Gene

KWMTBOMO01766  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006144

Annotation

PREDICTED:_elongation_factor_G?_mitochondrial_[Amyelois_transitella]

Location

Bomo_Chr4(+):4105009-4113713      View in EpiBrowser

Full name

Elongation factor G, mitochondrial      

Alternative Name

Elongation factor G 1, mitochondrial
Elongation factor G1
Protein iconoclast

Location in the cell

Cytoplasmic   Reliability : 3.148

CDS

ATGACAATTTCTTATGCATTTCGTTTAATAAATGCGCTTAAAAATACAAAAAAATCGAGTGTATTTCAAATTGAGTTACAGAAATATTCATCACATGTCAAATATGCAGAACACAAACCATTGGAAAATATTCGAAATATTGGTATATCAGCTCACATAGACTCTGGAAAGACAACACTCACTGAACGTATTTTGTTCTATACTGGACGAATAGACCAAATGCACGAGGTTAAAGGTAAAGACAATGTTGGTGCTGTTATGGACTCAATGGAGTTGGAACGTCAAAGAGGAATTACAATACAGTCTGCTGCAACATACACTATTTGGAAGGAACATAACATTAACATTATTGATACTCCAGGACATGTAGATTTCACAGTAGAAGTAGAAAGAGCATTAAGAGTTTTAGATGGGGCGATATTGGTGTTGTGTTCTGTAGGTGGTGTTCAGAGCCAAACTTTAACAGTCAACAGACAAATGAAACGGTATAATGTACCATGTCTTGCATTTATCAATAAACTGGACAGATTAGGAGCTAATCCAGAAAGAGTACTGAAACAAATGCGTTCAAAATTAAAACATAATGCTGCATTTATACATCTACCAATTGGCTTAGAAAAAGAGTGTCAAGGAATTTTGGACCTTGTTGAGGAGAAAGCTATATATTTTGATGGTGAATATGGCGAGCATGTGCGGCTCGATGAGATTCCACAAGATCGTAGAACCGAAGTTAAGGAAAGGAGACATGAATTGATTGAACATCTTTCAAATGTAGATGAAACATTGGGAGAGTTATTCCTAGAAGAGAAAACTCCGACAGTCAATGATCTCAAGCAAGCATTACGGCGTTCCACATTAAAACGAGCATTCACTCCAGTGCTTCTGGGTACAGCTCTAAAGAATAAGGGAATTCAACCCTTACTGGATGCTGTGCTCACATATCTACCGCATCCAGGAGAAGTAGAAAACACTGCCTTGTTAAATGAAAGCAAAGATGGTGAAGGCCAAACCATAGTGTTGGATCCGACTAGGGATAATAAGAAACCATTTGTTGGTTTGGCATTCAAGTTGGAAGTGAGCAAATTTGGTCAACTCACATACTTGAGGTGTTATCAAGGGATGTTGAAGAGAGGTGACCATATATTCAACGCCAGGACTTACAAAAAGGTAAAAATATCACGTTTAGTCCGCATGCACTCGAACAACATGGAAGAGGTTAACGAGGTCCTGGCCGGTGATATATTCGCGTTGTTCGGTGTGGACTGCGCTTCGGGAGACACATTCGTGAACGATGCCAAACTGCAGCTCGCAATGGAGTCCATACATGTTCCTGACCCAGTCGTGTCCATGTCCATCAAACCGAAGCAAAATAAAGACAGAGATAACTTTTCTAAGGCTGTTGCTAGATTCACAAAAGAAGATCCCACTTTCCAATTTCATTACGACTCCGACAATAAGGAAACTATAGTGTCCGGTATGGGCGAACTCCATCTTGAGATCTATGCTCAAAGAATGGAGAGAGAATACAACTGTCCGGTCGAACTTGGGAAACCCAAGGTTGCTTTCAGGGAGACGCTGATTTCGCCTTGCGCTTTCGACTATTTACATAAGAAACAGTCGGGCGGAGCTGGCCAGTACGCACGAGTCAGCGGCATCATAGAACCTTTACCTCCTCACCAAAACACAGTACTCGAATTCGTTGATGAAACTGTGGGTACGAACATTCCCAAGCAGTTCGTGCCGGGTGTTGAAAGAGGTTTCCTGGATACATGCGAGAAGGGCTACCTGTCCGGGCACAAGGTCTCCGGTGTGAAGTTCAGGCTTCAGGACGGAGCCCACCACATTGTGGACTCCAGTGAGCTGGCATTCTTCTTGGCAGCTAAGGGGGCCGTCAAGGATGTTTTCGACGTGGGAGCGTGGCAGATACTCGAACCGGTCATGTTCGTTGAAGTAACGTTGCCGGACGAGTTCCACGGCACGGTGGTCGGGCAGCTCAACAAACGCGGCGGCATCATCACCGGGACCGAGGGGGCCGAGGGCTGGACCTCCATCTACGCCGAGGTTCCTCTCAACAACATGTTCGGATACGCCGGAGAACTGAGGTCAATGACTCAAGGTAAAGGAGAGTTCAGTATGGAGTACAGCCGGTACTCGCCTTGTCTACCGGACGTGCAGGAGCAACTGATCAGGAAGCACCAAGAGGAAATGGGGCTGCTACCAGACCAGAAGAAAAAGAAAAATTAA

