Gene

KWMTBOMO01843  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006179

Annotation

PREDICTED:_uncharacterized_protein_LOC106127448_[Papilio_xuthus]

Location

Bomo_Chr4(+):6051876-6071830      View in EpiBrowser

Full name

Venom dipeptidyl peptidase 4      

Alternative Name

Venom dipeptidyl peptidase IV
Allergen C

Location in the cell

PlasmaMembrane   Reliability : 3.712

CDS

ATGGTCGGGATGTGGTGGTGCGTGTTAGCCGCTGTGGTTACAACTGCATCAAGCCAGAGCTCCTTCACTCTGGAGGAGTTCGTTACAGGACAATTTACGCAACGAGGTTTTACCGGCGTCTGGATTTCTGACACAGAATTCACGTACACAATTGCTGGTGAACCTGGTATTCACATGTTCAATGTACAAACTTTGACAAGTAGTGTACTTGTTGCTGGCGATCTTATGGCATTTTTGAATACTAACAATCCAATTCTGTCAGCTGATAGAGCCTACATTCTGGCTCCTAGTGAAGTTCAACAAGTTTACCGGTATTCAACGACAGCCAAGTTCGCCCTGTACAATATAGCTACAGCGACATCCGTCGACATCGCGAATGGCCAACGTCTCCAGTTATGCATCTTCGGCGGTGGACACTCCCTCGCCTATGTGCTTAACAACAACGTTTATTACCTACCCGAGAACAGGAATCAAGCTATTCAACTTACGAATGACGGTATCCCCGGAGTCATATACAATGGACACACCGATTGGGTGTACGAAGAGGACGTTATGTATACCGGACAAGCGACTTGGTTCTCTCGGGACGGTTCATATCTTGCGTTTGCAACGTTCAACGATACCGAAGTCGAAAGCTACTCGTATTACTACTTCGTGGACAAGTCCAACCCTGACGATTTATATCCCGAGCTTGTTGATCTTAAGTATCCGAAGGTCGGTCGTACCAATCCCACAGCCGTGCTGCGCGTAGTTAACTTGAGAGCTTTGGTTGAAAACAACAACTTTAATTTCATCACCGTTGAGCCCCCGGAGGAGGTGACTGCAGACCACATCCTCGGCGGAGTGGTGTGGCCAACCGACAACGAAATCGCGGTCCATTGGCTTAACAGACGTCAGAACAAAACTGTGTTGCGAATTTGTAATGTGGTCACATGGGTTTGTGAGAATGAGCATCGTGAGCAACCAAATGGCTGGGTACCGATCGCGTTGCCCCGCTTCAGTAGCGGAGGCGACTTCTACGTGTCTACCCGGTGGTCCTTCCCGCAAGCCGATGGTAACATCTGGCAGCACCTGTACGTCAGCATGAGGGTCGCCGGACAGATCATATCCAGTTCGATAACACCTGGAGCCTTCACCGTCAATAACTTCGTCGGAATGGATGAACAGAATCTAGCTTACTACTACACTCGCACGGTGACAGACATGCCGTGGCGGACCCAGTTGCACGTTGCGGGGGCCAATATAGGATGTCTGAGCTGCGATCTGGTGTTGCCGGACGGGGGACCCTGTACGTGGGCCACGGCCACGGCCAGCCGCGGCGGATCCTACCTCACCGTAACCTGCTCGTCGCCCAACGAGCCCTCTGCTACTTACATCATCAATCCGAGGACCCGTGAGACGTTATACGTGTGGGAGGACAACGCCATAGTCCGTCAGCGCTTGATCGGGAAGACTCGTCCGGGCAGCATCATCACGACGGTGCCACTTGAGAACGGGTTCCCGGCCCCCGTGAGGCTACATCTGCCGCCTGGACTGGACGTTAACGACCACACTACTAAATATCCCATGGTCTTCTATGTGTATTCAGGCCCCAACACTAACACGGTCTTTGACACGTTCACTGTAGGTTATCATTCGTATTTGACAACGAGTCGTAACATGATCTACATGGTAGCCGATGGCCGCGGCTCTGGTCTCAAAGGACAAGACATTCTGTATTCCCTCAACAATGCCCTCGGAACTGTCGAGATTGAAGATCATTTTGTCATACTGAAAGAAGTGTTGAATCGGTACGGGTTCATCGACCGCGACCGGATTGGCATGTGGGGCCACAGTTACGGCGGGTACGCGACGCTCTTAACGCTCGTCCACGACAATGACCATATGTTCCAGTGCGGTGTTTCAGGAGCCCCTGTTACTTCATGGCTGTATTATAATACAATGTACACGGAACGCTACATGGGACTTCCGACTCCAGAAGACAATTTGTCTGGATACGAAGCCGGTGACGTCACGCTCTTAGTTGACAAACTGGCCGGTCATGACTTCTACATCATGCACGGAAACGCCGACGATAATGTGCACTATCAAAACGCAGCGAAGCTTATGAGAGCGCTGCAAGAGAAGGACATACCTTTTGAGCAGATGTCATACCCAGATGAAGCTCACAGTTTGGCGGGAGTGAATATGCATCGGTACAACGCTATGGATAGATACTGGAATAGGTGTTTGCGTATGTAG

