Gene

KWMTBOMO01852  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005966

Annotation

PREDICTED:_glucose-6-phosphate_1-dehydrogenase_[Amyelois_transitella]

Location

Bomo_Chr4(-):6421275-6422912      View in EpiBrowser

Full name

Glucose-6-phosphate 1-dehydrogenase      

Alternative Name

Zwischenferment

Location in the cell

Nuclear   Reliability : 4.563

CDS

ATGGAAAACAAAACTGAATTTGATTATCCGCATACATTTGTACTCCTCGGTGCGTCTGGGGACTTGGCTAGAAAAAAAATTTATCCTACTATCTGGTATTTATATCGTGACAACCTTTTGCCGCATAACACCAAGTTTATTGGTTATGCGCGTACTAAGCAATCTGTTTCCGAAGTAAGAGAAAGGTGTCAAAAGTACATGAAAATACGCCCAGGAGAAGAAGAAAAATTAGAGACATTTTGGAATGCCAATAACTATGTAGCGGGATCTTATGATGGAAGAATAGATTATGAGTTTCTTAACCGAATCATCAGTAATCACGAGAAGGGCCCTATTGCAAACAGAATTTTTTATTTAGCTGTACCTCCAACGGTCTTTGAAGATGTTACTGTAAACATAAAAAATGCCTGTACATCTAGCAAAGGTTTTACTCGTGTTATTATTGAGAAACCTTTTGGACGTGATGATGTCAGCTCTGAGAAATTAAGTAATCACTTAGCTGGACTATTTATCGAAGAACAAATCTACAGAATTGATCATTACCTTGGTAAGGAAATGGTCCAAAACTTGATGACCATAAGATTTGCAAATCAAATATTCAATCCAGCTTGGAATAGAGAAAATATAGCATCTGTTCTTATATCATTTAAAGAACCATTTGGAACTGAAGGTAGAGGAGGGTACTTTGATGATTTTGGCATAATAAGAGATGTCATGCAAAATCATTTACTACAAATACTTTCTTTAGTTGCAATGGAAAAGCCTGTCACTCTAAATCCTAATGATATTAGAGATGAAAAAGTGAAAGTTTTGAGGCATATCCAACCAATAGAATTAAAAGACATTCTAATTGGGCAGTATGTCGGTAATCCTGAAGGTCAAGGTGAAGAAAAATTAGGTTATCTGGATGATCCAACTGTGCCTGGAGACTCCTTAACTCCCACATATGCTCTTGCTACTTTGTGGATCAACAATGCAAGATGGCAAGGTGTCCCCTTTATTCTAAGATGTGGAAAAGCTCTGAATGAAAGAAAAGCAGAAGTTCGTGTTCAGTATAAAGACGTTCCAGGTGATATATTTTCTGGACATGCAAAACGAAATGAACTGGTCATAAGAGTCCAGCCAGGAGAAGCCTTATACTTAAAAATGATGTCTAAATCTCCAGGAATGAAATTTGACTTAGTTGAAACAGAACTAGACCTCACTTATAGTGCACGCTACAAAGAAGCCAGTGTACCTGATGCATATGAAAGGCTCATATTGGATGTGTTCACTGGTACCCAAATGCATTTTGTGCGTAGTGATGAATTAAAAGAAGCATGGCGAGTATTTACACCTATTCTCAAAGATCTCGAAGATAATCACATTAAGCCAGTGCCATATGTTTATGGATCTAGAGGTCCTAAAGAAGCTGATGATAAACTGGCTGGATATGATTTCAAGTATTCTGGGTCTTATAAATGGAAAAAACCTATTCATTGA

