Gene

KWMTBOMO01991

Annotation

PREDICTED:_serine-protein_kinase_ATM_isoform_X1_[Amyelois_transitella]

Location

Bomo_Chr4(-):9423090-9454805      View in EpiBrowser

Full name

Non-specific serine/threonine protein kinase       + More
Serine-protein kinase ATM      

Alternative Name

Ataxia telangiectasia mutated homolog

Location in the cell

Nuclear   Reliability : 3.202

CDS

ATGGATTTAGAAACTACCTTTAAAGAAGTTTGTGACGGATTAAAACTGACTAGAAACACTGACCGCAAAAAAAACGCTGAAAATTTAAAAGAATATCTCACAAGAAATGCTGTTCCTTGCATGTTGACACATAATGCACTTCGTAAAACCGGGTACTGCTGGAGCAATGTTTTTGATGATATAAACGAATATTTTTTAAAGGAATGTGAAAAATTTGAAACCTCAAAAACATTCGATACAATTACTGTACCCCTTTGTACGTCACTGCTTCATCTATGTGTTGCTGGTTCCAATAAAGGTAGAGCATATGTAAGATGTGAAAAGATACTAGAAGCTTGCTATACTATCTTGAAAGATCCACGCCTTGCTACTGCTGTTGGCGATGCATATTTAACTTTATTATATAAATATGTTTTGCCTCTCGATCATTACCTTGGATTTATCAAACCATCTGATTGGGAAGATCTATTAAATATCGGTACTGCAACATGTTTAAAGTCTTACTCAAAATTGGATGATTTTACTAAGTTGAGATTCATTCTCATTGTTCTGAAAAATGGAAGTGAATACTGTCAATTTGCAGTTTCACTTAAAGAATCACTCTCACAAATAAAAAGATGCTTTTTGAGACTAGGACATGACAAAAAACTACAATCGGTCATCGTGGATATAACAATAGTATTAATAAAAACGTTATCCATGGAATGTCGCTTGACCATGTGCCAATTTACTGAGAGTATTTTGTCATCAATACTGAAATTTTACGACCCAAATCAGGATGTTTCCAAAAAGTCATCACTATTTCAATTGTTAAATTACACAATGGTGGTTCATCATCCACATGGAAGAAAACAAAATCAAGAATGCAGTCTGGCTTCTGATTGGATTCTATGGAATAAGCATCTTCACAACATATTAGAAATCATATGTTTAGAAGTGACTTATTTGCAGAAAAACCCGAAACACAGTACTATAAAACAATTTGAATATTTCTTTAGTTTAGCTGCTGCAGTGTATTTTCAAATTTTCGAAGGAATACAATCACTAGACGATGAGCCTGGACCATCGAACAAAAGGCAAAAAATAAGTTTTAACAAAATAAAAACTTTTCGGGATCTTTTAGACGAATTGCGAATTAATAGTGTTCCTTGGTTGGGAATCATACAAGTGTTCGTAAGAAAGTATGGCGACGAAATCGCCCCCCTTGATTACTTAACGTTGATAAATGTATTGGAGTCACTAATAACCAATGATAAAGCTAACGTGAACTGGGATATCTACGAGGAGTTAGCCTGTGACGTTCTAAAGAAGCTAACAGATGCCACATCCGGACAAGAAGATTCTAGTGCCGCGTCGCTGTTACTTTGGAATTCTTGTGTACGAAACTCGTCGTCTAATAGTTCGTCACATAAAGCGATGCATAGAATAATTCAGAGTTTATTGAATTTAAATATTTTGTCATTCAACAATATACAGACGCTAGTTAAATTTTACACCGAGAAAAGTATGCCGGTAACAAATTCTAGTGTGGCGACCGTCAATAGTATCTCGAAGAGGTTTTTCACCAAATTCAACAACCTGGAAACGAAAATAAGTTTATACTATTGGTTTGTTAATGGAGACAATCATTCCGTTGATATATCGGAAACTGAAGAATTTTTTTCGAGATTACTGGCACACGAGAATGTGAATGTTTACAGAAAAAAAATCGTTTCTGAAGACGGCCACTTCGATTTGTTATTTAATTCTATCGAGGATTGTATCTTGTTTAGCGAGTTTGATATTGATCTGCCCGAAATTGTAGAATACGGTGAGCTTAATATTGACCGGTTTGAACTACAGAGAGGCGTACTGAATCACATGACTAACGATTTTATCACAACTCTGAGGGAACATATCGAAAGATTGAAGAGAAAAGAAATCGATATTTTACGGTACATTGAATACACAACTATTGTTGTTGTGGCTATGGAATGCATGATAAAAAATAGCACGAACAAATGCGATTTTAAACAAGAGCTGCGGGAATCGATCGAATTGGCCGCGACGCAGATGTTCAAACGTTCACAAGATGTTTTAGTCAGTAACACACAAATTCCAGTCAAAATAAAATTATTGCAGCGCCTCGAAGACATTATGGCGGCTGACTTGAGTCCCGCTCTCGGCTCGCTAATTCGTAATTGTATTAATGAAGATTTCTTTCGTTGCATTAGTAATATATTGCACGTTGATACTAAGGATGAAAATGACGACATAGTTTGTGCCGAAGAGGACGACCTAGACATTGATGCTCTCAGACATCACTGCGTATACGTATTGGCTTCGTTTTGCAGAATTCCAGGGCCTTATAGAGATGAGCTGTTAGAATTGATTTTAGATTCCAAATGTTATACGTACAGCAAGGACACTCACTGTGCTCTTAGATGTATTGAAATCTTAAGTGATGGTCGTGTGGAGCAACCTCCTATAGGCTTAATGTTTCAGTTGATCGCAAACATTTGCAAGGAAATGTACAGAAATCCAAAAGCTTCGTTGGGAATTTTAAAAACGCTTTACAAAATGATCGAAAGTATTTGGTCTGAGAATGAAATTATGAAACAAAATTGTTGCATAATGATAAAGAGATATCTGCAGCGTTGCGAGAAGTCGTACTACCCTCCCGCGGTAGCCGCTGCGGTTTACAAATGTGCAGCCAAAATAGTTTCCTTGAATAACCGTCGGTATTTTTCTGACGAAACTATGTTTGAGGAATCTATAACGAATCAAATCCGAGGAGACATTCACAGCGTTCGCCTTTACTGTTGTTACTTGCTTCAATACGTCTTTACAAATTTTACGAATGACCACGTGTCTTCATACTTGGCTGGTTTATTAAATATGTTTCTGATAAACGTTCTGCACAAGAAGGACATTCTATTGAAAGACGAAGCCACTAACAGAACGCACACAATTTTGCGAGCGTATATATCTTTAGTGGAAATAAATAAATCGCTAGTTCATCAAGTGATAATGGAGGTGTTGCGATTCCAAAAGGAGAAAACTTTAAACATGCATTTAACAGAGAAGATTCTTAAAAGAATATGTCATATTTCAAACGTAAAGGAGATATCTGTTTATCTGGACGATAACGTTCTTTCGGTTTTGCATTTTTGGTTCACGAATAATTTAACGATTGAGACGTTGCCTCTTAATCTCTTTAAGTGCGATGATATTAACGTATTCCTTGAACGGTATAAGAGCTGGTTGATCCCAGCGGACGCACTGTGGAACAGCGGAGGCAACATCAAGGAAAGCTCTCTATTGCATTTAATAAAACAAAATAATAAGAAACAATCACTAGAAGAAATCATCGAGGACAGTTTTCCACACTTCGTAGCCCTGTCGTTACCTTACGTAGTGATCGACAAGTACAAACTTCATTGTTTGTCCGAACTGCCGGCCAGTTTTAAAGAGTCATTGGAAAACGGCCAGAAGATGTTTCATCAAACGGGACAAATGCTGACGCGCGACAAGTGGACCAATCTCTTCGTCGAAAACGTTGGAGAGATATTGATGTTGACCGCCGTGCACCTGTGCGATCACAGTGATGCTAACCGCTTGTTCGGAATCGATATACAGAATAAAAACCGAAGCTTTTATTATTCGAAACGAGTATACTTGTCTGTTTTGGATTTCATCGGGGAACTCTCCGATTGTAGCATAATGCAGTATCTCTGTGGAAATCAACCATTAGCAATATTCAACATATTATTCAAAGTATGGAGCCGCGTAATAAATGAAAATTGTCCAGAATCGAGAATTTCAGCGTTGCACGCCTACATTACAATTTTGGAAAGTATTCCGCAAGAACAATCTTCAGATGCATTCGTATGTAATTTTGCTTGCAAGAGCTTCGCCCATGCGATCAACGACAGTGATAATAGTAAAAATGTTGAAATTTACGTAAAGAGTTTAAAAATAATATTTGAAAGAATATTAATAAATAAAGCTGATCTGATTAAAACGTCAGTGTCTCAGCTGTTACCGATTTTGATGATAAAACAAGAAGAAGGTTTTGTAAAAGAATGCGAACCTTTGATACATTATTTGACAGTGGAAATGAAAGATTGCTTGAACGGTAGCGAAGACGTTCTAGACTTTATGAGTTCGGTTTCTCAAGGGTTTGTAGATGACATGGAATGCTCTACCGTGAGATCGTTCACTGAGAAGCTTAGGACGTACAAACTGAGCTTGGTGTATCCTAGTTACGAAACGCTTTTAAATTTACGAAAGTGTTTGATCACCAATAAACACTTCATCGATCGGTGCTTGAACGATTTGAACTCGAAAGGATTCTCAGAGGACTGCGGAACGAGCATTATACATCAAATTATAAATTCATTGAACGACATCTTGAAGTCAACAAGAGATAATAAGACGATTGTGGAAACGTGTAATTGCTTGGCAGAAATCGGTATTTACGATTTGAAAACTTTAGTGACCGTACCTCCACGCGACACGCACAAAGTCGTCAGCGTGACCCCTACCAAGTGTTTTGTAACGATTGTCGTAAAGTCTCTCTCTGAAACACTAATGGACGACAATCCCACCGTGACATCTAAAGCAGCCGAAACATTAAGCAACATTTTGAAATGCTTCGAGGATATCGATACAATTGATATAGATAGACAGTGCAAGCAGATACTGAAGCCCTTGGTGTCGGTCAATACGTTTCCCGTCACTATTAAACTTAACATACACGCATATACCGACTACAGCATTGAATATGTGGATGGAATTTTCTTGAGGGCTTTGATTTCTAATTGGAATAACAACAGCAAAGATGTAGGCCATGATTGGTTGCAACGAGTCACTTGCACTCTGCTGAAGCTCATAAAACCGACCTGTCCGTATTTGGATACGTTGTATGAAGTCTGCCAATTAAAGCCTCACGTCTGTAGAGATATTCTAGCGCCTTTGGTAGGTGTCCTGCTTTTTTCTAGTTCGACTGAAGGTAAAATCGAAATGCTCGGGACACAAATTAACGCAGTTTTTAATTATATTTGGGAACAAACTTTCGAGGATAAAGTCGACAGCAGTAGTAACAGTCGCGTGAGCTCCGCGTCGGGCCATGGTTTAGATTATGGACAAAAACAGATGATTCAATATATGTTGGATATTGTTGAATTCGTCCGCTTACAAAGAGCTTACTATTTGAGAATAAATACCGAAGTTGATTCATTAAACTATTTGAATCTAGAATATGACAAAGTTGCTTGGGCTGCAACGATTTCGGATCAAAATCTGATCGCAGTTTATTACGGCGAGCTCTGGGCGTTCGCTAAGAACGGCGGTGTTCCTCCGGCATCACCCGAAAAAGCTGCAAGCTTAGAAGGAGGGGAAAATATGCAACGGATATTAAGAAAGTGCTACGTGTCGATCGGCGACACGGACGCGGTGGAGGGCTGCGGCACGGCGCACCTCACCGTGGAGAGCGAGAAGCGCAAGTACCTAATCCACACGGGGCAGTTCGCGGACGCGCTGCTGCTGCACGACGCGGCGCTGTCCCGGGGCGCGCGCGCAGACCGCCCCCTGCACGCCGGCGTCGCGCGCTCGCTACACAAGTCGGGAATGCATCACCTCGCCTTGCAATACATTAAATCGTTGCCCGACAACGACTACTTAAACGAGATAAAGTACGAATGCATGTCGTTTTTGGGTGACTGGAGTGAATTTGTTGACACGCAGGAGTTAGACGAGAATTCGAGGAATGGTAATTTCAATCCGAATTCCATATTGAGAGCATTTCAATATGCCTGCCTCAGAGCGTGTGTTGGAGAGGAAACGACGCAAATTGATCTAGACAGAATAGTGCCCTTGAACAGAGCCAAAATAGCCGTAGCCACGCTTTGCCAGAACCTCAACATGGAGACCAGTCAGAGCGTATACAAAATCGTTCGAGAATTACACATATTCAAAGACATCGAAGATTACTATTCGGTTAGATCGGCCGATATATCGATAAACGATTTGCTCAAACGTTGGCGAACCGATAACCTACCTCGGTTTAACGACTTCAAGTACGTCGAGGCTCTGATTTCGCAACGCGTGATGATGCTGGAGCACGCCGCGGGCCGCTACCACGACTTGCTGAAAGATATCGTTTCGCTGCAGATACAATATGCCGAACTATCTCTCGCTCACGGCAGAATACAGATGTCTCAACGGCTAATTGCGACAGTAAAGGACCTGCAGGTGCCGGACGAGGTGACCTTAGCGGAAAGCGAAATATCTTGGGCGAAAGGACACAGAGAGATCGCTATTTCCTTGCTAAAGAATGTCGTTACCAATCCGACTGTAGATGCTACGACCAGTGCGGCTGCTCTAAGGCAGTACGGGTTGTGGATGGCAGAGTCGAAACGAGAGAACGTCAGAGACATCATTGAAAAGTACCTGTTGAAAAGTCTGGACGTCATGAATGCTACCGATCATAAACAGACGAGATTCAAAGTCTACTATGACATCGCCAAATTTGCTGACGCGGAGTACAAACAAGTCGAGGCGTACATGAACTCATCCGTTTTCGAGAACAAAGTGAAATGTTTAGAGAACATCAAGGACACCACATCATCATTACGTTCAACGCAACAATCACTGACCAGGGACGAGCAGAGAGCCCTAATTGTAAACGATCGATTTAGGAAGCTGGATGAAACCGAAATTGCTAATACTAAAGCCGTGAAGGAAAATTTTCTGAGTTTGGCCATGAGGTACTACTTACGTTCGTTGAAGCAATGCGAGCTGAACAATTTGTGTGTTTTTCGTGTCATTTCATTATGGCTCGACAATCCAAGTTTTGATTTCGAAGAGTCGAACGGCGAAAAGTTCACTGATTTGCTACACGCCATACCGTCGAGGAAGTTTATTACGGTACTGCCTCAGTTGGTGCCCAGATTGAATACTGAACGAACAGCGTTTGCAGAAAACTTGAAGAAGATCATAAAGAGATGTGCCATCGATCATCCCCACCACACACTTCCCATTCTGTTTAGTTTGAAGAATTCAGACAAAGACAAAACGATTACACTAAACTTAAAACCAGGAAATACACAGTCCAGAGCCCAAGAGCCCAGAGTCGTTGCCGCTCAGGCATTAAGTGTTGAAATAAGTAAAGAAAACGAATCTATGGCATCGATTATGTCCCAAATGGAAAGAATGTGCGATGCAATGATAGCTTTCGCTAACCTCGAACCTTCGTCGAAAGAAGTGAAACAAGCCATCCCGGCAACTGAACGAATACTGAGGCTTGGTCATTTGGACGCTATACCCGTGCCGACCGCGACGATACCTATTAGAGATGACTGCACGTACTCTGATTTTCCAGCTTTAAAATCATTCGACAACTACTTCGAATTGGTTGGAGGGATTAACTTCCCGAAAAAAGTGACATGCCTTGATTCGACGGGACAAAATAGGATACTGTTGATTAAGGGTAAAGATGATTTGAGGCAGGACGCGGTAATGCAACAAGTCTTCAACATAGTCAACGCTCTACTAGAAAACAATCCGGTCACTAGTCGAATCAAGCTGCTAATCCGAACATACAAGGTGGTGCCTCTGTCCCGCCAGTCGGGTGTACTGGAGTGGTGCGTGGGAACGATACCGCTGGGAGGATATTTGGTGGGCACAAAAAAATCACCCGGTGCGCATGCGCGTTATCGACCTAAGGACCTATCGTGCATGGATGCTCGAAAAAAGATGGAAATGAATCGCGAATCAAGGCAGAGTAACAATGAGAAGTTGACAGTTTTCTTGAACATTTTGAGAGACTTTAAACCGGTGTTTCATTACTTTTTCACTGAACATTATCACAATCCGGTGTCTTGGTACGAACGAAGACTGGCGTATACAAAAAGTGTGGCGGCGTCTTCCATGGTGGGATATATACTGGGCTTGGGCGATCGACACGTTCAGAACATATTGATCGATAAACATACTGCTGAAGTTATTCACATCGATTTTGGTATAGCGTTTGATCAAGGCAAGGCGCTGACAACACCCGAGACTGTTCCTTTTCGGCTAACCCAAGACCTGGTTTCTGGGTTCGGATCCAGCGGCGTTGAAGGAATATTTAGGAGGTCTTGTGAGAAAACAATGCAACTCCTCAGAGACAATCAGGAAACCTTATTGACGATATTGGAAGTGCTTCTATGTGATCCTTTGTACACTTGGATTATATCCCCTAAACAACAAAATACTCGTGGCAGTAAAGTCGATAACCTTAATTGTGGCAGTAGTTCGAAAAGTGGTCTCGCCCAGAGAGCTTTGCTAACTGTAAACAGTAAATTAAGCGGCACCGAAGGCGGTGTGGCGGGAGGCGTTGCAGTTCCTGGTCAAGTAGCACGTCTAATTCATACAGCAATGGACCCAAATAACTTGTGCCGGCTTTTCCCGGGGTGGCAACCCTATTTATAG

