Gene

KWMTBOMO01798  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005995

Annotation

PREDICTED:_myosin-VIIa-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr4(-):5125669-5136211      View in EpiBrowser

Full name

Peptidylprolyl isomerase       + More
Myosin-VIIa      

Alternative Name

Protein crinkled

Location in the cell

Mitochondrial   Reliability : 1.727

CDS

ATGACTGACCGAATTCGGCTTTCGGACCTGGTTTGGATAAAGCCACAAGGAAGGTCAGAATTTGACATTCCCGTGGCGGTCAAAATCTTAAACAGTTCCGGCGACAGGATCCAGGTTCAGGATGATGATGGCAAAGTGTTCTCGACCACGGTGCATGACGTCATCAAACCTCTTCATGCGACGTCAATTTGTGGAGTGGAAGACATGATAACTCTTGGCGAACTCCAGGAATATACGATACTCCGAAATCTACATTTAAGATATAATGAGCAATTGATTTATACATATACGGGTTCCATGTTAATAGCTATTAATCCATATGAAATTCTACCAATTTATACCATGGATCAGATACACTTCTATCAAAACAGTCAAATTGGAGATATACCACCACACATTTTTGCCATAGGAGACAATTCTTACAGGAAATTGATCGAGACTTCTTCCAACCAGTGCATAGTTATCAGTGGAGAAAGTGGAGCTGGAAAAACTGAAAGCACTAAGCTATTGTTACAATACTTAGCAGCAGCTAGCGGAAAACACTCTTGGATTGAACAACAAATTCAAGAAACCAATCCTATCCTTGAAGCTTTTGGTAATGCTAAAACAGTTAAAAACGACAATTCATCGAGATTTGGGAAATATGTGAACATTTATTTTAACAGAAAAGAAGTAGTAGATGCTGTGAACGCAAATAGAATAGCTACGCTTTTGGGCGTAAACAAAACTGATTTATGTGAGGCATTGACCAGGAAAACTTTTGTTGCTCACGGAGAAAAAGTTGTTTCTACATTAACAGTGGCTTCTGCCATCGAAAGTAGAGACGCACTTGTAAAAGCCATTTACGGGCATATATTCGAGTATATCGTGGATACTATTAATAAAACACTGCACAAAGACCAACAATTGACAAGTGGATCGGTTGGAATTTTGGATATTTTTGGTTTTGAAAACTTTGATTCTAACAGTTTTGAACAACTGTGCATCAATTACGCAAATGAAAACTTACAACAATTCTTTGTCAAGCATATTTTCAAACTTGAACAAGAACAGTACGAAAAAGAAGGTATTACATGGACAAATATCAACTACGTTGATAATCAAGAAAATCTGAACATGATCGGAATGAGACCAATGAATTTATTAGCGCTCATAGATGAAGAGTCACGGTTTCCTAAGGGGACAGATATCACACTATTATCAAAATTAAATAGTAATCACAGTAATAAGAATTGTTATATAGCTGCAAAATCTTCCCGTGAACATAGATTTGGCGTTAGGCACTTTGCTGGAGCCGTGTTTTATGAGGTTGCAGGTTTTTTGGACAAAAACAGAGATTTGCTTACAACAGACGTAAAGGAAATTATGTTTGATTCGAATAATCAATTCCTTAAAGGATTATTCGCATCAGAATTCACTGAAACGCGCAATAGTAGTCGAAAAACGATTTCTCTGAGTAATCAATTCAAAGCTTCACTTGATACTCTTATGAAAAATTTATACGCATGTCATCCATTTTTCGTTAGGTGTATAAAACCAAATGAACTGAAAAAACCAAGGGTTTTTGATAAAGCGCTCTGTGTGAGACAGCTAAGGTATGCAGGTTTAATGGAAACTGCAAAAATTAGACAGGCTGGTTACCCAATACGATATACCTACGTCTCATTTGTTCATCGTTACCGATTTTTAATACCTGGAATACCGCCCGCGGAAAGAACAGATTGTAAAAGTGCTACAAAAAAGATTTGTACTGAAGTTTTAAAAGATCAAGAATTCCGACTTGGACACACTAAAGTGTTTTTGAAAGATACACATGATTACTTACTTGAAGAATTGCGGCACACTATATTTACAACAGCTGTCATTAGAGTCCAAGCGAACGCAAGACGGTTTATTTGCAGAAGGAGATTCTTGAAGATGAGGGCTGCCGCTATAACAATTCAGAAACATTATCGTGCCCGTGGTTTACGCCATAGATTCCTTGTAATGCGAAGAGGGTACTCTCGTATTCAAGCCGTTATTAAATCAAGGGAATTGAGACGCACATTCTTACACTTGAGAAGCTTCTTCAGAAACTTACAGGCGCATTGTAGAGGCTACCTCATTAGAAAGTTAGTAAAAGAAAAAGGAACCTTAATAAAAGCTAAATTGTTACAACTTAAATCCGAAAAAGAAAAATTAGAAAAATCTGGAAAGGACGAACAATTTATCGCAGATGATCACGAAAAGAAGTTTACTGAACTGTTAAGGTCCATTTGGATAGTAAAAGAAATTGCTGTCGATGATAACGAACAGAACATCTCAGCTATTGATGATAGATACGTAGATGATGTTTTCGGTTTTCTTAAAGATAGTTCAACACCTGGTGGAACTGTGCGTGGAGCCGGATTTGGTGTTACTTCGACAGCTAAGCCAGAAATGTCGTCAATAATTCCAATGCCACAAGAATACGAAGAAGAACAGTTTGATGAATTCAACTTCAGGAAATTTGCGGCGACATATTTCTCTGGGAATACAAGTCACCAATATTCCCGCAAACCTTTGAGACACTCACTATTAGAGCTACCGTCACCAATGGATAAAGTTGCGTCTCAAGCACTGTGGATAACGATACTAAGATTTATGGGTGATTTGGCTGAACCTAAATATGTTGACGATAAAATTGATAATATTCCTGTTATGACTAAGTTAACTGACACTATTGGCCGAGCTTTTCAGAAGAGCAAAGAATTTGAGGAAATGCTAATCAAAGATGGAAATCAAAATAAAAGTCGATTGGTTTCCAAAACCTTGAAGAGGCAATCTAAATTAAATGAAGTATTCATCAAAAACTTATTAAATGACGAAACAACCAATGAAATGTACAGTCATTGGTTGAATTCGCGACGCAGTACGAACTTAGAAAAACTTCATTTCATTATAGGTCATGGAATTATCAGAAAAGAGCTAAGAGATGAAATATTTTGTCAGCTCTGTAAACAATTAACGAACAATCCATCAAAAACATCACATGCTCGTGGTTGGATACTTTTGTCCCTATGCGTTGGTTGTTTCCCACCCTCGGAGAGATTTGTGAAATACCTACGCTCTTTCATTCGCGGAGGACCACCGGGCTATGCACCATATTGTGAAGGTAGACTGGTAAGGACATTCAAGAACGGTCCTAGAACCCAACCACCTAGTTGGCTAGAATTACAGGCAACTAAAACTAAGAAACCGATTTTACTGACCGTCACTCTGATGGACGAGTCAATTAAAACTGTGCAATCGGATTCAGCATCTACGTCGGAAGAAATATGTCAACAGATAGCAGACAATATTGGTTTAACGGACACTTTTGGTTTTTCACTGTACATAACTTTGTATGATAAAGTGCTTTCATTGGGTAGCGAAGGAGAACACATCTGCGATGCGATATCGCAATGTGAGCAGTTTGCCAAAGAACATGGCACTCCTGAAAAGAGCGCACCATGGAGATTGTTCTATAGAAAAGAAGTTTTTACACCTTGGCACAATCCCGCCATTGATCCTATAGCGACTAATTTAATTTATAATCAAGTAGCTAAAGGTGTGAAGTTCGGAGAATATAGGTGTAATTCAGAAAATGACTTGGCGATGTTAGCTGCTCAACAACATTACATCGAATACGGTTCTCGATTAGATCCAAATGTTTTAAGAAAAGTTATTGTTAACTATATCCCGAATCAATTTATTCAATCGAATGATGCTGCCTTAACGAAATGGGAACATTTCGTAACGAAAGCATTTGATTCATGCCCCAATATTAAATCGAAAATAGATCCTTTAAGGTGTAAAGAAGATATAGTCATTTTTGCAAAACTCAAATGGCCCATGTTATTTTCAAGATTCTTCGAAGCTCTTAAACTAAAAGGCGATGCTATCAGTAAAGACATTATTATCGTTGCTGTAAACTGGACTGGCATATATATTGTTGACCAACTAGAGCATATACTTCTTGAGATAGCATATTCTGAAGTGACTTATGTGGCCTACGATGACGATACTGACTTGGAAAACATAGGAAAGGTCACTATCAGAACAATACAACAAGAAGAATTCGTATTTCAGAGTGTTGATGCAGGAGAAATGAGTTCCTTAATCATATATATTATTGATGGTTTAAAAAGAAGATCTGCATACGTTGTGGCCCAGAGTGATTCGCAAGGTTATGCTGATGCGTCATCTTTCCTTCAATTCAAAAAGGGTGATCTTATTACACTTTTGCATGATTCTACCGGAGAGACTTTAATGAATGCCACATGGGGTCATGGAGCTTGTAATGGCCAAGAAGGTTTATTCCCTACCGAACAAGTTTACATTTTGCCAACATTAGAAAAACCTTCGAATTCTGTACTCGAAGTATTTAAAAAGGGGACAGTAAACAATGATAAGAAACCATACCAATACAATACAGTGCAACGAAAGAGGATGCACACGTTAGAGAAATACGCGAAGGAATACTTCAGGGAAAATTATGATGTCAATACAACGGTATCACGACAATCAACACTAACTACCGCTAAGAAACCTATTGCCGGAGATTTATGGGTGCACAGTAGAGAGCCAATACGTAAGCCATTGTTAAAAAAAATACAAGATGATGAGAAACTATCTAAGAACGCAATCGCTGCTTATTACGCAATCTTGAAATACATGGGAGACATGCCAGCACCAAAACCTAAGTCGGCCACTGAATATACAGATGAAATATTTAAAAATGCAATATCGGAACCCGCATTGCGAGATGAAATATACTGTCACATAATGAAGCAATTGACCAACAATAGAATACAGTTGAGTGAAGAGAGAGGATGGGAGCTGCTTTGGTTGGCCACTGGCGTCTTCGCCTGTAGCCAAGTTTTAATGAAAGAACTAGTTGAATTCCTTAAAACACGACCTCATCCGATAGCCAAAGACTGTTTGAAACGATTATTTAAAACACAAAAATACGGATCAAGAATGTATGCTCCGTACGTTGTAGAGGTAGAAGCTATTCAACATAGAAGTATGCAGATATATCACAAAGTATACTTCCCAGACGATACTGATGAAGCTTTCGAGGTGGATTCATCTACAAAAGCGAGGGACTTGTGCGAGCAAATAACCGGAAGGCTAAATCTGAAGAATAGCGACGGTTTTAGTTTGTTTGTAAAAATAGCGGACAAGGTGTTTTCTGTCCCAGAAAACTATTACTTCTTCGACTTTGTTCATGAATTAGTTGAATGGATGAAACAAACGCGGCCAGTTCGAGGAGGTTCAACACAAATGCAAATGAACTACCAAATATTCTTCATGAAAAAGCTATGGATTAACACGGTTCCTGGTAGAGATAAAAATGCTGATCAAATTTTTTATTTTCCTCAAGAACTTCCAAAGTACTTGAGAGGATATCATAAGACTTCAAAGCAGGACCTCGTTGAACTTGCTGCATTGGTTTATAGGGCTAGATTCGGCAGTGATCAATCATTATTAGCACAAATATCCCATTTGCTTGAAGATTTTGTACCCTCTGATATGATTCGAATACAATCGAATTCTCAGTGGAAATCTTCAATAGTGACTGCGTACCTGCAACATGGAAATATGACTGAAAGCGAAGCTAAAGAACAATTCTTAAAGAAAATTTATCAGTTACCTACATTCGGCACAGCTTTCTTCGAAGTCAAGCAGACTTCAGACCCTGCTTATCCGGAAATGGTAATCGTAGGAATAAATAAAAATGGCGTTAGTCTTGTTCATCCACAAAGTCGGGATGTGTTGATCACGCACCCCTTTTCACAATTATCTAATTGGTCGTCTGGAAACACATTTTTTCACATGACAATGGGAAATTTCTTAAGAGGAACTAAGATACTGTGTGAAACTTCGCTTGGCTACAAAATGGATGATCTTATTTCATCATACATTGCTGTCCTCCGTGCTTCTTTAAATCAAAACAGTAGAGGTTAA

