Gene

KWMTBOMO02028

Pre Gene Modal

BGIBMGA002956

Annotation

PREDICTED:_protein_phosphatase_PHLPP-like_protein_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr4(+):10642011-10646411      View in EpiBrowser

Full name

Protein phosphatase PHLPP-like protein      

Alternative Name

PH domain leucine-rich repeat protein phosphatase
dPHLPP

Location in the cell

Nuclear   Reliability : 2.97

CDS

ATGGCGCCGGATGAAGAAAATAAAGTTGAATATCGTACTCCACTAACCAATGTTGATTTACGTCACAATAGATTAAAAGGAAGCATAATACTCGGAAATTATGAGCATTTAGTATGTTTAGATATATCGCATAATTCTGTGGAAGTTTTAGTCTTGTCTTCACTGCGGGGACTTCGGGAACTATACGCTTCACATAATGCACTCCAGCACGTGGCGCTTCATGGAGGCTCTTTACGAATTCTCCGAGCCCCCCACAATCAATTAGAATCATTGACAAGTACAGTCCCACCAATCAATTTAGTAGAAATCGACGTGTCATACAACAAATTGACGTTACTACCACCATGGATCAGCGGCTGTTCCGACCTCACCACGCTTCACGCGAGCAATAACCAATTAACCTCACTTCCAGACCATTTGTTCTGTAGTGAACTTTCAAGTCTGAGTAACCTGCATTTAGCCCATAATAAAATCTCTAGTATACCATCAATGCCGCGCCTAAGAGCTCCCCTTAAAGAATTACTGCTTCATGATAACTCTATTCAGTCACTGCCAGAAAACTTCTTTTCGGTATGTGACAGATTGGGCGTTTTAAATCTTTCGAATAACAGACTGAGCCGCTTACCTTTGGCAAGATGTACCTCATATTGTCTAGAGTATCTATACCTAACAGCTAACTGCTTGAATGACGATGCAACAGATGTTCTCATAGCATTCCGTGGCTTAAAGATTCTACATTTGGCCTACAACTGTCTAACGCGGCTTCCAGAAAACTGTGTCAACTATTGGCCCGATGTTGAAGAACTAGTACTCTCGGGGAACCTGTTTTCAAGATTGCCAGAAAATATGCCTCAGCTCAATAACATCAGAGTCGTAAGGGCTCACTCAAATAAACTACGTTCGGTACCTATGTTCGCATGTAGCGCTTCGGTGAAGATTTTAGATTTTGCTCACAACGAACTGGATAGGGTAGATTTACGGCTACTTGCACCAAAACAATTAAAATTTCTAGATATATCTTGTAACAAAAAATTACAAATGGACCCTTCACAGTTTAATTCCTATAAATGTCAAAGACCATTGAGCTTAGTAGATGTGACAGGGCGACGTTCAGTTTCGTGGACCCACAAAACAGGATATCACGAAGAATTAACTGGCATGACCCCGTGGAATACAGGATTTTCTGAATGCCCGGACAAATCATTGCAGTTATATTGTGCACAAATACGTCTTCCTTCGTTTTGTAATAAAGAGGGCCTTTTCGCCGTCATTGATGGTGAAACTGATATCGAAGTACCAAAAATTTTACAAACCAGTATACCAGGATTAGTTCTTGAAGAGAAATCAATCAAAGAAACTGTTAACGAATATATGAAATACGTAGTATTATCGGCTCATAGAGAATTGAAAGAAAAAGGTCAAAGAAAAGGAGCCTGCATGGTCATGTGCCACTTGTCTCCTATTAATGTACAAGAAAATGCATTCGGACAGGCGTTAAAAAAATATAGTTTAAAATTAGCTAACGTAGGCGATACTAGAGCAGTTTTAAGTAGACGTAATGGACCGTTGAGTTTGGGCATAGAAAATAAAAGACGTCTAGGATATTCCTGTCGCTATCCCAATACTGTCCCAGATCCGGATATCATCCAGACAGTTATTAAAGAAGACGACGAATTTCTGATATTAGCCAATGGGAAATTCTGGGGTGCTGTTAGTATAGATTCTGCAGTTTCTGAAGTAAGAGCAGAACGAAATCCTGTTCTTGCAGCAAAAAGATTACAAGACCTGGCCCAAAGCTATGGCATCGAAGAATGTATTTCAATTATAGTAATTAGGTTTGATAATGAAAGAGCTGATGTTGACCTTTTGATGAGAGAATTAAGGCAGACGATTAACGGGAATAAAACGACATGTCGATCGGATTGTTGTTGTTCACGTTTGGAACCTTGCTGTCACTCAATATCTCCGTCAAAGCCGAGCAGCGATCGATCTTCGCCAAGCGGGCAAAGTGACCGCCCTCTAAGTGAAGCAATAAACCATCAACATTACTCCAGTGTTCGATCGCAAAATAAAGCATCCGAAAGACGGAGCTGTCGCGGAGGCGTGGCTAGAGCAATTCGTGTTCGTGTTGAAGAAGAGAAAGAAGATCACCGAAATGAGGAAACTTCAAATCCAGAGGAACAATTTAAATGCTGGGAATACATGTTGGAACAGAACACTCAAATGCTGTTCGACAAGGAATTAGATAACTTATCGAAGGGTATTCGTTCGAATGGAAGTACTCTGAGGAACACAAAAGGGTTGTCGGGGAGTAGCCCTCAATTACATTTAAGTGGAAAAACTTCGAAAGTTCCATTCTTGTCTAAACATTTTGGTAGTGCAAGATCTTTTGGCACAGCTTTAAAGCCTGACTTTCGATTCGGCTCTGGAAGATTGCCGAATGGTGGTCCTAACGCTGCATATTTTGGTTCACTTCAACGACTCATGCCTTATCATTTAGAATATGACTTTGCCGTAATTCAAGAGAAAACAACACACTCCCAAGACTCGCTCGACCTCGAAGGAAGAATGTCACAATATTGGGGAGTCGCTACAACCGAATTATAA