Protein

MENKTEFDYPHTFVLLGASGDLARKKIYPTIWYLYRDNLLPHNTKFIGYARTKQSVSEVRERCQKYMKIRPGEEEKLETFWNANNYVAGSYDGRIDYEFLNRIISNHEKGPIANRIFYLAVPPTVFEDVTVNIKNACTSSKGFTRVIIEKPFGRDDVSSEKLSNHLAGLFIEEQIYRIDHYLGKEMVQNLMTIRFANQIFNPAWNRENIASVLISFKEPFGTEGRGGYFDDFGIIRDVMQNHLLQILSLVAMEKPVTLNPNDIRDEKVKVLRHIQPIELKDILIGQYVGNPEGQGEEKLGYLDDPTVPGDSLTPTYALATLWINNARWQGVPFILRCGKALNERKAEVRVQYKDVPGDIFSGHAKRNELVIRVQPGEALYLKMMSKSPGMKFDLVETELDLTYSARYKEASVPDAYERLILDVFTGTQMHFVRSDELKEAWRVFTPILKDLEDNHIKPVPYVYGSRGPKEADDKLAGYDFKYSGSYKWKKPIH

Description

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).

Catalytic Activity

D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH

Similarity

Belongs to the glucose-6-phosphate dehydrogenase family.

Keywords

Carbohydrate metabolism   Glucose metabolism   NADP   Oxidoreductase   Alternative splicing   Complete proteome   Phosphoprotein   Polymorphism   Reference proteome  

Feature

chain  Glucose-6-phosphate 1-dehydrogenase
splice variant  In isoform B.

Uniprot

H9J8X4   A0A2A4KAC6   A0A2A4K8R3   A0A2S1ZD90   A0A0L7LHT6   A0A194PLQ8   + More
A0A194R2D9   A0A212F7C7   A0A2H1WSU6   A0A1B1LYT7   D6WKK9   A0A139WIK4   A0A0P6IFH0   A0A164VXB2   A0A067QUT3   A0A1W5YLL4   Q2TLW4   Q2TLW3   A0A0L0CNS3   E9GCL9   A0A0P5FNE9   A0A0P5H692   A0A1I8NG84   A0A1I8NG95   T1PD22   A0A0N8BEX4   V5GYJ0   V5GUY6   B4MSQ8   A0A1Y1KAY8   A0A1I8PHW5   A0A1Y1KEA1   A0A3B0K230   Q29HY8   B4H4R3   A0A0A1XPD3   A0A0A1X5A3   U5EYC9   A0A154P6W4   A0A0R3NZK7   A0A2Z5RDW3   A0A336LTU8   A0A3B0K067   A0A034VUQ7   A0A0K8VCG7   A0A0P5R8T6   A0A0P5XSB4   P41571   A0A182QEB5   A0A0K8UEE3   W8B8T2   A0A084WAQ4   A0A1Q3FEU9   A0A2J7QYS6   A0A2P8Y838   W8ATS3   A0A1D2NGI6   A0A1B6D356   B0WHG8   B7FNK0   A0A2J7QYR4   A0A182FUC7   A0A182J8K4   A0A182P1B9   W5JU82   A0A182WXU3   A0A182NDA4   X2JEF0   A0A182VKK6   A0A182KV52   H2KMF3   A0A0L7QRK3   A0A2M4AU73   A0A226F0P3   B3MQC4   P12646   A0A182Y6T9   A0A0P9A5S1   A0A182WFS6   Q0IEL8   A0A195BFM2   A0A2M4AVT8   P12646-2   A0A182I5W4   A0A1Y9GJ71   A0A182GD35   U4UL56   Q1WKS9   A0A1Y9GIQ5   A0A0U2VLP2   A0A182MVE5   A0A310S6H7   N6TQG0   A0A232F7X7   A0A1J1HGQ8   B3NVS1   Q1WKS8   B4JJG9   A0A158NQV6   A0A0Q5TGW9  

EC Number

1.1.1.49

Pubmed

19121390    26227816    26354079    22118469    27392023    18362917    + More
19820115    24845553    16469065    26108605    21292972    25315136    17994087    28004739    15632085    25830018    26760975    25348373    8269100    24495485    24438588    29403074    27289101    20920257    23761445    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    20966253    12364791    14747013    17210077    2838391    8913747    12537569    18327897    25244985    17510324    26483478    23537049    16387879    28648823    21347285   