Protein

MTDRIRLSDLVWIKPQGRSEFDIPVAVKILNSSGDRIQVQDDDGKVFSTTVHDVIKPLHATSICGVEDMITLGELQEYTILRNLHLRYNEQLIYTYTGSMLIAINPYEILPIYTMDQIHFYQNSQIGDIPPHIFAIGDNSYRKLIETSSNQCIVISGESGAGKTESTKLLLQYLAAASGKHSWIEQQIQETNPILEAFGNAKTVKNDNSSRFGKYVNIYFNRKEVVDAVNANRIATLLGVNKTDLCEALTRKTFVAHGEKVVSTLTVASAIESRDALVKAIYGHIFEYIVDTINKTLHKDQQLTSGSVGILDIFGFENFDSNSFEQLCINYANENLQQFFVKHIFKLEQEQYEKEGITWTNINYVDNQENLNMIGMRPMNLLALIDEESRFPKGTDITLLSKLNSNHSNKNCYIAAKSSREHRFGVRHFAGAVFYEVAGFLDKNRDLLTTDVKEIMFDSNNQFLKGLFASEFTETRNSSRKTISLSNQFKASLDTLMKNLYACHPFFVRCIKPNELKKPRVFDKALCVRQLRYAGLMETAKIRQAGYPIRYTYVSFVHRYRFLIPGIPPAERTDCKSATKKICTEVLKDQEFRLGHTKVFLKDTHDYLLEELRHTIFTTAVIRVQANARRFICRRRFLKMRAAAITIQKHYRARGLRHRFLVMRRGYSRIQAVIKSRELRRTFLHLRSFFRNLQAHCRGYLIRKLVKEKGTLIKAKLLQLKSEKEKLEKSGKDEQFIADDHEKKFTELLRSIWIVKEIAVDDNEQNISAIDDRYVDDVFGFLKDSSTPGGTVRGAGFGVTSTAKPEMSSIIPMPQEYEEEQFDEFNFRKFAATYFSGNTSHQYSRKPLRHSLLELPSPMDKVASQALWITILRFMGDLAEPKYVDDKIDNIPVMTKLTDTIGRAFQKSKEFEEMLIKDGNQNKSRLVSKTLKRQSKLNEVFIKNLLNDETTNEMYSHWLNSRRSTNLEKLHFIIGHGIIRKELRDEIFCQLCKQLTNNPSKTSHARGWILLSLCVGCFPPSERFVKYLRSFIRGGPPGYAPYCEGRLVRTFKNGPRTQPPSWLELQATKTKKPILLTVTLMDESIKTVQSDSASTSEEICQQIADNIGLTDTFGFSLYITLYDKVLSLGSEGEHICDAISQCEQFAKEHGTPEKSAPWRLFYRKEVFTPWHNPAIDPIATNLIYNQVAKGVKFGEYRCNSENDLAMLAAQQHYIEYGSRLDPNVLRKVIVNYIPNQFIQSNDAALTKWEHFVTKAFDSCPNIKSKIDPLRCKEDIVIFAKLKWPMLFSRFFEALKLKGDAISKDIIIVAVNWTGIYIVDQLEHILLEIAYSEVTYVAYDDDTDLENIGKVTIRTIQQEEFVFQSVDAGEMSSLIIYIIDGLKRRSAYVVAQSDSQGYADASSFLQFKKGDLITLLHDSTGETLMNATWGHGACNGQEGLFPTEQVYILPTLEKPSNSVLEVFKKGTVNNDKKPYQYNTVQRKRMHTLEKYAKEYFRENYDVNTTVSRQSTLTTAKKPIAGDLWVHSREPIRKPLLKKIQDDEKLSKNAIAAYYAILKYMGDMPAPKPKSATEYTDEIFKNAISEPALRDEIYCHIMKQLTNNRIQLSEERGWELLWLATGVFACSQVLMKELVEFLKTRPHPIAKDCLKRLFKTQKYGSRMYAPYVVEVEAIQHRSMQIYHKVYFPDDTDEAFEVDSSTKARDLCEQITGRLNLKNSDGFSLFVKIADKVFSVPENYYFFDFVHELVEWMKQTRPVRGGSTQMQMNYQIFFMKKLWINTVPGRDKNADQIFYFPQELPKYLRGYHKTSKQDLVELAALVYRARFGSDQSLLAQISHLLEDFVPSDMIRIQSNSQWKSSIVTAYLQHGNMTESEAKEQFLKKIYQLPTFGTAFFEVKQTSDPAYPEMVIVGINKNGVSLVHPQSRDVLITHPFSQLSNWSSGNTFFHMTMGNFLRGTKILCETSLGYKMDDLISSYIAVLRASLNQNSRG