Protein

MTISYAFRLINALKNTKKSSVFQIELQKYSSHVKYAEHKPLENIRNIGISAHIDSGKTTLTERILFYTGRIDQMHEVKGKDNVGAVMDSMELERQRGITIQSAATYTIWKEHNINIIDTPGHVDFTVEVERALRVLDGAILVLCSVGGVQSQTLTVNRQMKRYNVPCLAFINKLDRLGANPERVLKQMRSKLKHNAAFIHLPIGLEKECQGILDLVEEKAIYFDGEYGEHVRLDEIPQDRRTEVKERRHELIEHLSNVDETLGELFLEEKTPTVNDLKQALRRSTLKRAFTPVLLGTALKNKGIQPLLDAVLTYLPHPGEVENTALLNESKDGEGQTIVLDPTRDNKKPFVGLAFKLEVSKFGQLTYLRCYQGMLKRGDHIFNARTYKKVKISRLVRMHSNNMEEVNEVLAGDIFALFGVDCASGDTFVNDAKLQLAMESIHVPDPVVSMSIKPKQNKDRDNFSKAVARFTKEDPTFQFHYDSDNKETIVSGMGELHLEIYAQRMEREYNCPVELGKPKVAFRETLISPCAFDYLHKKQSGGAGQYARVSGIIEPLPPHQNTVLEFVDETVGTNIPKQFVPGVERGFLDTCEKGYLSGHKVSGVKFRLQDGAHHIVDSSELAFFLAAKGAVKDVFDVGAWQILEPVMFVEVTLPDEFHGTVVGQLNKRGGIITGTEGAEGWTSIYAEVPLNNMFGYAGELRSMTQGKGEFSMEYSRYSPCLPDVQEQLIRKHQEEMGLLPDQKKKKN

Description

Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Essential during development as it acts as a retrograde signal from mitochondria to the nucleus to slow down cell proliferation if mitochondrial energy output is low (By similarity).
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). Essential during development as it acts as a retrograde signal from mitochondria to the nucleus to slow down cell proliferation if mitochondrial energy output is low.

Miscellaneous

This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

Similarity

Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

Keywords

Complete proteome   Elongation factor   GTP-binding   Mitochondrion   Nucleotide-binding   Protein biosynthesis   Reference proteome   Transit peptide  

Feature

chain  Elongation factor G, mitochondrial

Uniprot

A0A2A4JK07   A0A194R253   A0A194PZ19   A0A212F564   A0A1Q3FEM1   B0WGM1   + More
A0A336MWZ0   A0A182WGI1   A0A336KYM9   A0A1I8MS52   A0A1A9WUF6   A0A182GGX6   Q16S14   A0A023EVY5   A0A182M287   A0A182TUU2   A0A084WU39   A0A182HRY1   A0A182XN79   A0A182VJA8   A0A182KU31   A0A182P4Q7   Q7Q1K8   A0A2K7P6C4   A0A1A9YDN1   A0A182R3S7   A0A182NBQ5   A0A182Y0M7   A0A182F0X9   A0A1B0G1L1   A0A2H1X234   A0A0L0BS00   A0A1B0BKX1   A0A182K0G7   A0A182IX89   A0A1A9Z620   A0A1I8Q4C7   A0A182SQM6   A0A1A9V1H1   A0A182QYP8   W5JI53   A0A1J1I174   A0A2M4ADT9   A0A2M4BF04   T1DQ02   A0A2M4BF99   B4KKD5   A0A2M3Z4A2   A0A2M4BF03   A0A1W4UYC7   B4LS49   A0A1W4X6N8   B3N6A5   A0A0J9QX85   A0A034VEY2   A0A0M4EEV7   B4Q5D5   B4HY41   A0A0K8W112   U5EXB5   Q9VM33   B4NZM7   A0A0A1WI02   W8CD33   A0A1B0CWQ0   A0A3B0JMF7   B3MK91   D6WJJ3   B4MZW9   B4JQM7   A0A067QYF5   Q29N77   H9J9F1   A0A2J7RPP8   A0A1B6EF77   A0A0T6B5D7   A0A0L7L7V4   A0A1Y1M2G3   E2A0M4   A0A1L8DR80   K7JA58   A0A0J7L508   A0A195EZJ3   A0A232EEL7   A0A146LZS1   A0A1B6JPJ1   E9JBK2   F4W861   A0A0A9ZGU0   A0A348G619   A0A0K8T3P1   T1HPG2   A0A023F4E6   A0A0C9RR10   A0A195CLD9   A0A1B6G3A0   A0A0C9R809   A0A3L8E232   A0A195D8V1   A0A224X899  

