Gene

KWMTBOMO01919

Pre Gene Modal

BGIBMGA005935

Annotation

PREDICTED:_frizzled-7-B_[Amyelois_transitella]

Location

Bomo_Chr4(-):8062893-8065233      View in EpiBrowser

Full name

Frizzled-7-B       + More
Frizzled-7-A      
Frizzled-7      

Location in the cell

Cytoplasmic   Reliability : 1.151 Nuclear   Reliability : 2.775

CDS

ATGGCAAAATTTTGGAAACATTATGTTATTATATTCAGTCTGTTATGTCTTTTTGCGTTAACAAAAGGTTCTCGAGAGATTGTTTATCAAGGCGATAGTCTACCTCAACATGGACGTTGTGAACCCATTACCATTCAGTTTTGTCAGAAATTGCGTTATAATCAAACCATTTTTCCGAATATTTTAAATCAAGCACGACAAGAAGATGCAGCCGCAAACATGCTTCTGTTTACAACTCTCATTAAACTGAATTGCTCTCCTGATCTAAGATTCTTCTTGTGTTCAGTTTATGCACCCGTTTGCACGATACTAGATTCTGCGATACCGCCTTGTCGTCATTTATGTGAAGCTGCAAAACAAAGCTGTGATGTCGTCATACGAAAATTTGATTTTCCTTGGCCCCCTGAGCTTGAATGTTCTGAATTTCCTGAAGTATCTGATAATAACATATGTGTTGGTGACAATAATACTGCCCATGAATCTCGAAAACGCACTGATACCAAGTTTCGTAAGGTTGACTTCAAATCTAACATGGAGAGAGATCCGACTAGATTGCATGAGTTTGTGTGCCCAGTGCAGTTTAAAGTACCAAGACATTTAGATCTTGAATACTCTTTTAAAGTTGGAAATAGAGTTGAACATGACTGTGGAGCCCCATGCAATGGAATGTTCTTCAGTAAAGATGAAAAGAATTTTTCAAGGCTCTGGATTGGAATCTGGGCAGTCCTGTGTGCACTCAGTTGCCTTTTTACTGTGCTAACATTTTTAATAGATACAGATAGATTCAGGTATCCAGAAAGACCCATAATATTTTTGTCAGTTTGTTATCTAATGGTAGCTATTGCCTACATAATGGGTTGGAGTGCAGGTGATAATATAAGCTGCCAAGGGCCTTTTGTTTCTGCTGTCAGTGGAACAAGATTACCCAACATATCAGTTATCACACAAGGTACAAAACATGAGCCATGCACAATACTGTTTATGATAGTATATTTCTTTAGTATGGCTTCGAGTATATGGTGGGTCATATTAACCCTGACATGGTTTTTGGCTGCTGGCCTAAAATGGGGACATGAAGCAATAGAAGCAAATTCCCAATATTTTCATCTTGCTGCTTGGGCAGTACCAGCTGTGAAGACAATATCTATTCTAGCAATGGGGAAAGTAGATGGTGATGTACTGTCAGGTGTATGTTACGTTGGATTATGGGATGCAGAAGCTTTAAGAGGATTTGTGTTGGCACCTTTATGTGTCTATTTAGTGTTTGGAACAATCTTTCTTCTAGCTGGCTTTGTCTCACTGTTTCGGATCAGAACTGTCATGAAACATGATGGGACTAAAACTGATAAATTAGAGAAACTGATGATTCGCATTGGTGTGTTTGGTGTACTATACACCGTGCCTGCCCTCATAGTCATAGCATGTTTGTTCTATGAACAAGTTAATTTTGACAAATGGATGATTGCATGGCAACGAGACATGTGTTCGATACGACAATACTCAATTCCTTGTCCGATAATTCATGAAGAGATAGAAGGACCAAAGTTTGAAATGTTTATGATTAAATATCTAATGACAATGATTGTTGGTATAACATCTAGCTTTTGGATATGGTCTGGTAAAACTTTGATATCATGGTCTCAATTTTTTGACAAAGTTAAAGGTCGCAGAGTAGAAGCCTATGTGTAA

