Gene

KWMTBOMO01797

Pre Gene Modal

BGIBMGA005996

Annotation

PREDICTED:_inactive_peptidyl-prolyl_cis-trans_isomerase_shutdown-like_[Papilio_xuthus]

Location

Bomo_Chr4(-):5112852-5116391      View in EpiBrowser

Full name

Peptidylprolyl isomerase       + More
Inactive peptidyl-prolyl cis-trans isomerase shutdown      

Location in the cell

Extracellular   Reliability : 1.58 Mitochondrial   Reliability : 1.108

CDS

ATGTGTACCGTCACTTTAGAAAATGGACTAGATCTACGGGAATGTACAACTACAGGCTCTATTTTGCACATCAATGAGATATATGAAGAAAATGATGATAATGATACTACAGAGAGCAAAGTATTTAAGACAATTGACATTCTGGGAGAACCTGTAAAAAATTTTGAAGTCTTAAAAAATGAATTGATTCCTGTTGATGAAAATCACTATGTAATTAAGAAAATACTAGAAACTGGTGGAGGTATGCCCTTGCATGATGGATGCACAGTCTCAATAGCATTCTCTGGATACTGGGAAAATGAGTTACAACCATTTGACGTAATGAGTTTAAATAATCCAATGACTGTAGATCTCAAAGACAGTGGTTTACTACCAGGACTAGATATAGCTGTTAGATCAATGCTTGTTGTGCACTGA

Protein

MCTVTLENGLDLRECTTTGSILHINEIYEENDDNDTTESKVFKTIDILGEPVKNFEVLKNELIPVDENHYVIKKILETGGGMPLHDGCTVSIAFSGYWENELQPFDVMSLNNPMTVDLKDSGLLPGLDIAVRSMLVVH

Description

Co-chaperone required during oogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with Hsp83/HSP90 and is required for the biogenesis of all three piRNA major populations.

Catalytic Activity

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Subunit

Interacts with Hsp83.

Similarity

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Belongs to the FKBP6 family.
Belongs to the AB hydrolase superfamily. Lipase family.

Keywords

Complete proteome   Cytoplasm   Differentiation   Meiosis   Oogenesis   Reference proteome   Repeat   RNA-mediated gene silencing   TPR repeat  

Feature

chain  Inactive peptidyl-prolyl cis-trans isomerase shutdown

Uniprot

H9J904   A0A2A4KA46   A0A194PKM8   A0A194R279   A0A2H1X0J5   A0A212EQC1   + More
S4PB25   A0A0L7K2F0   A0A0L7LRS1   A0A240PJX4   A0A2L2YF89   A0A182MGT8   A0A084VU23   A0A084VV77   T1IHK7   A0A182T071   A0A182YPF5   W5JRX6   A0A182Q1X1   A0A0P4W9F9   A0A2S2PM08   A0A182FTD7   A0A182JWF1   A0A182WF59   A0A0M5IZM0   A0A1W4XBG3   A0A2H8TG04   A0A151IEV6   A0A182R8Q0   Q9W1I9   F6UPL4   A0A1W2WD62   T1IJ05   E2A4Y8   A0A2A3EFJ9   A0A2R7VTC0   A0A2T7PCS5   A0A131YQH4   A0A2R5L7K0   A0A2S2QU73   A0A2S2Q1C7   A0A3B0JKR6   B4QB02   B4I8U0   E2C0E2   J9K208   Q293G0   B4GBK4   A0A0J7L1A3   A0A0A1XP56   A0A2S2NAH8  

EC Number

5.2.1.8

Pubmed

19121390    26354079    22118469    23622113    26227816    26561354    + More
24438588    25244985    20920257    23761445    10731132    12537572    10978289    22902557    22753781    12481130    15114417    20798317    26830274    17994087    22936249    15632085    25830018   

EMBL

BABH01004803    BABH01004804    NWSH01000013    PCG80856.1    KQ459601    KPI93991.1    + More
KQ460855    KPJ11893.1    ODYU01012494    SOQ58831.1    AGBW02013271    OWR43685.1    GAIX01004776    JAA87784.1    JTDY01017280    KOB51858.1    JTDY01000232    KOB78158.1    IAAA01022285    IAAA01022286    LAA06687.1    AXCM01000254    ATLV01016628    KE525098    KFB41467.1    ATLV01017157    KE525157    KFB41871.1    JH429910    ADMH02000540    ETN66048.1    AXCN02002114    GDRN01070793    GDRN01070791    JAI63809.1    GGMR01017297    MBY29916.1    CP012524    ALC40886.1    GFXV01001194    MBW12999.1    KQ977854    KYM99352.1    AE013599    AY058554    EAAA01001361    JH430221    GL436770    EFN71505.1    KZ288269    PBC29989.1    KK854074    PTY10763.1    PZQS01000004    PVD31214.1    GEDV01007053    JAP81504.1    GGLE01001345    MBY05471.1    GGMS01011877    MBY81080.1    GGMS01002365    MBY71568.1    OUUW01000001    SPP75950.1    CM000362    CM002911    EDX08439.1    KMY96126.1    CH480824    EDW57015.1    GL451770    EFN78601.1    ABLF02022443    ABLF02022445    ABLF02022446    ABLF02061685    CM000071    EAL24651.2    CH479181    EDW31299.1    LBMM01001374    KMQ96426.1    GBXI01001622    JAD12670.1    GGMR01001167    MBY13786.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000037510    + More
UP000075880    UP000075883    UP000030765    UP000075901    UP000076408    UP000000673    UP000075886    UP000069272    UP000075881    UP000075920    UP000092553    UP000192223    UP000078542    UP000075900    UP000000803    UP000008144    UP000000311    UP000242457    UP000245119    UP000268350    UP000000304    UP000001292    UP000008237    UP000007819    UP000001819    UP000008744    UP000036403   