Description

Myosins are actin-based motor molecules with ATPase activity (PubMed:16585515). Unconventional myosins serve in intracellular movements: can function in cells as a single-molecule cargo transporter (PubMed:16585515). A very slow and high-duty-ratio motor, may be suitable for tension maintenance of actin filaments (PubMed:16585515). Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (PubMed:15579689). Plays a key role in the formation of cellular projections and other actin-based functions required for embryonic and larval viability (PubMed:15579689, PubMed:16585515). Necessary for auditory transduction: plays a role in Johnston's organ organization by functioning in scolopidial apical attachment and therefore to acoustic stimulus propagation from the antenna a2/a3 joint to transducing elements (PubMed:15886106, PubMed:27331610). Interaction with the myosin zip may be important for its function in scolopidial apical attachment (PubMed:27331610). During oogenesis it has Cad99c-dependent and Cad99c-independent roles in regulating the shape and spacing of the follicle cell microvilli which secrete eggshell material such as the vitelline membrane (PubMed:25236597). May be required for the normal expression of Cad99c in the follicle cell microvilli (PubMed:25236597).
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements: can function in cells as a single-molecule cargo transporter. A very slow and high-duty-ratio motor, may be suitable for tension maintenance of actin filaments. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Plays a key role in the formation of cellular projections and other actin-based functions required for embryonic and larval viability. Necessary for auditory transduction: plays a role in Johnston organ (JO) organization by functioning in scolopidial apical attachment and therefore to acoustic stimulus propagation from the antenna a2/a3 joint to transducing elements (By similarity).

Catalytic Activity

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Subunit

Homodimerizes in a two headed molecule through the formation of a coiled-coil rod (PubMed:16585515). Homodimers motility is approximately 8-10 times slower than that of myosin V, and its step size is 30 nm, which is consistent with the presence of five IQ motifs in its neck region (PubMed:16585515). Interacts with Cad99C (via the cytoplasmic domain) (PubMed:25236597, PubMed:27331610). Interacts with zip and Sans (PubMed:27331610).
Homodimerizes in a two headed molecule through the formation of a coiled-coil rod.

Similarity

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Keywords

Actin-binding   ATP-binding   Cell projection   Coiled coil   Complete proteome   Cytoplasm   Motor protein   Myosin   Nucleotide-binding   Phosphoprotein   Reference proteome   Repeat   SH3 domain  

Feature

chain  Myosin-VIIa

Uniprot

H9J903   A0A2A4K9A0   A0A194R2Z7   A0A194PS87   A0A0L7LRR9   A0A212EQE4   + More
A0A2H1X0J5   D6WJX5   A0A1B6ETW6   A0A1W4X3J6   K7J8Z2   A0A232EMR2   A0A067QNC8   A0A026WSA2   A0A195EXJ5   A0A348G641   A0A0C9RPF2   A0A195DUL7   F4W8A1   A0A158NSP1   D6WM41   A0A2A3E8T4   A0A195CAT1   A0A151XDL4   A0A154P506   A0A1Y1LTF3   A0A151HY88   U4UK26   A0A2A4JZM2   B4Q5Z3   A0A194PMR5   A0A0L7LIA5   B4JAX3   A0A1B6CKI8   A0A1I8N9D6   A0A0N1PEV6   T1ICE8   A0A2M4CMY6   A0A2M4CM41   A0A2M4B870   A0A2M4CMB7   A0A2M4A1G1   A0A182R007   A0A182FN67   W5JPK4   A0A1B0C0S5   A0A2M3YZS8   A0A2M4A185   A0A2M4B856   A0A182IPQ8   E2BI60   A0A084VL31   A0A0K8WG24   A0A034V390   N6TIU3   A0A0A1XPT4   B3MLC3   A0A1B0G9B5   B4LRY0   B3N5N5   G7H829   Q9V3Z6   E0VVF2   B4KLB7   B0WB21   B4HXL9   B4NYT1   A0A1I8NXV5   A0A2J7QBS1   A0A1W4WBQ5   A0A182TFZ3   A0A182VP23   A0A182LMR3   A0A1S4HE37   A0A182XNT2   A0A182I7D7   B4GK81   Q29P71   A0A0P6GEH4   A0A0P6DU95   A0A0P5HN39   A0A0P6FXT3   A0A0P5MR18   A0A0P6CXA4   A0A0P5IB22   A0A0P5R7B3   A0A0P6G4U9   A0A0P5Q1P0   A0A0P6DT15   A0A0P6E6W2   A0A0P5G985   A0A0P6DT69   A0A0P5QGY1   A0A0P6EGA9   A0A0P5HRB6   A0A0P5HSC7   A0A0P6DFS6   A0A0P5MIA8   A0A0P5RHZ5   A0A0N8C9M4  

EC Number

5.2.1.8

Pubmed

19121390    26354079    26227816    22118469    18362917    19820115    + More
20075255    28648823    24845553    24508170    30249741    21719571    21347285    28004739    23537049    17994087    22936249    25315136    20920257    23761445    20798317    24438588    25348373    25830018    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    15579689    15886106    16585515    18327897    25236597    27331610    20566863    18057021    17550304    20966253    15632085   

