Gene

KWMTBOMO01937  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005931

Annotation

PREDICTED:_carnitine_O-acetyltransferase-like_[Bombyx_mori]

Location

Bomo_Chr4(-):8280823-8299397      View in EpiBrowser

Full name

Carnitine O-acetyltransferase      

Alternative Name

Carnitine acetyltransferase

Location in the cell

Nuclear   Reliability : 4.499

CDS

ATGTTGCGTAGAATAAATATAATGAATGCCTACAAAGGATATTTATTAGAACCTTATACCTGTTGCCATCAAATAACAAGCAACTATGTTTCTGCCAAATATTCTACAAACGTCCAAAATTTACCCCGTCTACCTGTGCCAAAGCTAGAGACTACATTAAATAAATATTTGAAAACAGTTAGGCCTCACTTAAACGATCAAGAATATGAAATAACTAAATCACTTGTCAAAGACTTTATCTCAGAAGGGAGTACTGGACAAAAATTACAGAGTTTATTGGAAAATAGAGCAGAACATCATTCAAACTGGCTTGAACAATGGTGGCTGAATACTGCTTACTTAGAATACCGAGACCCTGTTGTTATTTTTTCAAGTCCTGGTCTAGTCTTTCCATTCAGACAGTTCAATACAAGAAAGGAACAGTTATTGTATGCAGCTAAAACATTGTTGGCAGCTGCTGATTACAAAGCACTGATTGATGGTGATAAAATACCAGTAGAAATGATGGGAAAAAATCCTCTAGACATGTCTCAATATAAGAAAATTTTCGGAACATGCAGAATACCTTGGGAAAAACGTGATAAATTGTCATATAATAATAGCAAGCATGTCACTGTCATCCATAATAATCATATATTCCATGTAGATGTTTGGGGTGAAGATGATATATTATTAAGTGAAGATCAACTTGTGCAAAGCTTAGAAAAAGTAATGGAGCTGTCCTCAACGCCGACGGAGGATGGTATTGGTATTCTCACATCCGAACATCGAGATACATGGGCTAAAGCGTATCAGATTCTAATAAAAGATAAAACGAACGAGGATTCACTTATCGATATTGAGAAGAGTTTGGCAGTACTGTGTCTAGATGCTCCTGTAGGATTGTGGAAGTGCGCCGATCCAAATGCCCGTAGAAATCTAGCAGGTGCTCAGACAATCCATGGCGGTGGCTCCAAAGCTAATGGCGGGAATAGATGGTTTGACAAAACAGTACAGTTCATTGTTGGTGCCGATGGAGTGACGGGACTAACCTACGAGCATTCCCCGGCGGAAGGTCAACCAATCGCGGTCATGACCGATTACATCGTCAACTACATAGATCAAGGTAAAGGTAACAAGAAACCATCAGCTAAGCCCAGTGAACCGAAACATTTGAGATTTAACGTGAAGCCTGAAGTAAAAGAAATGATTAAAGCTTCACAAACACATCTCGACAGATTAGTAGCTAATCTCGAGTTGAACTGTTTCCAATATGACAAATACGGTAAAAATTTCATAAAATCTCAAAAGCTCAGTCCGGACAGTTATTTGCAAATGGCGATGCAACTGGCTTTCTACAGACTACACAACACGCCCGGCGCGCACTACGAGTCAGCAGCAACAAGGATGTACGCGGGAGGGCGAACTGAAACCATAAGATCTTGTTCGATTGAATCTATAGAGTTTGCGAAAGCTATGCTGAATCCACAAATTGCACCGAAAGAGAAATTAACTAAACTACAAAACGCTATCAACGGACATAAAGATTACACTGTGCAGGCTCTTCAAGGATTTGGTGTGGACAGACATCTACTTGGTTTGAAGCTTATCGCACTTGAAAATGGTATCGAACTACCCAAGCTGTATACAGACCCAGGTTATACTAGAAGTGCGCATATGAGAATTTCAACAAGCCAGGTGGCGTGCAAGTGCGATGGGTTCATGTGTTACGGGCCCCTCGTGCCGGACGGCTACGCCACTTGCTATAACCCACGAGACAACGACGTCAACTTCGCAACCTCCGCATTCGTCGAAAATCCCGCTACCAGCTGTGACAAATACAGGCAAGCTTTGGAGCAGTCACTACAGGACATGCATGATTTACTTCTTAAAGTAACCAAATCTAAGCTCTAA

