Gene

KWMTBOMO01921  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005934

Annotation

PREDICTED:_integrator_complex_subunit_2_[Amyelois_transitella]

Location

Bomo_Chr4(-):8079835-8087243      View in EpiBrowser

Full name

Integrator complex subunit 2      

Location in the cell

Cytoplasmic   Reliability : 1.356 Extracellular   Reliability : 1.381

CDS

ATGGATATTGAATTCATGAAACCAGTTCAACCACACGTTTTCAAAGCCCTAAAAGATGTTGATATTCCGGGTCTTATGAAATGTAGTCCTGATGAAATAAGACCCATAATACCATGTCTTGTCCGAATGGCCTTGATATCTCCATTAGATATCACCAGATACTGTGCAGAAGCTAAGAAAGATATACTTACACTACTTTCAGGCATTGATTTAGTAAATTTCATAGTTTCACTTCTATCTATAGAATTTCATGTTCTAGAAGCAGATGTAAAAAAAGAACAACAAATGAGGCAAAAAAGTGGATCGCAATGCATTGAGTCAACACTAATTCCAAATATAATTAATGGTATTGCAAGTGATTTTGAACAGTCTGATTCTTCTAGGAGGGTTCGCCTTGTTCTATCAGAACTATTACAAATGCAAGCACAATTAGTTGAGTTCAATCAGACAAAAAATACAAATGCGGATTATACAATTAAGCCCTCTGAATTATTTGATAATGATGTGTATTTAGAAGAAATCACAGATGTTATATGTATAAGTTTAGCTGAAATACCGAATTTACTAAATATCTGTGATGTGGTTGAGGTTCTCCTTTATGTAAATAAGGGCCCTTCTATAATATCATGGGTGGTAGCAAATCAACCTGACATGTTGCAGGAAGTAGCGGAATCACTTGTATTAAATGCTGAACGAAGTGAAGAAGGTGGCATCAGAGCAAAGGCATTAGCTACCTTATGTGCTGTATTTCCACCTATTGCTGCCACCATAAGAGCAAAAGCAGCATCTGCTTCACGTCTACCATCTTTAGTCATTAATTTAACCTTGACTCACCATGAAGATGATCTTGTGTCATTTATATCAGGTCTGTTACTTGGATCTGACCAAACTACTAGAGGATGGTTTGCTACATTTTTACGAAATTCACACAAAAGAGGTAAAGGTGATGGTCATGCTGCATTGACAAAGTTAAGACAAGAATTATTAATTCGTCTAAAAGCTGCCACAGCTGGAGTAGATGCTTCAGCTTTACTAAGATTGTACTGTGCATTGAGGGGCATTGCCAGTATTAAGTTTCAGGATGATGAAGTAGCTTGGTTACTAAGACTAGTGACACAGAAACCTCCCCCAACCCCTGCTGGAGTCAGATTTGTCTCATTAAGTCTATGTATGATTTTAGCATGTCCATCCTTAATGGCTGCTCCAGATCATGAGAAAAAAGCTATAGAATGGGTCCAATGGTTGGTAAAAGAGGAAGCCTACTTCGAAAGCACTTCTGGTGTTACTGCATCTTTTGGTGAGATGTTGTTGCTGATTGCCATACATTTCCATTCCGGACAACTATCGGCAGTAGGTGAACTAGTGTGTGCAACACTTGGTATGCGTGTTCCAGTAAGACCTAATGGGCTGGCTAGAATAAAACAAGCCTTTACACAAGAAATATTTACAGAGCAGGTTGTGACAGCTCATGCAGTCAAAGTTCCTGTAACAGCTAATCTCAATAGCAATATTCCAGGATATTTGCCAGTTCATTGTATCCATCAACTACTAAAATCTAGAGCATTTTCGAAACACAAAGTGCCAATTAAAAATTGGATTTACCGACAAATATGTAACTGTACAGCACCTCTACATCCTGTTATGCCAGCACTGGTGGAGGTGTATGTCAATTCTATCCTTGTTGTAAACAACAAGGGTACTAACGAATATGTTAACAAACCTATAATGGAAGAAGAAATCCGTAAGGTTTTTAGAAACTCTATTTTTGGAGCAAATTTTGATGTAAAAAATAAATCAATAACTCCCATGGAAATAGATAATACTGAACAATCTGTAGAAATAAGACTAGAAAAACCAACGTTAGCTTCGCAGTTATTATTGATTTATTATTTGCTACTCTACGAAGATGTGCGATTGTCAAACACGGCAACGTTGCTTGCTAACGGTAGGAAGGTGAAAAGCTATTCAGCAGCATTTTTATCAGAATTGCCAATAAAATATCTATTGCACCAAGCCCAAAAAAATCAACTCAGTTATGGAGGTCTATTTAGTCCACTATTACGACTATTAGCGACACACTTCCCTCAATTATCTTTAGTCGATGACTGGATGGACGACCAAGTGTTTGCTGATATGAGTCGCTGTTATGTCGATTTCAATCTTTCCGAAACCACAATAAACGATGGATTCCTAAACATTGATGATAATCCGTATAAAACAGGAAAAGTTTTAAAAGCGATGTTAAGTAAAAATCCTACAGACATTTGGCCTTTTGCTGAGATATTCGTTAAATATATAAAAAGTGTATTAGGTGATAAAGTTCCTAGACATATACAAGAGTTATATCGGGAAGTTTGGTTACGACTCAATACTGTTTTACCCCGATGTTTGTGGATTATGACGATCAACGCTCTTCTAGATATTAACGGCATGGGTATTAAGAATGTTACTATTACACAAGAAAATGTTTTAGTTGATCCTTTACAAGTGCTGCGTTGCGATATGCGAGTATACAGATGTGGACCTATATTAAAAATTATTTTACGAATTCTCGAAGCAAGTTTGGCAGCTTCTAGAAGTCAACTATCACGTCACTTGCTCGATAAACCTTTATTAGAAAAAAGTGGCCAACTAACTTCCGATTCAGAAAGAGAAGAACTAAAAAATGCTTTAGTTGCAGCTCAAGAGAGCGCGGCCCTTCAAATATTATTAGAAGCCTGTCTAGAAACACCAGATGACCAAAAAAAACCTGAACTTATGTGGTCCCTTCGCGAAGTCCGAAGCATAATTTGTTCTTTTTTACATCAAATATTTATATCAGAACCATCTCTAGCAAAACTTGTGCATTTTCAAGGTTATCCCCGAGAACTTTTACCAGTAACAGTACAAGGCATTCCATCAATGCACATCTGTTTAGACTTTATACCAGAGCTATTAAGCCAAGCCTCTCTTGAAAAGCAAATATTTGCTGTTGACCTAGTATCTCATTTGTCCATCCAATATGCTTTACCTAAAGCAATGTCAATAGCCAGACTATGTGTGAATACTCTTTCAACACTATTATCTGTATTACCTAGTGATTTGCGTCTGGAATTATTCCAACCGGTTCTCAAGTCTCTGGAAAGGATATGCATCGCCTTTCCATCACTACTAGAAGATATTACATCTTTACTATTGCAGCTTGGCAGGATATGCGAATCCCAAGCGTCACTGGGACACTGTTGGAATGACACTCCCATATTAGGCGAAACTGCCTACGTTGATTCTGAAAGGCAACCTGAAACTAAAGTTCTAGTAGCGGAAGTCCTCAGTAGAGATATAAGGGTAACAATGAATGAAATTGTAAAAAAAGCTGTATTAAATGATAAATTATATTAA

