Gene

KWMTBOMO01886

Pre Gene Modal

BGIBMGA005947

Annotation

PREDICTED:_uncharacterized_protein_LOC101737309_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr4(-):7379275-7381858      View in EpiBrowser

Full name

Transcription termination factor, mitochondrial      

Alternative Name

Mitochondrial transcription termination factor

Location in the cell

Nuclear   Reliability : 3.075

CDS

ATGAAAACATTGCTTCACATATACAAGGTCACTATGAATGATGTTGAAAATGGTTTCTGTGAAAACCGGCTTTATTATTTGGCATCTCGATTAAAGTGTTCACCAACTGGCTTATGTGAAAAATTAACTAAAAGAATCTTTGTTTACTCCTTATCATTTGATTGGTTGAAAAATGCCTTAGATATTTTGTTAGAAATGGGTGTGTCTGAAGACAGAATAATTCGGGATTTATGGATATTAAAATATCATCATGAAACAATACGCCTAAGACTTCAACAAGTCAAAGATAAGGGTATTGACAACTTATATCCTTGGATGGTTAGATGCCCTGAGGAGGTACTAAATAGGTCAATTAGATTAAGCCAAGAAACTAAAAATATTCTAGGAGAAACAAAGTCGACACAGATTTATTTAGCTAATCGTCTGAATACATCACTTGATTCTGTGGAAGAGCTGTACTCAAAAACACCTGCATTAAAAACAATCAGAGTGACCAAAGCAAAAAAGTTCCTAGATTTTCTTATTAATGAAGGATTTACTGTTGAAGACATCGCTAATAAATCAAGAGTGTTATCAGCTTCTCAAAAAACTGTACAGCAAAGATTGGAAATGTTACGTGATTTGGGTGTCAATGACATAAATTTGAATGTTCTTTGTAGAAGTAGAAGAGATTTTAAAAAGTATTGTGATACCTTACAATTACTTGCTAAAAAGGATAAATAG

Protein

MKTLLHIYKVTMNDVENGFCENRLYYLASRLKCSPTGLCEKLTKRIFVYSLSFDWLKNALDILLEMGVSEDRIIRDLWILKYHHETIRLRLQQVKDKGIDNLYPWMVRCPEEVLNRSIRLSQETKNILGETKSTQIYLANRLNTSLDSVEELYSKTPALKTIRVTKAKKFLDFLINEGFTVEDIANKSRVLSASQKTVQQRLEMLRDLGVNDINLNVLCRSRRDFKKYCDTLQLLAKKDK

Description

Transcription termination factor (PubMed:12626700, PubMed:15845400, PubMed:16648357). Binds promoter DNA and regulates mitochondrial replication and transcription (PubMed:12626700, PubMed:15845400, PubMed:16648357, PubMed:24068965). Transcription termination activity may be polarized with highest termination activity occurring when its DNA-binding site is positioned in the reverse orientation with respect to the incoming RNA polymerase (PubMed:15845400). Required for normal topology and maintenance of mitochondrial DNA (mtDNA) levels (PubMed:24068965). Regulates mtDNA replication by promoting replication pausing, possibly by acting as a natural barrier to replication fork progression (PubMed:24068965). Its function in replication pausing prevents unregulated replication that may occur for example by collisions between the machineries of DNA replication and transcription during mtDNA synthesis (PubMed:24068965). This ensures the incorporation of RNA transcripts into replication intermediates at the replication fork and allow for proper fork progression (PubMed:24068965). Shares mtDNA binding sites with the mitochondrial termination factor mTerf5 and thereby may antagonize mTerf5 function during replication to regulate pausing (PubMed:22784680, PubMed:24068965). Likely to function downstream of Dref which activates genes involved in mtDNA replication and maintenance (PubMed:19032147, PubMed:24068965).

Similarity

Belongs to the mTERF family.

Keywords

Complete proteome   DNA replication   Mitochondrion   Reference proteome   Transcription   Transcription regulation   Transit peptide  

