Gene

KWMTBOMO02013  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003212

Annotation

PREDICTED:_26S_proteasome_non-ATPase_regulatory_subunit_6_[Papilio_machaon]

Location

Bomo_Chr4(-):10205780-10210305      View in EpiBrowser

Full name

26S proteasome non-ATPase regulatory subunit 6      

Alternative Name

26S proteasome regulatory subunit RPN7
26S proteasome regulatory subunit S10
Breast cancer-associated protein SGA-113M
Phosphonoformate immuno-associated protein 4
Proteasome regulatory particle subunit p44S10
p42A

Location in the cell

Cytoplasmic   Reliability : 3.244

CDS

ATGGAGCTATCAGCGGAGGGAAAAACACCTGAATACATGGCATTGGCCGGAATCAAATTCAAACTCAGTTTACCTGAATTCAAAGATAATATTCAGTTAAAGGAGCAGTTATTGAATGGAATAAAGGCTGGACACATGGCTCCTTATTATAAAGAGGTGTGCAATGACCTTGGCTGGACTTTTGACCAGAAGTTGTATGATGACATGACAAAAGAAAATCAAGACAGGCTATCTAAATTTGAAGAAGACGACTCTGAAACACCCGTTTGGCAAGATAGGCTTGATTACTTGTGTTCAGTTGGAGACAAAGAAACAGCTACTGCATTGGCAACATCTAAATATGAAGATTCAACATTGACTACAAACAGGAGGCTCGATGCTATATTTGCTTTGTTCAGAATTGCTTATTTCCATGGATGTAATGTGAAGGAAATGGGAAAAGCTATCAATAAGGCTCACGAGTTAGTTGATAAAGGTGGAGATTGGCGTTCAAGGAACAAGCTAAAAGCATATGAAGCTATATATTGCCTTGCTGTTAGAGATTACAGTCATGCAGCTGAATTATTCATTGACTGTGTGTCAACTTTTGAATCTTATGAACTGGTTGATTTCGGTACAATCATCCAGTACTGTGTTCTCGCTTGTGCCTTGGCCCTTGAAAGGCATGCTCTACAATCTGCTCTACGCAGGCAAGGTGCTGCAGTACAAGCTCTACGCTCTCGTTTCCCAGAGCTAAGAGAGCTAGTTGAATCTCTGCATGAGTGTAGATATGCTGATTTCTTGAAAAGCCTTGCTTGGGTGGAAACGCAAATCTGTGTAGACCCAGTATTCCACCCTCATTACCAGCACTATGTGCGCGAGGCTCGCATCAAGGCATATGTTCAGCTGCTGCGCGCCTACCGATCTCTCAGCTTGGATAATATTGCTGACACGTTTGGTGTCACCAGGGAGTTCATAGAAGAGGAGATTTCTACTTTCACGGCGGCCGGCCGTCTTCAGTGTCGCATCGACGCGGTGGCCGGCTGCGTGGTGACGGGCGCGGGGCGCGGCGCGGACGCGGACCGGTCGCAGCTGTACCAGGCGACGATCCGCGAGGGCGATTTACTCCTCAACCGGGTCAAGAAACTAGCGAGTGTAATCAATTTTTAA

Protein

MELSAEGKTPEYMALAGIKFKLSLPEFKDNIQLKEQLLNGIKAGHMAPYYKEVCNDLGWTFDQKLYDDMTKENQDRLSKFEEDDSETPVWQDRLDYLCSVGDKETATALATSKYEDSTLTTNRRLDAIFALFRIAYFHGCNVKEMGKAINKAHELVDKGGDWRSRNKLKAYEAIYCLAVRDYSHAAELFIDCVSTFESYELVDFGTIIQYCVLACALALERHALQSALRRQGAAVQALRSRFPELRELVESLHECRYADFLKSLAWVETQICVDPVFHPHYQHYVREARIKAYVQLLRAYRSLSLDNIADTFGVTREFIEEEISTFTAAGRLQCRIDAVAGCVVTGAGRGADADRSQLYQATIREGDLLLNRVKKLASVINF

Description

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Subunit

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD6, a base containing 6 ATPases and few additional components.