Protein

MAKFWKHYVIIFSLLCLFALTKGSREIVYQGDSLPQHGRCEPITIQFCQKLRYNQTIFPNILNQARQEDAAANMLLFTTLIKLNCSPDLRFFLCSVYAPVCTILDSAIPPCRHLCEAAKQSCDVVIRKFDFPWPPELECSEFPEVSDNNICVGDNNTAHESRKRTDTKFRKVDFKSNMERDPTRLHEFVCPVQFKVPRHLDLEYSFKVGNRVEHDCGAPCNGMFFSKDEKNFSRLWIGIWAVLCALSCLFTVLTFLIDTDRFRYPERPIIFLSVCYLMVAIAYIMGWSAGDNISCQGPFVSAVSGTRLPNISVITQGTKHEPCTILFMIVYFFSMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLAAWAVPAVKTISILAMGKVDGDVLSGVCYVGLWDAEALRGFVLAPLCVYLVFGTIFLLAGFVSLFRIRTVMKHDGTKTDKLEKLMIRIGVFGVLYTVPALIVIACLFYEQVNFDKWMIAWQRDMCSIRQYSIPCPIIHEEIEGPKFEMFMIKYLMTMIVGITSSFWIWSGKTLISWSQFFDKVKGRRVEAYV

Description

Receptor for Wnt proteins. Acts in both canonical and non-canonical Wnt pathways. Although different papers report differing Wnt preferences, wnt5a, wnt8b and wnt11 have been proposed as synergists. In the canonical Wnt pathway, acts via beta-catenin to promote the expression of the dorsal genes siamois, twin and nodal3 and to establish the dorsal axis of the embryo and induce dorsal mesoderm formation. In a non-canonical Wnt/planar cell polarity (PCP) pathway, acts with sdc4 and dvl2/dsh to regulate convergent extension cell movements during gastrulation. Triggers phosphorylation of dvl2/dsh and its translocation to the plasma membrane. In a third branch of Wnt signaling, acts in a non-canonical pathway via trimeric G proteins, and independently of dvl2/dsh, to recruit protein kinase C (PKC) to the membrane and thus activate PKC. PKC signaling controls cell sorting and tissue separation during gastrulation.
Receptor for Wnt proteins. Acts in both canonical and non-canonical Wnt pathways. Although different papers report differing Wnt preferences, wnt5a, wnt8b and wnt11 have been proposed as synergists. In the canonical Wnt pathway, acts via beta-catenin to promote the expression of the dorsal genes siamois, twin and nodal3 and to establish the dorsal axis of the embryo and induce dorsal mesoderm formation. In a non-canonical Wnt/planar cell polarity (PCP) pathway, acts with sdc4 and dvl2/dsh to regulate convergent extension movements in gastrulation. Triggers phosphorylation of dvl2/dsh and its translocation to the plasma membrane. In a third branch of Wnt signaling, acts in a non-canonical pathway via trimeric G proteins, and independently of dvl2/dsh, to recruit protein kinase C (PKC) to the membrane and thus activate PKC. PKC signaling controls cell sorting and tissue separation during gastrulation (By similarity).

Subunit

Interacts with wnt11 and sdc4. The extracellular domain interacts with the extracellular domain of pcdh8/papc (By similarity). Interacts (via C-terminus) with dvl1 (via PDZ domain).
Interacts with wnt11 and sdc4. The extracellular domain interacts with the extracellular domain of pcdh8/papc.
Interacts with wnt11 and sdc4. The extracellular domain interacts with the extracellular domain of pcdh8/papc (By similarity).

Similarity

Belongs to the G-protein coupled receptor Fz/Smo family.