Protein

MLRRINIMNAYKGYLLEPYTCCHQITSNYVSAKYSTNVQNLPRLPVPKLETTLNKYLKTVRPHLNDQEYEITKSLVKDFISEGSTGQKLQSLLENRAEHHSNWLEQWWLNTAYLEYRDPVVIFSSPGLVFPFRQFNTRKEQLLYAAKTLLAAADYKALIDGDKIPVEMMGKNPLDMSQYKKIFGTCRIPWEKRDKLSYNNSKHVTVIHNNHIFHVDVWGEDDILLSEDQLVQSLEKVMELSSTPTEDGIGILTSEHRDTWAKAYQILIKDKTNEDSLIDIEKSLAVLCLDAPVGLWKCADPNARRNLAGAQTIHGGGSKANGGNRWFDKTVQFIVGADGVTGLTYEHSPAEGQPIAVMTDYIVNYIDQGKGNKKPSAKPSEPKHLRFNVKPEVKEMIKASQTHLDRLVANLELNCFQYDKYGKNFIKSQKLSPDSYLQMAMQLAFYRLHNTPGAHYESAATRMYAGGRTETIRSCSIESIEFAKAMLNPQIAPKEKLTKLQNAINGHKDYTVQALQGFGVDRHLLGLKLIALENGIELPKLYTDPGYTRSAHMRISTSQVACKCDGFMCYGPLVPDGYATCYNPRDNDVNFATSAFVENPATSCDKYRQALEQSLQDMHDLLLKVTKSKL

Description

Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. May be specific for short chain fatty acids.

Catalytic Activity

(R)-carnitine + acetyl-CoA = CoA + O-acetyl-(R)-carnitine

Subunit

Monomer.

Similarity

Belongs to the carnitine/choline acetyltransferase family.

Keywords

Acyltransferase   Direct protein sequencing   Endoplasmic reticulum   Fatty acid metabolism   Lipid metabolism   Membrane   Mitochondrion   Mitochondrion inner membrane   Peroxisome   Transferase   Transport  

Feature

chain  Carnitine O-acetyltransferase

Uniprot

H9J8T9   A0A2H1WYU6   A0A2W1BWU5   A0A2A4K3R6   A0A194RBG5   A0A194PK91   + More
S4PFJ6   A0A212ETU6   A0A139WI10   D6WJ54   A0A0T6B7F2   A0A1B6MKJ0   U5EJ21   A0A1B6C8B2   T1IJQ1   A0A2P2HYR7   A0A0P4WK33   A0A1L8DZ20   A0A182K3P7   A0A1L8DZ57   A0A1B6EMK8   A0A1B6FW29   A0A182JAU3   A0A1B6FQJ5   A0A084VY70   A0A1U9W5J6   T1IGI0   A0A182F120   A0A0P4VMW2   W5JS91   A0A2M4AGB1   A0A336LXN3   A0A336M0H1   A0A336KGH1   A0A0V0G4K5   A0A069DV65   A0A1Y1N152   A0A1Y1N7M4   A0A1Q3FL28   B0XHW9   A0A1J1J7I0   A0A182QK19   A0A023F070   Q16Q99   A0A224XL00   A0A2L2YAT5   A0A2L2Y8L3   A0A182UZE3   A0A182KUT2   A0A182PDF7   A0A182X2Y8   A0A1S4H028   A0A182I4W7   A0A182MI90   A0A182GN37   A0A182UKI1   A0A182WGW9   A0A182R9S5   A0A171ATP5   A0A182YFH1   A0A2J7RPZ4   A0A182NF90   C3ZI46   A0A2J7QPH8   A0A1S3JZR8   A0A1S3K0A4   A0A0A9YTZ5   A0A146KXC3   W5M2G0   A0A2J7QLQ4   E9GEV4   A0A1V4J701   A0A1V4J6M0   M3XIE6   A0A226ESA3   A0A0Q3XAP2   A0A341CT48   A0A2Y9NGY8   A0A341CSS7   A0A2Y9NX65   A0A2Y9NMW7   A0A091H866   A0A1W5ADZ0   A0A210R0U7   A0A1W5ALU3   A0A2I0M3I5   A0A2Y9EL56   A0A2Y9EJ31   A0A1S3JZG5   P52826   A0A091V990   A0A091NWE4   A0A093CDM5   U3IHS8   R0LW10   A0A1W4YIX8   A0A091Q9P8   Q4VAG5   K7GIT1   Q642H6  

