Silkworm Genome Informatics Database

Gene

KWMTBOMO01922

Pre Gene Modal

BGIBMGA006212

Annotation

PREDICTED:_adenylate_cyclase_type_3_[Amyelois_transitella]

Location

Bomo_Chr4(+):8090344-8127313 View in EpiBrowser

Full name

Adenylate cyclase

Location in the cell

PlasmaMembrane Reliability : 4.004

CDS

ATGGAGAAATCACTACAAGGACAAGTCTTACAAAGATGTTCGTGCAATAATTGTTTTATACCACCATGGGGATTTACGGATCTGGAGGAAGAGAAGCTATACTCGGCTTACATCCAAAGACAGAGACAGCGCGCTGTTCCCCGTTTGCTTGCTATCGGAGTGCTGATTCAAGTGTTCGCTGTACTAGTTCCCGGAGAACGTGATTTATCCGTGGCATACTGTTCCGTTGTGATAGCGTTGCTCTTGAACTTGTTGGTAGCCGCAGCCTATATTTGCATACGGAAAGCTCGGCCAGCCCTCACGCATATAACATGGCTGGCATTATGGCTCCAATTACTATTCAGTACTTCACGCAGACTCGGCGATTCTTATAATGAACTACTAGGATGGGCTGTTGTCGTGCAATATTTTACTCTTGCAACAATGCCTTTTCATTACTTGCTGATGGTATTCTACAGCGCCGTTTCCCTGTCTACTTATCTTTTGGTGCAATATTACAACGCTTTAACAGCAGAAAGTACATTAGCCGATGATTTCCATTTCCAGCAAATTGCAAATGGAACATTATTACTGGGAGCCACGTTCCTCGGCGGTACCGCTTATGCAATTAGTGAAAGAAACCAGAGATGCTCTTTCCAGGAGACCAAGCGAAGTTTACGAGACAAATTGACTATTGAACAACAAAGCAAAGAACAGGAAAGGTTATTACTATCCGTACTTCCGGAGCACGTAGCTGTCCAAATGCGCAAAGAATTAGGGCTTATCGACACTCAATTCAAAAAAATTTATATGTCCCGACACGAGAACGTGAGTATCCTGTATGCAGATATCGTAGGCTTCACGGCTATTTCGTCTACATATTCAGCGCAAGATCTTGTTGCGATATTAAACGAGTTATTTGCCCGTTTCGATCGACTCGCCGAGAAATATCAACAGCTCCGAATCAAAATTCTGGGTGATTGCTATTATTGCATTAGCGGCGCACCGGTAGAAAGACCTGATCATGCCGTTCTCTGTGTGCACATGGGCTTGTCTATGGTTAAAGCTATTAAATACGTACAACAAATCACAAACTCACCGGTGGATATGAGAGTGGGTATACATACAGGAGCGGTATTGGCTGGCGTCTTGGGTCAGCGGCAGTGGCAGTTTGATGTTTATTCAAGAGATGTGGAATTGGCCAATAAGATGGAGAGTAGTGGAATGGCTGGGCGCGTTCATATATCGGAAGTTACTTTAAGTTTCTTGAACGATGAGTTCGAAGTGGAACCCGCGCATGGAGAGCGCCGCGAGGAGATGCTGCGCCAGTCAGGCATAAAAACTTACTTTATTGTACGAGTTTTGAAACCGTACCAGGGAGGCGAAGAAAAGATTGCGACGGCAAACGAAGCGCTTGGCGGAGAGCTCGCTGACACGCTATCTGACCTCAGAGACGACGATGAGGTCTCGGTTCTTTCACCACAAGACGAAGAAAAAGGAAACGAAGAATCAAAGATACTCTTGATGTTGGAAGAGGAACTCGTTAATAGAGATGATGATAGGGAATTGGCGGACGCAACAACATTGTGCCTTACTTTCAAGGGTTCCGAGGCTGAGCAGGCCTTCGTGAACCGTAACGATCCCTGTCCGCTGGCGCTCGCGGCTCCTCCGGTTCTGCTTCTACCGGCCGTGGTCGCAATCGCTAGTTTTGCGGTTCCCCCTACTTGGGCATTGAGTGCTGTTTACATGGCACTTGTTTTGGAGACAGGCCTTATAAACATCATCTATTATGTGCACTACAGATACTCACAATATAAGAAAAGGGACATCAACCCTCAGTGGAAGGTTACCTGTGGTATTTTCAATATATCCATGTTCGTCGCGGCAAACGTTGCTCCTCTGCTCATCTGCGGCAGTTTTGAATCAATGATCGACAGTGGAATTTCAGATAATTCGATGTCACATCTCACCGTGAGACGCTGTCTTCACCCCTCATATTACTATCACGTGGGTGCGGGCGCCGCGTGTGGTGCTTTGTGGGTGTCTCCGATGGGGGGATGGTCACGGTTCGTGTTCCTGGGAGCGCTGGCGTTGGCTCACGTGGTGCCGGCGGTGGTGCATCCCGCGTTGCTCGCCTCGCGTCCGAGCCTCGACCGTGACCCATTTCGCCTGCCGTTCAACGCATCTAAAGATTACGATGAAGACTTGTTTATGGCTCTTGCTCAAATTCATGGAGGCCGTAATCTACTGCTTTTGTTCTTCATTGTCGTTGCGATCCTAATATTGAATAGATACTTGGAGTCACTAGAGCGCGCCCGGCACTCCCGGGGCGAGCGCATGCGCGGTCAAGCCGAGCAGGCGAGCGACCTGCGCCGTCGCAACCAGCAGCTCATCCACAACGTGCTCCCGCCGCATGTCGCCACGCACTTCATGGGCGCACGACACCACCATCGCGACCTCTACAGTCAAAGCTACGCCGAAGTCGGGGTTCTATTTGCCTCAATGCCCAATTTTACAGAATTTTACTCGGAGGAAACAGTTAACAATCAAGGCCTAGAATGTTTGCGGTTTCTGAACGAAGTTATATCAGATTTCGATTTACTGCTGGAAGACCCTAAATATAGTAAGGATATCATAAAGATAAAAACGATTAGTTCCACATACATGGCAGCGTCCGGCCTAAATCCTACAAGACAAATGCAGCCATCAGATGGCGTGGTGGTGCGCTGGGCTCATCTCGCTTGTTTGGTTGAGTTCGCCCTGGAATTGCAACGTGTCCTCGCAGCAATAAACGAACAATCTTTCAATCATTTTGTACTTCGGATGGGAGTCAACCACGGTCCTATTACTGCTGGTGTGATCGGCGCTCGGAAACCACATTATGACATATGGGGGAATACAGTTAATGTCGCTTCTCGAATGGAGAGTACCGGAAAAGCTGGCTGCATTCAGGTTACTGAGGAGACATGCCAGATATTACAGAAGTTTGGTTACTACTTCGAGCAACGTGGTCTAGTTGCGGTCAAAGGCAAGGGCCAGCTAATGACCTACTATCTCCAGGGCAAACACGATAATCCGCCAGGCCATATGGACAAACCCAACGTCGAAGAATCGGTGTCTGATGCGAGTCCAGGAGATGCCCTCCTGGCAAACGGTGATGTTACGGGATCTAGCGAGGATGGTGCTCTTTCACGGAACGAAGCTGACCGTCCACTACTACAGTCTTAA

