Gene

KWMTBOMO01975  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014039

Annotation

PREDICTED:_collagen_alpha-1(IV)_chain_[Papilio_xuthus]

Location

Bomo_Chr4(+):8963242-8977601      View in EpiBrowser

Full name

Collagen alpha-1(IV) chain      

Alternative Name

Collagen type IV alpha 1

Location in the cell

Nuclear   Reliability : 4.45

CDS

ATGGTGGTCTACGTACTGTGGTTAGTAGCTGCTCTGGCACCTAAAATAATCGGAGTAAGCTCGCAAGATGATAGATATGCGGATTGGAATAACATATATTCCAGGGATTTGCCGCCGACTAACTGGCCTCGTGAAGTGGCGCCAGATACGGAGCGACCATACGCTGTAAATCAATATGGGTTGTATAATAGAAACGATATACCACCCCAATCAAGACCGGAACCAGAATTAGGGCAAAACTTCGCTGTGTATGATCCGGACACACGTCAAAGGACATCCACAGCTATTAATCGTAATTGTACAGCTCCAGGATGCTGTGTTCCTAAATGTTTCGCTGAGAAGGGTAACAGAGGATTTCCCGGCTCACCTGGACCACAAGGCCCACGTGGTCTTCCTGGCCATGAAGGTGCTGAAGGTGCGCAAGGACCTAAGGGGCAAAAAGGTCAAATAGGTCCACAGGGTCCACGTGGTCCTAAAGGTGACAAAGGCAAAACTGGAGCAAAAGGATTTGCTGGTAGAATGGGTATTCAAGGATCCCCTGGTGACCAAGGTAGACCGGGTATACCAGGAAGGGATGGTTGTAATGGAACTGATGGTGAACCTGGAATAGCTGGACCAAAAGGTTCTCAAGGACCGCGTGGTTACGCTGGATCCAAAGGAGATAAGGGAGATAAAGGTGAACCAGCTCACATTGGACGATATCCGAAAGGACAAAAAGGAGAACCTGGTGCAGATGGCATGCAAGGACAACCAGGTCTGGTTGGACCTCAAGGACCAGTTGGTTTGAAAGGACCAAAAGGCAGAGTTGGTCCTGCTGGCTTAACAGGACCTAAAGGAGATAAAGGTGCTAGAGGTGCAAAGGGCCACTCGATTCAAGGTGACAAAGGAGACAGAGGCGACAAAGGTGACCGAGGTCAAAGTTGTTCGCCAACTTCTTCCGTTGATTTCAATAATAAGGGAATTCACAAAAATATACAAGGAGATATGGGTGAAAAGGGTGACAAAGGAGAACCAGGTCGTATGGGACAAAAGGGTGATATTGGACCAATGGGGGAGCCTGGACTGTCAGGCCAGATGGGGATCAAAGGAGAAAAAGGCTTACGAGGAAATCCGGGTGAAAGGGGACGTGAAGGAATGTATGGCGCACCGGGGCCAATGGGTAATAAAGGAGAAAGAGGAAACGATGGATTATCTGGTTTAGCAGGAATACCTGGCCGAAAGGGTGAACCAGGTAGAGATGGAATTCCTGGACCTAGAGGCTTAAAAGGTGTTCCTGGTCCACCAGGGGGTCTTTCAGGTTCTCGGGGACCTCCTGGTCCCCCTGGTCCCAGAGGTTATGAGGGCCCACAAGGACCTAAAGGCACTGATGGAAGGCCGGGAGACAGAGGTCAAACAGGACCAATGGGCTCCCCAGGAAGTCAAGGTGAACCCGGAACACCAGGAATTGAGGGTCCTGCGGGACATAAAGGTGAAAAGGGAGAAGCTGGTTTTGATGGTCAAAAAGGAGAGTCTGGGCCTCGTGGATACGATGGAAATGTCGGACCCGTAGGACCTAGAGGAGAAAAAGGAGAAGATGGTCTATCCATAATTGGTCCAAAAGGAAATAGTGGCTTACCTGGTTTTTCCGGAGATAAGGGTCAAAAAGGAGAAAGAGGTTATACCGGTCTTAGAGGCGTACCAGGAAATTCCACCTTTGGTACACCTGGTATTCCAGGAGAAATAGGTCTTCCCGGAGAAAAGGGAGATAAAGGAATGCCTGGTTACGACGGTTTGCCTGGAAATACTGGACCCAAGGGTAACATAGGAGGTCGCTGCAATGAGTGCTCCCCCGGATCTTCCGGTCCAAAGGGAGACCGTGGCAACGATGGAGCAGTTGGTCCACGAGGCGAGAGGGGGCCAATAGGTCCAATTGGTTTTACTGGCGAACGAGGTGCTGATGGCATGCATGGCTTGCCTGGTGCACCTGGAGCACCTGGCGAACGGGGAGAAGATGGACCAACTGGTCCACCTGGAGATAGAGGAGCTGATGCCAACGTTCCGGTAAATTTAATTAAAGGTCCGAAGGGTGATAAAGGAAGTACAGGGCCCCGAGGTCCTCAGGGTCCTAAGGGTGAAATTGGTAGTGATGGTCCTAAAGGAGACCGAGGACAAGTTGGTATGCCAGGCCCAAAAGGAGACCGAGGCTATGAAGGACAGCCTGGTGTTGATGGTATACCTGGTGCAGATGGAATTCCTGGTATACCTGGAATAAAAGGAATATCTATAAAAGGAGACAAGGGCTTACCAGGTGATAGAGGGTTCAAAGGTGACAAAGGTAGTCCGGGTGATAGAGGTATAAAAGGCCAAGCAGGCCAATGTCCTGCTGATGTAAAAGAACTTACAAGAGGCGACAGAGGCGACAGAGGTGATACTGGCCCTCCAGGGCCTGCAGGTGAACCAGGAGAAAAGGGAGATAAAGGTTACATTGGATTGCAAGGTCAAAAAGGGGATATTGGTCCACCTGGTAGGCAGGGTCCTGTGGGAGCACGTGGGTTCCCAGGAATTCGAGGTGAAAAAGGAGAACTCGGTTCAAAAGGTTTTCCAGGAACTCCTGGTGAGAATGGGCCGCGAGGCTACCCCGGAAAACCAGGTTTTAAAGGAGATAAAGGAGAAGTCGGACCTTCCATCGTTGGTCCACCAGGCTTACCTGGTATACCAGGTCAAAAAGGTGACTCTGGTCTTCGAGGATTGCCAGGTATACCCGGTGATGATGGTCCGCCAGGTCCTCAAGGCTTACATGGAGAAAAGGGAGATCAAGGATTGGTGGGTAGACCTGGATTACCTGGTCAACCAGGTCAAAAAGGTGATGCAGGACCCGTGGGGCCCGCTGGGGTCCCAGGTATTCCTGGATTACCCGGTAAGGTTGGAGCAAAAGGACAACAAGGTTTCCCTGGAGAACCTGGTAGGCCAGGTGTTATTGGTTTGCCTGGTCAGAAAGGTGATATGGGAATCCAAGGGCCAGATGGCCAAAAAGGTTTTCCGGGTTCTCGAGGACGTCCTGGACCTCCAGGTCATCCGGGCGCACTAGGCTCACAGGGAGAAAAGGGTGATAAAGGAGAATTAGGGTATCCAGGTTCACCCGGTTCTCCAGGCCAGTCTGGACGTCCAGGTCCTGTCGGTCCTCAAGGACCTAAAGGAGATCAAGGATTTGAAGGCCCTCCAGGACTACCGGGATTACCTGGTCTATTGGGTCAAACTGGTGACAGAGGTTATACGGGCCCTAAAGGTGACAAAGGGGATGCTGGCTTAGCAGCTGAAAAGGGATCAAAAGGAGAACCTGGTCCACCTGGTCTACTTGGTATAGATGGTCTACCTGGTAGAGATGGAGAGAAAGGCGACACTGGTGAACCAGGAATACCTGGTCAAGGAATACCTGGGTATCCTGGCCAAAAAGGAGAAATGGGGATGCGTGGGTTTGATGGACTCTCGGGACCCATTGGAGAAAAAGGAAATCGTGGTCCTCAAGGAGTACCTGGTCTAAAGGGTAACTTGGGCATCTCAGGCGAGCCAGGTCGACCTGGAGTACCTGGTATCGATGGAGCACCTGGCCAGCCTGGTGATGTAGGCTTACCTGGTATTACTGGAGAAAAAGGAGATAAAGGTGAATTAGGTTTCCCCGGACGAGATGGATTAGGCGGGTTGAAAGGCGATCGTGGTCAACCTGGGGCAGAAGGTCCAATAGGACCAATAGGGTATCGAGGTCCTAAAGGAGACACGGGACTGCCAGGCGTATCCATAGATATTAAAGGTGACAAAGGAGAAGTGGGTCCAAGCGGTATTCCTGGTGAACCAGGTCAAAAGGGAGATCGAGGTCTCCCAGGATTACAAGGATTACAAGGTGAAAAAGGTGATCGTGGCTCACTAGGAGAAAAAGGAGACCAAGGTTTTACTGGGCGAATGGGAGAAAAAGGTGACACTGGTCCTATCGGTCCTACCGGCCTACCAGGCTTAACTATAAAAGGAGAAAAAGGCTTACCAGGAACTCATGGAAAACATGGGAGGCCAGGATTACCTGGTGCTCCAGGACAAAAAGGCGATCAAGGTCTACCAGGACTTCCGGGACAATTGGGTCGGCCTGGTATACCTGGGCTCCCAGGTGAAAAAGGACAAAAGGGTGATCAGGGTAATGAAGGTTTGGCAGGGCCACCAGGTCTTGTAGGTCCAACTGGACTACCTGGAACTCCTGGTATTACTGGGGAAAAAGGAGATCGAGGAGAGAAGGGGGCCACTGGGTTTGGTGCACCAGGGCAAAAAGGTGATCAAGGTCCCTCAGGTATACCAGGATTACCTGGTGAGAAAGGTGATAAAGGAGATCGTGGATTAGATGGATTACCTGGTCGAACCGGACCGATTGGTCCGCCAGGTCAGAAAGGTGATCGTGGCTATCCAGGAAGACCAGGCTTACAAGGTGAACAAGGGATGAAAGGTAATAAAGGCCAAGCGGCAGAACTCGTGTACGGCGCAAAAGGAGAACCAGGACCGCGTGGTTTGCCAGGAAATGATGGTCTACCAGGCGTAAACGGCGTTCCTGGTCGTCCAGGTAATAATGGACCCCCTGGTGAAAAGGGGGATAGAGGTTTTACTGGTGCTAGAGGTTTCCCGGGACCAAGAGGTCTCCCAGGTATACAGGGAATGGAAGGTGAAAGAGGAGAAATTGGTATGACAGGTCAAAGTGGACTTCCAGGAGCGCCTGGAGCACCATGCGTTAGTCAAGACTTCTTAACCGGAATTTTATTGGTACGACACAGTCAAAGAGAAGTCGTCCCACAATGTGAACCCAGTCACGTCAAATTATGGGATGGATATTCTTTATTGTACATAGATGGCAACGAAAAAGCCCATAATCAAGATTTAGGATATGCTGGTTCTTGTGTGAGAAAGTTCAGTACAATGCCATTCCTATTTTGTGACTTAAATGATGTCTGTAATTACGCAAGTCGTAACGACCGTAGTTATTGGTTATCCACTGGTCAACCAATACCAATGATGCCTGTTGAGGGACAAAATATTGCCAAATATATTTCAAGATGTGTGGTCTGTGAAGTACCGGCTAATGTGATTGCAGTACACAGTCAAACATTAGATATTCCGAGTTGCCCAGTTGGTTGGAATGAATTATGGATTGGTTACAGTTTTGTTATGCACACTGGTGCAGGAGGTCAAGGTGGAGGACAGGCTTTAGCAAGTCCTGGATCGTGCTTAGAAGATTTCCGTTCGATTCCATTTATAGAGTGTAATGGAGAAGGTGGAACTTGTCATCATTTTGCAAATAAACTTAGTTTCTGGCTAACTACTGTCGAAGATAGTCAACAGTTTAATGTACCGGAGCGCCAAACTCTAAAATCTGGTCAACTTCTTGAACGAGTCTCTCGATGTGCGGTTTGCATTAAGAATACGACATAG