Similarity

Belongs to the proteasome subunit S10 family.

Keywords

3D-structure   Alternative splicing   Complete proteome   Proteasome   Reference proteome  

Feature

chain  26S proteasome non-ATPase regulatory subunit 6
splice variant  In isoform 2.

Uniprot

H9J125   A0A1E1WF20   A0A437BJ99   A0A194R851   A0A2H1VLE5   I4DJH3   + More
A0A212ERN6   S4P7Z8   I4DR39   A0A0L7L4P9   A0A0A9XID1   A0A2R7W7Y4   R4WTL1   A0A0P4VUL5   R4G4V4   A0A069DTU0   A0A224XQY2   A0A023FAU4   A0A1B6IHC0   A0A1B6LTI9   A0A2S2QVX3   A0A2P8XYZ4   A0A0V0G642   J9K9U6   A0A2H8TZG4   A0A2S2NU61   A0A1B6ELQ8   A0A171BAV2   E0VCN5   A0A1B6DHU7   A0A0L7QU98   A0A182JF26   A0A084VG12   W5J7C6   A0A2M3Z745   A0A2M4AC96   A0A182FST9   A0A2M4BQT1   T1DFW2   A0A182QG82   A0A182N441   B0W8P3   A0A182YAQ3   A0A182G8H1   A0A023EQ47   A0A182P561   A0A182VZ63   A0A1Q3FEJ8   A0A182R676   A0A182MF18   A0A1S4FP45   A0A182LR48   A0A182X0B9   Q7PUS4   A0A182I009   A0A182ULB9   Q16U24   A0A0N0U5P9   A0A2A3END0   A0A182UW42   A0A423STL8   A0A0P4WTY2   A0A310SVQ9   A0A182K2N5   A0A2I4BC57   A0A2K6S0B3   U3CWZ7   A0A154P0T3   A0A1U7QPE5   G3HIS0   A0A2K5RYQ3   A0A088AUX6   Q6PCT9   E2BC89   A0A384AYJ5   A0A2A3E620   I3MJE7   A0A2K5ESA8   A0A3Q3VRH5   A0A3P9H9W9   A0A3B3BRS6   A0A2K6FF13   A0A437DCT7   A0A2K6B7R7   A0A2K6LH53   G3QP60   A0A2K6AIY1   A0A2R8ZEJ3   A0A096NDX7   A0A2K6RAZ9   A0A2K5LGI5   A0A2K5HMN5   H2PAC2   G7NZA4   F7GFM2   A0A2I3RF19   Q15008   A0A3B4DVS4   Q4SBC3   G1RMC4  

Pubmed

19121390    26354079    22651552    22118469    23622113    26227816    + More
25401762    26823975    23691247    27129103    26334808    25474469    29403074    20566863    24438588    20920257    23761445    25244985    26483478    24945155    20966253    12364791    14747013    17210077    17510324    25243066    21804562    23929341    29704459    15489334    15057822    15632090    29398115    20798317    17554307    29451363    22398555    22722832    25362486    17194215    22002653    17431167    25319552    16136131    10723133    7788527    17974005    14702039    16641997    1317798    17323924    21269460    22223895    22814378    24275569    27428775    27342858    15496914   