Pubmed

26354079    22118469    25315136    26483478    17510324    24945155    + More
24438588    20966253    12364791    25244985    26108605    20920257    23761445    17994087    22936249    25348373    21364917    10731132    12537572    25830018    24495485    18362917    19820115    24845553    15632085    19121390    26227816    28004739    20798317    20075255    28648823    26823975    21282665    21719571    25401762    25474469    30249741   

EMBL

NWSH01001317    PCG71732.1    KQ460855    KPJ11868.1    KQ459584    KPI98577.1    + More
AGBW02010235    OWR48878.1    GFDL01009051    JAV25994.1    DS231927    UFQT01002506    SSX33599.1    UFQS01001105    UFQT01001105    SSX09025.1    SSX28936.1    JXUM01062623    KQ562208    KXJ76412.1    CH477689    GAPW01000311    JAC13287.1    AXCM01001134    ATLV01026995    KE525421    KFB53733.1    APCN01001775    AAAB01008980    CCAG010021325    ODYU01012882    SOQ59410.1    JRES01001454    KNC22817.1    JXJN01016076    AXCN02000684    ADMH02001427    ETN62580.1    CVRI01000037    CRK93506.1    GGFK01005630    MBW38951.1    GGFJ01002488    MBW51629.1    GAMD01002874    JAA98716.1    GGFJ01002490    MBW51631.1    CH933807    GGFM01002527    MBW23278.1    GGFJ01002489    MBW51630.1    CH940649    CH954177    CM002910    KMY88722.1    GAKP01017086    JAC41866.1    CP012523    ALC38805.1    CM000361    CH480818    GDHF01007550    JAI44764.1    GANO01001033    JAB58838.1    AE014134    BT023763    CM000157    GBXI01015623    JAC98668.1    GAMC01002646    JAC03910.1    AJWK01032753    OUUW01000006    SPP82033.1    CH902620    KQ971342    EFA04773.2    CH963920    CH916372    KK852829    KDR15371.1    CH379060    BABH01004703    BABH01004704    BABH01004705    NEVH01001358    PNF42811.1    GEDC01000784    JAS36514.1    LJIG01009669    KRT82618.1    JTDY01002421    KOB71445.1    GEZM01042339    JAV79929.1    GL435626    EFN72927.1    GFDF01005108    JAV08976.1    AAZX01001625    LBMM01000752    KMQ97569.1    KQ981906    KYN33299.1    NNAY01005274    OXU16800.1    GDHC01005538    JAQ13091.1    GECU01006538    JAT01169.1    GL771210    EFZ09794.1    GL887888    EGI69731.1    GBHO01000786    JAG42818.1    FX985558    BBF97892.1    GBRD01006016    JAG59805.1    ACPB03001467    GBBI01002326    JAC16386.1    GBYB01004168    GBYB01004169    GBYB01009716    JAG73935.1    JAG73936.1    JAG79483.1    KQ977600    KYN01518.1    GECZ01012986    JAS56783.1    GBYB01004170    JAG73937.1    QOIP01000002    RLU26078.1    KQ981153    KYN08854.1    GFTR01007850    JAW08576.1   

Proteomes

UP000218220    UP000053240    UP000053268    UP000007151    UP000002320    UP000075920    + More
UP000095301    UP000091820    UP000069940    UP000249989    UP000008820    UP000075883    UP000075902    UP000030765    UP000075840    UP000076407    UP000075903    UP000075882    UP000075885    UP000007062    UP000092443    UP000075900    UP000075884    UP000076408    UP000069272    UP000092444    UP000037069    UP000092460    UP000075881    UP000075880    UP000092445    UP000095300    UP000075901    UP000078200    UP000075886    UP000000673    UP000183832    UP000009192    UP000192221    UP000008792    UP000192223    UP000008711    UP000092553    UP000000304    UP000001292    UP000000803    UP000002282    UP000092461    UP000268350    UP000007801    UP000007266    UP000007798    UP000001070    UP000027135    UP000001819    UP000005204    UP000235965    UP000037510    UP000000311    UP000002358    UP000036403    UP000078541    UP000215335    UP000007755    UP000015103    UP000078542    UP000279307    UP000078492   

