Gene

KWMTBOMO01771

Pre Gene Modal

BGIBMGA006146

Annotation

WNT_[Helicoverpa_armigera]

Location

Bomo_Chr4(+):4247639-4267866      View in EpiBrowser

Full name

Protein Wnt       + More
Protein Wnt-1      

Location in the cell

Nuclear   Reliability : 2.182

CDS

ATGGACCCGGCGGTTCACGCTACGCTAAGAAGAAAACAAAGAAGATTGGCCAGAGAGAACCCAGGAGTTTTGGCCGCAGTCGCCAAGGGCGCCAGTATGGCGGTCGCGGAGTGTCAACACCAATTCAAGTATAGAAGATGGAACTGCTCCACGAGAAACTTTCTAAGGGGCAAGAACTTGTTCGGAAAAATTGTGGATAGAGGTTGCCGTGAGACCGCCTTCATCTACGCTATAACGAGCGCCGGAGTAACCCACTCCGTGGCCCGCGCCTGCGCCGAGGGCTCCATAGAATCGTGCACGTGCGACTATTCGCACATCGACCGCGTGCCGCACAGAACCCGGTCGGCGGCCGCGGCCAACGTGCGCGTCTGGAAGTGGGGCGGCTGCAGCGACAACATCGGCTTCGGATTTCGCTTCAGCAGGGAGTTCGTTGATACCGGAGAACGAGGCAAGACTCTAAGGGAGAAAATGAACCTGCACAACAACGAAGCCGGCAGAGCGCACGTGCAAACGGAGATGAAGCAGGAGTGCAAGTGCCACGGCATGTCAGGCTCGTGCACCGTGAAGACTTGCTGGATGAGGCTGCCGAGCTTCAGGTCGGTGGGTGACTCGCTGAAGGACCGGTTCGATGGCGCGTCACGCGTGATGCTGTCGAAGGCGGAGCTCGAGACGCCGGCGCAGCGCAACGAGGCGGCGCCGCACCGGGTGCCGCGCAAAGACCGGTACCGGTTCCAGTTGCGGCCGCACAATCCGGACCACAAGTCGCCCGGGGTCAAAGACCTCGTCTACCTGGAATCGTCGCCGGGATTCTGCGAAAAGAATCCGCGTCTAGGCATCCCCGGCACGCACGGCCGCGCCTGCAACGACACTAGCATCGGCGTGGACGGCTGCGACCTGATGTGCTGCGGCCGCGGCTACAAGACAAACACGATGTTCGTGGTTGAGAGATGCAACTGCACGTTCCATTGGTGTTGCGAGGTCAAGTGCAAACTGTGTCGTACGGAAAAAGTGGTGCACACGTGTTTATAG

Protein

MDPAVHATLRRKQRRLARENPGVLAAVAKGASMAVAECQHQFKYRRWNCSTRNFLRGKNLFGKIVDRGCRETAFIYAITSAGVTHSVARACAEGSIESCTCDYSHIDRVPHRTRSAAAANVRVWKWGGCSDNIGFGFRFSREFVDTGERGKTLREKMNLHNNEAGRAHVQTEMKQECKCHGMSGSCTVKTCWMRLPSFRSVGDSLKDRFDGASRVMLSKAELETPAQRNEAAPHRVPRKDRYRFQLRPHNPDHKSPGVKDLVYLESSPGFCEKNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYKTNTMFVVERCNCTFHWCCEVKCKLCRTEKVVHTCL

Description

Ligand for members of the frizzled family of seven transmembrane receptors.
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:25451226). Developmental protein that promotes cell proliferation in the developing spinal cord (PubMed:25451226). Has a role in osteoblast function, bone development and bone homeostasis (By similarity).
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (By similarity).

Cofactor

Zn(2+)

Subunit

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with PORCN (PubMed:25451226).

Similarity

Belongs to the Wnt family.

