Gene

KWMTBOMO01947  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006225

Annotation

PREDICTED:_putative_leucine-rich_repeat-containing_protein_DDB_G0290503_[Bombyx_mori]

Location

Bomo_Chr4(+):8393828-8398305      View in EpiBrowser

Full name

Profilin      

Location in the cell

Nuclear   Reliability : 4.112

CDS

ATGGATGCCAGAGCTGCTAAATTAGAACTTGCTCGCAAAAAGTTGAGAGAACATCAAGAACAAAAACTAGGAAATGTTCAGAAAGAAACATGTCTGAAAACGAATGATCAAAATCATTCGCCACCTCAATTAGCTTCTGAAGTCAATGATTTTGACTCGTCTCCTCAGCAAAAGCAAAAAAATAGTGAAAACAATAATATTTTAGAGGAGAACTACGATAATAAGCTGCTTGAAAATACACTCAGTGCAACAGAAATTCTCATTTGTAATGAGAGAAAACTTGAAACGCAAGTCAGTGAGCTGCAATCAAAATTATCAGAGCTAGAACAGAAATATACTGATGCTGTAAAATTAATTAATCAATCTAATCAATCATTCCATAATTTGCAAAATGAAACCAAAACTTTACAAAACAATAGTTTGTTGTTGACTAATGAGTTGCTGATCAAAGATAACAAAATACAAGAATTAGAAAAGAGTAATTCCAGTCTCTCAGATGAAATTAATAATTTACAAGAACAACTGGAATTTACCAAAACAATGCTTACTGCTAAAGAAACAGAAAATAGTTCTCTCAATAGTCAATTATTCAACCTTCAAAATCAGCTTGATTCAACTCAGCTACAACTGCAGCAGCTTACGAATGGGGCTTATGCTTCTACTTCTGATGGGAGAAACACTAATGTTGAATCAAATGAGAGCTTAAAGCAAAAAAATTCTAGTTTAGAACAACAGTTAAAAACTCTACAAAAAGAAAAAGATAATATTCATACACATTATCAACATTATGTTATTGAATTAAATGAACATTTAAAAAATATGGTTTCACAAAATGAAAGTCTTGCTGGAGAGGTTGAGCGTTTATCTAACAGAGAAACTAGTCTTGTTGATCAGATAAGCGATTTGGAAATAAGATTGCAGAATTATAGTTCATACCGCACCCAAGTTACTGAAACATCAACATCTCGTAATAATAACAGTGATGACTTTAAAGAATTACAAAACAAATATGAAGAAACTAGTAAAAAACTCTGTGAATTGAGTAATAAATATGAACAACTAGAAACATTAAATAATGAAAACATTGCAAAAATTAAAGATTTAGAAAAAAACAAAGATTCTGAAGCGAAGCTTGAGGAAATAAGTCTATCCAAATTGAATGCGGACATAGCTAGTGACAAAATAGCTGCTCAAAAAGCCACCGAGCAAAACAAAATACTGAAACAGGACATGCAGAATTTAGAGGATGCATTTGTTAAAATGAGTAAAGACAAGTTAGAGTTAACAGAAAAATTGAGCGCTGAAAAATTTTTGAATCGCGAACTTACAATAAAATTAGCAGATGCAGAGGAGAAAGCAAAAGATATGTTAATTAAATTAAAAGCCAAAGATAGTGAAATGATAAGACTACAGTCAAGTTATAGGGAGATGGAAATAAACTTAAGAAACGCCGCAAAAAGTAATGAGTCTGCTAACGACGATATATCTAACGAAATTTCGGAATGCGAAAAACCGTTAGATAGTAAAATAGATTGTCTACGAACTGATGATACTGAGATATGTTTGAATCAAAATGATGTATGCAAACACGAAGTATTGGTTGATAATGGCAAAAAACCTGATATTTTAATCGCAAAGGACGATGCAATGAAGAAACTACAGGAACGTTTTTTAAAAATAATGAATGATGTTGCCGATTTATCTGATGAAAAGCATCGGCTTGAGCATATAATTTTACAATTGCAAAATGAAACCGATACTATTTGTGAATACGTAGCTTTATATCAGCAACAACGCAGCTTATTAAAAAGACGAGACGAAGAGCGAAGTATTCAGTTAAATATGTTTGAAACGGAATGTAGTAAACTTAAAAGACAGCTGGAAGAATTGACTGCTATCCTCGTAAAACTGTCTGAAGATGAAGACATCTCTTCTTGCTTACAAAAACACTCCAAGAATATTGAAATCGAGCAAATAATGAAACTCCTCACAAACTTGAACAATAATTCTTTAATCGATCCCATGAAGAAAAGTATTGATTTCAAAGATTTTTATCCTTGCAGTTGTTGTTCTGGAAAACTTATGGAAATATAA

Protein

MDARAAKLELARKKLREHQEQKLGNVQKETCLKTNDQNHSPPQLASEVNDFDSSPQQKQKNSENNNILEENYDNKLLENTLSATEILICNERKLETQVSELQSKLSELEQKYTDAVKLINQSNQSFHNLQNETKTLQNNSLLLTNELLIKDNKIQELEKSNSSLSDEINNLQEQLEFTKTMLTAKETENSSLNSQLFNLQNQLDSTQLQLQQLTNGAYASTSDGRNTNVESNESLKQKNSSLEQQLKTLQKEKDNIHTHYQHYVIELNEHLKNMVSQNESLAGEVERLSNRETSLVDQISDLEIRLQNYSSYRTQVTETSTSRNNNSDDFKELQNKYEETSKKLCELSNKYEQLETLNNENIAKIKDLEKNKDSEAKLEEISLSKLNADIASDKIAAQKATEQNKILKQDMQNLEDAFVKMSKDKLELTEKLSAEKFLNRELTIKLADAEEKAKDMLIKLKAKDSEMIRLQSSYREMEINLRNAAKSNESANDDISNEISECEKPLDSKIDCLRTDDTEICLNQNDVCKHEVLVDNGKKPDILIAKDDAMKKLQERFLKIMNDVADLSDEKHRLEHIILQLQNETDTICEYVALYQQQRSLLKRRDEERSIQLNMFETECSKLKRQLEELTAILVKLSEDEDISSCLQKHSKNIEIEQIMKLLTNLNNNSLIDPMKKSIDFKDFYPCSCCSGKLMEI

Description

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.

Subunit

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Similarity

Belongs to the profilin family.

Uniprot

Q9GQI6   A0A2A4JBZ0   A0A2H1W370   A0A1E1WU26   A0A1E1W2U3   A0A1E1WQ29   + More
A0A194PLH5   A0A194RGV9   A0A212ETU1   A0A0L7KRL9   A0A1Y1LQ73   A0A1L8DUZ7   A0A1L8DVE5   A0A1B6EFP9   Q7PSN9   A0A1B0CZ35   A0A1B0CKM3   A0A182LH95   A0A084WCI8   A0A1A9UWJ4   A0A182N3C2   A0A182WXH3   N6U6D4   A0A1S4H6E3   A0A182HY48   A0A182U7S2   A0A182VKD6   A0A182JU39   A0A182Y707   U4U942   A0A1A9W7R8   A0A1B0FRF4   A0A182Q379   E2BG57   D6WMW0   B4MQP4   A0A026W9K7   A0A182P5P7   A0A182JDE3   A0A182RLI9   A0A1A9Z5G1   A0A182MVC6   A0A151XK82   A0A158N9X6   F4WC97   A0A195EKH1   A0A3L8DD95   A0A2M4A377   A0A2M4A2T1   A0A195FSH0   A0A154PHE7   A0A195BIU1   A0A2M3ZG41   A0A2M4A3D1   A0A195C5E5   A0A1J1I3G7   E2A6K3   K7J3F3   A0A2A3ERU0   A0A232ES85   A0A2A3ERR5   A0A088ASB5   A0A0J7KHE6   A0A0M9A2K2   A0A310SHQ5   A0A182W1M6   A0A090XAJ9   A0A131XUR5   E0VY46  

Pubmed

15841250    26354079    22118469    26227816    28004739    12364791    + More
20966253    24438588    23537049    25244985    20798317    18362917    19820115    17994087    24508170    21347285    21719571    30249741    20075255    28648823    25970599    20566863   

EMBL

AF244891    AAG36875.1    NWSH01002188    PCG68950.1    ODYU01005961    SOQ47396.1    + More
GDQN01011520    GDQN01000505    JAT79534.1    JAT90549.1    GDQN01009780    GDQN01000836    JAT81274.1    JAT90218.1    GDQN01001935    JAT89119.1    KQ459601    KPI93848.1    KQ460398    KPJ15166.1    AGBW02012530    OWR44906.1    JTDY01006855    KOB65644.1    GEZM01049874    JAV75793.1    GFDF01003820    JAV10264.1    GFDF01003819    JAV10265.1    GEDC01000549    JAS36749.1    AAAB01008816    EAA05259.5    AJVK01009473    AJVK01009474    AJWK01016449    ATLV01022672    KE525335    KFB47932.1    APGK01037936    KB740949    ENN77195.1    APCN01004491    KB631923    ERL87141.1    CCAG010008014    AXCN02001113    GL448115    EFN85325.1    KQ971343    EFA04309.1    CH963849    EDW74433.1    KK107320    EZA52792.1    AXCM01001256    KQ982052    KYQ60610.1    ADTU01009899    GL888070    EGI68077.1    KQ978739    KYN28765.1    QOIP01000009    RLU18450.1    GGFK01001861    MBW35182.1    GGFK01001795    MBW35116.1    KQ981305    KYN42849.1    KQ434905    KZC11263.1    KQ976455    KYM85029.1    GGFM01006712    MBW27463.1    GGFK01001827    MBW35148.1    KQ978292    KYM95393.1    CVRI01000040    CRK94879.1    GL437132    EFN70960.1    KZ288191    PBC34427.1    NNAY01002487    OXU21202.1    PBC34428.1    LBMM01007291    KMQ89873.1    KQ435756    KOX75985.1    KQ761155    OAD58137.1    GBIH01000739    JAC93971.1    GEFM01006485    JAP69311.1    DS235843    EEB18302.1   

Proteomes

UP000218220    UP000053268    UP000053240    UP000007151    UP000037510    UP000007062    + More
UP000092462    UP000092461    UP000075882    UP000030765    UP000078200    UP000075884    UP000076407    UP000019118    UP000075840    UP000075902    UP000075903    UP000075881    UP000076408    UP000030742    UP000091820    UP000092444    UP000075886    UP000008237    UP000007266    UP000007798    UP000053097    UP000075885    UP000075880    UP000075900    UP000092445    UP000075883    UP000075809    UP000005205    UP000007755    UP000078492    UP000279307    UP000078541    UP000076502    UP000078540    UP000078542    UP000183832    UP000000311    UP000002358    UP000242457    UP000215335    UP000005203    UP000036403    UP000053105    UP000075920    UP000009046   

Pfam

PF15070   GOLGA2L5        + More
PF00235   Profilin
PF08449   UAA
PF10250   O-FucT
PF07539   DRIM
PF10168   Nup88

Interpro

IPR024858   Golgin_A        + More
IPR036140   PFN_sf       
IPR027310   Profilin_CS       
IPR020846   MFS_dom       
IPR013657   UAA       
IPR005455   PFN       
IPR027267   AH/BAR_dom_sf       
IPR019378   GDP-Fuc_O-FucTrfase       
IPR011430   DRIM       
IPR016024   ARM-type_fold       
IPR019321   Nucleoporin_Nup88       

SUPFAM

SSF55770   SSF55770        + More
SSF103657   SSF103657       
SSF48371   SSF48371       

CDD

cd00148  PROF
cd06174  MFS

ProteinModelPortal

Q9GQI6   A0A2A4JBZ0   A0A2H1W370   A0A1E1WU26   A0A1E1W2U3   A0A1E1WQ29   + More
A0A194PLH5   A0A194RGV9   A0A212ETU1   A0A0L7KRL9   A0A1Y1LQ73   A0A1L8DUZ7   A0A1L8DVE5   A0A1B6EFP9   Q7PSN9   A0A1B0CZ35   A0A1B0CKM3   A0A182LH95   A0A084WCI8   A0A1A9UWJ4   A0A182N3C2   A0A182WXH3   N6U6D4   A0A1S4H6E3   A0A182HY48   A0A182U7S2   A0A182VKD6   A0A182JU39   A0A182Y707   U4U942   A0A1A9W7R8   A0A1B0FRF4   A0A182Q379   E2BG57   D6WMW0   B4MQP4   A0A026W9K7   A0A182P5P7   A0A182JDE3   A0A182RLI9   A0A1A9Z5G1   A0A182MVC6   A0A151XK82   A0A158N9X6   F4WC97   A0A195EKH1   A0A3L8DD95   A0A2M4A377   A0A2M4A2T1   A0A195FSH0   A0A154PHE7   A0A195BIU1   A0A2M3ZG41   A0A2M4A3D1   A0A195C5E5   A0A1J1I3G7   E2A6K3   K7J3F3   A0A2A3ERU0   A0A232ES85   A0A2A3ERR5   A0A088ASB5   A0A0J7KHE6   A0A0M9A2K2   A0A310SHQ5   A0A182W1M6   A0A090XAJ9   A0A131XUR5   E0VY46  

PDB

5TBY     E-value=0.0162779,     Score=92

KEGG

101745577    K20358 golgin subfamily A member 2 | (RefSeq) putative leucine-rich repeat-containing protein DDB_G0

GO

GO:0005794   GO:0000137   GO:0032580   GO:0007030   GO:0005801   GO:0003779   GO:0016021   GO:0055085   GO:0005856   GO:0050775   GO:0005783   GO:0017137   GO:0007219   GO:0006004   GO:0008417   GO:0000179   GO:0008649   GO:0006480   GO:0008168   GO:0005737   GO:0016876   GO:0043039   GO:0004651   GO:0005634  

PANTHER

PTHR10881  

Length:

697

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00021

outside

1  -  697

 

 

Pi

221.97998

Theta

175.90564

Tajima's D

0.767064

CLR

0.099347

CSRT

0.593320333983301

Interpretation

Uncertain