Gene

KWMTBOMO01800  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006159

Annotation

inosine_triphosphatase_[Bombyx_mori]

Location

Bomo_Chr4(+):5141872-5142554      View in EpiBrowser

Full name

Inosine triphosphate pyrophosphatase       + More
Nucleotide diphosphatase      

Alternative Name

Non-canonical purine NTP pyrophosphatase
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase

Location in the cell

Nuclear   Reliability : 3.092

CDS

ATGGCAAATAAAACCATTACGTTTGTCACAGGAAATTTAAAAAAACTCGAAGAGTTTCGAGCCATATTAGGAGCAAATTTTCCATTTGAAGTCGTAAGTCACAAATTGGATTTGCCTGAACTACAAGGAGAAATTGATGAAGTGTCAATAAAAAAATGCCAAGAGGCCGCTCGACTCCTTAAGCAGGCTGTAATTGTGGAAGATACGAGTTTATGTTTCAATGCATTATGTGGCCTGCCCGGTCCTTATATTAAATGGTTCCTGGATAAATTGAAGCCGGAAGGACTGCCCAGATTATTGGCTGGATGGGAGGATAAATCTGCTGTAGCCGTCTGCACTTTTGCCTATTGTAGTGGTGAGAAAGATAATGTCATTCTGTTCCAAGGACGAACAAAAGGAATAATCGTAGAACCGAGAGGTACGAGGGATTTTGGATGGGATTGTGTCTTCCAACCAGCAGGTTACAACAAAACATATGCAGAATTACCAAAAACAGAGAAGAATTTAATTTCACACAGATACAAGGCTCTAGAAAAACTAAGAAACTATTTTATAGAAAACACAAACAATTGA

Protein

MANKTITFVTGNLKKLEEFRAILGANFPFEVVSHKLDLPELQGEIDEVSIKKCQEAARLLKQAVIVEDTSLCFNALCGLPGPYIKWFLDKLKPEGLPRLLAGWEDKSAVAVCTFAYCSGEKDNVILFQGRTKGIIVEPRGTRDFGWDCVFQPAGYNKTYAELPKTEKNLISHRYKALEKLRNYFIENTNN

Description

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)

Cofactor

Mg(2+)

Subunit

Homodimer.

Similarity

Belongs to the HAM1 NTPase family.

Keywords

Complete proteome   Cytoplasm   Hydrolase   Magnesium   Manganese   Metal-binding   Nucleotide metabolism   Nucleotide-binding   Reference proteome  

Feature

chain  Inosine triphosphate pyrophosphatase

Uniprot

Q1HPH5   A0A194PLX1   S4PF64   A0A2H1W6E3   A0A0L7LRR4   A0A2A4KAN4   + More
A0A212EQB2   B4GSH6   A0A3B0KA63   B4KFM5   Q29L15   B4NW90   B0W4H0   B4Q362   A0A182F4U3   B0XL39   A0A2M4C0N8   B3N4D5   A0A1W4UX07   A0A1Q3FCR1   B4I1A3   Q9VMW7   A0A0K8TSK0   A0A2M4C0Y9   A0A2M4C0W6   A0A2M3ZDS0   A0A026W4G1   A0A182NTZ0   A0A084W5X8   A0A1J1IK41   B4LQK5   Q16YB3   A0A182QE70   A0A182RDQ6   A0A151NSS0   A0A182J225   T1EA39   A0A0J7KV23   A0A154P7J6   A0A1I8MRF7   B4JR22   A0A182VNW0   A0A182TQ73   A0A182XFY6   Q7Q4F5   A0A1I8P803   A0A182IC73   A0A182G4P7   A0A2M4AZZ3   A0A088AGP9   A0A182JT49   W5MWL6   A0A2A3E9L0   B4N0K5   B3MP77   A0A182L0K6   A0A0N0BCQ9   A0A195FP33   A0A182W6G4   W5J660   A0A067QNW0   A0A0M4E1P3   A0A151JCC3   A0A182MD33   A0A1L8EBR8   W8BSE5   A0A195CU21   A0A0L7R6Q0   A0A195B3Y8   A0A158N8V8   E9IQQ1   E2C965   A0A1A8FWK2   D6WJY1   H9GJ52   W5MWK8   A0A3B4BMR0   F4WML8   A0A1A7WQ89   A0A1A8P3T7   A0A1A8Q866   A0A3B1K3M4   F7FQM6   A0A1W4ZZ01   E0VVF6   K7FFY3   A0A1L8GGC4   Q2NLA8   A0A2I4CZH0   A0A1A8BE14   A0A182PLQ7   A0A3B4FMS7   A0A182YDV1   A0A3P8PQV1   A0A3P9CV96   A0A0F8AFP0   B5FZN0   H1A3U7   A0A1A8E7G1   A0A1A8I3S2  

