Gene

KWMTBOMO01912

Pre Gene Modal

BGIBMGA005940

Annotation

Glass_bottom_boat_[Operophtera_brumata]

Location

Bomo_Chr4(-):8007059-8007543      View in EpiBrowser

Full name

ATP-dependent (S)-NAD(P)H-hydrate dehydratase       + More
Protein 60A      

Alternative Name

ATP-dependent NAD(P)HX dehydratase
Protein glass bottom boat

Location in the cell

Nuclear   Reliability : 1.921

CDS

ATGGCTGGTTTTGTGCAGTTGGTGTGTGCGTGTTTTGCATTGTTTACTGTGGTCACCGATGCCATACTTTCCGGACTTTACATTGACAATGGTGTTGATCAGACGATAATTCATCATACGATTACACGACACGAGCGCATGGTAGTAGAACATGAAATTTTAGATCTTTTAGGCTTAGGAGAAAGACCCAGAAGATCTAAATCTCCACCTTTGGATCGTTCGGCTCCAAGTTTCCTGTTGGACGTTTATAAGCAACTGGCTGAGGAGCACGAACAGGCACGCCCTACACGTAGTTCTGACATGGCTCTCAGCGGTGATGAGCAGCAAGCTATTGATGAAAGTGATTTAATTATGACTTTTCAAAGCAAAAGTAAGTTATTTTTTGTTTTCATTGCTATTTTATGTTAA

Protein

MAGFVQLVCACFALFTVVTDAILSGLYIDNGVDQTIIHHTITRHERMVVEHEILDLLGLGERPRRSKSPPLDRSAPSFLLDVYKQLAEEHEQARPTRSSDMALSGDEQQAIDESDLIMTFQSKSKLFFVFIAILC

Description

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Required for the growth of imaginal tissues and for patterning of the adult wing.

Catalytic Activity

(6S)-NADHX + ATP = ADP + H(+) + NADH + phosphate

Cofactor

Mg(2+)

Subunit

Homodimer; disulfide-linked.

Similarity

Belongs to the TGF-beta family.
Belongs to the NnrD/CARKD family.

Keywords

Cleavage on pair of basic residues   Complete proteome   Cytokine   Developmental protein   Disulfide bond   Glycoprotein   Growth factor   Reference proteome   Secreted   Signal  

Feature

chain  Protein 60A

Uniprot

H9J8U8   A0A0L7LT52   A0A1E1VXN5   A0A2H1WH31   A0A2W1BZ23   A0A2A4K4G5   + More
A0A194RBI3   A0A194PRW2   A0A1Y1LUV6   A0A1Y1LQU8   D6WJG3   A0A1L8DJ25   A0A1B0GHD8   A0A195FVG3   F4X2S4   A0A151IUA6   A0A151WJZ7   A0A0L7RK70   A0A1B6EYZ3   A0A2A3EIB7   A0A088AQN8   A0A0C9R4S4   A0A1B6ISE8   A0A154NXB3   A0A158NLQ9   A0A026WF31   A0A1B6MMV4   A0A310S5S8   A0A195BLC4   A0A2Z6BDT4   A0A0J7KRT5   E9IW90   E2BSG9   N6UC73   N6TER8   E0VF83   W5U0I7   E2A4X2   A0A2P8ZE83   A0A336LTQ2   K7IQP9   A0A1J1HH35   A0A224XQP6   A0A2J7RPU7   A0A023F1G9   A0A034W7Y8   U5EVA1   A0A0K8WJZ0   A0A0A1WFZ2   A0A0A1XGQ1   A0A0A1X5T4   A0A084WIH8   W8C0F6   F8V237   A0A1I8NX77   A0A182RVG2   A0A0L0BNJ5   A0A067QZV7   Q7PZI7   A0A182HHM3   A0A182QT77   A0A182GRV7   T1IAN6   A0A1Q3FZB2   A0A182J0T4   A0A182WE14   A0A182XJR0   A0A182N2S5   A0A182L566   A0A182TGG5   A0A182V5A8   A0A182H371   A0A2R7W580   A0A023ERU8   A0A182SBB8   A0A182Y9I4   A0A1Q3FU05   A0A1Q3FU91   A0A182PCA3   T1PBW0   A0A1I8N5Z4   A0A182M031   Q292R9   A0A3Q0INX4   Q16WN3   A0A182FB81   A0A182KC53   A0A3B0IZ07   W5JLI6   B0XHY1   B0XHY0   B4PA79   A0A0B4LGA7   P27091   A0A1W4UZN3   B4I8U4   B4QB06  

