Gene

KWMTBOMO01844  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006180

Annotation

dipeptidyl-peptidase_[Danaus_plexippus]

Location

Bomo_Chr4(+):6077566-6102545      View in EpiBrowser

Full name

Venom dipeptidyl peptidase 4      

Alternative Name

Venom dipeptidyl peptidase IV
Allergen C

Location in the cell

PlasmaMembrane   Reliability : 2.862

CDS

ATGGAGCAAGCTGTCTTTCTGCTCATGGGTTTGATATGCCACACGCAATCGTCGGCATATATTCAGGGGCAAAAAATATTTTCATTAGAAGAAATAGTACCTCTGATGGCCGAGTTTTATCCTGAAAGAATGTCCGTGCAATGGATATCAGATACAACGTATATATACAAAGATCCTGGTGGGATAAAGAAATACGACGCCTCCACGGATAAAGTCGTCACGATTCTCAATGAAATCGAATTGTATAATTTGAGCAATTATACGCTGTCTACGTTTTCTGAAGACGGAAAATACGTGCTGCTAACGAAAAATAGAAGAAAGATATACAGATATTCATTCCTTGCGGAGTATTCCGTGCTAGATATTGAAAAGAGATTAATCTACAAGCTAAGCGATTATCCGCTACAAGTCGTGGTTTGGGGTATTGGGAAATCTGTAGCTTACGTTCAAGATAACAATGTATACTACGTACCTGACATTACCCAAGCAGATTATGTTGGTGTCCTCACCACAGGAGGAGTGCCCGGCGAAGTATATTTCGGTGCTACTGACTGGATTTACGAAGAGGAGATATTTAATGCAGCAGAAGCATTATGGTTTTCTCCGGGAGGTACTTACCTCGCTGTTGCTTCCTTCAATGATACTAACGTTGAATCGGCCGTATTCCCTTATTACGGAGATCCTGGCAACATAAACAACCAGTACCCACAAATGGTGCAGTTTAAATATCCTAAGGTAGGTCGGACAAATCCGAGAGTGGGTTTACGCGTCTACAAACTGGACGAGCCCAATAGTGAGCCTTGGAGTATACCTGCACCGGTCGATGTGATTGGACTCGACAACATCCTCGGTCGTGTAAACTGGGCTTCAGACCAAAATCTAATTGTTCTCTGGCTGAACAGACGACAAAGTATTAGTATCCTGATCAATTGTGACTTGCAAAAAGACAAATGTAGCATAGTGAAAGAACACACGGAACCAAACGGTTGGATCGACATTAACGACCCAATTTTCGACAAAACTGGAACTAAAATGGTGGAGATACAGCCTTTGTATCATGCTGAACGTCGTTTCCCGCACGCCGCAAGGGTCGATTTCAATACTTTAACAACTGAAGATCTGAGTCCCGGTAACTCTACGGTTTTGGAAATTGTTGGCTGGAATCAAGATACCAATACAGTGTATTACATAGTAGCTCCTGGAAATTTACCATGGCTAAGGCAAATATGGGCAACTTCCGGCGGTGTGGTTAGATGTATCTCGTGCAAAGAACCGACTTGTAGGCACGTGTCGGCCATGTTTTCACCGGGAGCCAACTACGCCATAGTAACGTGTAGCGCCTGCAACATCCCTCCTAAAATATACCTGTATGATGCCAAGAAAGAGACATTCAAATTGATAAAAGACAACAAAAAACTCATTGATACCCTACAAATGTACCAACTACCTCTTACCCATTTCATCGCAATGTCAATAGGAAACGAAGTGAATGCAAACGTGAAACTCATTCTTCCAGCTGGGATAAAGCAAGGAGAACAGTATGCAATGGTGGTTAGAGTGTACGCTGGTCCCGGGACAACCCGAGTTCGCGATAACTACGATCTAGAATATTACAACTCGTACCTGGCTACAAACAGGAGTATAATAGTGGCCTCGATCGACGTACGAGGTTCAGGAGTGATGGGCGTGGAAGCCATGCATGCAGTCAACAGGGCTTTGGGAACTGTCGAAATATCCGATACTTTGGATACAATCAAGAGCTTAACTAGTTTGTATTCTTTCATCGACCCTGACCGGATAGGAGTGTGGGGCTGGAGTTACGGTGGCTATGCCACCACAATGATGTTGATTCAGGATCAGCGGAACATTGTGAAATGTGGGGCCGCTGTCGCCCCCGTTACCTCATGGCTCTATTACGATTCAATATACACGGAACGTTATATGGATACGCCTCAAGCGAACCCTTTGGGCTACGAACGATCTGACCTAACTAATCTAGCTGAAGGATTGCGAGGACGCAAATATTTGCTGGTTCACGGGAGCGGTGACGACAATGTGCATTACCAGCACAGCATGCAACTCGCCAAGCGATTGCAGCATAGCGATATTGCCTTCGAGCAAATGAGCTATACGGACGAGAATCATTCCTTGATGGGAGTGAGTCGACATTTCTACCACACGTTGGATCGCTTCTGGTCAGAGTGCTTCAAATTATAA

