Gene

KWMTBOMO01944

Pre Gene Modal

BGIBMGA005927

Annotation

PREDICTED:_N-terminal_Xaa-Pro-Lys_N-methyltransferase_1-A-like_[Papilio_machaon]

Location

Bomo_Chr4(-):8358369-8359387      View in EpiBrowser

Full name

Alpha N-terminal protein methyltransferase 1      

Alternative Name

X-Pro-Lys N-terminal protein methyltransferase 1

Location in the cell

Cytoplasmic   Reliability : 1.994

CDS

ATGAGTAATTTAGATTTTGATGATAACGACATAAGTTATGAAAGTGCCCAAAAATATTGGTCAGATATTCCTGCAACTGTTGATGGAGTTCTCGGTGGCTTTGGATTTATATCTGACATAGACATAGAAGGATCAAGAATTTTCCTTGAAAGTCTTTTATCGTGTAATAAAGCTCCATGCACTGATTTAGCACTTGACTGTGGTGCTGGTATAGGAAGGATAACAAAGAACTTACTATTGCCATACTTTCAATTAGTGGACGTTGTGGAGCCCGATAGTAAATTCATTAAAACAATAAAAAATTATGTTGGTGAACACCAATCAAAGATTGACACACTATACGAAGTTGGTTTACAAGATTTCAATCCTGTCAAAAGATATGATGTTATTTGGAACCAGTGGGTTCTAGGATATCTACTGGATCAGGATTTAATAGCTTACTTAAAACGCTGCAGAAATGCTTTAAAGACCAATGGAGTCATTGTAGTAAAAGAAAACGTAACTTCATCAGGTAAAAGTGAAAAGGATGAAACAGATTCCTCAGTTACACGATCACTACAACAGTTTCTTAGTATTTTTAAACAATCAAAACTGAAGAGATTAAAACAGTGTAAGCAAACTAATTTCCCTAATGGAATTTACCCTGTTTATATGTTTGCATTAGTTCCTATACAGGAAGATTATAATTCTGAGGATTTAAAGGTATAA

Protein

MSNLDFDDNDISYESAQKYWSDIPATVDGVLGGFGFISDIDIEGSRIFLESLLSCNKAPCTDLALDCGAGIGRITKNLLLPYFQLVDVVEPDSKFIKTIKNYVGEHQSKIDTLYEVGLQDFNPVKRYDVIWNQWVLGYLLDQDLIAYLKRCRNALKTNGVIVVKENVTSSGKSEKDETDSSVTRSLQQFLSIFKQSKLKRLKQCKQTNFPNGIYPVYMFALVPIQEDYNSEDLKV

Description

Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif (By similarity).

Catalytic Activity

N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine

Similarity

Belongs to the methyltransferase superfamily. NTM1 family.

Keywords

Complete proteome   Methyltransferase   Reference proteome   S-adenosyl-L-methionine   Transferase  

Feature

chain  Alpha N-terminal protein methyltransferase 1

Uniprot

H9J8T5   A0A1E1WA95   A0A2W1BUP6   A0A2H1WR58   A0A2A4K427   S4P8U4   + More
A0A194RD15   A0A212ETT5   I4DK75   A0A212EHU7   A0A2H1VP09   A0A0L7LVN7   A0A0P4VMP0   R4G383   A0A069DQY0   A0A0L7R794   A0A194QTT4   A0A0N1IQI3   A0A224XS88   A0A088A765   A0A194PMA8   A0A2A3E8E0   A0A154PC33   R4UML6   A0A2J7QPD8   A0A158NPN6   A0A195EL72   E2C5N1   A0A195ETI3   E2AC78   F4W7L1   A0A151WJ87   A0A151IDP6   A0A195ATR5   A0A182FBL3   D6WJE4   A0A182YE73   A0A182SG37   A0A182R8X0   A0A0C9R7A5   A0A026WTT6   A0A067R9C8   A0A182M1H5   E0VEK6   A0A182W8C1   K7ITS6   A0A1S4H3V6   A0A0M8ZST1   Q5TUE6   A0A2P8Z9P4   B3MEZ5   A0A1W4XGU2   A0A084W6U7   R4WDX2   A0A232FBV5   W5JUA1   Q17N31   A0A2M4AYU3   B3N6U6   A0A1B6CF25   B4NWM3   B4HM91   W8C5I1   A0A384ZCM4   Q6NN40   A0A1S4EX08   B4QHS7   A0A1I8PMU0   A0A0K8SZC3   A0A1W4UYZ3   A0A0A9Z911   A0A1B6IWF2   A0A1S3HJA8   A0A182IX10   A0A1S3HJB4   B4KMF7   A0A023ELG9   A0A1B6GQ92   A0A1B6L439   A0A182GF83   A0A3B0JIQ3   B4LNV6   A0A1Q3FJM2   B4MQY2   K1QC85   B4J614   U5EMU9   A0A0T6B7E7   A0A2H8TWN3   A0A0K8UTG4   A0A1A9W3Q4   A0A2R5LG95   A0A034WVW3   C4WXV9   A0A293M4J5   B4GAK0   C1BQM0   A0A1Y1M2K0   A0A182QGN4   Q291L3  