EC Number

4.2.1.93

Pubmed

19121390    26227816    28756777    26354079    28004739    18362917    + More
19820115    21719571    21347285    24508170    30249741    21282665    20798317    23537049    20566863    23595982    29403074    20075255    25474469    25348373    25830018    24438588    24495485    21627820    26108605    24845553    12364791    15302159    14747013    17210077    26483478    20966253    24945155    25244985    25315136    15632085    17994087    17510324    20920257    23761445    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    1924384    1601181    9636086    22936249   

EMBL

BABH01005042    JTDY01000181    KOB78411.1    GDQN01011569    JAT79485.1    ODYU01008632    + More
SOQ52380.1    KZ149895    PZC78834.1    NWSH01000193    PCG78552.1    KQ460398    KPJ15193.1    KQ459601    KPI93875.1    GEZM01049224    JAV76030.1    GEZM01049225    JAV76029.1    KQ971342    EFA04645.1    GFDF01007616    JAV06468.1    AJWK01004477    AJWK01004478    KQ981219    KYN44416.1    GL888591    EGI59270.1    KQ980968    KYN10951.1    KQ983020    KYQ48199.1    KQ414578    KOC71208.1    GECZ01026602    JAS43167.1    KZ288253    PBC31022.1    GBYB01011279    JAG81046.1    GECU01017844    JAS89862.1    KQ434777    KZC04243.1    ADTU01019668    ADTU01019669    KK107238    QOIP01000007    EZA54725.1    RLU20214.1    GEBQ01002703    JAT37274.1    KQ769580    OAD52857.1    KQ976450    KYM85666.1    LC373544    BBD17787.1    LBMM01003898    KMQ93016.1    GL766458    EFZ15168.1    GL450233    EFN81357.1    APGK01040727    APGK01040728    KB740984    KB631904    ENN76252.1    ERL87081.1    ENN76253.1    DS235107    EEB12039.1    KC810052    AHH30785.1    GL436756    EFN71514.1    PYGN01000083    PSN54809.1    UFQS01000116    UFQT01000116    SSW99961.1    SSX20341.1    CVRI01000004    CRK87195.1    GFTR01005953    JAW10473.1    NEVH01001355    PNF42854.1    GBBI01003392    JAC15320.1    GAKP01008728    GAKP01008727    JAC50225.1    GANO01001967    JAB57904.1    GDHF01001134    JAI51180.1    GBXI01016666    JAC97625.1    GBXI01004155    JAD10137.1    GBXI01008061    JAD06231.1    ATLV01023934    KE525347    KFB50022.1    GAMC01007445    GAMC01007444    JAB99111.1    JN006973    AEI25992.1    JRES01001597    KNC21612.1    KK853149    KDR10681.1    AY578795    AAAB01008986    AAT07300.1    EAA00276.3    APCN01002428    AXCN02001087    JXUM01083317    KQ563369    KXJ73969.1    ACPB03006699    ACPB03006700    GFDL01002141    JAV32904.1    JXUM01106765    JXUM01106766    KQ565082    KXJ71365.1    KK854344    PTY14887.1    GAPW01001675    JAC11923.1    GFDL01004000    JAV31045.1    GFDL01003999    JAV31046.1    KA646169    AFP60798.1    AXCM01001233    CM000071    EAL24792.2    CH477560    EAT38991.1    OUUW01000001    SPP73147.1    ADMH02001211    ETN63639.1    DS233229    EDS28827.1    EDS28826.1    CM000158    EDW92405.1    AE013599    AHN56581.1    M77012    M84795    CH480824    EDW57019.1    CM000362    CM002911    EDX08443.1    KMY96132.1   

Proteomes

UP000005204    UP000037510    UP000218220    UP000053240    UP000053268    UP000007266    + More
UP000092461    UP000078541    UP000007755    UP000078492    UP000075809    UP000053825    UP000242457    UP000005203    UP000076502    UP000005205    UP000053097    UP000279307    UP000078540    UP000036403    UP000008237    UP000019118    UP000030742    UP000009046    UP000000311    UP000245037    UP000002358    UP000183832    UP000235965    UP000030765    UP000095300    UP000075900    UP000037069    UP000027135    UP000007062    UP000075840    UP000075886    UP000069940    UP000249989    UP000015103    UP000075880    UP000075920    UP000076407    UP000075884    UP000075882    UP000075902    UP000075903    UP000075901    UP000076408    UP000075885    UP000095301    UP000075883    UP000001819    UP000079169    UP000008820    UP000069272    UP000075881    UP000268350    UP000000673    UP000002320    UP000002282    UP000000803    UP000192221    UP000001292    UP000000304   