Protein

MEQAVFLLMGLICHTQSSAYIQGQKIFSLEEIVPLMAEFYPERMSVQWISDTTYIYKDPGGIKKYDASTDKVVTILNEIELYNLSNYTLSTFSEDGKYVLLTKNRRKIYRYSFLAEYSVLDIEKRLIYKLSDYPLQVVVWGIGKSVAYVQDNNVYYVPDITQADYVGVLTTGGVPGEVYFGATDWIYEEEIFNAAEALWFSPGGTYLAVASFNDTNVESAVFPYYGDPGNINNQYPQMVQFKYPKVGRTNPRVGLRVYKLDEPNSEPWSIPAPVDVIGLDNILGRVNWASDQNLIVLWLNRRQSISILINCDLQKDKCSIVKEHTEPNGWIDINDPIFDKTGTKMVEIQPLYHAERRFPHAARVDFNTLTTEDLSPGNSTVLEIVGWNQDTNTVYYIVAPGNLPWLRQIWATSGGVVRCISCKEPTCRHVSAMFSPGANYAIVTCSACNIPPKIYLYDAKKETFKLIKDNKKLIDTLQMYQLPLTHFIAMSIGNEVNANVKLILPAGIKQGEQYAMVVRVYAGPGTTRVRDNYDLEYYNSYLATNRSIIVASIDVRGSGVMGVEAMHAVNRALGTVEISDTLDTIKSLTSLYSFIDPDRIGVWGWSYGGYATTMMLIQDQRNIVKCGAAVAPVTSWLYYDSIYTERYMDTPQANPLGYERSDLTNLAEGLRGRKYLLVHGSGDDNVHYQHSMQLAKRLQHSDIAFEQMSYTDENHSLMGVSRHFYHTLDRFWSECFKL

Description

Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. May process venom proteins into their active forms and/or modulate the chemotactic activity of immune cells after the insect sting.
Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. May process promelittin into its active form and/or modulate the chemotactic activity of immune cells after the insect sting.

Catalytic Activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Similarity

Belongs to the peptidase S9B family.
Belongs to the peptidase S9B family. DPPIV subfamily.

Keywords

Allergen   Aminopeptidase   Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Protease   Secreted   Signal   Complete proteome   Reference proteome  

Feature

chain  Venom dipeptidyl peptidase 4

Uniprot

H9J9I7   A0A437BSW5   A0A2A4JD71   A0A2H1W553   A0A194PS22   A0A212F613   + More
A0A0L7LI97   A0A194R3X6   A0A3L8DR73   E2AF09   A0A026WEB2   A0A2J7Q7T3   Q16EL4   F4WLY9   A0A1Q3FKC6   Q1DH03   B0WE34   A0A158N9M0   B1A4F7   A4UA14   A0A182JFB8   A0A023EV00   A0A348G603   V9PBD6   A0A182HC95   A0A084W3B1   A0A0P6JXV0   A0A1B6DL67   A0A212F622   A0A1B6EG93   A0A0P6A850   A0A182PPN8   A0A195BBI8   A0A164UG38   A0A0N8BLW1   A0A1B6FT22   A0A1B6HM76   A0A1B6ICV7   A0A182YMC6   A0A0P6E1N2   A0A0P5YLG7   E9FZG6   A0A0P4W4J7   A0A0V0G4N0   A0A023EXQ5   E2B8W2   A0A069DX38   A0A195FVS0   A0A195DE08   A0A023EZT7   A0A182NFA4   A0A1L8DPB2   A0A1S4H707   Q7PSF9   A0A182URD4   A0A182UKA9   A0A1B6DL51   A0A1L8DPL6   A0A146KL11   A0A310SPV5   A0A0A9XS95   A0A195C860   A0A182X7R6   A0A182LP15   H9J9I6   W5JGF1   A0A023EVT1   A0A336M465   A0A232ETT6   A0A182HN75   A0A0K8SCK7   D6WJ57   A0A0P5M9I8   A0A088A1D0   A0A023EVG2   B2D0J4   K7JAQ2   A0A1B6GG80   U5EWK1   A0A1Y1KXZ8   A0A1B0CY21   A0A2M4A0T9   A0A2M4A0V0   A0A2M4A0X2   A0A1W4U9C0   A0A0M4EGC5   A0A1L8EGB2   A0A1L8EFV7   Q16RL5   A0A2M4BE95   A0A182FBI4   A0A2M4BE23   A0A3R7LWT5   A0A182Y621   A0A0R1E3Q4   A0A1L8EG47   A0A0R3P7Z3   B3N577   A0A0J9RVJ9   A0A1L8EG80  