Keywords

Complete proteome   Developmental protein   Disulfide bond   Extracellular matrix   Glycoprotein   Lipoprotein   Reference proteome   Secreted   Signal   Wnt signaling pathway  

Feature

chain  Protein Wnt

Uniprot

H9J9F3   A0A2A4JXL3   A0A1L6KTF1   A0A2H1V5Y3   X2LDI0   A0A212EY54   + More
P49340   A0A194R3Q4   A0A0L7LHR0   A0A194PKQ4   I4DQX0   A0A0M4FID9   B0WGM4   A0A1S4EWA7   A0A2A4JWW9   A0A0P6K0M7   A0A182KU43   A0A2C9GPC8   Q17NQ3   A0A182UWG4   A0A182Y0M5   Q16S09   K7JA62   A0A182QN05   A0A1W2JPH8   M4LXP6   A0A084WU45   A0A0C9PMZ8   A0A088A2M9   A0A2A3E553   A0A154PGJ4   A0A158NDP6   A0A3L8DYW9   A0A195EYV2   T1HPD0   A0A026VXZ0   A0A0A9Y472   A0A146L7W9   E0VF97   A0A336JWF1   A0A2R7WMU2   A0A195CM15   A0A1B0REL5   A0A1Y1L7R6   A0A2Z6BDV1   A0A195BP95   A0A195DA29   E2A0L8   Q27671   Q8MZJ2   A0A151XEQ5   Q8MZJ5   Q9GRA6   D4Q9N9   E9G214   Q8MZJ4   A0A0S1NF57   D6WK66   Q8MZJ3   A0A0P6BSQ4   Q5TP56   A0A2J7RGC5   E9IYT7   E2B609   A0A1J1HZY3   A0A1D2MRM2   A0A226EZ64   A0A0P5JIH2   D3KSP2   T1IPG8   A0A0K1NZC2   A0A0U5LAV1   B7PV28   Q8T396   A0A2R4A6T8   A0A346FPY5   Q75PH9   W5MM44   A0A0P7UK18   A0A1D5PML8   U3JBK6   Q91029   A0A3B3QWM9   P21551   H0ZXE3   A0A0Q3P0T7   A0A091FUC8   A0A218U9N7   A0A1V4JVM5   H3BIA7   A0A3B5LHB7   W4Y7P9   A0A226P554   J9P890   F6YEQ6   A0A151N0A0   A0A147A667   A0A212DFJ7   A0A0L8GAT0  

Pubmed

19121390    25038464    22118469    26354079    26227816    22651552    + More
26999592    20966253    17510324    25244985    20075255    23430316    24438588    21347285    30249741    24508170    25401762    26823975    20566863    28004739    20798317    7912449    12114626    11003837    21292972    18362917    19820115    12364791    21282665    27289101    25895830    11874919    29567137    15592404    7821210    7577679    16258938    22046319    25451226    29240929    2259633    2017393    8508949    20360741    9215903    24621616    16341006    19892987    22293439    29294181   

