Gene

KWMTBOMO01998

Pre Gene Modal

BGIBMGA013557

Annotation

PREDICTED:_peptidyl-prolyl_cis-trans_isomerase?_rhodopsin-specific_isozyme_isoform_X2_[Papilio_xuthus]

Location

Bomo_Chr4(-):9675156-9677512      View in EpiBrowser

Full name

Peptidyl-prolyl cis-trans isomerase       + More
Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme      

Alternative Name

Rotamase

Location in the cell

Cytoplasmic   Reliability : 1.433 Extracellular   Reliability : 1.176

CDS

ATGAAGTTTCTACAAGTTCTTTATACAGTGATATACTTTTCTTTACTTTTAAATCTTGTAGACGGACGACAATTTCGTGTTACTGATCAAGTGTACTTAGATGTTAAGAATGAAGACAAGGACCTGGGAAGACTTGTTATTGGACTGTTCGGAGATTTAGCTCCAAAAGCGGTGAATAATTTCAAAGTTCTCGCTACTAAAGGCATAAATGGGAAATCGTATAAAGGAACTCGGTTTAATCGTATCATCAAAAGGTTTATGGTCCAAGGCGGTGACGTCGTCTCCGATGACGGTAGTGGTAGCATTAGTATTTATGGAGATACATTTGACGATGAAAATCTGGAAACCCAGCATAGTACAGGAGGATTTGTGTCAATGGCCAATAAAGGTAAAAACACAAATGGCTGTCAGTTTTTGATAACCACCACTGGTGCGCCTTGGTTAGATCAACTGCACACTGTAATTGGGAAAGTCGTAGAAGGTCAGAAAGTGGTGCATCTGTTGGAGCACACGCCAACCGATGTTGAGGATCGACCGTTGGAGCATGTATATATTTCAGACTGTGGTCTGCTGCCGACACCGCAACCTTACTATATCTCCGACGATCCATACGATTTGTGGGCGTGGATCAAGGCCTCTGCAGTGCCGCTGACGATGTCATTTTCGATACTTGGTTTCTTTCATTGGATGATTAGGAAAATGGAAATTTAA

Protein

MKFLQVLYTVIYFSLLLNLVDGRQFRVTDQVYLDVKNEDKDLGRLVIGLFGDLAPKAVNNFKVLATKGINGKSYKGTRFNRIIKRFMVQGGDVVSDDGSGSISIYGDTFDDENLETQHSTGGFVSMANKGKNTNGCQFLITTTGAPWLDQLHTVIGKVVEGQKVVHLLEHTPTDVEDRPLEHVYISDCGLLPTPQPYYISDDPYDLWAWIKASAVPLTMSFSILGFFHWMIRKMEI

Description

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction.

Catalytic Activity

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Similarity

Belongs to the cyclophilin-type PPIase family.

Keywords

Complete proteome   Glycoprotein   Isomerase   Membrane   Reference proteome   Rotamase   Sensory transduction   Signal   Transmembrane   Transmembrane helix   Vision  

Feature

chain  Peptidyl-prolyl cis-trans isomerase

Uniprot

A0A194RCB0   A0A2H1WSB3   A0A194PRM8   A0A0L7LST9   A0A212ESX9   A0A232FL48   + More
A0A1W4X0L7   A0A1L8DTW1   Q16VU6   A0A182V9Q1   Q7Q137   A0A182HR92   A0A182KZ43   A0A182XGY3   A0A182Y6A1   A0A182NP22   A0A1B0GLX0   A0A182RWQ9   A0A182W8R3   A0A087ZN42   A0A2A3EHQ6   A0A182Q1Y4   A0A084VSR9   A0A182J2S2   E2C9W8   V9IJJ4   A0A158ND00   A0A0L7R6E0   A0A1J1I1K6   A0A182K951   A0A1W7R7Y6   A0A182P7Z6   W5J602   T1DRZ2   A0A182M1R3   A0A182SF46   A0A336KUL6   A0A0M8ZSS3   A0A1Q3G5B3   A0A139WGQ8   A0A139WHB1   A0A195D0J8   E0VPS3   W8B9L2   G9C5E4   A0A1B6M828   A0A026WGV9   A0A0K8UM76   A0A0K8U0Z0   A0A1B6MRG3   B3MM51   A0A0A9XF44   A0A146LVT8   T1GQ69   A0A1I8MY03   B4P2Z0   B3N8A1   A0A034VWL3   Q540W6   P15425   A0A0J9QUC6   Q29NN3   A0A1A9VXN4   B4GQP2   A0A1W4V2D3   B4ID30   A0A1B0B4N9   B4K1T6   B4N0P5   A0A1A9XDQ9   A0A1A9ZIX0   A0A182FWX4   A0A3B0JUF4   A0A1A9W0K5   B4JDU7   A0A1I8P8X2   A0A0N8EB86   A0A0P5L1J7   A0A0P5PMN4   A0A224XY85   B4KF64   A0A0P5JIN6   A0A0P5PW62   A0A0P5PMS8   A0A0P5XHJ4   A0A164S936   T1H9G1   P28517   A0A0N8C9T7   A0A0P5LI06   A0A0P5GMW9   A0A0P6BH72   A0A0P5LP10   A0A0P5KTI5   A0A0P5KY89   A0A0L0BQW7   A0A2S2NZR4   A0A2H8TMM6   A0A0P5AP13  