Keywords

Cell membrane   Developmental protein   Disulfide bond   Endosome   G-protein coupled receptor   Glycoprotein   Membrane   Receptor   Signal   Transducer   Transmembrane   Transmembrane helix   Wnt signaling pathway   Complete proteome   Reference proteome  

Feature

chain  Frizzled-7-B

Uniprot

H9J8U3   A0A2W1BZZ7   A0A2A4K442   A0A2H1VHU6   A0A1E1WUB8   A0A194RGX7   + More
A0A0L7LLG7   A0A1B6FSU1   A0A067QHH7   A0A1B6DUK5   A0A195FKC0   K7IXM9   E2B9L1   E2AHT4   A0A023F262   A0A2A3EBH9   A0A088A6V2   A0A3L8DES9   A0A154PH96   A0A026WRU5   A0A1Y1NNJ7   A0A0A9VZ38   A0A0K8S350   U4U4I1   N6U9T1   D6WJY3   A0A143VP60   T1JLV3   A0A224XM69   A0A087T8F5   V5HFW8   B7PFK7   L7M581   A0A1W4XSY0   A0A2T7Q003   A0A131YWN6   V5SQJ2   E9G2J9   W5UR01   A0A2D0S5B5   Q98SI2   Q7SZR7   Q6NV44   V4CHR5   A0A3P8YED9   H3AZ03   A0A2K9RCG5   Q90ZT3   I3KZU0   A0A3N0XUZ5   A0A0P7TZS4   A0A3B4CXR7   Q8QFM3   A0A1S3JF10   C3YEA5   Q8AVJ9   A0A3P8ZXJ8   A0A3N0Y6C7   A0A1A7XST0   W5NMT4   A0A2U9AZV8   H3B255   W5MX40   A0A1L8EX17   A0A1W4Y9D2   A0A3P9C180   A0A3P9D6V3   Q9PUK8   A0A3B4FUC1   A0A3B4GD67   Q7ZU08   W5LU60   A0A3P8NK42   G7N8N7   A0A1W5B4Z9   A0A3B3CTI6   A0A2K6B3T9   A0A2K5URA6   Q5BL72   A0A3N0Y5I0   A0A1W4ZY33   A0A3P8QM51   A0A1U7QEK4   A0A2K5JJR2   I3JSE2   G1K3F4   F1SI18   A0A340Y6D5   A0A2I2U7V2   M3Z5C2   A0A1L8EPZ4   A0A1S3MVZ0   A0A250Y2V1   A0A341CGM7   H0XWH9   A0A2Y9N1H2   A0A3B4ZM92   H2MKU6   A0A1S3MQT5  

Pubmed

19121390    28756777    26354079    26227816    24845553    20075255    + More
20798317    25474469    30249741    24508170    28004739    25401762    26823975    23537049    18362917    19820115    25765539    25576852    26830274    24012522    21292972    23127152    11287199    23594743    23254933    25069045    9215903    29337984    25186727    12049772    12351181    18563158    10446283    10899005    11477687    14636582    27762356    10751186    10862746    10727861    10906785    10990458    11291855    11677610    15272309    16604063    25329095    22002653    29451363    20431018    30723633    17975172    28087693    17554307   