Protein

MEKSLQGQVLQRCSCNNCFIPPWGFTDLEEEKLYSAYIQRQRQRAVPRLLAIGVLIQVFAVLVPGERDLSVAYCSVVIALLLNLLVAAAYICIRKARPALTHITWLALWLQLLFSTSRRLGDSYNELLGWAVVVQYFTLATMPFHYLLMVFYSAVSLSTYLLVQYYNALTAESTLADDFHFQQIANGTLLLGATFLGGTAYAISERNQRCSFQETKRSLRDKLTIEQQSKEQERLLLSVLPEHVAVQMRKELGLIDTQFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVAILNELFARFDRLAEKYQQLRIKILGDCYYCISGAPVERPDHAVLCVHMGLSMVKAIKYVQQITNSPVDMRVGIHTGAVLAGVLGQRQWQFDVYSRDVELANKMESSGMAGRVHISEVTLSFLNDEFEVEPAHGERREEMLRQSGIKTYFIVRVLKPYQGGEEKIATANEALGGELADTLSDLRDDDEVSVLSPQDEEKGNEESKILLMLEEELVNRDDDRELADATTLCLTFKGSEAEQAFVNRNDPCPLALAAPPVLLLPAVVAIASFAVPPTWALSAVYMALVLETGLINIIYYVHYRYSQYKKRDINPQWKVTCGIFNISMFVAANVAPLLICGSFESMIDSGISDNSMSHLTVRRCLHPSYYYHVGAGAACGALWVSPMGGWSRFVFLGALALAHVVPAVVHPALLASRPSLDRDPFRLPFNASKDYDEDLFMALAQIHGGRNLLLLFFIVVAILILNRYLESLERARHSRGERMRGQAEQASDLRRRNQQLIHNVLPPHVATHFMGARHHHRDLYSQSYAEVGVLFASMPNFTEFYSEETVNNQGLECLRFLNEVISDFDLLLEDPKYSKDIIKIKTISSTYMAASGLNPTRQMQPSDGVVVRWAHLACLVEFALELQRVLAAINEQSFNHFVLRMGVNHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGCIQVTEETCQILQKFGYYFEQRGLVAVKGKGQLMTYYLQGKHDNPPGHMDKPNVEESVSDASPGDALLANGDVTGSSEDGALSRNEADRPLLQS