EMBL

BABH01004718    BABH01004719    NWSH01000422    PCG76506.1    KU640201    APR72350.1    + More
ODYU01000848    SOQ36227.1    KJ206240    AHN95659.1    AGBW02011632    OWR46374.1    D14169    KQ460855    KPJ11870.1    JTDY01001064    KOB74987.1    KQ459601    KPI94016.1    AK404816    BAM20310.1    KP245731    ALC76151.1    DS231927    EDS27053.1    PCG76505.1    GDUN01001120    JAN94799.1    APCN01001776    CH477197    EAT48350.1    CH477689    EAT37259.1    AAZX01007301    AAZX01009629    AAZX01015180    AXCN02000684    KJ680328    AHY30856.1    KC311252    AGG14205.1    ATLV01026998    ATLV01026999    KE525421    KFB53739.1    GBYB01002533    JAG72300.1    KZ288367    PBC26820.1    KQ434899    KZC10927.1    ADTU01012750    ADTU01012751    ADTU01012752    ADTU01012753    ADTU01012754    QOIP01000002    RLU25651.1    KQ981906    KYN33306.1    ACPB03014836    KK107578    EZA48658.1    GBHO01016635    JAG26969.1    GDHC01014138    JAQ04491.1    DS235107    EEB12053.1    UFQS01000004    UFQT01000004    SSW96789.1    SSX17176.1    KK854927    PTY19735.1    KQ977600    KYN01512.1    KM264384    AKE98364.1    GEZM01064057    JAV68841.1    LC373549    BBD17792.1    KQ976424    KYM88337.1    KQ981082    KYN09738.1    GL435626    EFN72921.1    L42142    AAB46368.1    AY101372    AAM33138.1    KQ982254    KYQ58811.1    AY101369    AAM33135.1    AB044713    BAB19660.1    AB465516    GDIP01156146    LRGB01000512    BAJ05334.1    JAJ67256.1    KZS18493.1    GL732530    EFX86386.1    AY101370    AAM33136.1    KT818597    ALL53296.1    KQ971342    EFA04660.2    AY101371    AAM33137.1    GDIP01010526    JAM93189.1    AAAB01008980    EAL39184.3    NEVH01004401    PNF39873.1    GL767051    EFZ14267.1    GL445900    EFN88870.1    CVRI01000037    CRK93523.1    LJIJ01000640    ODM95646.1    LNIX01000001    OXA61956.1    GDIQ01198661    JAK53064.1    AB439847    BAI79509.1    JH431262    KP013754    AKU77017.1    LN899787    CUS58512.1    ABJB010414227    ABJB010433212    ABJB010570271    ABJB010696084    ABJB010698419    ABJB010786141    ABJB010860670    ABJB011023140    ABJB011047525    ABJB011133600    DS797003    EEC10450.1    AJ315945    CAC87040.1    MH021973    AVR59260.1    MF416108    AXN72346.1    AB167808    BAD12586.1    AHAT01032561    JARO02009344    KPP61738.1    AADN05001526    AGTO01001701    KQ759375    X81693    AY655699    AY753286    X55270    ABQF01082430    LMAW01003082    KQK74139.1    KL447364    KFO72606.1    MUZQ01000571    OWK50301.1    LSYS01005895    OPJ76203.1    AFYH01001812    AAGJ04137089    AAGJ04137090    AWGT02000177    OXB74539.1    AAEX03015075    AKHW03004280    KYO30157.1    GCES01012526    JAR73797.1    MKHE01000003    OWK16980.1    KQ423077    KOF73635.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000037510    UP000053268    + More
UP000002320    UP000075882    UP000075840    UP000008820    UP000075903    UP000076408    UP000002358    UP000075886    UP000030765    UP000005203    UP000242457    UP000076502    UP000005205    UP000279307    UP000078541    UP000015103    UP000053097    UP000009046    UP000078542    UP000078540    UP000078492    UP000000311    UP000075809    UP000076858    UP000000305    UP000007266    UP000007062    UP000235965    UP000008237    UP000183832    UP000094527    UP000198287    UP000001555    UP000018468    UP000034805    UP000192224    UP000000539    UP000016665    UP000261540    UP000007754    UP000051836    UP000053760    UP000197619    UP000190648    UP000008672    UP000261380    UP000007110    UP000198419    UP000002254    UP000002281    UP000050525    UP000265000    UP000053454   

PRIDE

H9J9F3    P49340    Q91029    P21551   

Pfam

PF00110   wnt        + More
PF01400   Astacin

Interpro

IPR005817   Wnt        + More
IPR018161   Wnt_CS       
IPR024079   MetalloPept_cat_dom_sf       
IPR001506   Peptidase_M12A       
IPR006026   Peptidase_Metallo       
IPR009139   Wnt1       