EMBL

BABH01005049    KU291212    AMR93992.1    KZ149895    PZC78827.1    NWSH01000193    + More
PCG78523.1    ODYU01002642    SOQ40415.1    GDQN01000490    JAT90564.1    KQ460398    KPJ15186.1    JTDY01000698    KOB76184.1    GECZ01030998    GECZ01016509    JAS38771.1    JAS53260.1    KK853378    KDR08023.1    GEDC01007942    JAS29356.1    KQ981490    KYN41115.1    AAZX01011865    GL446556    EFN87644.1    GL439579    EFN67013.1    GBBI01003040    JAC15672.1    KZ288312    PBC28411.1    QOIP01000009    RLU18831.1    KQ434893    KZC10688.1    KK107119    EZA58747.1    GEZM01001643    JAV97627.1    GBHO01044156    GBHO01036410    GBHO01010232    JAF99447.1    JAG07194.1    JAG33372.1    GBRD01018111    GDHC01020404    JAG47716.1    JAP98224.1    KB632006    ERL87962.1    APGK01034123    KB740904    ENN78450.1    KQ971342    EFA04653.1    LN849082    CRI73784.1    JH431585    GFTR01006734    JAW09692.1    KK113932    KFM61394.1    GANP01012075    JAB72393.1    ABJB010293041    DS703155    EEC05379.1    GACK01006785    JAA58249.1    PZQS01000001    PVD39003.1    GEDV01004944    JAP83613.1    KC690271    AHB53231.1    GL732530    EFX86266.1    JT416322    AHH42008.1    AJ301617    CAC37335.1    BC056280    AAH56280.2    CR407547    BC068322    AAH68322.2    KB200430    ESP01680.1    AFYH01133944    MG711509    AUT31435.1    AF336123    AAK49948.1    AERX01013317    RJVU01059775    ROJ66271.1    JARO02005224    KPP67133.1    BX927225    AF437316    AF336124    AF510101    AAL87635.1    AAM00192.1    AAN03844.1    GG666505    EEN61413.1    AF159106    BC042228    AAH42228.1    RJVU01051519    ROL41742.1    HADW01019494    SBP20894.1    AHAT01034647    CP026243    AWO97156.1    AFYH01065303    AHAT01004650    CM004482    OCT63845.1    AF039215    AJ243323    AF179213    AF114151    BC049397    AAH49397.1    CM001264    EHH21587.1    AQIA01015569    AC149036    CR759995    BC090579    AAH90579.1    AAZ06130.1    CAJ82817.1    RJVU01051648    ROL41476.1    AERX01048603    AAMC01057529    AEMK02000100    DQIR01145990    HDB01467.1    AANG04002752    AEYP01060373    CM004483    OCT61339.1    GFFV01001978    JAV37967.1    AAQR03032755   

Proteomes

UP000005204    UP000218220    UP000053240    UP000037510    UP000027135    UP000078541    + More
UP000002358    UP000008237    UP000000311    UP000242457    UP000005203    UP000279307    UP000076502    UP000053097    UP000030742    UP000019118    UP000007266    UP000054359    UP000001555    UP000192223    UP000245119    UP000000305    UP000221080    UP000000437    UP000030746    UP000265140    UP000008672    UP000005207    UP000034805    UP000261440    UP000085678    UP000001554    UP000018468    UP000246464    UP000186698    UP000192224    UP000265160    UP000261460    UP000018467    UP000265100    UP000261560    UP000233120    UP000233100    UP000008143    UP000189706    UP000233080    UP000008227    UP000265300    UP000011712    UP000000715    UP000087266    UP000252040    UP000005225    UP000248483    UP000261400    UP000001038   

PRIDE

H9J8U3   

Pfam

PF01392   Fz        + More
PF01534   Frizzled

Interpro

IPR015526   Frizzled/SFRP        + More
IPR026552   FZD7       
IPR036790   Frizzled_dom_sf       
IPR017981   GPCR_2-like       
IPR020067   Frizzled_dom       
IPR000539   Frizzled/Smoothened_TM       
IPR026550   FZD2       
IPR026548   FZD1       

SUPFAM

SSF63501   SSF63501       

Gene 3D

1.10.2000.10    

ProteinModelPortal

H9J8U3   A0A2W1BZZ7   A0A2A4K442   A0A2H1VHU6   A0A1E1WUB8   A0A194RGX7   + More
A0A0L7LLG7   A0A1B6FSU1   A0A067QHH7   A0A1B6DUK5   A0A195FKC0   K7IXM9   E2B9L1   E2AHT4   A0A023F262   A0A2A3EBH9   A0A088A6V2   A0A3L8DES9   A0A154PH96   A0A026WRU5   A0A1Y1NNJ7   A0A0A9VZ38   A0A0K8S350   U4U4I1   N6U9T1   D6WJY3   A0A143VP60   T1JLV3   A0A224XM69   A0A087T8F5   V5HFW8   B7PFK7   L7M581   A0A1W4XSY0   A0A2T7Q003   A0A131YWN6   V5SQJ2   E9G2J9   W5UR01   A0A2D0S5B5   Q98SI2   Q7SZR7   Q6NV44   V4CHR5   A0A3P8YED9   H3AZ03   A0A2K9RCG5   Q90ZT3   I3KZU0   A0A3N0XUZ5   A0A0P7TZS4   A0A3B4CXR7   Q8QFM3   A0A1S3JF10   C3YEA5   Q8AVJ9   A0A3P8ZXJ8   A0A3N0Y6C7   A0A1A7XST0   W5NMT4   A0A2U9AZV8   H3B255   W5MX40   A0A1L8EX17   A0A1W4Y9D2   A0A3P9C180   A0A3P9D6V3   Q9PUK8   A0A3B4FUC1   A0A3B4GD67   Q7ZU08   W5LU60   A0A3P8NK42   G7N8N7   A0A1W5B4Z9   A0A3B3CTI6   A0A2K6B3T9   A0A2K5URA6   Q5BL72   A0A3N0Y5I0   A0A1W4ZY33   A0A3P8QM51   A0A1U7QEK4   A0A2K5JJR2   I3JSE2   G1K3F4   F1SI18   A0A340Y6D5   A0A2I2U7V2   M3Z5C2   A0A1L8EPZ4   A0A1S3MVZ0   A0A250Y2V1   A0A341CGM7   H0XWH9   A0A2Y9N1H2   A0A3B4ZM92   H2MKU6   A0A1S3MQT5  

PDB

6BD4     E-value=3.52885e-86,     Score=813

KEGG

101740238    K02432 frizzled 1/7 | (RefSeq) frizzled-7-B

PATHWAY

04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0007275   GO:0016021   GO:0042813   GO:0016055   GO:0017147   GO:0005886   GO:0035567   GO:0060070   GO:0090504   GO:0042074   GO:0060027   GO:0035988   GO:0004930   GO:0008104   GO:0001707   GO:0045545   GO:0009950   GO:0048729   GO:0010008   GO:0045944   GO:0031018   GO:0016477   GO:0061341   GO:0060271   GO:0001947   GO:0003146   GO:0007223   GO:0070654   GO:0060231   GO:0045893   GO:0055038   GO:0014834   GO:0005546   GO:0042327   GO:2000726   GO:0030165   GO:0048103   GO:0042666   GO:0033077   GO:0038031   GO:0019827   GO:0060828   GO:0010812   GO:0005109   GO:0034446   GO:0060054   GO:0005515   GO:0004888   GO:0007166   GO:0016020   GO:0003676   GO:0043401   GO:0003677   GO:0003707   GO:0004651   GO:0005634  

PANTHER

PTHR11309:SF31   PTHR11309   PTHR11309:SF34   PTHR11309:SF81  

Subcellular location

Cell membrane   Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions.   With evidence from 2 publications.
Endosome membrane   Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions.   With evidence from 2 publications.

SignalP

Position:   1 - 23,         Likelihood:  0.989725

 

 

Length:

562

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

163.3181

Exp number, first 60 AAs:

10.03284

Total prob of N-in:

0.47247

POSSIBLE N-term signal

sequence

outside

1  -  234

TMhelix

235  -  257

inside

258  -  269

TMhelix

270  -  289

outside

290  -  331

TMhelix

332  -  354

inside

355  -  366

TMhelix

367  -  386

outside

387  -  411

TMhelix

412  -  434

inside

435  -  454

TMhelix

455  -  477

outside

478  -  523

TMhelix

524  -  546

inside

547  -  562

 

 

Pi

140.565563

Theta

178.964311

Tajima's D

-0.874882

CLR

1184.20175

CSRT

0.161941902904855

Interpretation

Uncertain