Gene

KWMTBOMO02015

Pre Gene Modal

BGIBMGA003211

Annotation

PREDICTED:_geranylgeranyl_transferase_type-2_subunit_alpha_[Amyelois_transitella]

Location

Bomo_Chr4(-):10218648-10224385      View in EpiBrowser

Full name

Geranylgeranyl transferase type-2 subunit alpha      

Alternative Name

Geranylgeranyl transferase type II subunit alpha
Rab geranyl-geranyltransferase subunit alpha
Rab geranylgeranyltransferase subunit alpha

Location in the cell

Nuclear   Reliability : 3.347

CDS

ATGCACGGGAGAGTGAAAGTCAGAACTTCTGAGGAAGAGAAAGCCAGGAAAGAGAAAGAGAGAAATGAAAAATTGAAGATTTTCAAACATGCCATGCAAAAAATTCAAATCAAGAGAAAAGAATGCACTCTTGATAAAGAATTACTGGAACTGACAGGAAATGTGTTATCTTCTAATCCTGACATTTACACTTTATGGAATATAAGGAGAGACATTTTACAATTATTTAAAAAAAGCAATGATAATATTGAAGAAATGTCACAGGTGTACAATGCAGAATTGCATCTAACTGAATATTGCCTAAAAATAAACCCGAAGTCATATTGTGCCTGGCACCAAAGAGAGTGGGTGCTTCTGACTCGTGATGATCCTGACTGGCAAAAAGAATTGGAACTATGCAATACCTACCTGAAGTTAGATGAAAGGAATTTTCACACATGGGATTACAGAAGATTTGTTGTGAGTCAGTGCAAACCATCTCTAAAAGATGAATTTGATTACACTACAGAGAAATTAATGGATAATTTTTCAAATTATTCAGCATGGCACTACAGAAGTAAAATGCTTGTCGAATTATATCCTGATCGGAAAGGTGGAAGGCCAATTGAAGATAGTCATCACAAACATGAACTAAAAATGGTTCAAAATGCTGCATTCACTGATCCTGATGACACAAGTGCTTGGTTTTATCAAAGATGGTTGTTAGGTGCAGTTAAAACCACAATCGATCTAGTAAATTACACAGTTACACCAACAAAAAATACATTTGCATTCAGCAAACACGTAGACAAGAATTATGTTAGTGCAAAAACTAAATTATTAATCAATAATTGTGTTGTAAATGGCGAATGGGTTTCGTGTACAGGAAATTGTTATGATGTCTTGTGGATTTTTCAGCACTCAACACCAATAACGAAAAAAATAAATATTAAGGTTGAATATGAAATAGATAATGGACAAAAACAAATAATACAAGGCGTTGAGTGTAAAGAAATGTTTTATATTGGTAAAAATCAAATTAAATTTGAGCGAAATTATTCGGAGGCTGTTATAGAAGAGTTAAAGGACCAACTAGAGTCTTGTAGACAACTGTTGAATTTGGAACCTGACAGCAAATGGACAATGCTAACAACCACAATTTTCCTACATTGTATAGATGCCAAAGCATACCACACAGAGGCAATACAAAATTTACAAAAACTAAAAGTCATTGATAAATTACGAGCTGGCTACTATGATGATCTCATAGCAAAATGGTGCATTGAAAAACAATTGTGTTCAGACTACGAAAACGCAGATCTTGCATTAAAGTTTTCATTCCCTAGTCCTGTATCAAGCCTACCTTATCTACAATACTACAGTTACTGTGATAGCGTAGATTTATCCAATCAACAACTGACTTCTAATATATTTCCTTCTTTAATAGTTCTGCAACATTGCAAGAAATTATCATTGGAGAACAATAACTTGACAACAATGAAGAATTTTCCAGATTTGGATCTGGTAGAATTGAATTTGCTGGGTAATGAAAAGTTGGATAGAAACGAAATTGAATTATTTACAAAAAAGTATAATTTCAATATTATATACTAA

