Gene

KWMTBOMO01816

Annotation

endonuclease-reverse_transcriptase_[Bombyx_mori]

Location

Bomo_Chr4(-):5553633-5556161      View in EpiBrowser

Full name

Sodium/hydrogen exchanger       + More
Guanylate cyclase      

Location in the cell

Extracellular   Reliability : 3.681

CDS

ATGTATGAGGACATTTCCAGAGCCATGCATAGCTTTAAAACTCACATCACCATTGTCATGGGGGATTTCAACGCCAGACTGGGTAAACGGTCCGAGGGGGAGCTGCGAGTGGGACCATTTGGATTTGGGAATCGAAATCATCGGGGAAACTTACTTGCCGGTTTCATGGAGAAAGAAGAATTATTTATGATGAACTCTTTCTTCCAAAAACGGAATCACAGGAAGTGGACCTGGATGAGCCCCAATGGTGCCATCAAAAATGAGATAGATTTCATTATGTCGACAAAAAGGCAAATATTCAATGATGTCTCTGTGATCAATATGGTTAAAACAGGAAGTGATCATCGGATGGTAAGAGGCACATTGAACCTCAATATTAAGCTTGAGAGATTCCGACTGATAAGGTCTACGCTCCGTCCAGCACCAGCTCAGATCCAAAGTTCTGGGCACTTTCAGCTCGAACTTCAAAACCGCTTCGATTGCCTAGGAGGCTCCGTGGACGATTACAATGACGGGTTTGTGAATGCTGTCCATACGATTGGTTCCAAGTTTTTTGGAGCCCGTCGTACAAACAGAACCAAAAAACTCTCAGACCCTACTCTCAAACTCATGGAAGAACGTCGCGGAATGATTTTGCAGTCTTCAGAAGATTCGTTTAAATATCGGTCTCTCAACAGACAGATCTCAAAGTCTCTTAAATTTGATCTACGCCGTTTTAATACTGAGCGTATTAAAGAGGCTATAGAACGAAACAAAGGCTCCAAGGTGTTCGCGAGAGATTTGTCTCTTGGGAAAAGCCAGTTGACAAGACTGAAGATCGATGATGGCAGGATCATTTCGTCCAAGCCTGAGCTTTTGAGAGAGGTCGAGAAGTTCTATGGACAGCTATACACATCTACTCGACAACCCGTGGAATATCTAGCAAAGGATCCAAGAGCTAGATTAGTCCGACACTATACCGAAGATATCCCCGACATCAGCCTGTGCGAGATTAGAATGGCTCTCAAGCAACTTAAGGACAACAAGGCACCGGGCGAGGATGGAATTACCGTCGAACTTCTGAAGGCGGGTGGAAAACCAGTCCTTCGGGCCCTACAAAATTTATTTAATTCCGTCATTCTCGATGGGAATGTGGCCCTGGCATGGACCAGAAGTGTGGTGGTACTGTTCTTCAAAAAGGGTGACAATACTCGTTTGAAGAATTATAGACCCATCTCACTTCTGAGTCATGTCTATAAGTTGTTCTCGAGAGTTATTACGAACCGTCTCGCGCGCAGGTTTGATGACTTCCAGCCACCCGAACAAGCCGGTTTCCGAAAAGGCTATAGTACCGTAGACCACATTCATACGTTGCGGCAGATTGTACAAAAGACCGAGGAATATAACCTGCCGCTTTGCTTAGCATTTGTGGACTACGAGAAAGCCTTTGATTCGATTGAAACCTGGGCCGTGTTACAGTCTCTCCAACGGTGCCAAATTGATTATCGGTATATCGAAGTGTTGAGGTGTTTGTATGAAAACGCTACTATGTCAGTCCGAGTACAGGACCGGGCTTCAGAACCTATCCTTCTGCAGCGGGGCGTGAGGCAAGGAGATGTTATTTCTCCGAAACTATTTACCGCTGCGCTGGAAGATGTTTTCAAAGTTCTGGACTGGAAAGGACTAGGCATCAACATAAACGGCGAGTACATAACTCACCTTCGGTTCGCCGATGATATTGTGATTATGGCCGAGACCATGGAGGACCTCAGCACAATGCTCAAAGACCTCAGTAGGGCTTCTATCCGAGTGGGTCTAAATATGAACAAAGAAAAAACAAAAATTATGTTGAATGCTCATGTAGCGCCCACTCCAGTAAAGATCGGAGGCTCTACGCTCGAAGTTGTTGACGAGTATATTTACCTGGGACACACTGTCCAGCTAGGTAAGTCCAACTTCGAAAAAGAGGTCAACCGTCGAATCCAGCTCGGATGGGCAGCGTTCGGAAAGCTACGTAAAATCTTCTCATCACAAATACCACAGTGTCTCAAGACGAAAGTCTTTGACCAGTGTGTGTTGCCAGTGATGACATATGGCACTGAGACGTGGTCGCTCACAATGGGCCTTATGAGAAGGCTCAAGGTCACCCAAAGAGCAATGGAGAGGGCTATGCTCGGAGTTTCCCTGCGAGACCAAATCAGAAATGAGGAGATTCGCAGGAAAACCATGGTAACCGACATAGCCCAAAGGATTGCGACACTGAAGTGGCAGTGGGCAGGACACATTGCTCGCGGAACAGATGGCCGTTGGGGCCAGAAGGTTCTTGAGTGGCGACCGCGTACTGGGAGACGTAGCGTGGGTAGGCCTCCCACAAGGTGGGCCGACGACCTATTAAGGTTCGCGGGGATCCGCTGGATGCAGGCAGCGCAGGACCGGTCTTTGTGGCGAGGCTTGGGGGAGGCCTATGTCCAGCAGTGGACGTCCATGGGCTGA

Protein

MYEDISRAMHSFKTHITIVMGDFNARLGKRSEGELRVGPFGFGNRNHRGNLLAGFMEKEELFMMNSFFQKRNHRKWTWMSPNGAIKNEIDFIMSTKRQIFNDVSVINMVKTGSDHRMVRGTLNLNIKLERFRLIRSTLRPAPAQIQSSGHFQLELQNRFDCLGGSVDDYNDGFVNAVHTIGSKFFGARRTNRTKKLSDPTLKLMEERRGMILQSSEDSFKYRSLNRQISKSLKFDLRRFNTERIKEAIERNKGSKVFARDLSLGKSQLTRLKIDDGRIISSKPELLREVEKFYGQLYTSTRQPVEYLAKDPRARLVRHYTEDIPDISLCEIRMALKQLKDNKAPGEDGITVELLKAGGKPVLRALQNLFNSVILDGNVALAWTRSVVVLFFKKGDNTRLKNYRPISLLSHVYKLFSRVITNRLARRFDDFQPPEQAGFRKGYSTVDHIHTLRQIVQKTEEYNLPLCLAFVDYEKAFDSIETWAVLQSLQRCQIDYRYIEVLRCLYENATMSVRVQDRASEPILLQRGVRQGDVISPKLFTAALEDVFKVLDWKGLGININGEYITHLRFADDIVIMAETMEDLSTMLKDLSRASIRVGLNMNKEKTKIMLNAHVAPTPVKIGGSTLEVVDEYIYLGHTVQLGKSNFEKEVNRRIQLGWAAFGKLRKIFSSQIPQCLKTKVFDQCVLPVMTYGTETWSLTMGLMRRLKVTQRAMERAMLGVSLRDQIRNEEIRRKTMVTDIAQRIATLKWQWAGHIARGTDGRWGQKVLEWRPRTGRRSVGRPPTRWADDLLRFAGIRWMQAAQDRSLWRGLGEAYVQQWTSMG