Protein

MVGMWWCVLAAVVTTASSQSSFTLEEFVTGQFTQRGFTGVWISDTEFTYTIAGEPGIHMFNVQTLTSSVLVAGDLMAFLNTNNPILSADRAYILAPSEVQQVYRYSTTAKFALYNIATATSVDIANGQRLQLCIFGGGHSLAYVLNNNVYYLPENRNQAIQLTNDGIPGVIYNGHTDWVYEEDVMYTGQATWFSRDGSYLAFATFNDTEVESYSYYYFVDKSNPDDLYPELVDLKYPKVGRTNPTAVLRVVNLRALVENNNFNFITVEPPEEVTADHILGGVVWPTDNEIAVHWLNRRQNKTVLRICNVVTWVCENEHREQPNGWVPIALPRFSSGGDFYVSTRWSFPQADGNIWQHLYVSMRVAGQIISSSITPGAFTVNNFVGMDEQNLAYYYTRTVTDMPWRTQLHVAGANIGCLSCDLVLPDGGPCTWATATASRGGSYLTVTCSSPNEPSATYIINPRTRETLYVWEDNAIVRQRLIGKTRPGSIITTVPLENGFPAPVRLHLPPGLDVNDHTTKYPMVFYVYSGPNTNTVFDTFTVGYHSYLTTSRNMIYMVADGRGSGLKGQDILYSLNNALGTVEIEDHFVILKEVLNRYGFIDRDRIGMWGHSYGGYATLLTLVHDNDHMFQCGVSGAPVTSWLYYNTMYTERYMGLPTPEDNLSGYEAGDVTLLVDKLAGHDFYIMHGNADDNVHYQNAAKLMRALQEKDIPFEQMSYPDEAHSLAGVNMHRYNAMDRYWNRCLRM

Description

Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. May process venom proteins into their active forms and/or modulate the chemotactic activity of immune cells after the insect sting.
Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. May process promelittin into its active form and/or modulate the chemotactic activity of immune cells after the insect sting.

Catalytic Activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Similarity

Belongs to the peptidase S9B family.
Belongs to the peptidase S9B family. DPPIV subfamily.

Keywords

Allergen   Aminopeptidase   Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Protease   Secreted   Signal   Complete proteome   Reference proteome  

Feature

chain  Venom dipeptidyl peptidase 4

Uniprot

H9J9I6   A0A194PS22   A0A2A4JET8   A0A212F622   A0A194R348   A0A3S2TRM9   + More
A0A1Q3FKC6   B0WE34   A0A0L0BW21   A0A2J7Q7T3   A0A023EV00   Q1DH03   T1PEM9   A0A1I8Q015   A0A182HC95   A0A1L8EG80   Q16EL4   A0A1I8MXV9   A0A1L8EFV7   A0A1L8EG47   A0A1L8EGB2   A0A023EXQ5   W5JGF1   A0A182NFA4   A0A182F0R0   A0A182PPN8   A0A084W3B1   B4LRW2   A0A1L8DPL6   A0A1L8DPB2   A0A182QCR1   A0A182U3L5   A0A182JFB8   A0A182V2X2   A0A182WTX2   A0A1B0BLT2   B4JAY5   A0A023EVT1   B3MMM8   A0A182JT27   A0A182HUI8   A0A182M8A5   A0A182L190   A0A182RCP9   V9PBD6   B4KLA1   A0A182W6X9   A0A034W0Q2   A0A182H0T1   A0A023EVG2   Q7PNC7   A0A1S4GY71   B4MV18   A0A0A1WPL5   A0A1Y1KCG5   Q29PK4   B3N577   A0A182YMC6   B4P023   A0A1L8E898   A0A1J1HWS4   A0A0J9QWC7   E2AF09   A0A0R3NWQ8   A0A0J9QWG3   Q9VMM2   W8B5H7   A0A1W4WE52   A0A437BSW5   D6WJ57   A0A336M465   F4WLY9   A0A0M4EGC5   A0A1W4UN81   B4G6V4   B4Q429   B1A4F7   A0A088A1D0   A0A0P6A850   A0A164UG38   B2D0J4   A0A3L8DR73   A0A0P6JXV0   A0A182G5V4   A0A158N9M0   A0A2A4JD71   A0A0P5YLG7   A0A0P6E1N2   A0A026WEB2   A0A0N8BLW1   E9FZG6   A4UA14   A0A0P4W4J7   A0A0V0G4N0   A0A069DX38   A0A212F613   A0A023EZT7   A0A0K2UJ39   A0A348G604  