Protein

MVVYVLWLVAALAPKIIGVSSQDDRYADWNNIYSRDLPPTNWPREVAPDTERPYAVNQYGLYNRNDIPPQSRPEPELGQNFAVYDPDTRQRTSTAINRNCTAPGCCVPKCFAEKGNRGFPGSPGPQGPRGLPGHEGAEGAQGPKGQKGQIGPQGPRGPKGDKGKTGAKGFAGRMGIQGSPGDQGRPGIPGRDGCNGTDGEPGIAGPKGSQGPRGYAGSKGDKGDKGEPAHIGRYPKGQKGEPGADGMQGQPGLVGPQGPVGLKGPKGRVGPAGLTGPKGDKGARGAKGHSIQGDKGDRGDKGDRGQSCSPTSSVDFNNKGIHKNIQGDMGEKGDKGEPGRMGQKGDIGPMGEPGLSGQMGIKGEKGLRGNPGERGREGMYGAPGPMGNKGERGNDGLSGLAGIPGRKGEPGRDGIPGPRGLKGVPGPPGGLSGSRGPPGPPGPRGYEGPQGPKGTDGRPGDRGQTGPMGSPGSQGEPGTPGIEGPAGHKGEKGEAGFDGQKGESGPRGYDGNVGPVGPRGEKGEDGLSIIGPKGNSGLPGFSGDKGQKGERGYTGLRGVPGNSTFGTPGIPGEIGLPGEKGDKGMPGYDGLPGNTGPKGNIGGRCNECSPGSSGPKGDRGNDGAVGPRGERGPIGPIGFTGERGADGMHGLPGAPGAPGERGEDGPTGPPGDRGADANVPVNLIKGPKGDKGSTGPRGPQGPKGEIGSDGPKGDRGQVGMPGPKGDRGYEGQPGVDGIPGADGIPGIPGIKGISIKGDKGLPGDRGFKGDKGSPGDRGIKGQAGQCPADVKELTRGDRGDRGDTGPPGPAGEPGEKGDKGYIGLQGQKGDIGPPGRQGPVGARGFPGIRGEKGELGSKGFPGTPGENGPRGYPGKPGFKGDKGEVGPSIVGPPGLPGIPGQKGDSGLRGLPGIPGDDGPPGPQGLHGEKGDQGLVGRPGLPGQPGQKGDAGPVGPAGVPGIPGLPGKVGAKGQQGFPGEPGRPGVIGLPGQKGDMGIQGPDGQKGFPGSRGRPGPPGHPGALGSQGEKGDKGELGYPGSPGSPGQSGRPGPVGPQGPKGDQGFEGPPGLPGLPGLLGQTGDRGYTGPKGDKGDAGLAAEKGSKGEPGPPGLLGIDGLPGRDGEKGDTGEPGIPGQGIPGYPGQKGEMGMRGFDGLSGPIGEKGNRGPQGVPGLKGNLGISGEPGRPGVPGIDGAPGQPGDVGLPGITGEKGDKGELGFPGRDGLGGLKGDRGQPGAEGPIGPIGYRGPKGDTGLPGVSIDIKGDKGEVGPSGIPGEPGQKGDRGLPGLQGLQGEKGDRGSLGEKGDQGFTGRMGEKGDTGPIGPTGLPGLTIKGEKGLPGTHGKHGRPGLPGAPGQKGDQGLPGLPGQLGRPGIPGLPGEKGQKGDQGNEGLAGPPGLVGPTGLPGTPGITGEKGDRGEKGATGFGAPGQKGDQGPSGIPGLPGEKGDKGDRGLDGLPGRTGPIGPPGQKGDRGYPGRPGLQGEQGMKGNKGQAAELVYGAKGEPGPRGLPGNDGLPGVNGVPGRPGNNGPPGEKGDRGFTGARGFPGPRGLPGIQGMEGERGEIGMTGQSGLPGAPGAPCVSQDFLTGILLVRHSQREVVPQCEPSHVKLWDGYSLLYIDGNEKAHNQDLGYAGSCVRKFSTMPFLFCDLNDVCNYASRNDRSYWLSTGQPIPMMPVEGQNIAKYISRCVVCEVPANVIAVHSQTLDIPSCPVGWNELWIGYSFVMHTGAGGQGGGQALASPGSCLEDFRSIPFIECNGEGGTCHHFANKLSFWLTTVEDSQQFNVPERQTLKSGQLLERVSRCAVCIKNTT

Subunit

Trimers of two alpha 1(IV) and one alpha 2(IV) chain. Type IV collagen forms a mesh-like network linked through intermolecular interactions between 7S domains and between NC1 domains.