PRIDE

H9J904    Q9W1I9   

Pfam

PF00254   FKBP_C        + More
PF00063   Myosin_head
PF00784   MyTH4
PF00373   FERM_M
PF07653   SH3_2
PF09379   FERM_N
PF00027   cNMP_binding
PF00520   Ion_trans
PF07719   TPR_2
PF04148   Erv26
PF13181   TPR_8
PF00151   Lipase
PF02949   7tm_6

Interpro

IPR013026   TPR-contain_dom        + More
IPR011990   TPR-like_helical_dom_sf       
IPR001179   PPIase_FKBP_dom       
IPR042282   FKBP6/shu       
IPR019734   TPR_repeat       
IPR036028   SH3-like_dom_sf       
IPR041794   MyoVII_FERM_C2       
IPR027417   P-loop_NTPase       
IPR000299   FERM_domain       
IPR029071   Ubiquitin-like_domsf       
IPR018979   FERM_N       
IPR036961   Kinesin_motor_dom_sf       
IPR019748   FERM_central       
IPR001609   Myosin_head_motor_dom       
IPR011993   PH-like_dom_sf       
IPR041793   MyoVII_FERM_C1       
IPR038185   MyTH4_dom_sf       
IPR035963   FERM_2       
IPR036106   MYSc_Myo7       
IPR000048   IQ_motif_EF-hand-BS       
IPR014352   FERM/acyl-CoA-bd_prot_sf       
IPR019749   Band_41_domain       
IPR001452   SH3_domain       
IPR000857   MyTH4_dom       
IPR018490   cNMP-bd-like       
IPR014710   RmlC-like_jellyroll       
IPR018488   cNMP-bd_CS       
IPR000595   cNMP-bd_dom       
IPR005821   Ion_trans_dom       
IPR013105   TPR_2       
IPR036867   R3H_dom_sf       
IPR007277   Svp26/Tex261       
IPR023566   PPIase_FKBP       
IPR000734   TAG_lipase       
IPR029058   AB_hydrolase       
IPR004117   7tm6_olfct_rcpt       
IPR013818   Lipase/vitellogenin       
IPR033906   Lipase_N       

SUPFAM

SSF48452   SSF48452        + More
SSF52540   SSF52540       
SSF54236   SSF54236       
SSF50044   SSF50044       
SSF47031   SSF47031       
SSF51206   SSF51206       
SSF53474   SSF53474       

Gene 3D

1.25.40.10     1.20.80.10     1.25.40.530     2.30.29.30     3.40.850.10     2.60.120.10     3.30.1370.50     3.40.50.1820    

CDD

cd14473  FERM_B-lobe
cd13198  FERM_C1_MyoVII
cd01381  MYSc_Myo7
cd13199  FERM_C2_MyoVII
cd00038  CAP_ED
cd00707  Pancreat_lipase_like

ProteinModelPortal

H9J904   A0A2A4KA46   A0A194PKM8   A0A194R279   A0A2H1X0J5   A0A212EQC1   + More
S4PB25   A0A0L7K2F0   A0A0L7LRS1   A0A240PJX4   A0A2L2YF89   A0A182MGT8   A0A084VU23   A0A084VV77   T1IHK7   A0A182T071   A0A182YPF5   W5JRX6   A0A182Q1X1   A0A0P4W9F9   A0A2S2PM08   A0A182FTD7   A0A182JWF1   A0A182WF59   A0A0M5IZM0   A0A1W4XBG3   A0A2H8TG04   A0A151IEV6   A0A182R8Q0   Q9W1I9   F6UPL4   A0A1W2WD62   T1IJ05   E2A4Y8   A0A2A3EFJ9   A0A2R7VTC0   A0A2T7PCS5   A0A131YQH4   A0A2R5L7K0   A0A2S2QU73   A0A2S2Q1C7   A0A3B0JKR6   B4QB02   B4I8U0   E2C0E2   J9K208   Q293G0   B4GBK4   A0A0J7L1A3   A0A0A1XP56   A0A2S2NAH8  

KEGG

101742507    no KO assigned | (RefSeq) peptidyl-prolyl cis-trans isomerase FKBP20-1-like

GO

GO:0003755   GO:0003774   GO:0003779   GO:0005524   GO:0016459   GO:0016021   GO:0005216   GO:0003676   GO:0070725   GO:0005737   GO:0043186   GO:0051321   GO:0034587   GO:0031047   GO:0048477   GO:0000413   GO:0061077   GO:0005576   GO:0005549   GO:0006629   GO:0052689   GO:0004984  

PANTHER

PTHR46674   PTHR10516   PTHR11610  

Subcellular location

Cytoplasm  
Secreted  

Length:

138

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00613999999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.12109

outside

1  -  138

 

 

Pi

6.76472

Theta

36.982272

Tajima's D

-2.508192

CLR

342.905562

CSRT

0.000699965001749912

Interpretation

Possibly Positive selection