Protein

MDLETTFKEVCDGLKLTRNTDRKKNAENLKEYLTRNAVPCMLTHNALRKTGYCWSNVFDDINEYFLKECEKFETSKTFDTITVPLCTSLLHLCVAGSNKGRAYVRCEKILEACYTILKDPRLATAVGDAYLTLLYKYVLPLDHYLGFIKPSDWEDLLNIGTATCLKSYSKLDDFTKLRFILIVLKNGSEYCQFAVSLKESLSQIKRCFLRLGHDKKLQSVIVDITIVLIKTLSMECRLTMCQFTESILSSILKFYDPNQDVSKKSSLFQLLNYTMVVHHPHGRKQNQECSLASDWILWNKHLHNILEIICLEVTYLQKNPKHSTIKQFEYFFSLAAAVYFQIFEGIQSLDDEPGPSNKRQKISFNKIKTFRDLLDELRINSVPWLGIIQVFVRKYGDEIAPLDYLTLINVLESLITNDKANVNWDIYEELACDVLKKLTDATSGQEDSSAASLLLWNSCVRNSSSNSSSHKAMHRIIQSLLNLNILSFNNIQTLVKFYTEKSMPVTNSSVATVNSISKRFFTKFNNLETKISLYYWFVNGDNHSVDISETEEFFSRLLAHENVNVYRKKIVSEDGHFDLLFNSIEDCILFSEFDIDLPEIVEYGELNIDRFELQRGVLNHMTNDFITTLREHIERLKRKEIDILRYIEYTTIVVVAMECMIKNSTNKCDFKQELRESIELAATQMFKRSQDVLVSNTQIPVKIKLLQRLEDIMAADLSPALGSLIRNCINEDFFRCISNILHVDTKDENDDIVCAEEDDLDIDALRHHCVYVLASFCRIPGPYRDELLELILDSKCYTYSKDTHCALRCIEILSDGRVEQPPIGLMFQLIANICKEMYRNPKASLGILKTLYKMIESIWSENEIMKQNCCIMIKRYLQRCEKSYYPPAVAAAVYKCAAKIVSLNNRRYFSDETMFEESITNQIRGDIHSVRLYCCYLLQYVFTNFTNDHVSSYLAGLLNMFLINVLHKKDILLKDEATNRTHTILRAYISLVEINKSLVHQVIMEVLRFQKEKTLNMHLTEKILKRICHISNVKEISVYLDDNVLSVLHFWFTNNLTIETLPLNLFKCDDINVFLERYKSWLIPADALWNSGGNIKESSLLHLIKQNNKKQSLEEIIEDSFPHFVALSLPYVVIDKYKLHCLSELPASFKESLENGQKMFHQTGQMLTRDKWTNLFVENVGEILMLTAVHLCDHSDANRLFGIDIQNKNRSFYYSKRVYLSVLDFIGELSDCSIMQYLCGNQPLAIFNILFKVWSRVINENCPESRISALHAYITILESIPQEQSSDAFVCNFACKSFAHAINDSDNSKNVEIYVKSLKIIFERILINKADLIKTSVSQLLPILMIKQEEGFVKECEPLIHYLTVEMKDCLNGSEDVLDFMSSVSQGFVDDMECSTVRSFTEKLRTYKLSLVYPSYETLLNLRKCLITNKHFIDRCLNDLNSKGFSEDCGTSIIHQIINSLNDILKSTRDNKTIVETCNCLAEIGIYDLKTLVTVPPRDTHKVVSVTPTKCFVTIVVKSLSETLMDDNPTVTSKAAETLSNILKCFEDIDTIDIDRQCKQILKPLVSVNTFPVTIKLNIHAYTDYSIEYVDGIFLRALISNWNNNSKDVGHDWLQRVTCTLLKLIKPTCPYLDTLYEVCQLKPHVCRDILAPLVGVLLFSSSTEGKIEMLGTQINAVFNYIWEQTFEDKVDSSSNSRVSSASGHGLDYGQKQMIQYMLDIVEFVRLQRAYYLRINTEVDSLNYLNLEYDKVAWAATISDQNLIAVYYGELWAFAKNGGVPPASPEKAASLEGGENMQRILRKCYVSIGDTDAVEGCGTAHLTVESEKRKYLIHTGQFADALLLHDAALSRGARADRPLHAGVARSLHKSGMHHLALQYIKSLPDNDYLNEIKYECMSFLGDWSEFVDTQELDENSRNGNFNPNSILRAFQYACLRACVGEETTQIDLDRIVPLNRAKIAVATLCQNLNMETSQSVYKIVRELHIFKDIEDYYSVRSADISINDLLKRWRTDNLPRFNDFKYVEALISQRVMMLEHAAGRYHDLLKDIVSLQIQYAELSLAHGRIQMSQRLIATVKDLQVPDEVTLAESEISWAKGHREIAISLLKNVVTNPTVDATTSAAALRQYGLWMAESKRENVRDIIEKYLLKSLDVMNATDHKQTRFKVYYDIAKFADAEYKQVEAYMNSSVFENKVKCLENIKDTTSSLRSTQQSLTRDEQRALIVNDRFRKLDETEIANTKAVKENFLSLAMRYYLRSLKQCELNNLCVFRVISLWLDNPSFDFEESNGEKFTDLLHAIPSRKFITVLPQLVPRLNTERTAFAENLKKIIKRCAIDHPHHTLPILFSLKNSDKDKTITLNLKPGNTQSRAQEPRVVAAQALSVEISKENESMASIMSQMERMCDAMIAFANLEPSSKEVKQAIPATERILRLGHLDAIPVPTATIPIRDDCTYSDFPALKSFDNYFELVGGINFPKKVTCLDSTGQNRILLIKGKDDLRQDAVMQQVFNIVNALLENNPVTSRIKLLIRTYKVVPLSRQSGVLEWCVGTIPLGGYLVGTKKSPGAHARYRPKDLSCMDARKKMEMNRESRQSNNEKLTVFLNILRDFKPVFHYFFTEHYHNPVSWYERRLAYTKSVAASSMVGYILGLGDRHVQNILIDKHTAEVIHIDFGIAFDQGKALTTPETVPFRLTQDLVSGFGSSGVEGIFRRSCEKTMQLLRDNQETLLTILEVLLCDPLYTWIISPKQQNTRGSKVDNLNCGSSSKSGLAQRALLTVNSKLSGTEGGVAGGVAVPGQVARLIHTAMDPNNLCRLFPGWQPYL

Description

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Subunit

Homodimer (By similarity). Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomers rendering them catalytically active. Binds p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with RAD17; DNA damage promotes the association. Interacts with EEF1E1; the interaction, induced on DNA damage, up-regulates TP53. Interacts with DCLRE1C, KAT8, KAT5, NABP2, ATMIN and CEP164. Interacts with AP2B1 and AP3B2; the interaction occurs in cytoplasmic vesicles (By similarity). Interacts with TELO2 and TTI1. Interacts with DDX1. Interacts with BRAT1 (By similarity).
Homodimer (By similarity). Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomers rendering them catalytically active. Binds DNA ends, p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. DNA damage promotes association with RAD17. Interacts with EEF1E1; the interaction, induced on DNA damage, up-regulates TP53. Interacts with DCLRE1C, MYST1, KAT5, NABP2, ATMIN and CEP164 (By similarity). Interacts with AP2B1 AND AP3B2; the interaction occurs in cytoplasmic vesicles (PubMed:9707615). Interacts with TELO2 AND TTI1. Interacts with DDX1 (By similarity). Interacts with BRAT1 (By similarity).