Similarity

Belongs to the type IV collagen family.

Keywords

Basement membrane   Collagen   Complete proteome   Disulfide bond   Extracellular matrix   Glycoprotein   Hydroxylation   Reference proteome   Repeat   Secreted   Signal  

Feature

propeptide  N-terminal propeptide (7S domain)
chain  Collagen alpha-1(IV) chain

Uniprot

H9JWX5   A0A194PLE6   A0A212ELS9   S4P9P8   A0A2H1WSQ8   A0A2A4K242   + More
A0A2W1BLE7   A0A0L7KX52   A0A194RCY7   A0A0C9QL73   A0A1Q3FZ35   A0A1Q3FZ04   A0A1L8DIU9   A0A1L8DIT2   J9JR68   A0A2H8TTW9   A0A182F4P5   A0A182R6H3   A0A182NF64   A0A1B0D6J9   W8AM68   W4VRM6   A0A182K3K3   A0A1W4UI59   A0A2M4AFV6   A0A1Y9IW51   A0A067RJL7   W5J6W8   A0A182MSF9   A0A084WQP7   A0A2J7QCM5   A0A336M6J8   A0A0M4E8D6   B4LTV2   B4P3U6   P08120   B7FNQ3   B4JAS0   Q29L08   B4KGC9   B4I1B5   B3N4E4   A0A3B0K218   A0A232F1D9   A0A0J9TFV4   A0A1J1I6L8   A0A336KLW1   T1IZ13   A0A0K2UHU0   A0A146LFU6   W8B196   A0A182KUD3   A0A238BUG7   Q17163   A0A0C2HBK1  

Pubmed

19121390    26354079    22118469    23622113    28756777    26227816    + More
24495485    24845553    20920257    23761445    24438588    17994087    17550304    3142875    10731132    12537572    6210912    3106346    3109906    15632085    28648823    22936249    26823975    20966253    7637709   

EMBL

BABH01041525    KQ459601    KPI93818.1    AGBW02013994    OWR42428.1    GAIX01005366    + More
JAA87194.1    ODYU01010379    SOQ55454.1    NWSH01000276    PCG77833.1    KZ150090    PZC73686.1    JTDY01004730    KOB67822.1    KQ460398    KPJ15135.1    GBYB01001322    JAG71089.1    GFDL01002239    JAV32806.1    GFDL01002241    JAV32804.1    GFDF01007696    JAV06388.1    GFDF01007695    JAV06389.1    ABLF02028010    ABLF02028011    GFXV01004823    MBW16628.1    AJVK01003669    GAMC01019528    JAB87027.1    GANO01001294    JAB58577.1    GGFK01006350    MBW39671.1    KK852643    KDR19588.1    ADMH02001962    ETN60202.1    AXCM01007666    ATLV01025642    KE525396    KFB52541.1    NEVH01016289    PNF26332.1    UFQS01000618    UFQT01000618    SSX05466.1    SSX25825.1    CP012523    ALC38251.1    CH940649    EDW64003.2    CM000157    EDW88397.1    KRJ97759.1    J02727    M23704    M96575    AE014134    V00200    M28334    BT053743    ACK77661.1    CH916368    EDW03878.1    CH379061    EAL33016.2    CH933807    EDW11116.1    CH480820    EDW54322.1    CH954177    EDV57814.1    OUUW01000006    SPP81930.1    NNAY01001368    OXU24218.1    CM002910    KMY88215.1    KMY88216.1    KMY88217.1    CVRI01000038    CRK94057.1    SSX05469.1    SSX25828.1    JH431704    HACA01020289    CDW37650.1    GDHC01011943    GDHC01011608    JAQ06686.1    JAQ07021.1    GAMC01019529    JAB87026.1    KZ270010    OZC08330.1    U07224    AAC46611.1    KN726230    KIH69049.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000218220    UP000037510    UP000053240    + More
UP000007819    UP000069272    UP000075900    UP000075884    UP000092462    UP000075881    UP000192221    UP000075920    UP000027135    UP000000673    UP000075883    UP000030765    UP000235965    UP000092553    UP000008792    UP000002282    UP000000803    UP000001070    UP000001819    UP000009192    UP000001292    UP000008711    UP000268350    UP000215335    UP000183832    UP000075882   