Gene 3D

3.40.390.10    

ProteinModelPortal

H9J9F3   A0A2A4JXL3   A0A1L6KTF1   A0A2H1V5Y3   X2LDI0   A0A212EY54   + More
P49340   A0A194R3Q4   A0A0L7LHR0   A0A194PKQ4   I4DQX0   A0A0M4FID9   B0WGM4   A0A1S4EWA7   A0A2A4JWW9   A0A0P6K0M7   A0A182KU43   A0A2C9GPC8   Q17NQ3   A0A182UWG4   A0A182Y0M5   Q16S09   K7JA62   A0A182QN05   A0A1W2JPH8   M4LXP6   A0A084WU45   A0A0C9PMZ8   A0A088A2M9   A0A2A3E553   A0A154PGJ4   A0A158NDP6   A0A3L8DYW9   A0A195EYV2   T1HPD0   A0A026VXZ0   A0A0A9Y472   A0A146L7W9   E0VF97   A0A336JWF1   A0A2R7WMU2   A0A195CM15   A0A1B0REL5   A0A1Y1L7R6   A0A2Z6BDV1   A0A195BP95   A0A195DA29   E2A0L8   Q27671   Q8MZJ2   A0A151XEQ5   Q8MZJ5   Q9GRA6   D4Q9N9   E9G214   Q8MZJ4   A0A0S1NF57   D6WK66   Q8MZJ3   A0A0P6BSQ4   Q5TP56   A0A2J7RGC5   E9IYT7   E2B609   A0A1J1HZY3   A0A1D2MRM2   A0A226EZ64   A0A0P5JIH2   D3KSP2   T1IPG8   A0A0K1NZC2   A0A0U5LAV1   B7PV28   Q8T396   A0A2R4A6T8   A0A346FPY5   Q75PH9   W5MM44   A0A0P7UK18   A0A1D5PML8   U3JBK6   Q91029   A0A3B3QWM9   P21551   H0ZXE3   A0A0Q3P0T7   A0A091FUC8   A0A218U9N7   A0A1V4JVM5   H3BIA7   A0A3B5LHB7   W4Y7P9   A0A226P554   J9P890   F6YEQ6   A0A151N0A0   A0A147A667   A0A212DFJ7   A0A0L8GAT0  

PDB

6AHY     E-value=2.75717e-68,     Score=656

KEGG

692745    K03209 wingless-type MMTV integration site family, member 1 | (RefSeq) WNT-1, wgl, wingless, wingles

PATHWAY

04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)
04391    Hippo signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0016055   GO:0007275   GO:0005576   GO:0005102   GO:0004222   GO:0008270   GO:0045165   GO:0005615   GO:0005109   GO:0016021   GO:0030182   GO:0030917   GO:0035284   GO:0021587   GO:0021592   GO:0061184   GO:1904954   GO:0022408   GO:0045599   GO:0036520   GO:0005125   GO:0000578   GO:0042770   GO:0019904   GO:0005737   GO:0043066   GO:0044212   GO:0021536   GO:0030514   GO:0051091   GO:0048146   GO:0043568   GO:0090344   GO:0045747   GO:0071425   GO:0060348   GO:0001658   GO:0021551   GO:0009611   GO:1990403   GO:0021797   GO:0042472   GO:0010812   GO:0009986   GO:0021588   GO:0060061   GO:0021527   GO:2000059   GO:0007520   GO:0048664   GO:0001934   GO:0030512   GO:1903204   GO:0033077   GO:0045944   GO:0010592   GO:0030579   GO:0022004   GO:0033278   GO:0030509   GO:0006915   GO:0031334   GO:0048263   GO:0009953   GO:0048018   GO:0045893   GO:0060070   GO:0016020   GO:0005215   GO:0006810   GO:0006397   GO:0004651   GO:0005634  

PANTHER

PTHR12027  

Subcellular location

  
Secreted  
Extracellular space  
Extracellular matrix  

Length:

342

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.24928

Exp number, first 60 AAs:

0.23753

Total prob of N-in:

0.02975

outside

1  -  342

 

 

Pi

196.521465

Theta

181.544555

Tajima's D

0.084382

CLR

0.89968

CSRT

0.392180390980451

Interpretation

Uncertain