EC Number

5.2.1.8

Pubmed

26354079    26227816    22118469    28648823    17510324    12364791    + More
14747013    17210077    20966253    25244985    24438588    20798317    21347285    20920257    23761445    18362917    19820115    20566863    24495485    21835214    24508170    17994087    25401762    26823975    25315136    17550304    25348373    2493138    2664782    10731132    12537572    1707759    1644830    22936249    15632085    26108605   

EMBL

KQ460398    KPJ15104.1    ODYU01010684    SOQ55960.1    KQ459601    KPI93790.1    + More
JTDY01000158    KOB78538.1    AGBW02012699    OWR44598.1    NNAY01000063    OXU31392.1    GFDF01004203    JAV09881.1    CH477580    EAT38713.1    AAAB01008980    EAA13914.4    APCN01001659    AJVK01009166    KZ288242    PBC31238.1    AXCN02001964    ATLV01016140    KE525057    KFB41013.1    GL453904    EFN75266.1    JR048987    AEY60827.1    ADTU01012128    KQ414646    KOC66384.1    CVRI01000037    CRK93634.1    GEHC01000399    JAV47246.1    ADMH02002089    ETN59396.1    GAMD01000420    JAB01171.1    AXCM01000709    UFQS01000960    UFQT01000960    SSX07976.1    SSX28210.1    KQ435896    KOX69236.1    GFDL01000058    JAV34987.1    KQ971343    KYB27178.1    KYB27177.1    KQ977012    KYN06381.1    DS235371    EEB15379.1    GAMC01016689    JAB89866.1    HQ851385    AEV89763.1    GEBQ01007888    JAT32089.1    KK107213    EZA55302.1    GDHF01024711    JAI27603.1    GDHF01031947    JAI20367.1    GEBQ01001502    JAT38475.1    CH902620    EDV30866.1    GBHO01026172    GBHO01026171    JAG17432.1    JAG17433.1    GDHC01006808    JAQ11821.1    CAQQ02394226    CM000157    EDW87197.1    CH954177    EDV57288.1    GAKP01012737    GAKP01012735    JAC46215.1    AY119494    AAM50148.1    X14769    M22851    AE014134    CM002910    KMY87399.1    CH379059    EAL34185.2    CH479187    EDW39914.1    CH480829    EDW45456.1    JXJN01008377    CH917841    EDW04846.1    CH963920    EDW77658.1    OUUW01000004    SPP79110.1    CH916368    EDW03467.1    GDIQ01043780    JAN50957.1    GDIQ01177528    JAK74197.1    GDIQ01128253    JAL23473.1    GFTR01003377    JAW13049.1    CH933807    EDW13047.1    GDIQ01197824    JAK53901.1    GDIQ01129504    JAL22222.1    GDIQ01126806    JAL24920.1    GDIP01073820    JAM29895.1    LRGB01002076    KZS09378.1    ACPB03001101    GDIQ01100763    JAL50963.1    GDIQ01177529    JAK74196.1    GDIQ01242108    JAK09617.1    GDIP01014638    JAM89077.1    GDIQ01177526    JAK74199.1    GDIQ01180429    JAK71296.1    GDIQ01177527    JAK74198.1    JRES01001507    KNC22396.1    GGMR01009933    MBY22552.1    GFXV01003107    MBW14912.1    GDIP01210300    JAJ13102.1   

Proteomes

UP000053240    UP000053268    UP000037510    UP000007151    UP000215335    UP000192223    + More
UP000008820    UP000075903    UP000007062    UP000075840    UP000075882    UP000076407    UP000076408    UP000075884    UP000092462    UP000075900    UP000075920    UP000005203    UP000242457    UP000075886    UP000030765    UP000075880    UP000008237    UP000005205    UP000053825    UP000183832    UP000075881    UP000075885    UP000000673    UP000075883    UP000075901    UP000053105    UP000007266    UP000078542    UP000009046    UP000053097    UP000007801    UP000015102    UP000095301    UP000002282    UP000008711    UP000000803    UP000001819    UP000078200    UP000008744    UP000192221    UP000001292    UP000092460    UP000001070    UP000007798    UP000092443    UP000092445    UP000069272    UP000268350    UP000091820    UP000095300    UP000009192    UP000076858    UP000015103    UP000037069   

PRIDE

Q540W6    P15425    P28517   

Pfam

PF00160   Pro_isomerase        + More
PF00089   Trypsin

Interpro

IPR029000   Cyclophilin-like_dom_sf        + More
IPR002130   Cyclophilin-type_PPIase_dom       
IPR024936   Cyclophilin-type_PPIase       
IPR020892   Cyclophilin-type_PPIase_CS       
IPR033116   TRYPSIN_SER       
IPR018114   TRYPSIN_HIS       
IPR001254   Trypsin_dom       
IPR009003   Peptidase_S1_PA       

SUPFAM

SSF50891   SSF50891        + More
SSF50494   SSF50494       

Gene 3D

2.40.100.10    

CDD

cd00190  Tryp_SPc

ProteinModelPortal

A0A194RCB0   A0A2H1WSB3   A0A194PRM8   A0A0L7LST9   A0A212ESX9   A0A232FL48   + More
A0A1W4X0L7   A0A1L8DTW1   Q16VU6   A0A182V9Q1   Q7Q137   A0A182HR92   A0A182KZ43   A0A182XGY3   A0A182Y6A1   A0A182NP22   A0A1B0GLX0   A0A182RWQ9   A0A182W8R3   A0A087ZN42   A0A2A3EHQ6   A0A182Q1Y4   A0A084VSR9   A0A182J2S2   E2C9W8   V9IJJ4   A0A158ND00   A0A0L7R6E0   A0A1J1I1K6   A0A182K951   A0A1W7R7Y6   A0A182P7Z6   W5J602   T1DRZ2   A0A182M1R3   A0A182SF46   A0A336KUL6   A0A0M8ZSS3   A0A1Q3G5B3   A0A139WGQ8   A0A139WHB1   A0A195D0J8   E0VPS3   W8B9L2   G9C5E4   A0A1B6M828   A0A026WGV9   A0A0K8UM76   A0A0K8U0Z0   A0A1B6MRG3   B3MM51   A0A0A9XF44   A0A146LVT8   T1GQ69   A0A1I8MY03   B4P2Z0   B3N8A1   A0A034VWL3   Q540W6   P15425   A0A0J9QUC6   Q29NN3   A0A1A9VXN4   B4GQP2   A0A1W4V2D3   B4ID30   A0A1B0B4N9   B4K1T6   B4N0P5   A0A1A9XDQ9   A0A1A9ZIX0   A0A182FWX4   A0A3B0JUF4   A0A1A9W0K5   B4JDU7   A0A1I8P8X2   A0A0N8EB86   A0A0P5L1J7   A0A0P5PMN4   A0A224XY85   B4KF64   A0A0P5JIN6   A0A0P5PW62   A0A0P5PMS8   A0A0P5XHJ4   A0A164S936   T1H9G1   P28517   A0A0N8C9T7   A0A0P5LI06   A0A0P5GMW9   A0A0P6BH72   A0A0P5LP10   A0A0P5KTI5   A0A0P5KY89   A0A0L0BQW7   A0A2S2NZR4   A0A2H8TMM6   A0A0P5AP13  

PDB

4FRV     E-value=6.80917e-38,     Score=392

KEGG

101743827    no KO assigned | (RefSeq) peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme-like

GO

GO:0016021   GO:0003755   GO:0006457   GO:0016018   GO:0042026   GO:0051082   GO:0004252   GO:0005788   GO:0006517   GO:0006491   GO:0031410   GO:0016063   GO:0007603   GO:0070059   GO:0006458   GO:0007602   GO:0007601   GO:0050896   GO:0000413   GO:0030955   GO:0003824   GO:0005737   GO:0016876   GO:0043039   GO:0004651   GO:0005634  

Subcellular location

Membrane  

SignalP

Position:   1 - 22,         Likelihood:  0.984635

 

 

Length:

236

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

25.18755

Exp number, first 60 AAs:

5.16501

Total prob of N-in:

0.13427

outside

1  -  206

TMhelix

207  -  229

inside

230  -  236

 

 

Pi

343.620443

Theta

168.673644

Tajima's D

3.258319

CLR

0.374615

CSRT

0.987900604969752

Interpretation

Uncertain