EMBL

BABH01004904    NWSH01000026    PCG80602.1    PCG80601.1    MF374345    AWK22771.1    + More
JTDY01001136    KOB74771.1    KQ459601    KPI93928.1    KQ460855    KPJ11953.1    AGBW02009889    OWR49636.1    ODYU01010805    SOQ56140.1    KU664393    ANS59103.1    KQ971342    EFA03565.2    KYB27681.1    GDIQ01005290    JAN89447.1    LRGB01001361    KZS12751.1    KK852908    KDR13948.1    KX147677    ARI45081.1    AY845218    AAX45784.1    AAX45785.1    JRES01000127    KNC33970.1    GL732539    EFX82581.1    GDIQ01254445    JAJ97279.1    GDIQ01254444    JAJ97280.1    KA646005    AFP60634.1    GDIQ01184467    JAK67258.1    GALX01002988    JAB65478.1    GALX01002989    JAB65477.1    CH963851    EDW75147.2    GEZM01087461    JAV58672.1    GEZM01087462    JAV58671.1    OUUW01000011    SPP86722.1    CH379064    EAL31619.2    CH479209    EDW32675.1    GBXI01001869    JAD12423.1    GBXI01007778    JAD06514.1    GANO01002078    JAB57793.1    KQ434827    KZC07617.1    KRT06404.1    FX983730    BAX07229.1    UFQT01000107    SSX20059.1    SPP86723.1    GAKP01011886    JAC47066.1    GDHF01020138    GDHF01016889    GDHF01015777    GDHF01014827    GDHF01005170    JAI32176.1    JAI35425.1    JAI36537.1    JAI37487.1    JAI47144.1    GDIQ01104232    JAL47494.1    GDIP01068237    JAM35478.1    S67872    AXCN02001783    GDHF01034038    GDHF01027373    JAI18276.1    JAI24941.1    GAMC01016964    GAMC01016962    JAB89591.1    ATLV01022235    KE525330    KFB47298.1    GFDL01008969    JAV26076.1    NEVH01009083    PNF33729.1    PYGN01000816    PSN40423.1    GAMC01016963    JAB89592.1    LJIJ01000056    ODN04076.1    GEDC01017184    JAS20114.1    DS231936    EDS27746.1    BT053690    ACK77607.1    PNF33728.1    ADMH02000433    ETN66505.1    AE014298    AHN59926.1    AAAB01008848    EAL41092.3    KQ414775    KOC61257.1    GGFK01011034    MBW44355.1    LNIX01000001    OXA62506.1    CH902621    EDV44550.1    M26674    M26673    U42738    U42739    U42740    U42741    U42742    U42743    U42744    U42745    U42746    U42747    U42748    U42749    U43165    U43166    U43167    U44721    U45985    AY052079    KPU81635.1    CH477586    EAT38627.1    KQ976500    KYM83009.1    GGFK01011511    MBW44832.1    APCN01003532    JXUM01055187    JXUM01055188    KQ561855    KXJ77310.1    KB632399    ERL94809.1    DQ167797    ABB29562.1    KT279821    ALS35388.1    AXCM01006507    KQ767803    OAD53294.1    APGK01024793    KB740562    ENN80288.1    NNAY01000733    OXU26765.1    CVRI01000003    CRK87059.1    CH954180    EDV46736.1    DQ167798    ABB29563.1    CH916370    EDV99721.1    ADTU01023604    ADTU01023605    KQS30103.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053268    UP000053240    UP000007151    + More
UP000007266    UP000076858    UP000027135    UP000037069    UP000000305    UP000095301    UP000007798    UP000095300    UP000268350    UP000001819    UP000008744    UP000076502    UP000075886    UP000030765    UP000235965    UP000245037    UP000094527    UP000002320    UP000069272    UP000075880    UP000075885    UP000000673    UP000076407    UP000075884    UP000000803    UP000075903    UP000075882    UP000007062    UP000053825    UP000198287    UP000007801    UP000076408    UP000075920    UP000008820    UP000078540    UP000075840    UP000069940    UP000249989    UP000030742    UP000075883    UP000019118    UP000215335    UP000183832    UP000008711    UP000001070    UP000005205   

