Gene

KWMTBOMO01831

Pre Gene Modal

BGIBMGA006175

Annotation

PREDICTED:_cysteine_protease_ATG4B_isoform_X1_[Amyelois_transitella]

Location

Bomo_Chr4(+):5856406-5862929      View in EpiBrowser

Full name

Cysteine protease      

Location in the cell

PlasmaMembrane   Reliability : 2.862

CDS

ATGGATGCTGTATTTGATATGTGTTATCTATCGGGAGCGGATGGTAATAATGTTGAACCTAACGATATTCCTAAAACAAAGGAAAGTATCTGGGTACTGGGGAAAAAATACAGTGCTATACAAGATTTGGATCGTATTAGAAGAGATATCACATCAATAATATGGTGTACGTACAGAAAAGGCTTTGTACCAATTGGTGATGAAGGTTTGACTTCTGATAAAGGATGGGGCTGTATGTTACGATGTGGACAGATGGTATTAGGTGTTGCTCTTGTCAGAGTACACTTATCTGTTGACTGGGTATGGTCACCAGAAACAAGGGATCCAACTTATTTAAAGATCATACAAAGGTTTGAAGAAAGGAAACAAGCACCTTATTCTATCCATCAAGTGGCATTGATGGGTGCCTCTGAAGGAAAAGAAGTTGGCCAGTGGTTTGGACCTAATACAATCGCTCAAGTTTTAAAAAAACTGACTGTGTATGACAAGTGGAGTTCATTAGCAATTCATGTTGCTTTAGATAATACTGTTGTCAAGGAAGATATCTTGCAACAATGTTTAGTTAACAATGATAGAGGTGACACTTCTTCAGCGCCTGACGGTGTGGTGTCAGACTGGATGCCTCTATTGTTAATAGTTCCACTGCGGCTCGGACTTAGCGAAATTAATCCTGTCTACGTAAATGGATTAAAGATGTGCTTTCAATGTCCGCAATCGATTGGAGTCATAGGAGGCAAACCAAATCAAGCTCTGTACCTGATTGGTTGTGTTGAAGATGAAGTTATTTATTTAGATCCCCATACAACTCAACGGTCTGGATTAGTTGAGAGTAAGATTACTGACGATCAAAAGGAAATGGACTGTACATATCATTGTAAATATGCATCTCGAATACCTATCCTCTCCATGGATCCTTCAGTGGCGGTGTGTTTCCTTTGTCGTACTAGAGGTGATTTTTATGAGCTGTGTGAAACTATAGAACAGGAGTTTATGAAAGAAAGCCAACCATTGTTCGAAATATGCGAGAAACGACCGTCGCATTGGGGACCGAACACAACCGACATTGACTTTCAAAGCACTTCACTCTTTACGGAGTTTGAAGACGTGGACAGACAGTTTGACGACTCGGATGAAGAATTCGAAATTCTTTGA

Protein

MDAVFDMCYLSGADGNNVEPNDIPKTKESIWVLGKKYSAIQDLDRIRRDITSIIWCTYRKGFVPIGDEGLTSDKGWGCMLRCGQMVLGVALVRVHLSVDWVWSPETRDPTYLKIIQRFEERKQAPYSIHQVALMGASEGKEVGQWFGPNTIAQVLKKLTVYDKWSSLAIHVALDNTVVKEDILQQCLVNNDRGDTSSAPDGVVSDWMPLLLIVPLRLGLSEINPVYVNGLKMCFQCPQSIGVIGGKPNQALYLIGCVEDEVIYLDPHTTQRSGLVESKITDDQKEMDCTYHCKYASRIPILSMDPSVAVCFLCRTRGDFYELCETIEQEFMKESQPLFEICEKRPSHWGPNTTDIDFQSTSLFTEFEDVDRQFDDSDEEFEIL

Description

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy.

Similarity

Belongs to the peptidase C54 family.