Protein

MHGRVKVRTSEEEKARKEKERNEKLKIFKHAMQKIQIKRKECTLDKELLELTGNVLSSNPDIYTLWNIRRDILQLFKKSNDNIEEMSQVYNAELHLTEYCLKINPKSYCAWHQREWVLLTRDDPDWQKELELCNTYLKLDERNFHTWDYRRFVVSQCKPSLKDEFDYTTEKLMDNFSNYSAWHYRSKMLVELYPDRKGGRPIEDSHHKHELKMVQNAAFTDPDDTSAWFYQRWLLGAVKTTIDLVNYTVTPTKNTFAFSKHVDKNYVSAKTKLLINNCVVNGEWVSCTGNCYDVLWIFQHSTPITKKINIKVEYEIDNGQKQIIQGVECKEMFYIGKNQIKFERNYSEAVIEELKDQLESCRQLLNLEPDSKWTMLTTTIFLHCIDAKAYHTEAIQNLQKLKVIDKLRAGYYDDLIAKWCIEKQLCSDYENADLALKFSFPSPVSSLPYLQYYSYCDSVDLSNQQLTSNIFPSLIVLQHCKKLSLENNNLTTMKNFPDLDLVELNLLGNEKLDRNEIELFTKKYNFNIIY

Description

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

Catalytic Activity

geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]

Subunit

Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp (By similarity).

Similarity

Belongs to the protein prenyltransferase subunit alpha family.

Keywords

Complete proteome   Leucine-rich repeat   Phosphoprotein   Prenyltransferase   Reference proteome   Repeat   Transferase  

Feature

chain  Geranylgeranyl transferase type-2 subunit alpha

Uniprot

H9J124   A0A2H1VLJ4   A0A212ERQ9   A0A194R8J4   A0A0L7KPY4   A0A1B0CI47   + More
A0A1L8DUE0   A0A1L8DUF8   A0A336MNI1   A0A336M0Z2   A0A1B0DAL6   A0A182RY56   A0A182Y0L2   A0A182LWV0   A0A182WGG1   A0A182IK03   U5EX13   A0A182K124   A0A1Q3FJH0   A0A182PEM2   A0A182KU63   A0A182VIP2   A0A084WU74   A0A182XN60   A0A182HS01   Q7Q1L8   A0A1B6LIP6   A0A182F101   B0WGK7   A0A2M4CHT5   A0A182QYP0   A0A067R2K8   A0A2M4CHR6   A0A182NBN5   A0A1B6HXV7   A0A1B6C520   E0W2C3   W5JGL0   A0A2M4APW0   A0A1B6FDA8   A0A2M4AQ11   A0A0P4VSZ4   A0A2M4AQB8   A0A023FBC7   A0A1S4EWC7   A0A2M4AQ25   A0A069DUZ7   A0A0A9XHW1   A0A182GN40   A0A146L7A6   A0A2M4BKC8   A0A0V0G4N9   A0A2M4BK27   A0A0K8SUZ0   A0A182TYN8   Q17NP5   T1GSK2   A0A2M3ZJZ7   A0A2J7RAZ3   A0A2M3ZCZ4   B4NI78   R4WR25   A0A2J7RAY8   A0A0A1XEV3   A0A0K8W807   X2A7L7   B3M159   A0A195DYJ2   B4JSQ7   A0A0C9PZA5   A0A034W8F6   A0A195AYN9   E1ZVX7   B4GFF8   A0A151WXB0   A0A158NPC3   A0A3B0JR44   C3Y8M1   K1QZ11   W8C072   Q296A1   A0A1J1IKR1   A0A1J1IJE9   B3P292   E2BGN4   B4PUK1   A0A1S3IUX9   B4QW75   A0A154PC47   A0A026W2I9   A0A195CIA0   A0A210PGE2   A0A0L0BSZ0   A0A195F8X3   A0A1B0G9R2   A0A1I8PGS3   A0A293LRF9   A5A779  

EC Number

2.5.1.60

Pubmed

19121390    22118469    26354079    26227816    25244985    20966253    + More
24438588    12364791    24845553    20566863    20920257    23761445    27129103    25474469    26334808    25401762    26483478    26823975    17510324    17994087    23691247    25830018    23254933    25348373    20798317    21347285    18563158    22992520    24495485    15632085    17550304    24508170    28812685    26108605   

