  454

 

 

Pi

41.848147

Theta

37.170523

Tajima's D

-1.05387

CLR

0.902437

CSRT

0.125393730313484

Interpretation

Uncertain