Feature

chain  Transcription termination factor, mitochondrial

Uniprot

H9J8V5   A0A2H1W9A7   A0A2A4JBQ4   A0A2A4JB43   A0A1E1W7M0   A0A1E1WRW3   + More
A0A1E1WMV2   A0A212F0R6   A0A1E1W075   I4DPM5   W8BAU0   A0A0J9R2C6   B4HXG1   Q9V3F3   B3MKK1   B4KEI8   A0A0A1XC43   B4MZB4   B4P0K1   A0A0K8URD3   A0A194PMD2   B4JEB0   A0A034VYE0   A0A3B0KBQ3   A0A1W4UW90   B3N9T1   A0A0M3QU30   B4M8S1   Q29KB5   B4GX69   A0A1B0DHV8   A0A1J1INZ3   B4Q5I6   A0A1L8E036   A0A0L0BZ47   A0A1B0CAM7   A0A067RC32   A0A1I8MZ29   A0A1A9VQC6   A0A1A9X634   A0A1B0BIX3   A0A182H6I7   A0A1B0FKW8   Q16TT0   A0A1J1IHY1   A0A1Q3F9B0   A0A1A9VZM1   B0WBZ9   A0A1I8QBK8   A0A2S2Q4L3   A0A182P686   Q7PWR6   A0A2J7QCP4   A0A182LMZ6   A0A182V726   A0A182I765   A0A182XDD7   A0A1S4H088   A0A182QGG9   A0A182TXE7   A0A182NGK7   A0A182F5R4   A0A182RUR2   A0A182M8S3   A0A182VU96   A0A182Y943   W5J488   A0A2S2PSK2   A0A182SIY5   J9K150   A0A182JSD7   A0A084VYM4   C4WVK7   A0A336LM22   A0A182JFU3   A0A1Y1MAU0   A0A1B6IH65   A0A1W4WDC3   A0A293LNZ5   A0A0K8SF31   A0A146M9E4   A0A2R5LLH0   A0A0T6BE24   A0A0L7LGN5   A0A1D2N964   A0A026WIZ3   A0A2P8Y7N6   A0A1S3D0R3   A0A1W4WPH9   A0A087TTM2   A0A195FB18  

Pubmed

19121390    22118469    22651552    24495485    22936249    17994087    + More
12626700    10731132    12537572    12537569    15845400    16648357    19032147    22784680    24068965    18057021    25830018    17550304    26354079    25348373    15632085    26108605    24845553    25315136    26483478    17510324    12364791    20966253    25244985    20920257    23761445    24438588    28004739    26823975    26227816    27289101    24508170    30249741    29403074   

EMBL

BABH01004994    ODYU01007034    SOQ49422.1    NWSH01002168    PCG68984.1    PCG68986.1    + More
GDQN01008203    JAT82851.1    GDQN01001304    JAT89750.1    GDQN01002739    JAT88315.1    AGBW02011047    OWR47322.1    GDQN01010712    JAT80342.1    AK403678    BAM19865.1    GAMC01008175    JAB98380.1    CM002910    KMY90238.1    CH480818    EDW51741.1    AY196479    AE014134    AY075225    AAL68092.1    AAO38861.1    CH902620    EDV31554.1    CH933807    EDW11867.1    KRG02957.1    GBXI01005772    JAD08520.1    CH963913    EDW77387.1    CM000157    EDW88995.1    GDHF01023163    JAI29151.1    KQ459601    KPI93894.1    CH916368    EDW03630.1    GAKP01010636    JAC48316.1    OUUW01000006    SPP82481.1    CH954177    EDV58576.1    CP012523    ALC39943.1    CH940654    EDW57597.1    CH379061    EAL33260.2    CH479195    EDW27396.1    AJVK01061659    CVRI01000055    CRL01276.1    CM000361    EDX05030.1    GFDF01001966    JAV12118.1    JRES01001125    KNC25308.1    AJWK01004116    KK852561    KDR21317.1    JXJN01015223    JXUM01114158    KQ565759    KXJ70692.1    CCAG010013161    CH477641    EAT37912.1    CVRI01000049    CRK99140.1    GFDL01010957    JAV24088.1    DS231884    EDS43059.1    GGMS01003451    MBY72654.1    AAAB01008984    EAA14996.4    NEVH01016288    PNF26345.1    APCN01003368    AXCN02002086    AXCM01000336    ADMH02002160    ETN58188.1    GGMR01019764    MBY32383.1    ABLF02032773    ATLV01018379    KE525231    KFB43068.1    AK341566    BAH71927.1    UFQT01000006    SSX17407.1    GEZM01038284    JAV81680.1    GECU01037121    GECU01021975    GECU01021450    GECU01018158    GECU01014831    JAS70585.1    JAS85731.1    JAS86256.1    JAS89548.1    JAS92875.1    GFWV01003715    MAA28445.1    GBRD01014112    JAG51714.1    GDHC01002957    JAQ15672.1    GGLE01006041    MBY10167.1    LJIG01001567    KRT85373.1    JTDY01001163    KOB74688.1    LJIJ01000138    ODN01803.1    KK107182    QOIP01000011    EZA55963.1    RLU17039.1    PYGN01000830    PSN40269.1    KK116685    KFM68461.1    KQ981693    KYN37623.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000001292    UP000000803    UP000007801    + More
UP000009192    UP000007798    UP000002282    UP000053268    UP000001070    UP000268350    UP000192221    UP000008711    UP000092553    UP000008792    UP000001819    UP000008744    UP000092462    UP000183832    UP000000304    UP000037069    UP000092461    UP000027135    UP000095301    UP000078200    UP000092443    UP000092460    UP000069940    UP000249989    UP000092444    UP000008820    UP000091820    UP000002320    UP000095300    UP000075885    UP000007062    UP000235965    UP000075882    UP000075903    UP000075840    UP000076407    UP000075886    UP000075902    UP000075884    UP000069272    UP000075900    UP000075883    UP000075920    UP000076408    UP000000673    UP000075901    UP000007819    UP000075881    UP000030765    UP000075880    UP000192223    UP000037510    UP000094527    UP000053097    UP000279307    UP000245037    UP000079169    UP000054359    UP000078541   