EMBL

BABH01010622    ODYU01003220    SOQ41681.1    AGBW02012969    OWR44149.1    KQ460597    + More
KPJ13824.1    JTDY01007243    KOB65347.1    AJWK01013036    GFDF01004021    JAV10063.1    GFDF01004024    JAV10060.1    UFQS01001741    UFQT01001741    SSX12150.1    SSX31610.1    UFQT01000397    SSX23996.1    AJVK01013342    AXCM01005495    GANO01002727    JAB57144.1    GFDL01007393    JAV27652.1    ATLV01027003    KE525421    KFB53768.1    APCN01001786    AAAB01008980    EAA14206.4    GEBQ01016416    JAT23561.1    DS231927    EDS27036.1    GGFL01000685    MBW64863.1    AXCN02000682    KK852804    KDR16242.1    GGFL01000686    MBW64864.1    GECU01028190    JAS79516.1    GEDC01028711    JAS08587.1    DS235876    EEB19779.1    ADMH02001592    ETN61934.1    GGFK01009486    MBW42807.1    GECZ01021816    GECZ01002964    JAS47953.1    JAS66805.1    GGFK01009536    MBW42857.1    GDKW01001497    JAI55098.1    GGFK01009642    MBW42963.1    GBBI01000398    JAC18314.1    GGFK01009560    MBW42881.1    GBGD01001021    JAC87868.1    GBHO01025201    JAG18403.1    JXUM01075579    KQ562894    KXJ74894.1    GDHC01014318    JAQ04311.1    GGFJ01004270    MBW53411.1    GECL01003476    JAP02648.1    GGFJ01004269    MBW53410.1    GBRD01008698    JAG57123.1    CH477197    EAT48358.1    CAQQ02392149    GGFM01008027    MBW28778.1    NEVH01006564    PNF37998.1    GGFM01005612    MBW26363.1    CH964272    EDW84770.1    AK418146    BAN21361.1    PNF37996.1    GBXI01004800    JAD09492.1    GDHF01005130    JAI47184.1    AMQN01012456    CH902617    EDV44329.1    KQ980066    KYN17943.1    CH916373    EDV94797.1    GBYB01006853    JAG76620.1    GAKP01008538    GAKP01008537    GAKP01008535    JAC50415.1    KQ976703    KYM77155.1    GL434663    EFN74669.1    CH479182    EDW34343.1    KQ982668    KYQ52544.1    ADTU01022253    OUUW01000008    SPP84605.1    GG666491    EEN63458.1    JH816626    EKC42272.1    GAMC01004137    JAC02419.1    CM000070    EAL28557.2    CVRI01000054    CRL00354.1    CRL00355.1    CH954181    EDV47842.1    GL448193    EFN85162.1    CM000160    EDW95723.1    CM000364    EDX11674.1    KQ434870    KZC09465.1    KK107468    EZA50218.1    KQ977791    KYM99803.1    NEDP02076721    OWF35560.1    JRES01001516    KNC22329.1    KQ981727    KYN36831.1    CCAG010010300    GFWV01005906    MAA30636.1    AB271949   

Proteomes

UP000005204    UP000007151    UP000053240    UP000037510    UP000092461    UP000092462    + More
UP000075900    UP000076408    UP000075883    UP000075920    UP000075880    UP000075881    UP000075885    UP000075882    UP000075903    UP000030765    UP000076407    UP000075840    UP000007062    UP000069272    UP000002320    UP000075886    UP000027135    UP000075884    UP000009046    UP000000673    UP000069940    UP000249989    UP000075902    UP000008820    UP000015102    UP000235965    UP000007798    UP000007801    UP000078492    UP000001070    UP000078540    UP000000311    UP000008744    UP000075809    UP000005205    UP000268350    UP000001554    UP000005408    UP000001819    UP000183832    UP000008711    UP000008237    UP000002282    UP000085678    UP000000304    UP000076502    UP000053097    UP000078542    UP000242188    UP000037069    UP000078541    UP000092444    UP000095300    UP000008227   

PRIDE

H9J124    A5A779   

Pfam

PF01239   PPTA        + More
PF07711   RabGGT_insert
PF04627   ATP-synt_Eps
PF01607   CBM_14
PF05444   DUF753