Protein

MAPDEENKVEYRTPLTNVDLRHNRLKGSIILGNYEHLVCLDISHNSVEVLVLSSLRGLRELYASHNALQHVALHGGSLRILRAPHNQLESLTSTVPPINLVEIDVSYNKLTLLPPWISGCSDLTTLHASNNQLTSLPDHLFCSELSSLSNLHLAHNKISSIPSMPRLRAPLKELLLHDNSIQSLPENFFSVCDRLGVLNLSNNRLSRLPLARCTSYCLEYLYLTANCLNDDATDVLIAFRGLKILHLAYNCLTRLPENCVNYWPDVEELVLSGNLFSRLPENMPQLNNIRVVRAHSNKLRSVPMFACSASVKILDFAHNELDRVDLRLLAPKQLKFLDISCNKKLQMDPSQFNSYKCQRPLSLVDVTGRRSVSWTHKTGYHEELTGMTPWNTGFSECPDKSLQLYCAQIRLPSFCNKEGLFAVIDGETDIEVPKILQTSIPGLVLEEKSIKETVNEYMKYVVLSAHRELKEKGQRKGACMVMCHLSPINVQENAFGQALKKYSLKLANVGDTRAVLSRRNGPLSLGIENKRRLGYSCRYPNTVPDPDIIQTVIKEDDEFLILANGKFWGAVSIDSAVSEVRAERNPVLAAKRLQDLAQSYGIEECISIIVIRFDNERADVDLLMRELRQTINGNKTTCRSDCCCSRLEPCCHSISPSKPSSDRSSPSGQSDRPLSEAINHQHYSSVRSQNKASERRSCRGGVARAIRVRVEEEKEDHRNEETSNPEEQFKCWEYMLEQNTQMLFDKELDNLSKGIRSNGSTLRNTKGLSGSSPQLHLSGKTSKVPFLSKHFGSARSFGTALKPDFRFGSGRLPNGGPNAAYFGSLQRLMPYHLEYDFAVIQEKTTHSQDSLDLEGRMSQYWGVATTEL

Description

Protein phosphatase that specifically mediates dephosphorylation of 'Ser-586' of Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-586' of Akt1 triggers apoptosis and suppression of tumor growth.

Catalytic Activity

H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate
H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate

Cofactor

Mn(2+)

Similarity

Belongs to the CRISP family.

Keywords

Apoptosis   Complete proteome   Hydrolase   Leucine-rich repeat   Manganese   Metal-binding   Protein phosphatase   Reference proteome   Repeat  