Protein

MDIEFMKPVQPHVFKALKDVDIPGLMKCSPDEIRPIIPCLVRMALISPLDITRYCAEAKKDILTLLSGIDLVNFIVSLLSIEFHVLEADVKKEQQMRQKSGSQCIESTLIPNIINGIASDFEQSDSSRRVRLVLSELLQMQAQLVEFNQTKNTNADYTIKPSELFDNDVYLEEITDVICISLAEIPNLLNICDVVEVLLYVNKGPSIISWVVANQPDMLQEVAESLVLNAERSEEGGIRAKALATLCAVFPPIAATIRAKAASASRLPSLVINLTLTHHEDDLVSFISGLLLGSDQTTRGWFATFLRNSHKRGKGDGHAALTKLRQELLIRLKAATAGVDASALLRLYCALRGIASIKFQDDEVAWLLRLVTQKPPPTPAGVRFVSLSLCMILACPSLMAAPDHEKKAIEWVQWLVKEEAYFESTSGVTASFGEMLLLIAIHFHSGQLSAVGELVCATLGMRVPVRPNGLARIKQAFTQEIFTEQVVTAHAVKVPVTANLNSNIPGYLPVHCIHQLLKSRAFSKHKVPIKNWIYRQICNCTAPLHPVMPALVEVYVNSILVVNNKGTNEYVNKPIMEEEIRKVFRNSIFGANFDVKNKSITPMEIDNTEQSVEIRLEKPTLASQLLLIYYLLLYEDVRLSNTATLLANGRKVKSYSAAFLSELPIKYLLHQAQKNQLSYGGLFSPLLRLLATHFPQLSLVDDWMDDQVFADMSRCYVDFNLSETTINDGFLNIDDNPYKTGKVLKAMLSKNPTDIWPFAEIFVKYIKSVLGDKVPRHIQELYREVWLRLNTVLPRCLWIMTINALLDINGMGIKNVTITQENVLVDPLQVLRCDMRVYRCGPILKIILRILEASLAASRSQLSRHLLDKPLLEKSGQLTSDSEREELKNALVAAQESAALQILLEACLETPDDQKKPELMWSLREVRSIICSFLHQIFISEPSLAKLVHFQGYPRELLPVTVQGIPSMHICLDFIPELLSQASLEKQIFAVDLVSHLSIQYALPKAMSIARLCVNTLSTLLSVLPSDLRLELFQPVLKSLERICIAFPSLLEDITSLLLQLGRICESQASLGHCWNDTPILGETAYVDSERQPETKVLVAEVLSRDIRVTMNEIVKKAVLNDKLY

Description

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

Subunit

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.

Similarity

Belongs to the Integrator subunit 2 family.

Keywords

Complete proteome   Cytoplasm   Membrane   Nucleus   Polymorphism   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Integrator complex subunit 2
sequence variant  In dbSNP:rs606072.

Uniprot

H9J8U2   A0A2W1BYU7   A0A2A4K2P8   A0A2H1VHU9   A0A194RCI7   A0A194PKL3   + More
A0A212ETV4   A0A0L7LLW8   E2BUF7   F4W7M7   A0A151WJ29   A0A2J7Q795   A0A0C9Q7Q4   A0A3L8D732   A0A158NPM6   A0A067QT10   E9I8Q0   E2AXQ5   A0A195ESH2   A0A2A3E5M2   A0A195ATS2   A0A026W1K7   A0A088AVZ3   A0A195EM91   A0A0L7QP88   A0A154PLI3   A0A0J7KRV1   A0A151IMN2   K7J951   A0A232F4L6   A0A310SP61   U5ETJ7   E0VMM5   A0A1Q3F509   A0A0P6IWG5   B0X5M1   A0A1S4FSB1   A0A182JDV3   Q16QV6   A0A1W4X6V2   A0A182VEN4   A0A182LFR1   Q5TU39   A0A182TYT0   A0A182N622   A0A182JZH3   A0A182W082   A0A182HU99   A0A182WRH8   A0A084VRE5   A0A182MDC8   A0A1B6CUF6   A0A182Q203   A0A182Y4B8   A0A182RNP3   A0A182G3Z7   A0A1Q3F584   A0A182PAA8   A0A0A9VRS4   A0A1Y1MAS2   A0A023F3Y1   D2A4V3   A0A336MQH9   A0A336LMB4   A0A1J1ID50   A0A1S3D595   A0A0M9A8K3   T1IXD4   E9G4S7   A0A087TK98   A0A0P5A9S8   A0A0P5K1P9   A0A0P5MQR3   A0A182SC39   A0A0P6IGV9   A0A0P6CPE4   A0A131XRZ2   A0A0N8CGX1   A0A147BNQ3   A0A2R5L534   A0A0P5VN97   A0A162N9D3   A0A1Z5KUH2   A0A0T6B323   A0A0P4Y623   A0A1Z5L4M5   A0A2L2YLM1   A0A2K5Y2N4   A0A2K6NSA0   F6U3W7   A0A024QZ48   A0A341CFJ0   A0A2U4C6E2   A0A340Y0F6   A0A2Y9ETB7   A0A2J8W7E3   J3KMZ7   Q9H0H0   A0A2Y9QYN7  