Interpro

IPR032955   RabGGTase_alpha        + More
IPR002088   Prenyl_trans_a       
IPR032675   LRR_dom_sf       
IPR009087   RabGGT_asu_insert-domain       
IPR001611   Leu-rich_rpt       
IPR036254   RabGGT_asu_insert-dom_sf       
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR036508   Chitin-bd_dom_sf       
IPR008472   DUF753       
IPR036742   ATP_synth_F1_esu_sf_mt       
IPR006721   ATP_synth_F1_esu_mt       
IPR002557   Chitin-bd_dom       
IPR036280   Multihaem_cyt_sf       

SUPFAM

SSF49594   SSF49594        + More
SSF48695   SSF48695       
SSF48690   SSF48690       
SSF57625   SSF57625       

Gene 3D

3.80.10.10     1.10.1620.20    

CDD

cd12153  F1-ATPase_epsilon

ProteinModelPortal

H9J124   A0A2H1VLJ4   A0A212ERQ9   A0A194R8J4   A0A0L7KPY4   A0A1B0CI47   + More
A0A1L8DUE0   A0A1L8DUF8   A0A336MNI1   A0A336M0Z2   A0A1B0DAL6   A0A182RY56   A0A182Y0L2   A0A182LWV0   A0A182WGG1   A0A182IK03   U5EX13   A0A182K124   A0A1Q3FJH0   A0A182PEM2   A0A182KU63   A0A182VIP2   A0A084WU74   A0A182XN60   A0A182HS01   Q7Q1L8   A0A1B6LIP6   A0A182F101   B0WGK7   A0A2M4CHT5   A0A182QYP0   A0A067R2K8   A0A2M4CHR6   A0A182NBN5   A0A1B6HXV7   A0A1B6C520   E0W2C3   W5JGL0   A0A2M4APW0   A0A1B6FDA8   A0A2M4AQ11   A0A0P4VSZ4   A0A2M4AQB8   A0A023FBC7   A0A1S4EWC7   A0A2M4AQ25   A0A069DUZ7   A0A0A9XHW1   A0A182GN40   A0A146L7A6   A0A2M4BKC8   A0A0V0G4N9   A0A2M4BK27   A0A0K8SUZ0   A0A182TYN8   Q17NP5   T1GSK2   A0A2M3ZJZ7   A0A2J7RAZ3   A0A2M3ZCZ4   B4NI78   R4WR25   A0A2J7RAY8   A0A0A1XEV3   A0A0K8W807   X2A7L7   B3M159   A0A195DYJ2   B4JSQ7   A0A0C9PZA5   A0A034W8F6   A0A195AYN9   E1ZVX7   B4GFF8   A0A151WXB0   A0A158NPC3   A0A3B0JR44   C3Y8M1   K1QZ11   W8C072   Q296A1   A0A1J1IKR1   A0A1J1IJE9   B3P292   E2BGN4   B4PUK1   A0A1S3IUX9   B4QW75   A0A154PC47   A0A026W2I9   A0A195CIA0   A0A210PGE2   A0A0L0BSZ0   A0A195F8X3   A0A1B0G9R2   A0A1I8PGS3   A0A293LRF9   A5A779  

PDB

1LTX     E-value=3.15713e-71,     Score=684

KEGG

101747224    K14050 geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60] | (RefSeq) geranylgeranyl trans

GO

GO:0008318   GO:0018344   GO:0005968   GO:0004663   GO:0008270   GO:0005737   GO:0046933   GO:0008061   GO:0005576   GO:0015986   GO:0006030   GO:0000275   GO:0017137   GO:0005654   GO:0018342   GO:0008408   GO:0006412   GO:0005634   GO:0016876   GO:0043039   GO:0004651  

PANTHER

PTHR11129:SF2  

Length:

530

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01209

Exp number, first 60 AAs:

0.0021

Total prob of N-in:

0.00959

outside

1  -  530

 

 

Pi

246.953732

Theta

153.310094

Tajima's D

2.414699

CLR

0.781034

CSRT

0.936803159842008

Interpretation

Uncertain