EC Number

3.4.14.5

Pubmed

19121390    26354079    22118469    26227816    30249741    20798317    + More
24508170    17510324    21719571    21347285    20348419    17298553    24945155    26483478    24438588    25244985    21292972    27129103    26334808    25474469    12364791    26823975    25401762    20966253    20920257    23761445    28648823    18362917    19820115    17073008    20075255    28004739    17994087    17550304    15632085    22936249   

EMBL

BABH01004877    RSAL01000014    RVE53279.1    NWSH01001848    PCG69921.1    ODYU01006093    + More
SOQ47634.1    KQ459601    KPI93935.1    AGBW02010086    OWR49177.1    JTDY01001074    KOB74961.1    KQ460855    KPJ11945.1    QOIP01000005    RLU22782.1    GL438984    EFN67964.1    KK107293    EZA53369.1    NEVH01017440    PNF24641.1    CH478666    EAT32671.1    GL888217    EGI64633.1    GFDL01007083    JAV27962.1    CH899921    EAT32433.1    DS231904    EDS45210.1    ADTU01001408    EU420987    DQ661743    ABG57265.1    GAPW01000318    JAC13280.1    FX985542    BBF97876.1    KC282404    AGX25161.1    JXUM01126919    KQ567125    KXJ69612.1    ATLV01019900    KE525284    KFB44705.1    GDIQ01004025    JAN90712.1    GEDC01010864    JAS26434.1    OWR49178.1    GEDC01000404    JAS36894.1    GDIP01033893    JAM69822.1    KQ976528    KYM81921.1    LRGB01001581    KZS11328.1    GDIQ01164971    GDIQ01067404    JAK86754.1    GECZ01016434    JAS53335.1    GECU01031918    JAS75788.1    GECU01022932    JAS84774.1    GDIQ01070450    JAN24287.1    GDIP01056093    JAM47622.1    GL732528    EFX87272.1    GDKW01000335    JAI56260.1    GECL01003131    JAP02993.1    GAPW01000319    JAC13279.1    GL446390    EFN87861.1    GBGD01000523    JAC88366.1    KQ981264    KYN43954.1    KQ980989    KYN10654.1    GBBI01003949    JAC14763.1    GFDF01005805    JAV08279.1    AAAB01008834    EAA05700.5    GEDC01010885    GEDC01001959    JAS26413.1    JAS35339.1    GFDF01005804    JAV08280.1    GDHC01021358    JAP97270.1    KQ760343    OAD60840.1    GBHO01021085    GBHO01021084    GBHO01021083    GBHO01015182    JAG22519.1    JAG22520.1    JAG22521.1    JAG28422.1    KQ978220    KYM96356.1    BABH01004876    ADMH02001286    ETN63166.1    GAPW01000407    JAC13191.1    UFQS01000538    UFQT01000538    SSX04703.1    SSX25066.1    NNAY01002223    OXU21775.1    APCN01001877    GBRD01015321    JAG50505.1    KQ971343    EFA04427.1    GDIQ01182517    JAK69208.1    GAPW01000606    JAC12992.1    EU564832    AAZX01013515    GECZ01013355    GECZ01008349    JAS56414.1    JAS61420.1    GANO01000531    JAB59340.1    GEZM01070829    JAV66262.1    AJWK01035258    AJWK01035259    GGFK01001058    MBW34379.1    GGFK01001051    MBW34372.1    GGFK01001049    MBW34370.1    CP012523    ALC39730.1    GFDG01001186    JAV17613.1    GFDG01001189    JAV17610.1    CH477704    EAT37053.1    GGFJ01002221    MBW51362.1    GGFJ01002151    MBW51292.1    QCYY01002917    ROT66607.1    CM000159    KRK01895.1    GFDG01001183    JAV17616.1    CH379069    KRT07558.1    CH954177    EDV57907.1    CM002912    KMY99602.1    GFDG01001190    JAV17609.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053268    UP000007151    UP000037510    + More
UP000053240    UP000279307    UP000000311    UP000053097    UP000235965    UP000008820    UP000007755    UP000002320    UP000005205    UP000075880    UP000069940    UP000249989    UP000030765    UP000075885    UP000078540    UP000076858    UP000076408    UP000000305    UP000008237    UP000078541    UP000078492    UP000075884    UP000007062    UP000075903    UP000075902    UP000078542    UP000076407    UP000075882    UP000000673    UP000215335    UP000075840    UP000007266    UP000005203    UP000002358    UP000092461    UP000192221    UP000092553    UP000069272    UP000283509    UP000002282    UP000001819    UP000008711   