EMBL

BABH01004805    NWSH01000013    PCG80855.1    KQ460855    KPJ11894.1    KQ459601    + More
KPI93990.1    JTDY01000232    KOB78155.1    AGBW02013271    OWR43684.1    ODYU01012494    SOQ58831.1    KQ971342    EFA03648.1    GECZ01028367    JAS41402.1    NNAY01003312    OXU19644.1    KK853129    KDR10964.1    KK107111    QOIP01000011    EZA58907.1    RLU16549.1    KQ981948    KYN32622.1    FX985580    BBF97914.1    GBYB01009046    JAG78813.1    KQ980322    KYN16600.1    GL887898    EGI69596.1    ADTU01025086    ADTU01025087    ADTU01025088    ADTU01025089    KQ971343    EFA03361.1    KZ288322    PBC28193.1    KQ978023    KYM97974.1    KQ982275    KYQ58443.1    KQ434809    KZC06404.1    GEZM01051100    JAV75175.1    KQ976723    KYM76657.1    KB632357    ERL93472.1    NWSH01000324    PCG77465.1    CM000361    CM002910    EDX05096.1    KMY90323.1    KQ459598    KPI94607.1    JTDY01000998    KOB75157.1    CH916368    EDW02843.1    GEDC01025701    GEDC01023358    JAS11597.1    JAS13940.1    KQ461183    KPJ07555.1    ACPB03003006    ACPB03003007    ACPB03003008    GGFL01002524    MBW66702.1    GGFL01002232    MBW66410.1    GGFJ01000103    MBW49244.1    GGFL01002304    MBW66482.1    GGFK01001239    MBW34560.1    AXCN02000794    ADMH02000481    ETN66322.1    JXJN01023741    JXJN01023742    GGFM01000990    MBW21741.1    GGFK01001253    MBW34574.1    GGFJ01000094    MBW49235.1    GL448450    EFN84631.1    ATLV01014402    KE524970    KFB38675.1    GDHF01032785    GDHF01002196    JAI19529.1    JAI50118.1    GAKP01022340    JAC36612.1    APGK01024675    KB740558    ENN80359.1    GBXI01001246    GBXI01000160    JAD13046.1    JAD14132.1    CH902620    EDV30712.1    CCAG010021883    CH940649    EDW63656.2    CH954177    EDV57994.1    BT132752    AE014134    AET07635.1    AHN54463.1    AHN54464.1    AY069438    BT011332    AAF53435.1    AAR96124.1    DS235811    EEB17358.1    CH933807    EDW11778.1    KRG02912.1    KRG02913.1    DS231876    EDS41979.1    CH480818    EDW51799.1    CM000157    EDW89782.1    NEVH01016296    PNF26019.1    APCN01003381    CH479184    EDW37047.1    CH379058    EAL34422.1    GDIQ01084623    GDIQ01066741    GDIQ01034392    JAN60345.1    GDIQ01072731    JAN22006.1    GDIQ01225775    JAK25950.1    GDIQ01041397    GDIQ01038445    JAN53340.1    GDIQ01175340    JAK76385.1    GDIQ01086171    JAN08566.1    GDIQ01217376    JAK34349.1    GDIQ01114010    JAL37716.1    GDIQ01189883    GDIQ01063185    GDIQ01038446    GDIQ01029350    JAN56291.1    GDIQ01120964    JAL30762.1    GDIQ01072729    JAN22008.1    GDIQ01072730    JAN22007.1    GDIQ01265954    JAJ85770.1    GDIQ01072728    JAN22009.1    GDIQ01120962    JAL30764.1    GDIQ01063186    JAN31551.1    GDIQ01229424    JAK22301.1    GDIQ01223377    JAK28348.1    GDIQ01078025    GDIQ01078022    JAN16715.1    GDIQ01155249    JAK96476.1    GDIQ01101266    JAL50460.1    GDIQ01101267    JAL50459.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000037510    UP000007151    + More
UP000007266    UP000192223    UP000002358    UP000215335    UP000027135    UP000053097    UP000279307    UP000078541    UP000078492    UP000007755    UP000005205    UP000242457    UP000078542    UP000075809    UP000076502    UP000078540    UP000030742    UP000000304    UP000001070    UP000095301    UP000015103    UP000075886    UP000069272    UP000000673    UP000092460    UP000075880    UP000008237    UP000030765    UP000019118    UP000007801    UP000092444    UP000008792    UP000008711    UP000000803    UP000009046    UP000009192    UP000002320    UP000001292    UP000002282    UP000095300    UP000235965    UP000192221    UP000075902    UP000075903    UP000075882    UP000076407    UP000075840    UP000008744    UP000001819   