PRIDE

H9J8X4    P41571    X2JEF0    P12646   

Pfam

PF00479   G6PD_N        + More
PF02781   G6PD_C
PF11952   XTBD
PF01585   G-patch
PF01424   R3H

Interpro

IPR022675   G6P_DH_C        + More
IPR019796   G6P_DH_AS       
IPR022674   G6P_DH_NAD-bd       
IPR036291   NAD(P)-bd_dom_sf       
IPR001282   G6P_DH       
IPR000859   CUB_dom       
IPR021859   XTBD       
IPR001374   R3H_dom       
IPR000467   G_patch_dom       
IPR036867   R3H_dom_sf       

SUPFAM

SSF51735   SSF51735        + More
SSF82708   SSF82708       

Gene 3D

3.30.1370.50    

ProteinModelPortal

H9J8X4   A0A2A4KAC6   A0A2A4K8R3   A0A2S1ZD90   A0A0L7LHT6   A0A194PLQ8   + More
A0A194R2D9   A0A212F7C7   A0A2H1WSU6   A0A1B1LYT7   D6WKK9   A0A139WIK4   A0A0P6IFH0   A0A164VXB2   A0A067QUT3   A0A1W5YLL4   Q2TLW4   Q2TLW3   A0A0L0CNS3   E9GCL9   A0A0P5FNE9   A0A0P5H692   A0A1I8NG84   A0A1I8NG95   T1PD22   A0A0N8BEX4   V5GYJ0   V5GUY6   B4MSQ8   A0A1Y1KAY8   A0A1I8PHW5   A0A1Y1KEA1   A0A3B0K230   Q29HY8   B4H4R3   A0A0A1XPD3   A0A0A1X5A3   U5EYC9   A0A154P6W4   A0A0R3NZK7   A0A2Z5RDW3   A0A336LTU8   A0A3B0K067   A0A034VUQ7   A0A0K8VCG7   A0A0P5R8T6   A0A0P5XSB4   P41571   A0A182QEB5   A0A0K8UEE3   W8B8T2   A0A084WAQ4   A0A1Q3FEU9   A0A2J7QYS6   A0A2P8Y838   W8ATS3   A0A1D2NGI6   A0A1B6D356   B0WHG8   B7FNK0   A0A2J7QYR4   A0A182FUC7   A0A182J8K4   A0A182P1B9   W5JU82   A0A182WXU3   A0A182NDA4   X2JEF0   A0A182VKK6   A0A182KV52   H2KMF3   A0A0L7QRK3   A0A2M4AU73   A0A226F0P3   B3MQC4   P12646   A0A182Y6T9   A0A0P9A5S1   A0A182WFS6   Q0IEL8   A0A195BFM2   A0A2M4AVT8   P12646-2   A0A182I5W4   A0A1Y9GJ71   A0A182GD35   U4UL56   Q1WKS9   A0A1Y9GIQ5   A0A0U2VLP2   A0A182MVE5   A0A310S6H7   N6TQG0   A0A232F7X7   A0A1J1HGQ8   B3NVS1   Q1WKS8   B4JJG9   A0A158NQV6   A0A0Q5TGW9  

PDB

5UKW     E-value=0,     Score=1718

KEGG

101746394    K00036 glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363] | (RefSeq) glucose-6-phosphate 1-

PATHWAY

00030    Pentose phosphate pathway - Bombyx mori (domestic silkworm)
00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0004345   GO:0050661   GO:0006098   GO:0006006   GO:0003676   GO:0006739   GO:0051156   GO:0016021   GO:0003824   GO:0005524   GO:0006259   GO:0006355   GO:0006397   GO:0004651   GO:0005634   GO:0055114   GO:0016614  

PANTHER

PTHR23429  

Length:

493

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03123

Exp number, first 60 AAs:

0.02941

Total prob of N-in:

0.00463

outside

1  -  493

 

 

Pi

14.553743

Theta

37.726901

Tajima's D

-1.596032

CLR

0.646933

CSRT

0.0501474926253687

Interpretation

Uncertain