EC Number

3.6.1.9

Pubmed

19121390    26354079    23622113    26227816    22118469    17994087    + More
15632085    17550304    22936249    10731132    12537572    12537569    26369729    24508170    30249741    24438588    17510324    22293439    25315136    12364791    26483478    20966253    20920257    23761445    24845553    24495485    21347285    21282665    20798317    18362917    19820115    21881562    21719571    25329095    18464734    20566863    17381049    27762356    25244985    25186727    25835551    17018643    20360741   

EMBL

BABH01004806    DQ443427    ABF51516.1    KQ459601    KPI93988.1    GAIX01006740    + More
JAA85820.1    ODYU01006621    SOQ48628.1    JTDY01000232    KOB78148.1    NWSH01000013    PCG80853.1    AGBW02013271    OWR43682.1    CH479189    EDW25335.1    OUUW01000006    SPP81941.1    CH933807    EDW13140.1    CH379061    EAL33009.2    CM000157    EDW88407.1    DS231837    EDS33553.1    CM000361    CM002910    EDX03778.1    KMY88193.1    DS234228    GGFJ01009745    MBW58886.1    CH954177    EDV57805.1    GFDL01009715    JAV25330.1    CH480820    EDW54310.1    AE014134    AY071428    GDAI01000251    JAI17352.1    GGFJ01009822    MBW58963.1    GGFJ01009809    MBW58950.1    GGFM01005887    MBW26638.1    KK107455    QOIP01000010    EZA50486.1    RLU17389.1    ATLV01020706    KE525305    KFB45622.1    CVRI01000054    CRL00552.1    CH940649    EDW64462.1    CH477519    AXCN02000807    AKHW03002184    KYO39803.1    GAMD01000772    JAB00819.1    LBMM01002954    KMQ94141.1    KQ434822    KZC07090.1    CH916372    EDV99352.1    AAAB01008964    APCN01000778    JXUM01144169    KQ569733    KXJ68531.1    GGFK01012971    MBW46292.1    AHAT01000155    KZ288326    PBC27972.1    CH963920    EDW77618.1    CH902620    EDV32196.1    KQ435896    KOX69334.1    KQ981382    KYN42213.1    ADMH02002111    ETN58888.1    KK853129    KDR11000.1    CP012523    ALC39341.1    KQ979054    KYN23195.1    AXCM01000782    GFDG01002621    JAV16178.1    GAMC01002265    JAC04291.1    KQ977279    KYN04191.1    KQ414646    KOC66504.1    KQ976618    KYM79203.1    ADTU01008824    GL764888    EFZ17105.1    GL453780    EFN75538.1    HAEB01016716    HAEC01003771    SBQ63243.1    KQ971342    EFA03919.1    AAWZ02023900    GL888218    EGI64495.1    HADW01006485    HADX01013177    SBP07885.1    HAEI01001390    HAEH01016954    SBR75970.1    HAEF01004650    HAEG01011417    SBR89726.1    DS235811    AGCU01141515    CM004473    OCT82901.1    BC110771    HADZ01001528    SBP65469.1    KQ042254    KKF17002.1    KKF17005.1    DQ214593    EF191956    ACH44491.1    ABQF01040858    HAEA01013418    SBQ41898.1    HAED01005481    HAEE01014345    SBQ91511.1   