Uniprot

A0A2H1WGE5   A0A159R7N1   A0A2A4K8L4   A0A1E1WT56   H9J9I2   A0A212F652   + More
S4P9P2   A0A3S2P626   A0A194PLS9   A0A194R2B8   J9XNW6   A0A0L7LPB5   V5GLN2   A0A026VU50   A0A158NSR0   F4W881   A0A088AQN4   A0A2A3EH25   A0A2J7R7L8   A0A1Y1KRW7   A0A154NZ05   E9IN42   A0A2P8Y7Y6   R4UVS3   A0A067RC43   A0A3Q8CBR7   A0A151HYK3   A0A0L7RK46   A0A232FI29   A0A195EXN7   D6WLQ9   A0A0T6B1D7   K7J1F7   A0A195CCQ8   A0A151X004   A0A195DVJ0   A0A310SC79   A0A224XRW1   A0A0V0G5M3   A0A0P4VM70   T1IGH4   E0VF88   A0A1W4X9U8   A0A023FCF6   A0A034WIN4   A0A1B0CGC5   A0A1L8E5C2   A0A0K8VVT0   A0A1S4FFU1   A0A023ER91   Q172X8   J3JY33   R4WEH3   U5EYR5   A0A1B6JLH8   A0A0A1XAV9   A0A1B6D9Q3   A0A182P3B6   A0A0K8TP81   A0A182WHI0   A0A1I8NR00   A0A2M4AFN9   A0A182Y5K3   A0A182RRJ1   A0A034WL87   W5JPX3   A0A182JNG8   T1DQA7   W8BJI3   A0A2J7R7J4   A0A2M3Z9L0   W8AWV9   A0A0K8VJG6   A0A1Y9G8C5   A0A0K8VWZ2   A0A1A9Z9B8   A0A182MES6   A0A1B0G8W7   J9JMI9   A0A2M4BRL4   A0A2H8TMH8   A0A1A9Y4Y3   A0A0A1XK67   A0A1I8NR05   A0A0L0CG96   A0A1I8MX07   A0A084VL65   A0A2S2NWI0   A0A182QE77   B4KET6   A0A0M5IW67   B4JQF1   N6U3T3   A0A182ISQ7   B4MDT0   U4TZN4   A0A1A9UY80   A0A1I8MX00   A0A182VKH2   A0A1Q3FI28  

EC Number

3.4.22.-

Pubmed

19121390    22118469    23622113    26354079    26227816    24508170    + More
30249741    21347285    21719571    28004739    21282665    29403074    24845553    28648823    18362917    19820115    20075255    27129103    20566863    25474469    25348373    24945155    26483478    17510324    22516182    23691247    25830018    26369729    25244985    20920257    23761445    24495485    26108605    25315136    24438588    17994087    23537049   

EMBL

ODYU01008500    SOQ52155.1    KR060080    AML76276.1    NWSH01000024    PCG80625.1    + More
GDQN01000874    JAT90180.1    BABH01004860    AGBW02010086    OWR49189.1    GAIX01003679    JAA88881.1    RSAL01000014    RVE53292.1    KQ459601    KPI93948.1    KQ460855    KPJ11933.1    JX313130    AFS31124.1    JTDY01000422    KOB77265.1    GALX01003497    JAB64969.1    KK107965    QOIP01000001    EZA47041.1    RLU26943.1    ADTU01025108    ADTU01025109    GL887898    EGI69576.1    KZ288253    PBC31018.1    NEVH01006731    PNF36806.1    GEZM01081458    JAV61627.1    KQ434777    KZC04248.1    GL764272    EFZ18025.1    PYGN01000830    PSN40264.1    KC571847    AGM32346.1    KK852561    KDR21327.1    KY053221    ATX63056.1    KQ976723    KYM76676.1    KQ414578    KOC71204.1    NNAY01000193    OXU30109.1    KQ981948    KYN32644.1    KQ971343    EFA03418.1    LJIG01016254    KRT81154.1    KQ978023    KYM98006.1    KQ982624    KYQ53686.1    KQ980322    KYN16579.1    KQ769580    OAD52853.1    GFTR01005707    JAW10719.1    GECL01002779    JAP03345.1    GDKW01000383    JAI56212.1    ACPB03001109    DS235107    EEB12044.1    GBBI01000264    JAC18448.1    GAKP01004413    JAC54539.1    AJWK01011025    GFDF01000134    JAV13950.1    GDHF01009327    GDHF01004339    JAI42987.1    JAI47975.1    JXUM01010373    JXUM01010374    GAPW01001913    KQ560305    JAC11685.1    KXJ83145.1    CH477429    EAT41101.1    BT128157    AEE63118.1    AK418407    BAN21584.1    GANO01000175    JAB59696.1    GECU01007585    JAT00122.1    GBXI01005863    JAD08429.1    GEDC01014926    GEDC01011093    JAS22372.1    JAS26205.1    GDAI01001898    JAI15705.1    GGFK01006211    MBW39532.1    GAKP01004414    JAC54538.1    ADMH02000447    ETN66442.1    GAMD01002644    JAA98946.1    GAMC01013129    JAB93426.1    PNF36802.1    GGFM01004478    MBW25229.1    GAMC01013130    JAB93425.1    GDHF01013285    JAI39029.1    GDHF01008922    JAI43392.1    AXCM01001953    CCAG010006989    ABLF02016209    ABLF02016212    GGFJ01006277    MBW55418.1    GFXV01003385    MBW15190.1    GBXI01002975    JAD11317.1    JRES01000438    KNC31242.1    ATLV01014417    KE524970    KFB38709.1    GGMR01008921    MBY21540.1    AXCN02000748    CH933807    EDW12986.2    CP012523    ALC38736.1    CH916372    EDV99131.1    APGK01040727    KB740984    ENN76250.1    CH940661    EDW71341.1    KB631904    ERL87079.1    GFDL01007873    JAV27172.1   