PRIDE

Q7Q1K8    Q9VM33    H9J9F1   

Pfam

PF14492   EFG_II        + More
PF00679   EFG_C
PF00009   GTP_EFTU
PF03144   GTP_EFTU_D2
PF03764   EFG_IV
PF04129   Vps52
PF07714   Pkinase_Tyr

Interpro

IPR005517   Transl_elong_EFG/EF2_IV        + More
IPR041095   EFG_II       
IPR035649   EFG_V       
IPR009000   Transl_B-barrel_sf       
IPR004161   EFTu-like_2       
IPR027417   P-loop_NTPase       
IPR020568   Ribosomal_S5_D2-typ_fold       
IPR035647   EFG_III/V       
IPR031157   G_TR_CS       
IPR000640   EFG_V-like       
IPR005225   Small_GTP-bd_dom       
IPR014721   Ribosomal_S5_D2-typ_fold_subgr       
IPR000795   TF_GTP-bd_dom       
IPR009022   EFG_III       
IPR004540   Transl_elong_EFG/EF2       
IPR007258   Vps52       
IPR017441   Protein_kinase_ATP_BS       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR000719   Prot_kinase_dom       
IPR011009   Kinase-like_dom_sf       

SUPFAM

SSF52540   SSF52540        + More
SSF54980   SSF54980       
SSF50447   SSF50447       
SSF54211   SSF54211       
SSF56112   SSF56112       

Gene 3D

3.30.230.10    

CDD

cd16262  EFG_III
cd04097  mtEFG1_C
cd01434  EFG_mtEFG1_IV

ProteinModelPortal

A0A2A4JK07   A0A194R253   A0A194PZ19   A0A212F564   A0A1Q3FEM1   B0WGM1   + More
A0A336MWZ0   A0A182WGI1   A0A336KYM9   A0A1I8MS52   A0A1A9WUF6   A0A182GGX6   Q16S14   A0A023EVY5   A0A182M287   A0A182TUU2   A0A084WU39   A0A182HRY1   A0A182XN79   A0A182VJA8   A0A182KU31   A0A182P4Q7   Q7Q1K8   A0A2K7P6C4   A0A1A9YDN1   A0A182R3S7   A0A182NBQ5   A0A182Y0M7   A0A182F0X9   A0A1B0G1L1   A0A2H1X234   A0A0L0BS00   A0A1B0BKX1   A0A182K0G7   A0A182IX89   A0A1A9Z620   A0A1I8Q4C7   A0A182SQM6   A0A1A9V1H1   A0A182QYP8   W5JI53   A0A1J1I174   A0A2M4ADT9   A0A2M4BF04   T1DQ02   A0A2M4BF99   B4KKD5   A0A2M3Z4A2   A0A2M4BF03   A0A1W4UYC7   B4LS49   A0A1W4X6N8   B3N6A5   A0A0J9QX85   A0A034VEY2   A0A0M4EEV7   B4Q5D5   B4HY41   A0A0K8W112   U5EXB5   Q9VM33   B4NZM7   A0A0A1WI02   W8CD33   A0A1B0CWQ0   A0A3B0JMF7   B3MK91   D6WJJ3   B4MZW9   B4JQM7   A0A067QYF5   Q29N77   H9J9F1   A0A2J7RPP8   A0A1B6EF77   A0A0T6B5D7   A0A0L7L7V4   A0A1Y1M2G3   E2A0M4   A0A1L8DR80   K7JA58   A0A0J7L508   A0A195EZJ3   A0A232EEL7   A0A146LZS1   A0A1B6JPJ1   E9JBK2   F4W861   A0A0A9ZGU0   A0A348G619   A0A0K8T3P1   T1HPG2   A0A023F4E6   A0A0C9RR10   A0A195CLD9   A0A1B6G3A0   A0A0C9R809   A0A3L8E232   A0A195D8V1   A0A224X899  

PDB

4W29     E-value=2.49919e-158,     Score=1436

KEGG

101738219    K02355 elongation factor G | (RefSeq) elongation factor G, mitochondrial-like

GO

GO:0005525   GO:0003924   GO:0005739   GO:0003746   GO:0070125   GO:0005634   GO:0004672   GO:0005524   GO:0005622   GO:0006414   GO:0008138   GO:0006370   GO:0006397   GO:0004651  

Subcellular location

Mitochondrion  

Length:

747

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0410700000000002

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00199

outside

1  -  747

 

 

Pi

185.718917

Theta

158.597291

Tajima's D

0.807044

CLR

0.532606

CSRT

0.609669516524174

Interpretation

Uncertain