EC Number

2.3.1.7

Pubmed

19121390    28756777    26354079    23622113    22118469    18362917    + More
19820115    24438588    27129103    20920257    23761445    26334808    28004739    25474469    17510324    26561354    20966253    12364791    26483478    25244985    18563158    25401762    26823975    21292972    9215903    28812685    23371554    7832757    23749191    20431018    17381049    23594743   

EMBL

BABH01005071    BABH01005072    BABH01005073    ODYU01012086    SOQ58198.1    KZ149895    + More
PZC78811.1    NWSH01000193    PCG78548.1    KQ460398    KPJ15173.1    KQ459601    KPI93856.1    GAIX01003987    JAA88573.1    AGBW02012530    OWR44913.1    KQ971342    KYB27566.1    EFA03882.1    LJIG01009341    KRT83273.1    GEBQ01003564    JAT36413.1    GANO01002401    JAB57470.1    GEDC01027565    JAS09733.1    JH430339    IACF01001204    LAB66918.1    GDRN01083575    JAI61645.1    GFDF01002376    JAV11708.1    GFDF01002375    JAV11709.1    GECZ01030638    JAS39131.1    GECZ01015438    JAS54331.1    GECZ01017284    JAS52485.1    ATLV01018323    KE525231    KFB42914.1    KX892707    AQY19418.1    ACPB03001109    GDKW01002396    JAI54199.1    ADMH02000504    ETN66173.1    GGFK01006441    MBW39762.1    UFQS01000285    UFQT01000285    SSX02427.1    SSX22802.1    SSX02426.1    SSX22801.1    UFQS01000393    UFQT01000393    SSX03559.1    SSX23924.1    GECL01003174    JAP02950.1    GBGD01000941    JAC87948.1    GEZM01015462    JAV91632.1    GEZM01015465    GEZM01015464    GEZM01015463    JAV91627.1    GFDL01006810    JAV28235.1    DS233223    EDS28815.1    CVRI01000073    CRL07732.1    AXCN02000824    GBBI01004548    JAC14164.1    CH477756    EAT36562.1    GFTR01007316    JAW09110.1    IAAA01012449    LAA04470.1    IAAA01012450    IAAA01012451    IAAA01012452    LAA04473.1    AAAB01008984    APCN01003737    AXCM01001875    JXUM01075555    KQ562892    KXJ74900.1    GEMB01000670    JAS02465.1    NEVH01001354    PNF42901.1    GG666626    EEN47788.1    NEVH01012093    PNF30453.1    GBHO01007092    GBRD01010116    JAG36512.1    JAG55708.1    GDHC01018364    GDHC01010531    JAQ00265.1    JAQ08098.1    AHAT01021663    AHAT01021664    NEVH01013241    PNF29520.1    GL732541    EFX82015.1    LSYS01008925    OPJ67795.1    OPJ67796.1    AFYH01046078    AFYH01046079    AFYH01046080    AFYH01046081    AFYH01046082    LNIX01000002    OXA59671.1    LMAW01000170    KQL60244.1    KL448313    KFO82457.1    NEDP02000942    OWF54638.1    AKCR02000043    PKK24232.1    U08229    KK733774    KFQ99354.1    KK642495    KFP96810.1    KL462552    KFV14015.1    ADON01030708    KB742651    EOB05945.1    KK690201    KFQ16291.1    AAMC01126159    BC096389    AAH96389.1    AGCU01121635    AGCU01121636    CR925757    BC081647    AAH81647.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000007266    + More
UP000075881    UP000075880    UP000030765    UP000015103    UP000069272    UP000000673    UP000002320    UP000183832    UP000075886    UP000008820    UP000075903    UP000075882    UP000075885    UP000076407    UP000075840    UP000075883    UP000069940    UP000249989    UP000075902    UP000075920    UP000075900    UP000076408    UP000235965    UP000075884    UP000001554    UP000085678    UP000018468    UP000000305    UP000190648    UP000008672    UP000198287    UP000051836    UP000252040    UP000248483    UP000053760    UP000192224    UP000242188    UP000053872    UP000248484    UP000053605    UP000016666    UP000008143    UP000007267    UP000000437   

PRIDE

H9J8T9    P52826   

Pfam

PF00755   Carn_acyltransf        + More
PF13532   2OG-FeII_Oxy_2
PF00782   DSPc
PF01331   mRNA_cap_enzyme
PF03919   mRNA_cap_C
PF00253   Ribosomal_S14