EMBL

BABH01010623    GDQN01005461    JAT85593.1    RSAL01000048    RVE50463.1    KQ460597    + More
KPJ13822.1    ODYU01003220    SOQ41679.1    AK401441    KQ459601    BAM18063.1    KPI93778.1    AGBW02012969    OWR44147.1    GAIX01006176    JAA86384.1    AK404928    BAM20379.1    JTDY01002973    KOB70390.1    GBHO01026744    GBRD01017576    GDHC01004495    JAG16860.1    JAG48251.1    JAQ14134.1    KK854377    PTY15241.1    AK418027    BAN21242.1    GDKW01000876    JAI55719.1    ACPB03015511    GAHY01001050    JAA76460.1    GBGD01001703    JAC87186.1    GFTR01005873    JAW10553.1    GBBI01000669    JAC18043.1    GECU01021390    JAS86316.1    GEBQ01013030    JAT26947.1    GGMS01012682    MBY81885.1    PYGN01001142    PSN37230.1    GECL01003293    JAP02831.1    ABLF02031046    ABLF02031051    GFXV01006743    MBW18548.1    GGMR01008144    MBY20763.1    GECZ01030947    JAS38822.1    GEMB01000052    JAS03057.1    DS235060    EEB11141.1    GEDC01012108    JAS25190.1    KQ414735    KOC62218.1    ATLV01012594    KE524806    KFB36906.1    ADMH02002125    ETN58689.1    GGFM01003591    MBW24342.1    GGFK01005068    MBW38389.1    GGFJ01006278    MBW55419.1    GAMD01003001    JAA98589.1    AXCN02000024    DS231859    EDS39093.1    JXUM01151997    KQ571347    KXJ68192.1    GAPW01001916    JAC11682.1    GFDL01009066    JAV25979.1    AXCM01005075    AAAB01008987    EAA01099.3    APCN01002029    CH477634    EAT38017.1    KQ435776    KOX74924.1    KZ288215    PBC32649.1    QCYY01002801    ROT67540.1    GDRN01060552    JAI65348.1    KQ759866    OAD62473.1    GAMT01007787    GAMS01011178    GAMR01009865    GAMQ01001362    GAMP01006484    JAB04074.1    JAB11958.1    JAB24067.1    JAB40489.1    JAB46271.1    KQ434792    KZC05457.1    JH000408    KE664346    RAZU01001824    EGV94626.1    ERE90032.1    RLQ57415.1    AABR07017139    BC059159    CH474010    AAH59159.1    EDL94116.1    GL447257    EFN86625.1    KZ288356    PBC27187.1    AGTP01082516    CM012441    RVE72753.1    CABD030021841    AJFE02036745    AHZZ02019981    ABGA01017250    NDHI03003502    PNJ31388.1    AQIA01039978    AB170078    CM001277    BAE87141.1    EHH51207.1    JSUE03023480    JU337362    JU478059    JV045711    CM001254    AFE81113.1    AFH34863.1    AFI35782.1    EHH16253.1    AACZ04000375    GABC01000759    GABD01008007    GABE01005357    NBAG03000218    JAA10579.1    JAA25093.1    JAA39382.1    PNI79920.1    AF215935    AF530062    AY359879    AY568086    D14663    BX647742    AK290205    AC012557    CH471055    BC000630    BC000904    BC012369    CAAE01014674    CAG02059.1    ADFV01077847   

Proteomes

UP000005204    UP000283053    UP000053240    UP000053268    UP000007151    UP000037510    + More
UP000015103    UP000245037    UP000007819    UP000009046    UP000053825    UP000075880    UP000030765    UP000000673    UP000069272    UP000075886    UP000075884    UP000002320    UP000076408    UP000069940    UP000249989    UP000075885    UP000075920    UP000075900    UP000075883    UP000075882    UP000076407    UP000007062    UP000075840    UP000075902    UP000008820    UP000053105    UP000242457    UP000075903    UP000283509    UP000075881    UP000192220    UP000233220    UP000008225    UP000076502    UP000189706    UP000001075    UP000030759    UP000273346    UP000233040    UP000005203    UP000002494    UP000008237    UP000261681    UP000005215    UP000233020    UP000261620    UP000265200    UP000261560    UP000233160    UP000233120    UP000233180    UP000001519    UP000233140    UP000240080    UP000028761    UP000233200    UP000233060    UP000233080    UP000001595    UP000009130    UP000233100    UP000006718    UP000002277    UP000005640    UP000261440    UP000007303    UP000001073   

PRIDE

H9J125    G3HIS0    Q15008   

Pfam

PF10602   RPN7        + More
PF01399   PCI
PF00929   RNase_T

Interpro

IPR000717   PCI_dom        + More
IPR036390   WH_DNA-bd_sf       
IPR019585   Rpn7/CSN1       
IPR035268   PSMD6       
IPR012337   RNaseH-like_sf       
IPR013520   Exonuclease_RNaseT/DNA_pol3       
IPR036397   RNaseH_sf       
IPR011990   TPR-like_helical_dom_sf       