Proteomes

UP000005204    UP000053268    UP000037510    UP000218220    UP000007151    UP000008744    + More
UP000268350    UP000009192    UP000001819    UP000002282    UP000002320    UP000000304    UP000069272    UP000008711    UP000192221    UP000001292    UP000000803    UP000053097    UP000279307    UP000075884    UP000030765    UP000183832    UP000008792    UP000008820    UP000075886    UP000075900    UP000050525    UP000075880    UP000036403    UP000076502    UP000095301    UP000001070    UP000075903    UP000075902    UP000076407    UP000007062    UP000095300    UP000075840    UP000069940    UP000249989    UP000005203    UP000075881    UP000018468    UP000242457    UP000007798    UP000007801    UP000075882    UP000053105    UP000078541    UP000075920    UP000000673    UP000027135    UP000092553    UP000078492    UP000075883    UP000078542    UP000053825    UP000078540    UP000005205    UP000008237    UP000007266    UP000001646    UP000261440    UP000007755    UP000018467    UP000002279    UP000192224    UP000009046    UP000007267    UP000186698    UP000192220    UP000075885    UP000261460    UP000076408    UP000265100    UP000265160    UP000007754   

PRIDE

Q1HPH5    Q9VMW7    Q7Q4F5    Q2NLA8   

Pfam

PF01725   Ham1p_like

Interpro

IPR029001   ITPase-like_fam        + More
IPR027502   ITPase       
IPR002637   Ham1p-like       

SUPFAM

SSF52972   SSF52972       

Gene 3D

3.90.950.10    

CDD

cd00515  HAM1

ProteinModelPortal

Q1HPH5   A0A194PLX1   S4PF64   A0A2H1W6E3   A0A0L7LRR4   A0A2A4KAN4   + More
A0A212EQB2   B4GSH6   A0A3B0KA63   B4KFM5   Q29L15   B4NW90   B0W4H0   B4Q362   A0A182F4U3   B0XL39   A0A2M4C0N8   B3N4D5   A0A1W4UX07   A0A1Q3FCR1   B4I1A3   Q9VMW7   A0A0K8TSK0   A0A2M4C0Y9   A0A2M4C0W6   A0A2M3ZDS0   A0A026W4G1   A0A182NTZ0   A0A084W5X8   A0A1J1IK41   B4LQK5   Q16YB3   A0A182QE70   A0A182RDQ6   A0A151NSS0   A0A182J225   T1EA39   A0A0J7KV23   A0A154P7J6   A0A1I8MRF7   B4JR22   A0A182VNW0   A0A182TQ73   A0A182XFY6   Q7Q4F5   A0A1I8P803   A0A182IC73   A0A182G4P7   A0A2M4AZZ3   A0A088AGP9   A0A182JT49   W5MWL6   A0A2A3E9L0   B4N0K5   B3MP77   A0A182L0K6   A0A0N0BCQ9   A0A195FP33   A0A182W6G4   W5J660   A0A067QNW0   A0A0M4E1P3   A0A151JCC3   A0A182MD33   A0A1L8EBR8   W8BSE5   A0A195CU21   A0A0L7R6Q0   A0A195B3Y8   A0A158N8V8   E9IQQ1   E2C965   A0A1A8FWK2   D6WJY1   H9GJ52   W5MWK8   A0A3B4BMR0   F4WML8   A0A1A7WQ89   A0A1A8P3T7   A0A1A8Q866   A0A3B1K3M4   F7FQM6   A0A1W4ZZ01   E0VVF6   K7FFY3   A0A1L8GGC4   Q2NLA8   A0A2I4CZH0   A0A1A8BE14   A0A182PLQ7   A0A3B4FMS7   A0A182YDV1   A0A3P8PQV1   A0A3P9CV96   A0A0F8AFP0   B5FZN0   H1A3U7   A0A1A8E7G1   A0A1A8I3S2  

PDB

2I5D     E-value=3.98452e-66,     Score=634

KEGG

733043    K01519 inosine triphosphate pyrophosphatase [EC:3.6.1.-] | (RefSeq) inosine triphosphatase

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0000166   GO:0009117   GO:0035529   GO:0046872   GO:0047429   GO:0009204   GO:0005737   GO:0009143   GO:0042802   GO:0005829   GO:0016787   GO:0016459   GO:0005515   GO:0006810   GO:0006397   GO:0004651   GO:0005634  

PANTHER

PTHR11067  

Subcellular location

Cytoplasm  

Length:

190

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0499000000000001

Exp number, first 60 AAs:

0.00052

Total prob of N-in:

0.24967

outside

1  -  190

 

 

Pi

143.792472

Theta

129.662206

Tajima's D

0.342294

CLR

0.899724

CSRT

0.467276636168192

Interpretation

Uncertain