EC Number

3.4.14.5

Pubmed

19121390    26354079    22118469    26108605    24945155    17510324    + More
26483478    25315136    20920257    23761445    24438588    17994087    20966253    25348373    12364791    25830018    28004739    15632085    25244985    17550304    22936249    20798317    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    24495485    18362917    19820115    21719571    20348419    17073008    30249741    21347285    24508170    21292972    17298553    27129103    26334808    25474469   

EMBL

BABH01004876    BABH01004877    KQ459601    KPI93935.1    NWSH01001848    PCG69922.1    + More
AGBW02010086    OWR49178.1    KQ460855    KPJ11944.1    RSAL01000014    RVE53280.1    GFDL01007083    JAV27962.1    DS231904    EDS45210.1    JRES01001249    KNC24245.1    NEVH01017440    PNF24641.1    GAPW01000318    JAC13280.1    CH899921    EAT32433.1    KA647196    AFP61825.1    JXUM01126919    KQ567125    KXJ69612.1    GFDG01001190    JAV17609.1    CH478666    EAT32671.1    GFDG01001189    JAV17610.1    GFDG01001183    JAV17616.1    GFDG01001186    JAV17613.1    GAPW01000319    JAC13279.1    ADMH02001286    ETN63166.1    ATLV01019900    KE525284    KFB44705.1    CH940649    EDW63638.2    GFDF01005804    JAV08280.1    GFDF01005805    JAV08279.1    AXCN02000822    JXJN01016550    CH916368    EDW02855.1    GAPW01000407    JAC13191.1    CH902620    EDV31919.2    APCN01002463    AXCM01003124    KC282404    AGX25161.1    CH933807    EDW11762.2    GAKP01009776    JAC49176.1    JXUM01101898    KQ564683    KXJ71904.1    GAPW01000606    JAC12992.1    AAAB01008964    EAA12398.5    CH963857    EDW76363.2    GBXI01013303    JAD00989.1    GEZM01088452    JAV58188.1    CH379058    EAL34289.2    CH954177    EDV57907.1    CM000157    EDW88888.1    GFDG01003915    JAV14884.1    CVRI01000020    CRK90577.1    CM002910    KMY88377.1    GL438984    EFN67964.1    KRT03360.1    KMY88378.1    AE014134    AAF52291.2    AHN54153.1    GAMC01018014    JAB88541.1    RVE53279.1    KQ971343    EFA04427.1    UFQS01000538    UFQT01000538    SSX04703.1    SSX25066.1    GL888217    EGI64633.1    CP012523    ALC39730.1    CH479180    EDW28273.1    CM000361    EDX03862.1    EU420987    GDIP01033893    JAM69822.1    LRGB01001581    KZS11328.1    EU564832    QOIP01000005    RLU22782.1    GDIQ01004025    JAN90712.1    JXUM01146652    KQ570216    KXJ68421.1    ADTU01001408    PCG69921.1    GDIP01056093    JAM47622.1    GDIQ01070450    JAN24287.1    KK107293    EZA53369.1    GDIQ01164971    GDIQ01067404    JAK86754.1    GL732528    EFX87272.1    DQ661743    ABG57265.1    GDKW01000335    JAI56260.1    GECL01003131    JAP02993.1    GBGD01000523    JAC88366.1    OWR49177.1    GBBI01003949    JAC14763.1    HACA01020704    CDW38065.1    FX985543    BBF97877.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000007151    UP000053240    UP000283053    + More
UP000002320    UP000037069    UP000235965    UP000008820    UP000095300    UP000069940    UP000249989    UP000095301    UP000000673    UP000075884    UP000069272    UP000075885    UP000030765    UP000008792    UP000075886    UP000075902    UP000075880    UP000075903    UP000076407    UP000092460    UP000001070    UP000007801    UP000075881    UP000075840    UP000075883    UP000075882    UP000075900    UP000009192    UP000075920    UP000007062    UP000007798    UP000001819    UP000008711    UP000076408    UP000002282    UP000183832    UP000000311    UP000000803    UP000192221    UP000007266    UP000007755    UP000092553    UP000008744    UP000000304    UP000005203    UP000076858    UP000279307    UP000005205    UP000053097    UP000000305   