Similarity

Belongs to the PI3/PI4-kinase family.
Belongs to the PI3/PI4-kinase family. ATM subfamily.

Keywords

Acetylation   ATP-binding   Cell cycle   Complete proteome   Cytoplasmic vesicle   DNA damage   DNA-binding   Kinase   Nucleotide-binding   Nucleus   Phosphoprotein   Reference proteome   Transferase   Tumor suppressor  

Feature

chain  Serine-protein kinase ATM

Uniprot

A0A2H1X1L0   A0A2A4J584   A0A212ESY2   A0A194PM36   A0A194RGR1   A0A067R4Q0   + More
D7EIC9   A0A226EXP6   A0A0C9QFQ2   A0A0C9R2P1   A0A232F3D5   K7J932   A0A1D2NG62   A0A146SAH4   Q6PQD5   G3WB56   A0A287A9E0   F1SV20   A0A2Y9EZ30   A0A2Y9M8A0   G5BXR2   H0VI73   A0A3Q0CP75   A0A2Y9M6F8   A0A091CT98   Q62388   M3Y3L9   G1T7X7   A0A3Q0HD24   A0A146ZU23   A0A087XK65   G3T1D5   B9EHX4   A0A0G2K3I0   A0A2K6L9Z6   A0A2K6QRY5   D4ACL8   A0A3P9PRP7   F6XCB4   A0A146VQM9  

EC Number

2.7.11.1

Pubmed

22118469    26354079    24845553    18362917    19820115    28648823    + More
20075255    27289101    21709235    21993625    21993624    26319212    28071753    8661102    19468303    8689683    9000145    9697112    9707615    11571274    19047460    19448632    21183079    12040188    15489334    15057822    22673903    25362486    15632090    17431167   

EMBL

ODYU01012768    SOQ59240.1    NWSH01002987    PCG67141.1    AGBW02012699    OWR44587.1    + More
KQ459601    KPI93799.1    KQ460398    KPJ15116.1    KK852699    KDR18216.1    KQ971310    EFA11787.2    LNIX01000001    OXA61844.1    GBYB01002229    GBYB01013363    JAG71996.1    JAG83130.1    GBYB01002230    JAG71997.1    NNAY01001115    OXU25092.1    AAZX01005394    LJIJ01000050    ODN04229.1    GCES01108620    JAQ77702.1    AY587061    AEFK01115011    AEFK01115012    AEFK01115013    AEFK01115014    AEFK01115015    AEFK01115016    AEMK02000070    JH172395    GEBF01006111    EHB14073.1    JAN97521.1    AAKN02053834    AAKN02053835    AAKN02053836    AAKN02053837    AAKN02053838    AAKN02053839    KN124601    KFO20710.1    U43678    AC079869    AC156640    AEYP01061336    AEYP01061337    AEYP01061338    AEYP01061339    AEYP01061340    AEYP01061341    AAGW02009206    AAGW02009207    AAGW02009208    AAGW02009209    AAGW02009210    AAGW02009211    GCES01016513    JAR69810.1    AYCK01016490    BC138525    CH466522    AAI38526.1    EDL25796.1    AABR07073407    AC133262    CH473975    EDL95516.1    JSUE03013373    JSUE03013374    GCES01066540    JAR19783.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000053240    UP000027135    UP000007266    + More
UP000198287    UP000215335    UP000002358    UP000094527    UP000008227    UP000007648    UP000248484    UP000248483    UP000006813    UP000005447    UP000189706    UP000028990    UP000000589    UP000000715    UP000001811    UP000189705    UP000028760    UP000007646    UP000002494    UP000233180    UP000233200    UP000242638    UP000006718   