Interpro

IPR023213   CAT-like_dom_sf        + More
IPR042232   Cho/carn_acyl_trans_1       
IPR042231   Cho/carn_acyl_trans_2       
IPR039551   Cho/carn_acyl_trans       
IPR000542   Carn_acyl_trans       
IPR029021   Prot-tyrosine_phosphatase-like       
IPR037151   AlkB-like_sf       
IPR016130   Tyr_Pase_AS       
IPR012340   NA-bd_OB-fold       
IPR000387   TYR_PHOSPHATASE_dom       
IPR001339   mRNA_cap_enzyme       
IPR005123   Oxoglu/Fe-dep_dioxygenase       
IPR013846   mRNA_cap_enzyme_C       
IPR027450   AlkB-like       
IPR000340   Dual-sp_phosphatase_cat-dom       
IPR001209   Ribosomal_S14       

SUPFAM

SSF52799   SSF52799        + More
SSF50249   SSF50249       

Gene 3D

3.30.559.10     3.30.559.40     3.30.559.70     2.60.120.590     3.90.190.10    

ProteinModelPortal

H9J8T9   A0A2H1WYU6   A0A2W1BWU5   A0A2A4K3R6   A0A194RBG5   A0A194PK91   + More
S4PFJ6   A0A212ETU6   A0A139WI10   D6WJ54   A0A0T6B7F2   A0A1B6MKJ0   U5EJ21   A0A1B6C8B2   T1IJQ1   A0A2P2HYR7   A0A0P4WK33   A0A1L8DZ20   A0A182K3P7   A0A1L8DZ57   A0A1B6EMK8   A0A1B6FW29   A0A182JAU3   A0A1B6FQJ5   A0A084VY70   A0A1U9W5J6   T1IGI0   A0A182F120   A0A0P4VMW2   W5JS91   A0A2M4AGB1   A0A336LXN3   A0A336M0H1   A0A336KGH1   A0A0V0G4K5   A0A069DV65   A0A1Y1N152   A0A1Y1N7M4   A0A1Q3FL28   B0XHW9   A0A1J1J7I0   A0A182QK19   A0A023F070   Q16Q99   A0A224XL00   A0A2L2YAT5   A0A2L2Y8L3   A0A182UZE3   A0A182KUT2   A0A182PDF7   A0A182X2Y8   A0A1S4H028   A0A182I4W7   A0A182MI90   A0A182GN37   A0A182UKI1   A0A182WGW9   A0A182R9S5   A0A171ATP5   A0A182YFH1   A0A2J7RPZ4   A0A182NF90   C3ZI46   A0A2J7QPH8   A0A1S3JZR8   A0A1S3K0A4   A0A0A9YTZ5   A0A146KXC3   W5M2G0   A0A2J7QLQ4   E9GEV4   A0A1V4J701   A0A1V4J6M0   M3XIE6   A0A226ESA3   A0A0Q3XAP2   A0A341CT48   A0A2Y9NGY8   A0A341CSS7   A0A2Y9NX65   A0A2Y9NMW7   A0A091H866   A0A1W5ADZ0   A0A210R0U7   A0A1W5ALU3   A0A2I0M3I5   A0A2Y9EL56   A0A2Y9EJ31   A0A1S3JZG5   P52826   A0A091V990   A0A091NWE4   A0A093CDM5   U3IHS8   R0LW10   A0A1W4YIX8   A0A091Q9P8   Q4VAG5   K7GIT1   Q642H6  

PDB

1T7Q     E-value=1.07688e-145,     Score=1326

KEGG

101742645    K00624 carnitine O-acetyltransferase [EC:2.3.1.7] | (RefSeq) carnitine O-acetyltransferase-like

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0016746   GO:0004092   GO:0019254   GO:0005777   GO:0004484   GO:0016491   GO:0006370   GO:0004725   GO:0008138   GO:0006412   GO:0003735   GO:0005840   GO:0005743   GO:0006631   GO:0005783   GO:0005739   GO:0005102   GO:0007264   GO:0005524   GO:0006419   GO:0000166   GO:0005737   GO:0016876   GO:0043039   GO:0004651   GO:0005634  

PANTHER

PTHR22589  

Subcellular location

Endoplasmic reticulum  
Peroxisome  
Mitochondrion inner membrane  

Length:

630

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02469

Exp number, first 60 AAs:

0.00382

Total prob of N-in:

0.00273

outside

1  -  630

 

 

Pi

216.987008

Theta

183.269859

Tajima's D

0.521103

CLR

0.576848

CSRT

0.52052397380131

Interpretation

Uncertain