PRIDE

H9J9I6    Q9VMM2    B2D0J4   

Pfam

PF00326   Peptidase_S9        + More
PF00930   DPPIV_N
PF16294   RSB_motif
PF01593   Amino_oxidase

Interpro

IPR038554   Peptidase_S9B_N_sf        + More
IPR001375   Peptidase_S9       
IPR029058   AB_hydrolase       
IPR002469   Peptidase_S9B_N       
IPR035979   RBD_domain_sf       
IPR032552   RSB_motif       
IPR034257   Acinus_RRM       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR000504   RRM_dom       
IPR010916   TonB_box_CS       
IPR036188   FAD/NAD-bd_sf       
IPR002937   Amino_oxidase       

SUPFAM

SSF53474   SSF53474        + More
SSF54928   SSF54928       
SSF51905   SSF51905       

Gene 3D

2.140.10.30     3.40.50.1820     3.30.70.330     3.50.50.60    

CDD

cd12432  RRM_ACINU

ProteinModelPortal

H9J9I6   A0A194PS22   A0A2A4JET8   A0A212F622   A0A194R348   A0A3S2TRM9   + More
A0A1Q3FKC6   B0WE34   A0A0L0BW21   A0A2J7Q7T3   A0A023EV00   Q1DH03   T1PEM9   A0A1I8Q015   A0A182HC95   A0A1L8EG80   Q16EL4   A0A1I8MXV9   A0A1L8EFV7   A0A1L8EG47   A0A1L8EGB2   A0A023EXQ5   W5JGF1   A0A182NFA4   A0A182F0R0   A0A182PPN8   A0A084W3B1   B4LRW2   A0A1L8DPL6   A0A1L8DPB2   A0A182QCR1   A0A182U3L5   A0A182JFB8   A0A182V2X2   A0A182WTX2   A0A1B0BLT2   B4JAY5   A0A023EVT1   B3MMM8   A0A182JT27   A0A182HUI8   A0A182M8A5   A0A182L190   A0A182RCP9   V9PBD6   B4KLA1   A0A182W6X9   A0A034W0Q2   A0A182H0T1   A0A023EVG2   Q7PNC7   A0A1S4GY71   B4MV18   A0A0A1WPL5   A0A1Y1KCG5   Q29PK4   B3N577   A0A182YMC6   B4P023   A0A1L8E898   A0A1J1HWS4   A0A0J9QWC7   E2AF09   A0A0R3NWQ8   A0A0J9QWG3   Q9VMM2   W8B5H7   A0A1W4WE52   A0A437BSW5   D6WJ57   A0A336M465   F4WLY9   A0A0M4EGC5   A0A1W4UN81   B4G6V4   B4Q429   B1A4F7   A0A088A1D0   A0A0P6A850   A0A164UG38   B2D0J4   A0A3L8DR73   A0A0P6JXV0   A0A182G5V4   A0A158N9M0   A0A2A4JD71   A0A0P5YLG7   A0A0P6E1N2   A0A026WEB2   A0A0N8BLW1   E9FZG6   A4UA14   A0A0P4W4J7   A0A0V0G4N0   A0A069DX38   A0A212F613   A0A023EZT7   A0A0K2UJ39   A0A348G604  

PDB

5LLS     E-value=3.43058e-96,     Score=900

KEGG

NA   

GO

GO:0008236   GO:0003723   GO:0008239   GO:0004177   GO:0005576   GO:0016021   GO:0016491   GO:0006508   GO:0004672   GO:0005524   GO:0006357   GO:0032784   GO:0006355   GO:0006397   GO:0004651   GO:0005634  

Subcellular location

Secreted  

SignalP

Position:   1 - 18,         Likelihood:  0.982915

 

 

Length:

746

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.2136

Exp number, first 60 AAs:

0.967929999999999

Total prob of N-in:

0.04903

outside

1  -  746

 

 

Pi

21.795211

Theta

177.948827

Tajima's D

1.161291

CLR

0.417736

CSRT

0.702864856757162

Interpretation

Uncertain