Pubmed

19121390    28756777    26354079    22118469    26227816    20798317    + More
21719571    30249741    21347285    24845553    21282665    24508170    20075255    28648823    20566863    26999592    17510324    20966253    12364791    14747013    17210077    24438588    25244985    26483478    25401762    28004739    25474469    18362917    19820115    21292972    29652888    28528879    26561354    25362486    19892987    11181995    16625196    10574462    11230166    16239144    23904267   

EMBL

BABH01005051    BABH01005052    BABH01005053    KZ149895    PZC78825.1    NWSH01000193    + More
PCG78525.1    ODYU01002642    SOQ40417.1    KQ460398    KPJ15184.1    KQ459601    KPI93867.1    AGBW02012530    OWR44923.1    JTDY01000698    KOB76181.1    GL450640    EFN80684.1    GL887844    EGI69900.1    KQ983049    KYQ47852.1    NEVH01017447    PNF24457.1    GBYB01010193    JAG79960.1    QOIP01000012    RLU16031.1    ADTU01022615    KK853054    KDR12003.1    GL761642    EFZ23053.1    GL443628    EFN61801.1    KQ981986    KYN31195.1    KZ288360    PBC27037.1    KQ976745    KYM75384.1    KK107488    EZA49947.1    KQ978730    KYN28994.1    KQ414843    KOC60311.1    KQ434971    KZC12729.1    LBMM01003940    KMQ92974.1    KQ977026    KYN06219.1    NNAY01001028    OXU25429.1    KQ761546    OAD57408.1    GANO01001887    JAB57984.1    DS235317    EEB14631.1    GFDL01012394    JAV22651.1    GDUN01000479    JAN95440.1    DS232386    EDS40958.1    CH477729    EAT36795.1    AAAB01008859    EAL40780.3    APCN01000613    ATLV01015610    KE525023    KFB40539.1    AXCM01000851    GEDC01020244    JAS17054.1    AXCN02000193    JXUM01041643    KQ561292    KXJ79094.1    GFDL01012329    JAV22716.1    GBHO01044527    JAF99076.1    GEZM01036155    JAV82932.1    GBBI01003053    JAC15659.1    KQ971344    EFA05171.1    UFQS01001992    UFQT01001992    SSX12898.1    SSX32340.1    UFQT01000056    SSX19126.1    CVRI01000047    CRK98160.1    KQ435711    KOX79427.1    JH431646    GL732532    EFX85507.1    KK115611    KFM65537.1    GDIP01214515    JAJ08887.1    GDIQ01190494    GDIQ01190493    GDIQ01190492    GDIQ01190491    GDIQ01190490    JAK61233.1    GDIQ01164159    JAK87566.1    GDIQ01004719    JAN90018.1    GDIP01011465    JAM92250.1    GEFM01006881    JAP68915.1    GDIP01132879    JAL70835.1    GEGO01002997    JAR92407.1    GGLE01000498    MBY04624.1    GDIP01097726    JAM05989.1    LRGB01000568    KZS17794.1    GFJQ02008214    JAV98755.1    LJIG01016082    KRT81668.1    GDIP01233063    JAI90338.1    GFJQ02004604    JAW02366.1    IAAA01035255    LAA08996.1    CH471179    EAW51436.1    NDHI03003397    PNJ65694.1    PNJ65695.1    AC060798    KF456301    AB033113    AL136800    CR533582    BK005721   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000037510    + More
UP000008237    UP000007755    UP000075809    UP000235965    UP000279307    UP000005205    UP000027135    UP000000311    UP000078541    UP000242457    UP000078540    UP000053097    UP000005203    UP000078492    UP000053825    UP000076502    UP000036403    UP000078542    UP000002358    UP000215335    UP000009046    UP000002320    UP000075880    UP000008820    UP000192223    UP000075903    UP000075882    UP000007062    UP000075902    UP000075884    UP000075881    UP000075920    UP000075840    UP000076407    UP000030765    UP000075883    UP000075886    UP000076408    UP000075900    UP000069940    UP000249989    UP000075885    UP000007266    UP000183832    UP000079169    UP000053105    UP000000305    UP000054359    UP000075901    UP000076858    UP000233140    UP000233200    UP000002281    UP000252040    UP000245320    UP000265300    UP000248484    UP000005640    UP000248480   