EC Number

2.1.1.244

Pubmed

19121390    28756777    23622113    26354079    22118469    22651552    + More
26227816    27129103    26334808    21347285    20798317    21719571    18362917    19820115    25244985    24508170    30249741    24845553    20566863    20075255    12364791    29403074    17994087    24438588    23691247    28648823    20920257    23761445    17510324    17550304    24495485    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    22936249    25401762    26823975    24945155    26483478    22992520    25348373    28004739    15632085   

EMBL

BABH01005080    GDQN01007189    JAT83865.1    KZ149895    PZC78802.1    ODYU01010437    + More
SOQ55543.1    NWSH01000172    PCG78776.1    GAIX01009325    JAA83235.1    KQ460398    KPJ15165.1    AGBW02012530    OWR44903.1    AK401693    KQ459601    BAM18315.1    KPI93847.1    AGBW02014796    OWR41059.1    ODYU01003586    SOQ42536.1    JTDY01000006    KOB79500.1    GDKW01002469    JAI54126.1    ACPB03010444    GAHY01001911    JAA75599.1    GBGD01002773    JAC86116.1    KQ414642    KOC66752.1    KQ461154    KPJ08410.1    LADJ01015901    KPJ21027.1    GFTR01003738    JAW12688.1    KQ459599    KPI94457.1    KZ288353    PBC27321.1    KQ434869    KZC09347.1    KC571866    AGM32365.1    NEVH01012093    PNF30439.1    ADTU01022666    KQ978730    KYN28973.1    GL452776    EFN76742.1    KQ981986    KYN31217.1    GL438428    EFN68972.1    GL887844    EGI69884.1    KQ983049    KYQ47870.1    KQ977926    KYM98792.1    KQ976745    KYM75405.1    KQ971342    EFA03687.1    GBYB01012204    JAG81971.1    KK107105    QOIP01000011    EZA59475.1    RLU16422.1    KK852846    KDR15110.1    AXCM01001621    DS235093    EEB11812.1    AAAB01008849    KQ435916    KOX68799.1    EAL41027.3    PYGN01000135    PSN53220.1    CH902619    EDV36616.1    ATLV01020956    KE525310    KFB45941.1    AK417944    BAN21159.1    NNAY01000473    OXU28135.1    ADMH02000071    ETN67907.1    CH477202    EAT48112.1    GGFK01012626    MBW45947.1    CH954177    EDV58195.1    GEDC01025244    JAS12054.1    CM000157    EDW89568.1    CH480816    EDW47168.1    GAMC01001737    JAC04819.1    AE013599    AWM95304.1    BT011456    CM000362    CM002911    EDX06411.1    KMY92598.1    GBRD01007183    JAG58638.1    GBHO01002685    GDHC01006113    JAG40919.1    JAQ12516.1    GECU01016451    JAS91255.1    CH933808    EDW09845.1    GAPW01003500    JAC10098.1    GECZ01005178    JAS64591.1    GEBQ01021586    JAT18391.1    JXUM01059550    KQ562059    KXJ76791.1    OUUW01000001    SPP73309.1    CH940648    EDW61125.2    GFDL01007343    JAV27702.1    CH963849    EDW74521.1    JH818976    EKC26415.1    CH916367    EDW01872.1    GANO01000856    JAB59015.1    LJIG01009341    KRT83274.1    GFXV01006147    MBW17952.1    GDHF01030958    GDHF01022526    JAI21356.1    JAI29788.1    GGLE01004408    MBY08534.1    GAKP01000228    JAC58724.1    ABLF02041191    AK342871    BAH72729.1    GFWV01011164    GFWV01020995    MAA35893.1    CH479181    EDW31952.1    BT076899    ACO11323.1    GEZM01041969    JAV80084.1    AXCN02002298    CM000071    EAL25099.3   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000053268    UP000037510    + More
UP000015103    UP000053825    UP000005203    UP000242457    UP000076502    UP000235965    UP000005205    UP000078492    UP000008237    UP000078541    UP000000311    UP000007755    UP000075809    UP000078542    UP000078540    UP000069272    UP000007266    UP000076408    UP000075901    UP000075900    UP000053097    UP000279307    UP000027135    UP000075883    UP000009046    UP000075920    UP000002358    UP000053105    UP000007062    UP000245037    UP000007801    UP000192223    UP000030765    UP000215335    UP000000673    UP000008820    UP000008711    UP000002282    UP000001292    UP000000803    UP000000304    UP000095300    UP000192221    UP000085678    UP000075880    UP000009192    UP000069940    UP000249989    UP000268350    UP000008792    UP000007798    UP000005408    UP000001070    UP000091820    UP000007819    UP000008744    UP000075886    UP000001819   

PRIDE

H9J8T5    Q6NN40   

Pfam

PF05891   Methyltransf_PK

Interpro

IPR020596   rRNA_Ade_Mease_Trfase_CS        + More
IPR008576   MeTrfase_NTM1       
IPR029063   SAM-dependent_MTases       

SUPFAM

SSF53335   SSF53335       

ProteinModelPortal

H9J8T5   A0A1E1WA95   A0A2W1BUP6   A0A2H1WR58   A0A2A4K427   S4P8U4   + More
A0A194RD15   A0A212ETT5   I4DK75   A0A212EHU7   A0A2H1VP09   A0A0L7LVN7   A0A0P4VMP0   R4G383   A0A069DQY0   A0A0L7R794   A0A194QTT4   A0A0N1IQI3   A0A224XS88   A0A088A765   A0A194PMA8   A0A2A3E8E0   A0A154PC33   R4UML6   A0A2J7QPD8   A0A158NPN6   A0A195EL72   E2C5N1   A0A195ETI3   E2AC78   F4W7L1   A0A151WJ87   A0A151IDP6   A0A195ATR5   A0A182FBL3   D6WJE4   A0A182YE73   A0A182SG37   A0A182R8X0   A0A0C9R7A5   A0A026WTT6   A0A067R9C8   A0A182M1H5   E0VEK6   A0A182W8C1   K7ITS6   A0A1S4H3V6   A0A0M8ZST1   Q5TUE6   A0A2P8Z9P4   B3MEZ5   A0A1W4XGU2   A0A084W6U7   R4WDX2   A0A232FBV5   W5JUA1   Q17N31   A0A2M4AYU3   B3N6U6   A0A1B6CF25   B4NWM3   B4HM91   W8C5I1   A0A384ZCM4   Q6NN40   A0A1S4EX08   B4QHS7   A0A1I8PMU0   A0A0K8SZC3   A0A1W4UYZ3   A0A0A9Z911   A0A1B6IWF2   A0A1S3HJA8   A0A182IX10   A0A1S3HJB4   B4KMF7   A0A023ELG9   A0A1B6GQ92   A0A1B6L439   A0A182GF83   A0A3B0JIQ3   B4LNV6   A0A1Q3FJM2   B4MQY2   K1QC85   B4J614   U5EMU9   A0A0T6B7E7   A0A2H8TWN3   A0A0K8UTG4   A0A1A9W3Q4   A0A2R5LG95   A0A034WVW3   C4WXV9   A0A293M4J5   B4GAK0   C1BQM0   A0A1Y1M2K0   A0A182QGN4   Q291L3  

PDB

5CVE     E-value=2.80478e-49,     Score=490

KEGG

101743128    K16219 protein N-terminal methyltransferase [EC:2.1.1.244] | (RefSeq) alpha N-terminal protein methy

GO

GO:0000179   GO:0006480   GO:0008168   GO:0071885   GO:0005737   GO:0005634   GO:0018016   GO:0042054   GO:0018024   GO:0035568   GO:0016571   GO:0000154   GO:0008649   GO:0016876   GO:0043039   GO:0004651  

PANTHER

PTHR12753  

Length:

235

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.6954

Exp number, first 60 AAs:

0.10987

Total prob of N-in:

0.07011

outside

1  -  235

 

 

Pi

257.722356

Theta

204.776181

Tajima's D

0.469729

CLR

0

CSRT

0.504124793760312

Interpretation

Uncertain