PRIDE

Q6PQD5    Q62388    D4ACL8   

Pfam

PF00454   PI3_PI4_kinase        + More
PF02260   FATC
PF11640   TAN
PF02259   FAT

Interpro

IPR011009   Kinase-like_dom_sf        + More
IPR000403   PI3/4_kinase_cat_dom       
IPR014009   PIK_FAT       
IPR016024   ARM-type_fold       
IPR015519   ATM/Tel1       
IPR036940   PI3/4_kinase_cat_sf       
IPR018936   PI3/4_kinase_CS       
IPR003152   FATC_dom       
IPR021668   TAN       
IPR011989   ARM-like       
IPR003151   PIK-rel_kinase_FAT       
IPR018278   Ribosomal_S21_CS       

SUPFAM

SSF56112   SSF56112        + More
SSF48371   SSF48371       

Gene 3D

1.10.1070.11     1.25.10.10    

ProteinModelPortal

A0A2H1X1L0   A0A2A4J584   A0A212ESY2   A0A194PM36   A0A194RGR1   A0A067R4Q0   + More
D7EIC9   A0A226EXP6   A0A0C9QFQ2   A0A0C9R2P1   A0A232F3D5   K7J932   A0A1D2NG62   A0A146SAH4   Q6PQD5   G3WB56   A0A287A9E0   F1SV20   A0A2Y9EZ30   A0A2Y9M8A0   G5BXR2   H0VI73   A0A3Q0CP75   A0A2Y9M6F8   A0A091CT98   Q62388   M3Y3L9   G1T7X7   A0A3Q0HD24   A0A146ZU23   A0A087XK65   G3T1D5   B9EHX4   A0A0G2K3I0   A0A2K6L9Z6   A0A2K6QRY5   D4ACL8   A0A3P9PRP7   F6XCB4   A0A146VQM9  

PDB

5NP1     E-value=1.59671e-167,     Score=1521

KEGG

101746600    K04728 serine-protein kinase ATM [EC:2.7.11.1] | (RefSeq) serine-protein kinase ATM

PATHWAY

03440    Homologous recombination - Bombyx mori (domestic silkworm)
04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04214    Apoptosis - fly - Bombyx mori (domestic silkworm)

GO

GO:0016301   GO:0004674   GO:0005524   GO:0006974   GO:0005634   GO:0000077   GO:0000723   GO:0008630   GO:1904262   GO:0010212   GO:0090399   GO:0016572   GO:0006281   GO:0003677   GO:0046777   GO:0007094   GO:0006412   GO:0003735   GO:0031410   GO:0006975   GO:0071044   GO:0047485   GO:0005840   GO:0002331   GO:0016303   GO:0035264   GO:0045944   GO:0048538   GO:0030889   GO:0051402   GO:0008340   GO:0009791   GO:0044877   GO:0000724   GO:0045785   GO:0042159   GO:0043517   GO:0071480   GO:1904354   GO:0071481   GO:0045141   GO:0071500   GO:0002377   GO:0030335   GO:0048599   GO:0033151   GO:0032212   GO:0004677   GO:0007143   GO:0097694   GO:0007140   GO:0005730   GO:1990391   GO:0007050   GO:0046983   GO:0000781   GO:0001756   GO:1904884   GO:0007420   GO:0072434   GO:0036289   GO:0001541   GO:0043525   GO:0005819   GO:0007507   GO:0071300   GO:0010506   GO:1905843   GO:0070192   GO:2001022   GO:0043065   GO:1904358   GO:0006468   GO:0005737   GO:0005654   GO:0033129   GO:0002376   GO:0004672   GO:1901216   GO:0051726   GO:0032210   GO:0010628   GO:0007292   GO:0018105   GO:0001666   GO:1903626   GO:0008585   GO:1903978   GO:0010389   GO:0006915   GO:0005515   GO:0005488   GO:0008168   GO:0016876   GO:0043039   GO:0004651  

PANTHER

PTHR11139:SF72  

Subcellular location

Nucleus  
Cytoplasmic vesicle   Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.   With evidence from 2 publications.

Length:

2817

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.14038

Exp number, first 60 AAs:

0.00016

Total prob of N-in:

0.00156

outside

1  -  2817

 

 

Pi

208.03364

Theta

168.222243

Tajima's D

0.795458

CLR

0.237608

CSRT

0.598970051497425

Interpretation

Uncertain