PRIDE

H9J8U2    J3KMZ7    Q9H0H0   

Pfam

PF14750   INTS2        + More
PF10477   EIF4E-T

Interpro

IPR026236   Int2_metazoa        + More
IPR029321   INTS2       
IPR016024   ARM-type_fold       
IPR018862   eIF4E-T       

SUPFAM

SSF48371   SSF48371       

ProteinModelPortal

H9J8U2   A0A2W1BYU7   A0A2A4K2P8   A0A2H1VHU9   A0A194RCI7   A0A194PKL3   + More
A0A212ETV4   A0A0L7LLW8   E2BUF7   F4W7M7   A0A151WJ29   A0A2J7Q795   A0A0C9Q7Q4   A0A3L8D732   A0A158NPM6   A0A067QT10   E9I8Q0   E2AXQ5   A0A195ESH2   A0A2A3E5M2   A0A195ATS2   A0A026W1K7   A0A088AVZ3   A0A195EM91   A0A0L7QP88   A0A154PLI3   A0A0J7KRV1   A0A151IMN2   K7J951   A0A232F4L6   A0A310SP61   U5ETJ7   E0VMM5   A0A1Q3F509   A0A0P6IWG5   B0X5M1   A0A1S4FSB1   A0A182JDV3   Q16QV6   A0A1W4X6V2   A0A182VEN4   A0A182LFR1   Q5TU39   A0A182TYT0   A0A182N622   A0A182JZH3   A0A182W082   A0A182HU99   A0A182WRH8   A0A084VRE5   A0A182MDC8   A0A1B6CUF6   A0A182Q203   A0A182Y4B8   A0A182RNP3   A0A182G3Z7   A0A1Q3F584   A0A182PAA8   A0A0A9VRS4   A0A1Y1MAS2   A0A023F3Y1   D2A4V3   A0A336MQH9   A0A336LMB4   A0A1J1ID50   A0A1S3D595   A0A0M9A8K3   T1IXD4   E9G4S7   A0A087TK98   A0A0P5A9S8   A0A0P5K1P9   A0A0P5MQR3   A0A182SC39   A0A0P6IGV9   A0A0P6CPE4   A0A131XRZ2   A0A0N8CGX1   A0A147BNQ3   A0A2R5L534   A0A0P5VN97   A0A162N9D3   A0A1Z5KUH2   A0A0T6B323   A0A0P4Y623   A0A1Z5L4M5   A0A2L2YLM1   A0A2K5Y2N4   A0A2K6NSA0   F6U3W7   A0A024QZ48   A0A341CFJ0   A0A2U4C6E2   A0A340Y0F6   A0A2Y9ETB7   A0A2J8W7E3   J3KMZ7   Q9H0H0   A0A2Y9QYN7  

KEGG

101740375    K13139 integrator complex subunit 2 | (RefSeq) integrator complex subunit 2

GO

GO:0016180   GO:0032039   GO:0034472   GO:0005737   GO:0005634   GO:0005622   GO:0005654   GO:0016021   GO:0031965   GO:0042795   GO:0016020   GO:0007166   GO:0003676   GO:0043401   GO:0003677   GO:0003707   GO:0004651  

PANTHER

PTHR28608  

Subcellular location

Nucleus membrane  
Cytoplasm  

Length:

1125

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.07223000000003

Exp number, first 60 AAs:

0.0064

Total prob of N-in:

0.09286

outside

1  -  1125

 

 

Pi

158.87166

Theta

195.697292

Tajima's D

0.327477

CLR

0.207023

CSRT

0.459977001149942

Interpretation

Uncertain