Feature

chain  Protein phosphatase PHLPP-like protein

Uniprot

H9J0C0   A0A2H1W8Z9   A0A2A4JXX1   A0A0L7LKN1   A0A194R8K4   A0A194PK03   + More
A0A212ESM7   D6WLS2   A0A1B0DQW8   A0A1Y1LIB7   A0A1S4H022   A0A182I4X6   A0A182U465   A0A182KUS7   A0A182X2X8   A0A182UZM4   Q7PW55   A0A182K9A3   A0A182SHF0   A0A182QHB5   A0A182YFG4   A0A182IWW6   A0A0A9XBC9   A0A182NEV3   A0A084VMD4   N6TAC1   A0A2J7RAW6   U5EXY9   A0A336M0J4   A0A336KQA3   A0A067R0H2   A0A2P8ZIF3   B0X2D7   A0A182M9I8   W5JCZ5   A0A1J1HZP3   E2ACQ4   F4W688   E2BUY5   A0A151WHU8   A0A182F5I1   A0A3L8DDB4   A0A195FJ86   A0A182R9R6   A0A151ILH3   A0A182WGX8   A0A195DMH4   A0A182PDE7   Q173L1   A0A0N0BED4   A0A088ACL7   A0A310SPR8   T1GVH3   A0A026WA02   A0A158P2K6   A0A195AW70   A0A1I8P3Y6   A0A0A9XEP9   T1HYD9   A0A0L7QZ03   A0A1B0GK67   A0A154PJC9   B4LS13   B4KE63   A0A0M4E297   B3MNQ6   A0A0J9R5D9   B4Q9F6   A0A0L0BXF2   B4I5Q6   M9PBD5   Q9VJ07   B3NMA1   B4PAG1   B4N146   A0A3Q0J5Q0   A0A1W4VXJ6   A0A3B0K0N3   K7J905   A0A0K8WI19   A0A1B0F9U0   A0A1A9XGV0   A0A1B0BJG8   A0A1A9W036   B4JAM4   A0A1A9V9L5   A0A1B0A513   A0A1I8NFV6   A0A2A3ENE2   Q29PI5   B4GKT8   K1QUE9  

EC Number

3.1.3.16

Pubmed

19121390    26227816    26354079    22118469    18362917    19820115    + More
28004739    12364791    20966253    25244985    25401762    24438588    23537049    24845553    29403074    20920257    23761445    20798317    21719571    30249741    17510324    24508170    21347285    17994087    18057021    22936249    26108605    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    15808505    17550304    20075255    25315136    15632085    23185243    22992520   

EMBL

BABH01010595    BABH01010596    ODYU01007084    SOQ49540.1    NWSH01000407    PCG76616.1    + More
JTDY01000830    KOB75746.1    KQ460597    KPJ13834.1    KQ459601    KPI93766.1    AGBW02012749    OWR44506.1    KQ971343    EFA04777.2    AJVK01008787    GEZM01054811    JAV73384.1    AAAB01008984    APCN01003737    EAA14746.4    AXCN02000840    GBHO01026305    JAG17299.1    ATLV01014585    ATLV01014586    KE524975    KFB39128.1    APGK01037103    APGK01037104    APGK01037105    KB740948    ENN77219.1    NEVH01006564    PNF37972.1    GANO01000670    JAB59201.1    UFQT01000222    SSX21947.1    UFQS01000634    UFQT01000634    SSX05605.1    SSX25964.1    KK852804    KDR16236.1    PYGN01000048    PSN56260.1    DS232286    EDS39160.1    AXCM01002871    ADMH02001866    ETN60765.1    CVRI01000037    CRK93493.1    GL438568    EFN68798.1    GL887707    EGI70223.1    GL450772    EFN80522.1    KQ983112    KYQ47375.1    QOIP01000010    RLU18152.1    KQ981523    KYN40431.1    KQ977120    KYN05594.1    KQ980724    KYN14100.1    CH477422    EAT41218.2    KQ435840    KOX71414.1    KQ761289    OAD57914.1    CAQQ02194901    KK107310    EZA52875.1    ADTU01006944    ADTU01006945    ADTU01006946    ADTU01006947    ADTU01006948    ADTU01006949    ADTU01006950    ADTU01006951    KQ976731    KYM76280.1    GBHO01026306    JAG17298.1    ACPB03007941    KQ414685    KOC63792.1    AJWK01028404    AJWK01028405    KQ434936    KZC11955.1    CH940649    EDW63689.2    KRF81248.1    CH933807    EDW11808.1    CP012523    ALC39678.1    CH902620    EDV31143.1    CM002910    KMY90934.1    CM000361    EDX05463.1    JRES01001289    KNC23914.1    CH480822    EDW55712.1    AE014134    AGB93093.1    CH954179    EDV54701.1    CM000158    EDW90369.1    CH963920    EDW78136.1    OUUW01000010    SPP86222.1    GDHF01001518    JAI50796.1    CCAG010003100    JXJN01015387    CH916368    EDW02810.1    KZ288204    PBC33237.1    CH379058    EAL34308.2    KRT03375.1    CH479184    EDW37254.1    JH816884    EKC25171.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053240    UP000053268    UP000007151    + More
UP000007266    UP000092462    UP000075840    UP000075902    UP000075882    UP000076407    UP000075903    UP000007062    UP000075881    UP000075901    UP000075886    UP000076408    UP000075880    UP000075884    UP000030765    UP000019118    UP000235965    UP000027135    UP000245037    UP000002320    UP000075883    UP000000673    UP000183832    UP000000311    UP000007755    UP000008237    UP000075809    UP000069272    UP000279307    UP000078541    UP000075900    UP000078542    UP000075920    UP000078492    UP000075885    UP000008820    UP000053105    UP000005203    UP000015102    UP000053097    UP000005205    UP000078540    UP000095300    UP000015103    UP000053825    UP000092461    UP000076502    UP000008792    UP000009192    UP000092553    UP000007801    UP000000304    UP000037069    UP000001292    UP000000803    UP000008711    UP000002282    UP000007798    UP000079169    UP000192221    UP000268350    UP000002358    UP000092444    UP000092443    UP000092460    UP000091820    UP000001070    UP000078200    UP000092445    UP000095301    UP000242457    UP000001819    UP000008744    UP000005408   

PRIDE

H9J0C0    Q9VJ07   

Pfam

PF13855   LRR_8        + More
PF00481   PP2C
PF13516   LRR_6
PF08562   Crisp
PF00188   CAP
PF00560   LRR_1
PF18701   DUF5641
PF00169   PH

Interpro

IPR032675   LRR_dom_sf        + More
IPR036457   PPM-type_dom_sf       
IPR001932   PPM-type_phosphatase_dom       
IPR001611   Leu-rich_rpt       
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR014044   CAP_domain       
IPR013871   Cysteine_rich_secretory       
IPR035940   CAP_sf       
IPR001283   CRISP-related       
IPR002413   V5_allergen-like       
IPR018244   Allrgn_V5/Tpx1_CS       
IPR040676   DUF5641       
IPR019787   Znf_PHD-finger       
IPR013083   Znf_RING/FYVE/PHD       
IPR001965   Znf_PHD       
IPR011011   Znf_FYVE_PHD       
IPR019786   Zinc_finger_PHD-type_CS       
IPR011993   PH-like_dom_sf       
IPR001849   PH_domain       

SUPFAM

SSF81606   SSF81606        + More
SSF55797   SSF55797       
SSF57903   SSF57903       

Gene 3D

3.60.40.10     3.80.10.10     3.40.33.10     3.30.40.10     2.30.29.30    

CDD

cd00143  PP2Cc

ProteinModelPortal

H9J0C0   A0A2H1W8Z9   A0A2A4JXX1   A0A0L7LKN1   A0A194R8K4   A0A194PK03   + More
A0A212ESM7   D6WLS2   A0A1B0DQW8   A0A1Y1LIB7   A0A1S4H022   A0A182I4X6   A0A182U465   A0A182KUS7   A0A182X2X8   A0A182UZM4   Q7PW55   A0A182K9A3   A0A182SHF0   A0A182QHB5   A0A182YFG4   A0A182IWW6   A0A0A9XBC9   A0A182NEV3   A0A084VMD4   N6TAC1   A0A2J7RAW6   U5EXY9   A0A336M0J4   A0A336KQA3   A0A067R0H2   A0A2P8ZIF3   B0X2D7   A0A182M9I8   W5JCZ5   A0A1J1HZP3   E2ACQ4   F4W688   E2BUY5   A0A151WHU8   A0A182F5I1   A0A3L8DDB4   A0A195FJ86   A0A182R9R6   A0A151ILH3   A0A182WGX8   A0A195DMH4   A0A182PDE7   Q173L1   A0A0N0BED4   A0A088ACL7   A0A310SPR8   T1GVH3   A0A026WA02   A0A158P2K6   A0A195AW70   A0A1I8P3Y6   A0A0A9XEP9   T1HYD9   A0A0L7QZ03   A0A1B0GK67   A0A154PJC9   B4LS13   B4KE63   A0A0M4E297   B3MNQ6   A0A0J9R5D9   B4Q9F6   A0A0L0BXF2   B4I5Q6   M9PBD5   Q9VJ07   B3NMA1   B4PAG1   B4N146   A0A3Q0J5Q0   A0A1W4VXJ6   A0A3B0K0N3   K7J905   A0A0K8WI19   A0A1B0F9U0   A0A1A9XGV0   A0A1B0BJG8   A0A1A9W036   B4JAM4   A0A1A9V9L5   A0A1B0A513   A0A1I8NFV6   A0A2A3ENE2   Q29PI5   B4GKT8   K1QUE9  

PDB

5A5C     E-value=1.60712e-11,     Score=171

KEGG

101745921    K16340 PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16] | (RefSeq) pro

GO

GO:0003824   GO:0005576   GO:0004722   GO:0042981   GO:0006915   GO:0046872   GO:0006470   GO:0005515   GO:0042176   GO:0007155   GO:0016876   GO:0043039   GO:0004651   GO:0005634  

Length:

868

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00301

Exp number, first 60 AAs:

0.00221

Total prob of N-in:

0.00016

outside

1  -  868

 

 

Pi

70.154016

Theta

176.57484

Tajima's D

-2.016088

CLR

0.516297

CSRT

0.0140492975351232

Interpretation

Uncertain