SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO01969
Pre Gene Modal
BGIBMGA005920
Annotation
PREDICTED:_WD_repeat-containing_protein_35-like_[Bombyx_mori]
Full name
WD repeat-containing protein 35      
Alternative Name
Intraflagellar transport protein 121 homolog
Naofen
Location in the cell
Nuclear   Reliability : 3.525
 

Sequence

CDS
ATGTTTATTTACATGAGTAAAAAGATAGCCATCCCAAAGCAGTCAAAAGTTTCTTGCATATCATGGAATCATTCATCGGGATATATTGCAGTTGGTGGAGAAGAAGGGATGTTAAAAGTTTTAAAATTGGAATCGGGTGGTGGAGGAAATTTGTCAATGAATTTGAGTCTCGAGGGTCACACTGGCCAAATATGTGTGGCAATATGGAATGAAGTTTTCCAGAAACTAACAACTAGTGATGAACATGGTGTCATTATTGTATGGATGCTATACAAGGGATCTTGGTATGAAGAAATGATAAATAATAGAAATAAATCAACTGTTTCCAGTATGTGTTGGGGTTCGGATGGACAAAAAATTTGCATTGCTTATGAAGATGGAGCCGTAATTGTTGGTTCTGTAGATGGATCTCGAGTGTGGGGTAAAGATATAAAAGGACCAGGCTTGGCTGCTGTTCAATGGTCTCCGGATAATTCAAGTCTACTTTTTGCATTAAGTAATGGGGAACTGCATTTATATGACGACCAAGGAAACTTTATGATGCCAGTAGCTGTGAATGGCATTAATGGACCTATGGAAGTAACTACCATGGATTGGTTTGCTGGCACGGCTCCACGCAATAGACCTGTTTTAGCAGTTTGCTACCGTGGAGGTATGCTGTTACTCATGAAGAATTGCATTGAAGAAGATAGTATTCTAATAGATACGAATATGACGACAATTGATTGTCATTGGAATCACATTGGTACAGTACTAGCTGTAGCAGGTCACACTAGCGATAATACAAATGTAGTGCAATTTTTTACTGCGTATGGGGAGCATATAAGAACGTTACGGGTACCAGGTGGTACAATGAGAGCACTGTCGTGGGAGAAGCGCTCGCTGCGACTCGCTATAGCGGTAGATTCGTTCATATATTTTGCAAATGTGAGACCGGATCACAAATACGCCTTCTACGGAAATACGTTAGCTTTCATATCTGGCGCTGAAACTGTTACTTTTTGGGACACTGTAACTAACCAGTCTTGGGTGAATCATATACCTGACGTTATAGACATGTATGGAGCAGAGGAGTATTGTATAATTGCAACAGTAAATACGCTTATAATATCGAATCAACAGGGAATCCAGTGTGACGCTAAAACAGTAAACGTATCCATGACTTATGTTACAATCAATAGCAAAGCTATTGCAGTTGCAGCGTCGAAAGAATCCTTCATGGTATGGAAATTTTCAACTCCGTCTCGATCATTGACTTCAGAACAGCTGTTCCATCCCGACGGTAGTTTATTAACAGCTAACGGTACCGCGTTTCAAGACGACACGATATGTTGTCTCGCGTGCTCCGACAGTCATCTACTGATCGGTCGAGATTCCGGTACGATACTGCTGTTCTCTTTACTAAGCTTCAAAAGAATCACGTCGATCAACATAAATTCGAGACCGTATAAAATGAGCTTGAACTCTAATTCAAGTAAGTTTCTAGTTATCGATCAGCCGGGATGTCTACATATTTTGGACACTGATATGTCAAATAATATAAGCGTCGGTCAAGCGTTGCGCAAGGACGTGTGGAGCGCGATGTGGGCCACGGACAACCCTCACATGCTGGCTGCGGCTGAGAAGGCGCGACTCTACGTCATGCGGGATAATGAACCCGAGGAGCCGCTCGTCATGCAGGGATATCTATGTAAATTTAAGGAACTGGAAATAACTACAGCATTATTGGATAACTTGTCAGACAAATGTTCACCACAACACATAGTACGTGTCGAAGTGAAATCGCTCAGAGACACGAGGCAGCTCATTGAAAAAGTCGGATTGAAAGAAGCGGAAAATTTTATAAAAGATAATCCCCATCCGCAATTATGGTTACTGCTCGCTGAAGCGGCCTTGAGGAAATTTGAATCTGAGAACGCAGTCGAAACGGCCGAAGCTGCGTTTGTTAGGCGAAATGATTACGCAGGAATTAAATTTGTATCGCGACTGAATGCACTACATTCCAGTGCCCTTAAGAAAGCCGAAATAATGGCATATTTCAAAGACTTCGATGCCGCTGAAAAGATTTATTTAAATGAAGACAGACGAGATTTAGCTATAGCTTTACGTAAACGTTTGGGACATTGGTTTCGTGTGGTTGAACTTTTGAAAATGTCGGCGAACACCACCGATGCACACATTAAACAAGCTTACGTCAATATTGGGGACTTCTACATTGATAGACAAAATTGGAGCGGTGCTTTGGAATACTATAAAATGTCCAATAACACAGAAGGATTGAAGAAATGTTACATGGCATTAGAGGATAATGAATCACTTTCCAAATTATTCATAAGTTCTCCGAGAACCGCAAAGGATACAAAATTAAAACAAAATGACGCTGAACTCTTGGACAGCTGCTAA
Protein
MFIYMSKKIAIPKQSKVSCISWNHSSGYIAVGGEEGMLKVLKLESGGGGNLSMNLSLEGHTGQICVAIWNEVFQKLTTSDEHGVIIVWMLYKGSWYEEMINNRNKSTVSSMCWGSDGQKICIAYEDGAVIVGSVDGSRVWGKDIKGPGLAAVQWSPDNSSLLFALSNGELHLYDDQGNFMMPVAVNGINGPMEVTTMDWFAGTAPRNRPVLAVCYRGGMLLLMKNCIEEDSILIDTNMTTIDCHWNHIGTVLAVAGHTSDNTNVVQFFTAYGEHIRTLRVPGGTMRALSWEKRSLRLAIAVDSFIYFANVRPDHKYAFYGNTLAFISGAETVTFWDTVTNQSWVNHIPDVIDMYGAEEYCIIATVNTLIISNQQGIQCDAKTVNVSMTYVTINSKAIAVAASKESFMVWKFSTPSRSLTSEQLFHPDGSLLTANGTAFQDDTICCLACSDSHLLIGRDSGTILLFSLLSFKRITSININSRPYKMSLNSNSSKFLVIDQPGCLHILDTDMSNNISVGQALRKDVWSAMWATDNPHMLAAAEKARLYVMRDNEPEEPLVMQGYLCKFKELEITTALLDNLSDKCSPQHIVRVEVKSLRDTRQLIEKVGLKEAENFIKDNPHPQLWLLLAEAALRKFESENAVETAEAAFVRRNDYAGIKFVSRLNALHSSALKKAEIMAYFKDFDAAEKIYLNEDRRDLAIALRKRLGHWFRVVELLKMSANTTDAHIKQAYVNIGDFYIDRQNWSGALEYYKMSNNTEGLKKCYMALEDNESLSKLFISSPRTAKDTKLKQNDAELLDSC