Catalytic Activity

GTP = 3',5'-cyclic GMP + diphosphate

Similarity

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

Feature

chain  Sodium/hydrogen exchanger

Uniprot

D7F164   D7F158   D7F159   D7F157   D7F160   D7F165   + More
D7F166   A0A2G8JFM9   A0A2W1BZV1   A0A2H1VS24   A0A0K0FAW8   A0A023EXV2   D7F176   A0A016SG46   A0A016TK11   A0A016W4R1   D7F179   D7F177   A0A016T7J7   A0A016V419   A0A016S1D2   A0A0N5C0B1   A0A016RUR3   W4YXJ0   A0A016RV73   A0A016RRX8   A0A069DX96   A0A023EWU8   D7F178   A0A016WPY4   A0A016WCB8   A0A016ULU9   A0A0P4VWD0   A0A016SLV8   A0A016U784   A0A069DZM5   A0A016S403   E3NC15   A0A016WA79   A0A016S795   E3MH09   A0A016WEQ1   A0A016S5B2   A0A016VVN3   A0A016THC6   A0A2H2JFN0   A0A016SGC3   A0A016SX67   A0A2H1WF27   A0A016RY50   A0A2H2JKG1   A0A2H2JCS8   A0A2H2ITH9   A0A2H2JKX8   K7IG36   A0A016UN79   K7I2A2   K7I2A1   K7ICT2   K7IG35   K7ICT1   K7IBZ6   A0A016U3L3   A0A016U352   K7IBZ5   K7I2A3   A0A016SVA2   A0A2H2J8I4   A0A016V6A2   A0A2H2J2F1   A0A016SW37   A0A1S3HCU5   A0A016T9D3   A0A016WE57   K7H0Q8   A0A016T9A5   A0A016T590   K7HDM3   K7H0R0   K7H0Q9   K7HDM2   A0A016SKW2   A0A016VEC1   A0A016VCD9   A0A016SPR9   A0A016TNL1   A0A016TNH6   A0A016TNS4   A0A016TMT8   A0A016T4C4   A0A016T5Z1   A0A016VCU3   A0A016WVQ3  

EC Number

4.6.1.2

Pubmed

20470440    29023486    28756777    25474469    25730766    26334808    + More
27129103   

EMBL

FJ265549    ADI61817.1    FJ265543    ADI61811.1    FJ265544    ADI61812.1    + More
FJ265542    ADI61810.1    FJ265545    ADI61813.1    FJ265550    ADI61818.1    FJ265551    ADI61819.1    MRZV01002136    PIK34564.1    KZ149907    PZC78256.1    ODYU01004088    SOQ43598.1    GBBI01004876    JAC13836.1    FJ265561    ADI61829.1    JARK01001565    EYB89683.1    JARK01001676    JARK01001446    JARK01001433    EYB83199.1    EYC01126.1    EYC02928.1    JARK01001337    EYC34625.1    FJ265564    ADI61832.1    FJ265562    ADI61830.1    JARK01001736    JARK01001462    JARK01001379    JARK01001338    EYB80775.1    EYB98943.1    EYC13646.1    EYC33347.1    JARK01001354    EYC21986.1    JARK01001655    EYB84321.1    JARK01001711    EYB81734.1    AAGJ04050748    JARK01001700    JARK01001393    EYB82228.1    EYC10181.1    JARK01001730    EYB81048.1    GBGD01000453    JAC88436.1    GBBI01004877    JAC13835.1    FJ265563    ADI61831.1    JARK01000173    EYC41342.1    JARK01000388    EYC37469.1    JARK01001370    EYC16150.1    GDKW01001596    JAI54999.1    JARK01001543    EYB91356.1    JARK01001389    EYC11015.1    GBGD01000380    JAC88509.1    JARK01001639    EYB85201.1    DS268591    EFO92565.1    JARK01000460    EYC36749.1    JARK01001621    EYB86109.1    DS268444    EFP01729.1    JARK01000347    EYC38051.1    JARK01001626    EYB85833.1    JARK01001340    EYC30828.1    JARK01001438    EYC02111.1    JARK01001568    EYB89432.1    JARK01001500    JARK01001343    EYB95040.1    EYC28825.1    ODYU01008249    SOQ51673.1    JARK01001683    EYB82909.1    EYC16376.1    JARK01001395    EYC09730.1    EYC09729.1    JARK01001505    EYB94618.1    JARK01001353    EYC22263.1    EYB94617.1    JARK01001459    EYB99276.1    JARK01000343    EYC38099.1    EYB99275.1    JARK01001473    EYB97806.1    EYB91353.1    JARK01001348    EYC25048.1    EYC25050.1    JARK01001531    EYB92324.1    JARK01001424    EYC04316.1    EYC04315.1    EYC04317.1    EYC04314.1    JARK01001475    EYB97550.1    JARK01001470    JARK01000204    EYB98082.1    EYC40602.1    EYC25046.1    JARK01000077    EYC43894.1   

Proteomes

UP000230750    UP000035680    UP000024635    UP000046392    UP000007110    UP000008281    + More
UP000005237    UP000085678   