PRIDE

H9J903    G7H829    Q9V3Z6    Q29P71   

Pfam

PF00784   MyTH4        + More
PF00063   Myosin_head
PF00612   IQ
PF09379   FERM_N
PF00373   FERM_M
PF07653   SH3_2
PF01398   JAB
PF13012   MitMem_reg
PF00254   FKBP_C
PF00018   SH3_1
PF16087   DUF4817
PF15866   DUF4729

Interpro

IPR036106   MYSc_Myo7        + More
IPR035963   FERM_2       
IPR038185   MyTH4_dom_sf       
IPR008989   Myosin_S1_N       
IPR041793   MyoVII_FERM_C1       
IPR000857   MyTH4_dom       
IPR001452   SH3_domain       
IPR019749   Band_41_domain       
IPR014352   FERM/acyl-CoA-bd_prot_sf       
IPR000048   IQ_motif_EF-hand-BS       
IPR029071   Ubiquitin-like_domsf       
IPR000299   FERM_domain       
IPR027417   P-loop_NTPase       
IPR041794   MyoVII_FERM_C2       
IPR036028   SH3-like_dom_sf       
IPR011993   PH-like_dom_sf       
IPR001609   Myosin_head_motor_dom       
IPR019748   FERM_central       
IPR036961   Kinesin_motor_dom_sf       
IPR018979   FERM_N       
IPR037518   MPN       
IPR000555   JAMM/MPN+_dom       
IPR033858   MPN_RPN7_8       
IPR024969   Rpn11/EIF3F_C       
IPR001179   PPIase_FKBP_dom       
IPR011990   TPR-like_helical_dom_sf       
IPR032135   DUF4817       
IPR031732   DUF4729       

SUPFAM

SSF52540   SSF52540        + More
SSF47031   SSF47031       
SSF50044   SSF50044       
SSF54236   SSF54236       
SSF48452   SSF48452       

Gene 3D

1.20.80.10     1.25.40.530     2.30.29.30     2.30.30.360     3.40.850.10     1.25.40.10    

CDD

cd13199  FERM_C2_MyoVII
cd14473  FERM_B-lobe
cd01381  MYSc_Myo7
cd13198  FERM_C1_MyoVII
cd08062  MPN_RPN7_8

ProteinModelPortal

H9J903   A0A2A4K9A0   A0A194R2Z7   A0A194PS87   A0A0L7LRR9   A0A212EQE4   + More
A0A2H1X0J5   D6WJX5   A0A1B6ETW6   A0A1W4X3J6   K7J8Z2   A0A232EMR2   A0A067QNC8   A0A026WSA2   A0A195EXJ5   A0A348G641   A0A0C9RPF2   A0A195DUL7   F4W8A1   A0A158NSP1   D6WM41   A0A2A3E8T4   A0A195CAT1   A0A151XDL4   A0A154P506   A0A1Y1LTF3   A0A151HY88   U4UK26   A0A2A4JZM2   B4Q5Z3   A0A194PMR5   A0A0L7LIA5   B4JAX3   A0A1B6CKI8   A0A1I8N9D6   A0A0N1PEV6   T1ICE8   A0A2M4CMY6   A0A2M4CM41   A0A2M4B870   A0A2M4CMB7   A0A2M4A1G1   A0A182R007   A0A182FN67   W5JPK4   A0A1B0C0S5   A0A2M3YZS8   A0A2M4A185   A0A2M4B856   A0A182IPQ8   E2BI60   A0A084VL31   A0A0K8WG24   A0A034V390   N6TIU3   A0A0A1XPT4   B3MLC3   A0A1B0G9B5   B4LRY0   B3N5N5   G7H829   Q9V3Z6   E0VVF2   B4KLB7   B0WB21   B4HXL9   B4NYT1   A0A1I8NXV5   A0A2J7QBS1   A0A1W4WBQ5   A0A182TFZ3   A0A182VP23   A0A182LMR3   A0A1S4HE37   A0A182XNT2   A0A182I7D7   B4GK81   Q29P71   A0A0P6GEH4   A0A0P6DU95   A0A0P5HN39   A0A0P6FXT3   A0A0P5MR18   A0A0P6CXA4   A0A0P5IB22   A0A0P5R7B3   A0A0P6G4U9   A0A0P5Q1P0   A0A0P6DT15   A0A0P6E6W2   A0A0P5G985   A0A0P6DT69   A0A0P5QGY1   A0A0P6EGA9   A0A0P5HRB6   A0A0P5HSC7   A0A0P6DFS6   A0A0P5MIA8   A0A0P5RHZ5   A0A0N8C9M4  