PRIDE

H9J8V5    Q9V3F3   

Pfam

PF02536   mTERF        + More
PF07542   ATP12
PF10996   Beta-Casp
PF16661   Lactamase_B_6
PF07521   RMMBL

Interpro

IPR038538   MTERF_sf        + More
IPR003690   MTERF       
IPR023335   ATP12_ortho_dom_sf       
IPR042272   ATP12_ATP_synth-F1-assembly_N       
IPR011419   ATP12_ATP_synth-F1-assembly       
IPR036866   RibonucZ/Hydroxyglut_hydro       
IPR001279   Metallo-B-lactamas       
IPR022712   Beta_Casp       
IPR041897   INTS11-like_MBL-fold       
IPR011108   RMMBL       

SUPFAM

SSF56281   SSF56281       

Gene 3D

1.25.70.10     1.10.3580.10     3.30.2180.30     3.60.15.10    

CDD

cd16291  INTS11-like_MBL-fold

ProteinModelPortal

H9J8V5   A0A2H1W9A7   A0A2A4JBQ4   A0A2A4JB43   A0A1E1W7M0   A0A1E1WRW3   + More
A0A1E1WMV2   A0A212F0R6   A0A1E1W075   I4DPM5   W8BAU0   A0A0J9R2C6   B4HXG1   Q9V3F3   B3MKK1   B4KEI8   A0A0A1XC43   B4MZB4   B4P0K1   A0A0K8URD3   A0A194PMD2   B4JEB0   A0A034VYE0   A0A3B0KBQ3   A0A1W4UW90   B3N9T1   A0A0M3QU30   B4M8S1   Q29KB5   B4GX69   A0A1B0DHV8   A0A1J1INZ3   B4Q5I6   A0A1L8E036   A0A0L0BZ47   A0A1B0CAM7   A0A067RC32   A0A1I8MZ29   A0A1A9VQC6   A0A1A9X634   A0A1B0BIX3   A0A182H6I7   A0A1B0FKW8   Q16TT0   A0A1J1IHY1   A0A1Q3F9B0   A0A1A9VZM1   B0WBZ9   A0A1I8QBK8   A0A2S2Q4L3   A0A182P686   Q7PWR6   A0A2J7QCP4   A0A182LMZ6   A0A182V726   A0A182I765   A0A182XDD7   A0A1S4H088   A0A182QGG9   A0A182TXE7   A0A182NGK7   A0A182F5R4   A0A182RUR2   A0A182M8S3   A0A182VU96   A0A182Y943   W5J488   A0A2S2PSK2   A0A182SIY5   J9K150   A0A182JSD7   A0A084VYM4   C4WVK7   A0A336LM22   A0A182JFU3   A0A1Y1MAU0   A0A1B6IH65   A0A1W4WDC3   A0A293LNZ5   A0A0K8SF31   A0A146M9E4   A0A2R5LLH0   A0A0T6BE24   A0A0L7LGN5   A0A1D2N964   A0A026WIZ3   A0A2P8Y7N6   A0A1S3D0R3   A0A1W4WPH9   A0A087TTM2   A0A195FB18  

KEGG

101737309    no KO assigned | (RefSeq) uncharacterized LOC101737309

GO

GO:0006355   GO:0003690   GO:0005739   GO:0006393   GO:0003677   GO:0006260   GO:0043461   GO:0016021  

Subcellular location

Mitochondrion  

Length:

240

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01

Exp number, first 60 AAs:

0.00682

Total prob of N-in:

0.09420

outside

1  -  240

 

 

Pi

236.100501

Theta

187.433845

Tajima's D

0.812524

CLR

0.480275

CSRT

0.603469826508675

Interpretation

Possibly Positive selection