Gene

KWMTBOMO01814

Pre Gene Modal

BGIBMGA001333

Annotation

uricase_[Bombyx_mori]

Location

Bomo_Chr4(-):5517910-5521301      View in EpiBrowser

Full name

Uricase      

Alternative Name

Urate oxidase

Location in the cell

Nuclear   Reliability : 3.529

CDS

ATGCCTTGGACAAGCACAAATAGAATATACGCTAAGCCCTCAAGCACGAGTGCTAATGAGACTCCTTCACCTTCTTTGGCCAGCCCTAGGGTAGCTTTAACTGCTGCCGAGGACTCCGGCGGTAGGTTTGAACTCTGCGACCACGGATACGGCAAAAGTTCGGTTAAGCTTCTCCACGTTCATCGAGACGAAGGACATCACGTTATCAGGGAGTTTGAAGTCTTTACGGAACTTAAATTGGCTTCAGAGACAGCATACATTTTAGGTGACAATAAAGAAGTCGTTGCGACCGATTCACAAAAGAATACAGTGTATTTACTCGCGAAGAAATACGGAGTGAAGACTCCTGAAGAATTTGGTGCTGTAGTTGTTAATCATTTTTTGTATATGTACAAGCAAGTGCTGGAAGCAAAATGTCGCGTTATCGAGTACCCCTGGGAGCGACTGCAGGCGGGGACACCTCACAGCCATGCTTTTGTTTTTTCACCAATCGCCACGCGGTGGTCGGAAGTATCACAAACTCGTCACGAGGCAGTGGTAGTTAAGTCTGGCCTTAGCGGACTCCGTGTATTGAAAACAACACAATCAGCATTTGTTGACTTCGTACAAGATGAATACACAACACTGACTGATGCCGTAGAGCGAATATTTAGCACGATCGTCGAAGCGGAATGGATTTATGACAATATGCGTACAGCTGATTTCGATAACGCATGGCTTACAGTCAAGGATGCCATACTGGACAAATTCGCCGGCCCTCCCGATACGGGGGTGTATTCACCCTCCGTCCAGCACACCTTATATCAGGCTGAAAAAACTGTTCTCGAAAAAGTTAGCGAGATAACATGGATTAAGATGACAATGCCGAACAAACACTACCTGAACATCGATATGTCCAAGTTCCCAGTGAACGTGACCAAAGGGGACCCGAGACATTTCATTTACCATCCCATAGATCAACCCGCGGGACTGATCTATGCGCAACTGCGACGTAGGCCCAAGAGCAAGCTGTGA

Protein

MPWTSTNRIYAKPSSTSANETPSPSLASPRVALTAAEDSGGRFELCDHGYGKSSVKLLHVHRDEGHHVIREFEVFTELKLASETAYILGDNKEVVATDSQKNTVYLLAKKYGVKTPEEFGAVVVNHFLYMYKQVLEAKCRVIEYPWERLQAGTPHSHAFVFSPIATRWSEVSQTRHEAVVVKSGLSGLRVLKTTQSAFVDFVQDEYTTLTDAVERIFSTIVEAEWIYDNMRTADFDNAWLTVKDAILDKFAGPPDTGVYSPSVQHTLYQAEKTVLEKVSEITWIKMTMPNKHYLNIDMSKFPVNVTKGDPRHFIYHPIDQPAGLIYAQLRRRPKSKL

Description

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.

Catalytic Activity

H2O + O2 + urate = 5-hydroxyisourate + H2O2

Similarity

Belongs to the uricase family.

Keywords

Oxidoreductase   Peroxisome   Purine metabolism   Complete proteome   Reference proteome  

Feature

chain  Uricase

Uniprot

Q3HWK9   A0A2A4JIG4   A0A2H1VTU1   A0A194R2I8   I4DMC6   A0A194PKW6   + More
A0A212EKB7   A0A0L7KSB4   A0A2J7RDP2   A0A2P8YMS2   A0A1Y1MWZ3   E9ILA5   E2ACC1   A0A068TJT1   A0A232ERN4   A0A0J7L1P5   A0A1Q3FBU4   K7IUT3   U5ERF2   B0W8Y2   A0A182HCX8   Q17J02   A0A084W1X8   W5J4A5   A0A182TZV8   A0A146KTL3   A0A1S4GYA5   A0A182VJJ6   A0A182X117   A0A182L0D0   A0A182IC09   A0A0A9WCJ7   Q7Q4K6   A0A182MDB4   A0A182YA06   A0A182PAR6   A0A182WHE4   A0A0T6BAW0   A0A182QLU5   A0A182RRP0   A0A195FFB8   A0A1D2MSC6   A0A182MZ25   A0A195B7T2   A0A158NGN6   A0A151XAQ0   E9FVX2   F4WZW5   A0A195DXR5   A0A1L8E4L5   A0A1L8E4H1   A0A0P5Z5X8   A0A151ICF2   A0A226EJ39   A0A0P4WX96   A0A0P6E9F3   A0A182IWS7   A0A0P5EYS8   A0A0P5GI01   A0A182F2E3   A0A1S6QN26   B4JEU7   A0A3B0K7Z4   B4K8G4   O44111   A0A0P6CYT0   A0A023EPE2   B4G8E6   P22673   A0A0K8UFX7   A0A0M4EAK4   A0A0A1XDL3   A0A034VT11   A0A1D2N2Q4   A0A1W4W767   A0A0L0C6E6   A0A1L8E4E0   B4NZH1   B4M6K8   W8BME7   A0A0C9REM4   T1P9Z3   A0A0N8EIU8   P23194   A0A1I8PLP4   A0A1I8M196   A0A210R0W3   A0A1J1I1B1   A0A1J1HPB3   A0A0M4EQI2   A0A1S3HEX0   Q56RC9   A0A336MQ84   Q56RC7   A0A336MHH9   A0A1W4YDV1   Q56RC5   U4KJC3   M3XGK0   H3B1J2  