PRIDE

H9JWX5    P08120    B7FNQ3   

Pfam

PF01413   C4        + More
PF14808   TMEM164
PF01391   Collagen
PF01529   DHHC
PF00155   Aminotran_1_2

Interpro

IPR008160   Collagen        + More
IPR016187   CTDL_fold       
IPR001442   Collagen_IV_NC       
IPR026508   TMEM164       
IPR036954   Collagen_IV_NC_sf       
IPR001594   Palmitoyltrfase_DHHC       
IPR003134   Hs1_Cortactin       
IPR004838   NHTrfase_class1_PyrdxlP-BS       
IPR015422   PyrdxlP-dep_Trfase_dom1       
IPR005958   TyrNic_aminoTrfase       
IPR015424   PyrdxlP-dep_Trfase       
IPR005957   Tyrosine_aminoTrfase       
IPR004839   Aminotransferase_I/II       
IPR015421   PyrdxlP-dep_Trfase_major       

SUPFAM

SSF56436   SSF56436        + More
SSF53383   SSF53383       

Gene 3D

2.170.240.10     3.40.640.10     3.90.1150.10    

ProteinModelPortal

H9JWX5   A0A194PLE6   A0A212ELS9   S4P9P8   A0A2H1WSQ8   A0A2A4K242   + More
A0A2W1BLE7   A0A0L7KX52   A0A194RCY7   A0A0C9QL73   A0A1Q3FZ35   A0A1Q3FZ04   A0A1L8DIU9   A0A1L8DIT2   J9JR68   A0A2H8TTW9   A0A182F4P5   A0A182R6H3   A0A182NF64   A0A1B0D6J9   W8AM68   W4VRM6   A0A182K3K3   A0A1W4UI59   A0A2M4AFV6   A0A1Y9IW51   A0A067RJL7   W5J6W8   A0A182MSF9   A0A084WQP7   A0A2J7QCM5   A0A336M6J8   A0A0M4E8D6   B4LTV2   B4P3U6   P08120   B7FNQ3   B4JAS0   Q29L08   B4KGC9   B4I1B5   B3N4E4   A0A3B0K218   A0A232F1D9   A0A0J9TFV4   A0A1J1I6L8   A0A336KLW1   T1IZ13   A0A0K2UHU0   A0A146LFU6   W8B196   A0A182KUD3   A0A238BUG7   Q17163   A0A0C2HBK1  

PDB

1T61     E-value=1.6246e-81,     Score=777

KEGG

692625    K06237 collagen, type IV, alpha | (RefSeq) Let-2; collagen, type IV

PATHWAY

04512    ECM-receptor interaction - Bombyx mori (domestic silkworm)
04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0005581   GO:0005201   GO:0016021   GO:0071711   GO:0048621   GO:0035848   GO:0060729   GO:0005604   GO:0055013   GO:0007391   GO:0005587   GO:0009072   GO:0009058   GO:0004838   GO:0030170   GO:0016020   GO:0051013   GO:0008168   GO:0005737   GO:0016876   GO:0043039   GO:0004651   GO:0005634  

Subcellular location

  

SignalP

Position:   1 - 21,         Likelihood:  0.966088

 

 

Length:

1813

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.552189999999998

Exp number, first 60 AAs:

0.55128

Total prob of N-in:

0.02914

outside

1  -  1813

 

 

Pi

214.824443

Theta

179.234655

Tajima's D

0.837672

CLR

0.165168

CSRT

0.620768961551922

Interpretation

Uncertain