SUPFAM

SSF46785   SSF46785        + More
SSF53098   SSF53098       
SSF48452   SSF48452       

Gene 3D

3.30.420.10    

ProteinModelPortal

H9J125   A0A1E1WF20   A0A437BJ99   A0A194R851   A0A2H1VLE5   I4DJH3   + More
A0A212ERN6   S4P7Z8   I4DR39   A0A0L7L4P9   A0A0A9XID1   A0A2R7W7Y4   R4WTL1   A0A0P4VUL5   R4G4V4   A0A069DTU0   A0A224XQY2   A0A023FAU4   A0A1B6IHC0   A0A1B6LTI9   A0A2S2QVX3   A0A2P8XYZ4   A0A0V0G642   J9K9U6   A0A2H8TZG4   A0A2S2NU61   A0A1B6ELQ8   A0A171BAV2   E0VCN5   A0A1B6DHU7   A0A0L7QU98   A0A182JF26   A0A084VG12   W5J7C6   A0A2M3Z745   A0A2M4AC96   A0A182FST9   A0A2M4BQT1   T1DFW2   A0A182QG82   A0A182N441   B0W8P3   A0A182YAQ3   A0A182G8H1   A0A023EQ47   A0A182P561   A0A182VZ63   A0A1Q3FEJ8   A0A182R676   A0A182MF18   A0A1S4FP45   A0A182LR48   A0A182X0B9   Q7PUS4   A0A182I009   A0A182ULB9   Q16U24   A0A0N0U5P9   A0A2A3END0   A0A182UW42   A0A423STL8   A0A0P4WTY2   A0A310SVQ9   A0A182K2N5   A0A2I4BC57   A0A2K6S0B3   U3CWZ7   A0A154P0T3   A0A1U7QPE5   G3HIS0   A0A2K5RYQ3   A0A088AUX6   Q6PCT9   E2BC89   A0A384AYJ5   A0A2A3E620   I3MJE7   A0A2K5ESA8   A0A3Q3VRH5   A0A3P9H9W9   A0A3B3BRS6   A0A2K6FF13   A0A437DCT7   A0A2K6B7R7   A0A2K6LH53   G3QP60   A0A2K6AIY1   A0A2R8ZEJ3   A0A096NDX7   A0A2K6RAZ9   A0A2K5LGI5   A0A2K5HMN5   H2PAC2   G7NZA4   F7GFM2   A0A2I3RF19   Q15008   A0A3B4DVS4   Q4SBC3   G1RMC4  

PDB

6MSK     E-value=1.70344e-80,     Score=762

KEGG

101735567    K03037 26S proteasome regulatory subunit N7 | (RefSeq) 26S proteasome non-ATPase regulatory subunit

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0030234   GO:0000502   GO:0005838   GO:0043161   GO:0003676   GO:0022624   GO:0070306   GO:0034774   GO:0002479   GO:0031145   GO:0050852   GO:0010972   GO:0033209   GO:0060071   GO:0005576   GO:0090090   GO:1901990   GO:0002223   GO:0031146   GO:0061418   GO:1902036   GO:0006521   GO:0038061   GO:0090263   GO:0006508   GO:0016887   GO:1904813   GO:0043488   GO:0070498   GO:0038095   GO:0043312   GO:0055085   GO:0005829   GO:0000209   GO:0016579   GO:0005654   GO:0043687   GO:0000165   GO:0005515   GO:0046872   GO:0005840   GO:0006412   GO:0005634   GO:0005737   GO:0016876   GO:0043039   GO:0004651  

PANTHER

PTHR14145:SF1  

Length:

382

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03977

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00461

outside

1  -  382

 

 

Pi

273.632991

Theta

198.091002

Tajima's D

1.1848

CLR

1.403078

CSRT

0.704014799260037

Interpretation

Uncertain