PRIDE

H9J8U8    P27091   

Pfam

PF00688   TGFb_propeptide        + More
PF00019   TGF_beta
PF01256   Carb_kinase

Interpro

IPR001111   TGF-b_propeptide        + More
IPR015615   TGF-beta-rel       
IPR029034   Cystine-knot_cytokine       
IPR001839   TGF-b_C       
IPR017948   TGFb_CS       
IPR000631   CARKD       
IPR029056   Ribokinase-like       
IPR013026   TPR-contain_dom       
IPR011990   TPR-like_helical_dom_sf       
IPR019734   TPR_repeat       

SUPFAM

SSF57501   SSF57501        + More
SSF53613   SSF53613       
SSF48452   SSF48452       

Gene 3D

2.10.90.10     3.40.1190.20     1.25.40.10    

CDD

cd01171  YXKO-related

ProteinModelPortal

H9J8U8   A0A0L7LT52   A0A1E1VXN5   A0A2H1WH31   A0A2W1BZ23   A0A2A4K4G5   + More
A0A194RBI3   A0A194PRW2   A0A1Y1LUV6   A0A1Y1LQU8   D6WJG3   A0A1L8DJ25   A0A1B0GHD8   A0A195FVG3   F4X2S4   A0A151IUA6   A0A151WJZ7   A0A0L7RK70   A0A1B6EYZ3   A0A2A3EIB7   A0A088AQN8   A0A0C9R4S4   A0A1B6ISE8   A0A154NXB3   A0A158NLQ9   A0A026WF31   A0A1B6MMV4   A0A310S5S8   A0A195BLC4   A0A2Z6BDT4   A0A0J7KRT5   E9IW90   E2BSG9   N6UC73   N6TER8   E0VF83   W5U0I7   E2A4X2   A0A2P8ZE83   A0A336LTQ2   K7IQP9   A0A1J1HH35   A0A224XQP6   A0A2J7RPU7   A0A023F1G9   A0A034W7Y8   U5EVA1   A0A0K8WJZ0   A0A0A1WFZ2   A0A0A1XGQ1   A0A0A1X5T4   A0A084WIH8   W8C0F6   F8V237   A0A1I8NX77   A0A182RVG2   A0A0L0BNJ5   A0A067QZV7   Q7PZI7   A0A182HHM3   A0A182QT77   A0A182GRV7   T1IAN6   A0A1Q3FZB2   A0A182J0T4   A0A182WE14   A0A182XJR0   A0A182N2S5   A0A182L566   A0A182TGG5   A0A182V5A8   A0A182H371   A0A2R7W580   A0A023ERU8   A0A182SBB8   A0A182Y9I4   A0A1Q3FU05   A0A1Q3FU91   A0A182PCA3   T1PBW0   A0A1I8N5Z4   A0A182M031   Q292R9   A0A3Q0INX4   Q16WN3   A0A182FB81   A0A182KC53   A0A3B0IZ07   W5JLI6   B0XHY1   B0XHY0   B4PA79   A0A0B4LGA7   P27091   A0A1W4UZN3   B4I8U4   B4QB06  

KEGG

101739275    K16621 bone morphogenetic protein 7 | (RefSeq) protein 60A

PATHWAY

04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0008083   GO:0005576   GO:0005125   GO:0010862   GO:0070700   GO:0048468   GO:0005160   GO:0043408   GO:0060395   GO:0030509   GO:0042981   GO:0005615   GO:0052855   GO:0047453   GO:0005524   GO:0046496   GO:0046928   GO:0008586   GO:0007474   GO:0031045   GO:0097467   GO:0045887   GO:0036099   GO:0007274   GO:0007528   GO:0099504   GO:0035222   GO:0048636   GO:0030707   GO:0012505   GO:0007419   GO:0007391   GO:0040007   GO:0015074   GO:0008026   GO:0003723   GO:0043401   GO:0003677   GO:0003707   GO:0004651   GO:0005634  

PANTHER

PTHR11848  

Subcellular location

Secreted  

SignalP

Position:   1 - 21,         Likelihood:  0.794294

 

 

Length:

135

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

20.47895

Exp number, first 60 AAs:

20.41454

Total prob of N-in:

0.32313

POSSIBLE N-term signal

sequence

outside

1  -  3

TMhelix

4  -  26

inside

27  -  135

 

 

Pi

10.075078

Theta

14.00891

Tajima's D

-0.937512

CLR

574.647327

CSRT

0.146742662866857

Interpretation

Uncertain