PRIDE

H9J9I7    H9J9I6    B2D0J4   

Pfam

PF01593   Amino_oxidase        + More
PF00930   DPPIV_N
PF00326   Peptidase_S9
PF10247   Romo1

Interpro

IPR038554   Peptidase_S9B_N_sf        + More
IPR036188   FAD/NAD-bd_sf       
IPR029058   AB_hydrolase       
IPR001375   Peptidase_S9       
IPR002937   Amino_oxidase       
IPR002469   Peptidase_S9B_N       
IPR018450   Romo1/Mgr2       

SUPFAM

SSF53474   SSF53474        + More
SSF51905   SSF51905       

Gene 3D

2.140.10.30     3.40.50.1820     3.50.50.60    

ProteinModelPortal

H9J9I7   A0A437BSW5   A0A2A4JD71   A0A2H1W553   A0A194PS22   A0A212F613   + More
A0A0L7LI97   A0A194R3X6   A0A3L8DR73   E2AF09   A0A026WEB2   A0A2J7Q7T3   Q16EL4   F4WLY9   A0A1Q3FKC6   Q1DH03   B0WE34   A0A158N9M0   B1A4F7   A4UA14   A0A182JFB8   A0A023EV00   A0A348G603   V9PBD6   A0A182HC95   A0A084W3B1   A0A0P6JXV0   A0A1B6DL67   A0A212F622   A0A1B6EG93   A0A0P6A850   A0A182PPN8   A0A195BBI8   A0A164UG38   A0A0N8BLW1   A0A1B6FT22   A0A1B6HM76   A0A1B6ICV7   A0A182YMC6   A0A0P6E1N2   A0A0P5YLG7   E9FZG6   A0A0P4W4J7   A0A0V0G4N0   A0A023EXQ5   E2B8W2   A0A069DX38   A0A195FVS0   A0A195DE08   A0A023EZT7   A0A182NFA4   A0A1L8DPB2   A0A1S4H707   Q7PSF9   A0A182URD4   A0A182UKA9   A0A1B6DL51   A0A1L8DPL6   A0A146KL11   A0A310SPV5   A0A0A9XS95   A0A195C860   A0A182X7R6   A0A182LP15   H9J9I6   W5JGF1   A0A023EVT1   A0A336M465   A0A232ETT6   A0A182HN75   A0A0K8SCK7   D6WJ57   A0A0P5M9I8   A0A088A1D0   A0A023EVG2   B2D0J4   K7JAQ2   A0A1B6GG80   U5EWK1   A0A1Y1KXZ8   A0A1B0CY21   A0A2M4A0T9   A0A2M4A0V0   A0A2M4A0X2   A0A1W4U9C0   A0A0M4EGC5   A0A1L8EGB2   A0A1L8EFV7   Q16RL5   A0A2M4BE95   A0A182FBI4   A0A2M4BE23   A0A3R7LWT5   A0A182Y621   A0A0R1E3Q4   A0A1L8EG47   A0A0R3P7Z3   B3N577   A0A0J9RVJ9   A0A1L8EG80  

PDB

4KR0     E-value=1.74902e-102,     Score=954

KEGG

101745874    K01278 dipeptidyl-peptidase 4 [EC:3.4.14.5] | (RefSeq) venom dipeptidyl peptidase 4-like

GO

GO:0008236   GO:0016491   GO:0004177   GO:0005576   GO:0016021   GO:0008239   GO:0006508   GO:0004672   GO:0005524   GO:0006357   GO:0032784   GO:0006355   GO:0006397   GO:0004651   GO:0005634  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.975971

 

 

Length:

738

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.10109

Exp number, first 60 AAs:

0.02591

Total prob of N-in:

0.00147

outside

1  -  738

 

 

Pi

257.881386

Theta

181.963068

Tajima's D

1.150692

CLR

0.625463

CSRT

0.699915004249787

Interpretation

Uncertain