Summary

Description
As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.
As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (PubMed:21473986, PubMed:28400947, PubMed:29220510). May promote CASP3 activation and TNF-stimulated apoptosis.
As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (By similarity). May promote CASP3 activation and TNF-stimulated apoptosis (PubMed:20193664).
Subunit
Component of the IFT complex A (IFT-A) complex (PubMed:20889716, PubMed:27932497, PubMed:29220510). IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B (PubMed:27932497, PubMed:29220510). Interacts directy with IFT122, ITF43 and TTC21B (PubMed:29220510, PubMed:27932497). Interacts with IFT43 (PubMed:19450523).
Component of the IFT complex A (IFT-A) complex. IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B. Interacts directy with IFT122, ITF43 and TTC21B. Interacts with IFT43.
Keywords
Alternative splicing   Cell projection   Ciliopathy   Cilium   Complete proteome   Cytoplasm   Cytoskeleton   Disease mutation   Ectodermal dysplasia   Polymorphism   Reference proteome   Repeat   WD repeat  
Feature
chain  WD repeat-containing protein 35
splice variant  In isoform 2.
sequence variant  In dbSNP:rs1060742.
EMBL
ODYU01005527    SOQ46462.1    KQ459601    KPI93822.1    NWSH01000880    PCG73738.1    + More
KQ460398    KPJ15140.1    KK852580    KDR20897.1    AFYH01117825    AFYH01117826    AFYH01117827    AFYH01117828    AFYH01117829    AFYH01117830    AFYH01117831    AFYH01117832    AHAT01029893    HAAF01001271    CCP73097.1    AEYP01019022    AEYP01019023    AEYP01019024    AEYP01019025    AEYP01019026    AGCU01192689    AGCU01192690    AGCU01192691    AGCU01192692    AGCU01192693    CM004475    OCT79015.1    NEDP02001201    OWF53860.1    AGTP01025357    AGTP01025358    AAEX03010756    AAEX03010757    AEFK01036829    AEFK01036830    AEFK01036831    AEFK01036832    AANG04003329    JARO02001476    KPP75372.1    AKHW03000178    KYO48907.1    ACTA01067980    ACTA01075980    AACZ04002101    GABC01001152    GABF01007202    GABE01003588    NBAG03000227    JAA10186.1    JAA14943.1    JAA41151.1    PNI72660.1    CABD030014049    CABD030014050    AB037757    AK122917    AC079145    CH471053    BC036659    AJFE02094828    NDHI03003655    PNJ11540.1    JH816455    EKC35340.1    ADON01041377    AAGW02055028    AAGW02055029    AAGW02055030    AHZZ02004993    GABD01007407    JAA25693.1    AQIA01018941    AQIA01018942    JSUE03010303    JU321160    AFE64916.1    ADFV01090791    PNI72659.1    ABGA01366300    ABGA01366301    ABGA01366302    ABGA01366303    ABGA01366304    ABGA01366305    ABGA01366306    ABGA01366307    ABGA01366308    PNJ11541.1    KK656104    KFQ05027.1    AEMK02000021    DQIR01295886    DQIR01309881    HDC51364.1    GEDC01001272    JAS36026.1    EF613262    CH473947    KK735179    KFR12964.1    AKCR02000002    PKK33588.1    PNI72661.1    KL429188    KFW91112.1    KB030580    ELK14004.1    JU321166    AFE64922.1    CM001288    EHH55385.1    AC013400    GL192410    EFB19810.1    PNJ11543.1    GABZ01003826    JAA49699.1   
Pfam
PF12894   ANAPC4_WD40
Interpro
IPR036322   WD40_repeat_dom_sf        + More
IPR011990   TPR-like_helical_dom_sf       
IPR017233   WDR35       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR024977   Apc4_WD40_dom       
IPR016024   ARM-type_fold       
IPR011047   Quinoprotein_ADH-like_supfam       
IPR011041   Quinoprot_gluc/sorb_DH       
IPR019734   TPR_repeat       
IPR011044   Quino_amine_DH_bsu       
SUPFAM
SSF50978   SSF50978        + More
SSF48452   SSF48452       
SSF48371   SSF48371       
SSF50998   SSF50998       
SSF50952   SSF50952       
SSF50969   SSF50969       
Gene 3D

Ontologies

Topology

Subcellular location
Cytoplasm  
Cytoskeleton  
Microtubule organizing center  
Centrosome  
Cilium basal body  
Cilium axoneme  
Length:
800
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.03475
Exp number, first 60 AAs:
0.00404
Total prob of N-in:
0.00149
outside
1  -  800
 
 

Population Genetic Test Statistics

Pi
270.002734
Theta
168.660585
Tajima's D
2.095314
CLR
0.320456
CSRT
0.893955302234888
Interpretation
Uncertain
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