Proteomes

UP000218220    UP000005204    UP000007151    UP000283053    UP000053268    UP000053240    + More
UP000037510    UP000053097    UP000279307    UP000005205    UP000007755    UP000005203    UP000242457    UP000235965    UP000076502    UP000245037    UP000027135    UP000078540    UP000053825    UP000215335    UP000078541    UP000007266    UP000002358    UP000078542    UP000075809    UP000078492    UP000015103    UP000009046    UP000192223    UP000092461    UP000069940    UP000249989    UP000008820    UP000075885    UP000075920    UP000095300    UP000076408    UP000075900    UP000000673    UP000075881    UP000069272    UP000092445    UP000075883    UP000092444    UP000007819    UP000092443    UP000037069    UP000095301    UP000030765    UP000075886    UP000009192    UP000092553    UP000001070    UP000019118    UP000075880    UP000008792    UP000030742    UP000078200    UP000075903   

PRIDE

H9J9I2   

Pfam

PF03416   Peptidase_C54        + More
PF07690   MFS_1

Interpro

IPR005078   Peptidase_C54        + More
IPR032916   ATG4B_met       
IPR038765   Papain-like_cys_pep_sf       
IPR033474   ATG4A       
IPR020846   MFS_dom       
IPR011701   MFS       
IPR036259   MFS_trans_sf       
IPR000961   AGC-kinase_C       

SUPFAM

SSF54001   SSF54001        + More
SSF103473   SSF103473       

CDD

cd06174  MFS

ProteinModelPortal

A0A2H1WGE5   A0A159R7N1   A0A2A4K8L4   A0A1E1WT56   H9J9I2   A0A212F652   + More
S4P9P2   A0A3S2P626   A0A194PLS9   A0A194R2B8   J9XNW6   A0A0L7LPB5   V5GLN2   A0A026VU50   A0A158NSR0   F4W881   A0A088AQN4   A0A2A3EH25   A0A2J7R7L8   A0A1Y1KRW7   A0A154NZ05   E9IN42   A0A2P8Y7Y6   R4UVS3   A0A067RC43   A0A3Q8CBR7   A0A151HYK3   A0A0L7RK46   A0A232FI29   A0A195EXN7   D6WLQ9   A0A0T6B1D7   K7J1F7   A0A195CCQ8   A0A151X004   A0A195DVJ0   A0A310SC79   A0A224XRW1   A0A0V0G5M3   A0A0P4VM70   T1IGH4   E0VF88   A0A1W4X9U8   A0A023FCF6   A0A034WIN4   A0A1B0CGC5   A0A1L8E5C2   A0A0K8VVT0   A0A1S4FFU1   A0A023ER91   Q172X8   J3JY33   R4WEH3   U5EYR5   A0A1B6JLH8   A0A0A1XAV9   A0A1B6D9Q3   A0A182P3B6   A0A0K8TP81   A0A182WHI0   A0A1I8NR00   A0A2M4AFN9   A0A182Y5K3   A0A182RRJ1   A0A034WL87   W5JPX3   A0A182JNG8   T1DQA7   W8BJI3   A0A2J7R7J4   A0A2M3Z9L0   W8AWV9   A0A0K8VJG6   A0A1Y9G8C5   A0A0K8VWZ2   A0A1A9Z9B8   A0A182MES6   A0A1B0G8W7   J9JMI9   A0A2M4BRL4   A0A2H8TMH8   A0A1A9Y4Y3   A0A0A1XK67   A0A1I8NR05   A0A0L0CG96   A0A1I8MX07   A0A084VL65   A0A2S2NWI0   A0A182QE77   B4KET6   A0A0M5IW67   B4JQF1   N6U3T3   A0A182ISQ7   B4MDT0   U4TZN4   A0A1A9UY80   A0A1I8MX00   A0A182VKH2   A0A1Q3FI28  

PDB

2CY7     E-value=7.34389e-89,     Score=834

KEGG

101745143    K08342 cysteine protease ATG4 [EC:3.4.22.-] | (RefSeq) cysteine protease ATG4B

PATHWAY

04136    Autophagy - other - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)

GO

GO:0005737   GO:0006914   GO:0015031   GO:0004197   GO:0008234   GO:0000045   GO:0051697   GO:0055085   GO:0016021   GO:0008233   GO:0010506   GO:0004674   GO:0005524  

PANTHER

PTHR22624   PTHR22624:SF39   PTHR22624:SF35  

Subcellular location

Cytoplasm  

Length:

383

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01315

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00625

outside

1  -  383

 

 

Pi

294.200956

Theta

202.828938

Tajima's D

0.325938

CLR

0.000001

CSRT

0.468626568671566

Interpretation

Uncertain