EC Number

1.7.3.3

Pubmed

19121390    26354079    22651552    22118469    26227816    29403074    + More
28004739    21282665    20798317    28648823    20075255    26483478    17510324    18182492    24438588    20920257    23761445    26823975    12364791    20966253    25401762    25244985    27289101    21347285    21292972    21719571    28235562    17994087    9720289    24945155    1556745    15632085    15545653    25830018    25348373    26108605    17550304    24495485    25315136    28812685    16547107    9215903   

EMBL

BABH01042313    DQ189992    ABA39861.1    NWSH01001371    PCG71498.1    ODYU01004368    + More
SOQ44176.1    KQ460855    KPJ11912.1    AK402444    BAM19066.1    KQ459601    KPI93972.1    AGBW02014299    OWR41920.1    JTDY01006492    KOB65966.1    NEVH01005285    PNF38957.1    PYGN01000485    PSN45555.1    GEZM01021227    JAV89080.1    GL764074    EFZ18656.1    GL438491    EFN68911.1    HG965798    CDO39394.1    NNAY01002573    OXU21020.1    LBMM01001283    KMQ96581.1    GFDL01009994    JAV25051.1    AAZX01011897    GANO01002831    JAB57040.1    DS231860    EDS39260.1    JXUM01033717    JXUM01033718    JXUM01033719    KQ560999    KXJ80084.1    EF676030    CH477236    ABV44610.1    EAT46590.1    ATLV01019471    KE525272    KFB44222.1    ADMH02002094    ETN59267.1    GDHC01020409    GDHC01008620    JAP98219.1    JAQ10009.1    AAAB01008964    APCN01000766    GBHO01038075    GBHO01006589    JAG05529.1    JAG37015.1    EAA12876.4    AXCM01001632    LJIG01002509    KRT84431.1    AXCN02000792    KQ981625    KYN39056.1    LJIJ01000596    ODM95997.1    KQ976574    KYM80305.1    ADTU01015151    KQ982339    KYQ57348.1    GL732525    EFX89027.1    GL888480    EGI60255.1    KQ980107    KYN17621.1    GFDF01000407    JAV13677.1    GFDF01000457    JAV13627.1    GDIQ01223267    GDIP01048718    LRGB01000024    JAK28458.1    JAM54997.1    KZS21625.1    KQ978053    KYM97773.1    LNIX01000003    OXA57238.1    GDIP01250676    JAI72725.1    GDIQ01071725    JAN23012.1    GDIQ01265897    JAJ85827.1    GDIQ01247710    JAK04015.1    KX840071    AQW35192.1    CH916369    EDV93228.1    OUUW01000004    SPP79648.1    CH933806    EDW14363.1    AF025816    GDIQ01085615    JAN09122.1    GAPW01003239    JAC10359.1    CH479180    EDW28626.1    X57113    CH379060    AY754579    GDHF01026750    JAI25564.1    CP012523    ALC39438.1    GBXI01005240    JAD09052.1    GAKP01013735    JAC45217.1    LJIJ01000270    ODM99567.1    JRES01000841    KNC27822.1    GFDF01000466    JAV13618.1    CM000157    EDW87720.1    CH940652    EDW59284.1    GAMC01004275    JAC02281.1    GBYB01015059    JAG84826.1    KA645499    AFP60128.1    GDIQ01022484    JAN72253.1    X57114    NEDP02000942    OWF54647.1    CVRI01000037    CRK93380.1    CVRI01000014    CRK89803.1    CP012525    ALC44530.1    AY754578    AAX13153.1    UFQS01002065    UFQT01002065    SSX13132.1    SSX32572.1    AY754580    AAX13155.1    UFQS01001288    UFQT01001288    SSX10130.1    SSX29852.1    AY754581    AY754582    AY754583    AY754584    AY754585    AY754586    AY754587    AY754588    AY754589    AY754590    AY754591    AAX13156.1    AAX13157.1    AAX13158.1    AAX13159.1    AAX13160.1    AAX13161.1    AAX13162.1    AAX13163.1    AAX13164.1    AAX13165.1    AAX13166.1    HF678434    CCT61357.1    AFYH01051860    AFYH01051861    AFYH01051862    AFYH01051863   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000037510    + More
UP000235965    UP000245037    UP000000311    UP000215335    UP000036403    UP000002358    UP000002320    UP000069940    UP000249989    UP000008820    UP000030765    UP000000673    UP000075902    UP000075903    UP000076407    UP000075882    UP000075840    UP000007062    UP000075883    UP000076408    UP000075885    UP000075920    UP000075886    UP000075900    UP000078541    UP000094527    UP000075884    UP000078540    UP000005205    UP000075809    UP000000305    UP000007755    UP000078492    UP000076858    UP000078542    UP000198287    UP000075880    UP000069272    UP000001070    UP000268350    UP000009192    UP000008744    UP000001819    UP000092553    UP000192221    UP000037069    UP000002282    UP000008792    UP000095300    UP000095301    UP000242188    UP000183832    UP000085678    UP000192224    UP000008672   

PRIDE

Q3HWK9    P23194   

Pfam

PF01014   Uricase        + More
PF00412   LIM
PF00431   CUB

Interpro

IPR019842   Uricase_CS        + More
IPR002042   Uricase       
IPR001781   Znf_LIM       
IPR035914   Sperma_CUB_dom_sf       
IPR000859   CUB_dom       

SUPFAM

SSF49854   SSF49854       

Gene 3D

2.60.120.290    

CDD

cd00041  CUB

ProteinModelPortal

Q3HWK9   A0A2A4JIG4   A0A2H1VTU1   A0A194R2I8   I4DMC6   A0A194PKW6   + More
A0A212EKB7   A0A0L7KSB4   A0A2J7RDP2   A0A2P8YMS2   A0A1Y1MWZ3   E9ILA5   E2ACC1   A0A068TJT1   A0A232ERN4   A0A0J7L1P5   A0A1Q3FBU4   K7IUT3   U5ERF2   B0W8Y2   A0A182HCX8   Q17J02   A0A084W1X8   W5J4A5   A0A182TZV8   A0A146KTL3   A0A1S4GYA5   A0A182VJJ6   A0A182X117   A0A182L0D0   A0A182IC09   A0A0A9WCJ7   Q7Q4K6   A0A182MDB4   A0A182YA06   A0A182PAR6   A0A182WHE4   A0A0T6BAW0   A0A182QLU5   A0A182RRP0   A0A195FFB8   A0A1D2MSC6   A0A182MZ25   A0A195B7T2   A0A158NGN6   A0A151XAQ0   E9FVX2   F4WZW5   A0A195DXR5   A0A1L8E4L5   A0A1L8E4H1   A0A0P5Z5X8   A0A151ICF2   A0A226EJ39   A0A0P4WX96   A0A0P6E9F3   A0A182IWS7   A0A0P5EYS8   A0A0P5GI01   A0A182F2E3   A0A1S6QN26   B4JEU7   A0A3B0K7Z4   B4K8G4   O44111   A0A0P6CYT0   A0A023EPE2   B4G8E6   P22673   A0A0K8UFX7   A0A0M4EAK4   A0A0A1XDL3   A0A034VT11   A0A1D2N2Q4   A0A1W4W767   A0A0L0C6E6   A0A1L8E4E0   B4NZH1   B4M6K8   W8BME7   A0A0C9REM4   T1P9Z3   A0A0N8EIU8   P23194   A0A1I8PLP4   A0A1I8M196   A0A210R0W3   A0A1J1I1B1   A0A1J1HPB3   A0A0M4EQI2   A0A1S3HEX0   Q56RC9   A0A336MQ84   Q56RC7   A0A336MHH9   A0A1W4YDV1   Q56RC5   U4KJC3   M3XGK0   H3B1J2  

PDB

5M98     E-value=1.59775e-62,     Score=606

KEGG

692784    K00365 urate oxidase [EC:1.7.3.3] | (RefSeq) uricase

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00232    Caffeine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006144   GO:0019628   GO:0004846   GO:0005777   GO:0046872   GO:0051289   GO:0016021   GO:0000166   GO:0016459   GO:0006810   GO:0006397   GO:0004651   GO:0005634   GO:0055114  

Subcellular location

Peroxisome  

Length:

337

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0028

Exp number, first 60 AAs:

0

Total prob of N-in:

0.07596

outside

1  -  337

 

 

Pi

212.873186

Theta

18.064809

Tajima's D

-0.844828

CLR

21.645864

CSRT

0.165591720413979

Interpretation

Uncertain