PRIDE

D7F164    D7F158    D7F159    D7F157    D7F160    D7F165    + More
D7F166    D7F176    D7F179    D7F177    D7F178   

Pfam

PF00078   RVT_1        + More
PF14529   Exo_endo_phos_2
PF03372   Exo_endo_phos
PF10328   7TM_GPCR_Srx
PF00999   Na_H_Exchanger
PF00069   Pkinase
PF00201   UDPGT
PF00211   Guanylate_cyc
PF07714   Pkinase_Tyr
PF01094   ANF_receptor

Interpro

IPR000477   RT_dom        + More
IPR036691   Endo/exonu/phosph_ase_sf       
IPR005135   Endo/exonuclease/phosphatase       
IPR001507   ZP_dom       
IPR016186   C-type_lectin-like/link_sf       
IPR016187   CTDL_fold       
IPR019430   7TM_GPCR_serpentine_rcpt_Srx       
IPR017452   GPCR_Rhodpsn_7TM       
IPR018422   Cation/H_exchanger_CPA1       
IPR006153   Cation/H_exchanger       
IPR004709   NaH_exchanger       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR017441   Protein_kinase_ATP_BS       
IPR000719   Prot_kinase_dom       
IPR002213   UDP_glucos_trans       
IPR029052   Metallo-depent_PP-like       
IPR001828   ANF_lig-bd_rcpt       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR001170   ANPR/GUC       
IPR028082   Peripla_BP_I       
IPR001054   A/G_cyclase       
IPR029787   Nucleotide_cyclase       

SUPFAM

SSF56219   SSF56219        + More
SSF56436   SSF56436       
SSF56112   SSF56112       
SSF53822   SSF53822       
SSF55073   SSF55073       

Gene 3D

3.60.10.10     3.10.100.10     3.60.21.10     3.30.70.1230    

ProteinModelPortal

D7F164   D7F158   D7F159   D7F157   D7F160   D7F165   + More
D7F166   A0A2G8JFM9   A0A2W1BZV1   A0A2H1VS24   A0A0K0FAW8   A0A023EXV2   D7F176   A0A016SG46   A0A016TK11   A0A016W4R1   D7F179   D7F177   A0A016T7J7   A0A016V419   A0A016S1D2   A0A0N5C0B1   A0A016RUR3   W4YXJ0   A0A016RV73   A0A016RRX8   A0A069DX96   A0A023EWU8   D7F178   A0A016WPY4   A0A016WCB8   A0A016ULU9   A0A0P4VWD0   A0A016SLV8   A0A016U784   A0A069DZM5   A0A016S403   E3NC15   A0A016WA79   A0A016S795   E3MH09   A0A016WEQ1   A0A016S5B2   A0A016VVN3   A0A016THC6   A0A2H2JFN0   A0A016SGC3   A0A016SX67   A0A2H1WF27   A0A016RY50   A0A2H2JKG1   A0A2H2JCS8   A0A2H2ITH9   A0A2H2JKX8   K7IG36   A0A016UN79   K7I2A2   K7I2A1   K7ICT2   K7IG35   K7ICT1   K7IBZ6   A0A016U3L3   A0A016U352   K7IBZ5   K7I2A3   A0A016SVA2   A0A2H2J8I4   A0A016V6A2   A0A2H2J2F1   A0A016SW37   A0A1S3HCU5   A0A016T9D3   A0A016WE57   K7H0Q8   A0A016T9A5   A0A016T590   K7HDM3   K7H0R0   K7H0Q9   K7HDM2   A0A016SKW2   A0A016VEC1   A0A016VCD9   A0A016SPR9   A0A016TNL1   A0A016TNH6   A0A016TNS4   A0A016TMT8   A0A016T4C4   A0A016T5Z1   A0A016VCU3   A0A016WVQ3  

PDB

6AR3     E-value=2.71331e-06,     Score=125

KEGG

100158253    K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta | (RefSeq) Pi3k60, pi3k; phosph

GO

GO:0003964   GO:0004519   GO:0016021   GO:0016758   GO:0006885   GO:0015385   GO:0004672   GO:0005524   GO:0035556   GO:0004383  

PANTHER

PTHR10110  

Length:

823

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.04381

Exp number, first 60 AAs:

0.000690000000000001

Total prob of N-in:

0.00068

outside

1  -  823

 

 

Pi

138.243749

Theta

150.55299

Tajima's D

0.113044

CLR

0.024962

CSRT

0.3970801459927

Interpretation

Uncertain