PDB

3PVL     E-value=0,     Score=1725

KEGG

101739883    K10359 myosin VIIa | (RefSeq) myosin-VIIa-like

GO

GO:0003774   GO:0016459   GO:0005524   GO:0051015   GO:0003779   GO:0005838   GO:0003755   GO:0045296   GO:0005902   GO:0008586   GO:0007015   GO:0045179   GO:0035293   GO:0031477   GO:0030898   GO:0045180   GO:0048800   GO:0035182   GO:0070825   GO:0008407   GO:0030048   GO:0007605   GO:0032027   GO:0035317   GO:0032529   GO:0016021   GO:0016887   GO:0007469   GO:0042623   GO:0005737   GO:0007423   GO:0016461   GO:0005938   GO:0005856   GO:0005515   GO:0006810   GO:0006397   GO:0004651   GO:0005634  

Subcellular location

Cytoplasm   In scolopale cells (radially organized units in the Johnston's organ), protein is concentrated along actin-rich scolopale rods and more apically near scolopale cell-cap cell junctions (PubMed:15886106). In neurons, protein is concentrated near the basal body where neurons are tethered to the scolopale cell (PubMed:15886106). In germline and associated somatic cells of the ovary, it has a punctate distribution and associates with specific F-actin cell structures (PubMed:25236597). In germline cells, expressed in the F-actin-rich cytocortex of the oocyte (from stage 3, peaking at stages 9 to 10a) and in the cortex of nurse cells (from stage 6) (PubMed:25236597). Expressed in the microvilli and terminal web of follicle cells (PubMed:25236597). High expression at the base of the follicle cell microvilli in the brush border (PubMed:25236597).   With evidence from 10 publications.
Cell cortex   In scolopale cells (radially organized units in the Johnston's organ), protein is concentrated along actin-rich scolopale rods and more apically near scolopale cell-cap cell junctions (PubMed:15886106). In neurons, protein is concentrated near the basal body where neurons are tethered to the scolopale cell (PubMed:15886106). In germline and associated somatic cells of the ovary, it has a punctate distribution and associates with specific F-actin cell structures (PubMed:25236597). In germline cells, expressed in the F-actin-rich cytocortex of the oocyte (from stage 3, peaking at stages 9 to 10a) and in the cortex of nurse cells (from stage 6) (PubMed:25236597). Expressed in the microvilli and terminal web of follicle cells (PubMed:25236597). High expression at the base of the follicle cell microvilli in the brush border (PubMed:25236597).   With evidence from 10 publications.
Cell projection   In scolopale cells (radially organized units in the Johnston's organ), protein is concentrated along actin-rich scolopale rods and more apically near scolopale cell-cap cell junctions (PubMed:15886106). In neurons, protein is concentrated near the basal body where neurons are tethered to the scolopale cell (PubMed:15886106). In germline and associated somatic cells of the ovary, it has a punctate distribution and associates with specific F-actin cell structures (PubMed:25236597). In germline cells, expressed in the F-actin-rich cytocortex of the oocyte (from stage 3, peaking at stages 9 to 10a) and in the cortex of nurse cells (from stage 6) (PubMed:25236597). Expressed in the microvilli and terminal web of follicle cells (PubMed:25236597). High expression at the base of the follicle cell microvilli in the brush border (PubMed:25236597).   With evidence from 10 publications.
Microvillus   In scolopale cells (radially organized units in the Johnston's organ), protein is concentrated along actin-rich scolopale rods and more apically near scolopale cell-cap cell junctions (PubMed:15886106). In neurons, protein is concentrated near the basal body where neurons are tethered to the scolopale cell (PubMed:15886106). In germline and associated somatic cells of the ovary, it has a punctate distribution and associates with specific F-actin cell structures (PubMed:25236597). In germline cells, expressed in the F-actin-rich cytocortex of the oocyte (from stage 3, peaking at stages 9 to 10a) and in the cortex of nurse cells (from stage 6) (PubMed:25236597). Expressed in the microvilli and terminal web of follicle cells (PubMed:25236597). High expression at the base of the follicle cell microvilli in the brush border (PubMed:25236597).   With evidence from 10 publications.

Length:

1989

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

4.7784

Exp number, first 60 AAs:

5e-05

Total prob of N-in:

0.21563

outside

1  -  1989

 

 

Pi

211.48884

Theta

199.673891

Tajima's D

0.123786

CLR

0.357862

CSRT

0.403329833508325

Interpretation

Uncertain