Description

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Catalytic Activity

ATP = 3',5'-cyclic AMP + diphosphate

Cofactor

Mg(2+)

Similarity

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Uniprot

A0A2A4K3D0 A0A2H1VHV6 A0A2W1BZ14 A0A212ETT9 A0A194PKA1 A0A1Y1M754 + More
A0A3L8DGC9 A0A195D4J1 K7J585 A0A0C9Q386 A0A151XFQ4 E9J2R4 W4Z644

EC Number

4.6.1.1

Pubmed

28756777 22118469 26354079 28004739 30249741 20075255 + More
21282665

EMBL

NWSH01000193 PCG78526.1 ODYU01002642 SOQ40418.1 KZ149895 PZC78824.1 + More
AGBW02012530 OWR44922.1 KQ459601 KPI93866.1 GEZM01043425 JAV79137.1 QOIP01000008 RLU19233.1 KQ976870 KYN07797.1 AAZX01000338 AAZX01000350 GBYB01008548 JAG78315.1 KQ982194 KYQ59110.1 GL767998 EFZ12886.1 AAGJ04000111 AAGJ04000112 AAGJ04000113

Proteomes

UP000218220 UP000007151 UP000053268 UP000279307 UP000078542 UP000002358 + More
UP000075809 UP000007110

Pfam

PF16214 AC_N + More
PF00211 Guanylate_cyc

Interpro

IPR018297   A/G_cyclase_CS        + More
IPR032628   AC_N
IPR029787   Nucleotide_cyclase
IPR001054   A/G_cyclase
IPR030672   Adcy

SUPFAM

SSF55073 SSF55073

Gene 3D

3.30.70.1230

ProteinModelPortal

A0A2A4K3D0 A0A2H1VHV6 A0A2W1BZ14 A0A212ETT9 A0A194PKA1 A0A1Y1M754 + More
A0A3L8DGC9 A0A195D4J1 K7J585 A0A0C9Q386 A0A151XFQ4 E9J2R4 W4Z644

PDB

3MAA E-value=1.08101e-62, Score=613

KEGG

105842081 K08043 adenylate cyclase 3 [EC:4.6.1.1] | (RefSeq) adenylate cyclase type 3-like

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0016021 GO:0035556 GO:0000166 GO:0016849 GO:0009190 GO:0004016 GO:0005524 GO:0006171 GO:0046872 GO:0005886 GO:0016829 GO:0005887 GO:0007189 GO:0007166 GO:0016020 GO:0003676 GO:0043401 GO:0003677 GO:0003707 GO:0004651 GO:0005634

Length:

1068

Number of predicted TMHs:

10

Exp number of AAs in TMHs:

217.75015

Exp number, first 60 AAs:

15.21539

Total prob of N-in:

0.98978

POSSIBLE N-term signal

sequence

inside

1 - 44

TMhelix

45 - 64

outside

65 - 68

TMhelix

69 - 91

inside

92 - 143

TMhelix

144 - 166

outside

167 - 180

TMhelix

181 - 203

inside

204 - 542

TMhelix

543 - 565

outside

566 - 568

TMhelix

569 - 591

inside

592 - 610

TMhelix

611 - 633

outside

634 - 658

TMhelix

659 - 676

inside

677 - 682

TMhelix

683 - 705

outside

706 - 736

TMhelix

737 - 759

inside

760 - 1068

Pi

201.494461

Theta

174.129718

Tajima's D

0.711996

CLR

0.440568

CSRT

0.576671166441678

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics