Gene

KWMTBOMO01765

Annotation

PREDICTED:_cAMP-dependent_protein_kinase_catalytic_subunit_alpha-like_[Amyelois_transitella]

Location

Bomo_Chr4(+):4087889-4089118      View in EpiBrowser

Full name

cAMP-dependent protein kinase catalytic subunit 1      

Alternative Name

Protein kinase DC0

Location in the cell

Nuclear   Reliability : 3.561 PlasmaMembrane   Reliability : 3.438

CDS

ATGTTTTCTCGTAAAACTTATGCCTCTAAGGAATTGTCTCTTAGAACAGATTCACAGAACACGACCACATCAATAAACGACGGATATTCTGAACAACAGCAACAGCAGTATGTGACGTACTTGAAACAATTAAAAAGTGAATTTGACGAACGCTGGTGCCAAAAACCGAAATACTCAATAGAATTTTCGGAGTTGGAGCGCATCAAGACTCTTGGCACGGGTGCATTCGGTAGGGTGTTTTTGTTGAAGCACACGAAGAATAATAGATTATACGCAATGAAAGTTCTAGAAAAAGAAAACATTGTAAAGATGAAACAGGTCGAGCACACACTTTACGAAAAGCGAGTTCTTGAAGCTATTAGATTTCCTTTTACCGTCTCGATGGAGTTTAGCTTCAAGGACAACAGTTACATCTATTTCATAATGCCTTTCGTGCCAGGCGGTGAAATGTTTACCCATCTGCGTCGAATGAAAAAATTTGAAGAAACACTTGCGAAATTTTACGCTAGCCAGGTCATTTTGGCTTTAGAATATCTTCATTTCTGTAATCTTGTCTATAGAGATTTGAAGCCTGAAAATATATTAATCGACAGGAATGGTTATCTGAAAATAACAGATTTCGGATTTTGCAAAGTAATGCGCGGGAGAACGTGGACTCTGTGCGGAACACCGGAATATTTAGCACCCGAATTAATCCTTAGTAGGGGCTATGGTTTTTCAGTTGATTGGTGGTCTTTCGGTGTACTAATGTTCGAAATGAATGCGGGATACCCTCCGTTTTATTCAAACGAACCGATGAAGACTTACGAGAGCATCGTAGCCGGTAGATACCGATGTCCGTCTAGTTTCAGTACGGATCTGCGAGACCTAATCCGGAACACCCTGCAGGTAGACATAACTAAGCGTTACGGCGTCATGAAGAACAGTGTTTTGGATTTCAAGAATCACAAGTGGTTCAAGGGCATCGAATGGGACGCCATTCTCAACTGTAAAGTAACTCCGCCTTTTGTGCCGAAATGTAAATCGCTTCATGACACGAGCAATTTCGATAAATATAACGAAGAACCAGTTGTTCCAGGCTCATACTGTCGCTTCGAATCCGAATTTGTCGATTTTTGA

Protein

MFSRKTYASKELSLRTDSQNTTTSINDGYSEQQQQQYVTYLKQLKSEFDERWCQKPKYSIEFSELERIKTLGTGAFGRVFLLKHTKNNRLYAMKVLEKENIVKMKQVEHTLYEKRVLEAIRFPFTVSMEFSFKDNSYIYFIMPFVPGGEMFTHLRRMKKFEETLAKFYASQVILALEYLHFCNLVYRDLKPENILIDRNGYLKITDFGFCKVMRGRTWTLCGTPEYLAPELILSRGYGFSVDWWSFGVLMFEMNAGYPPFYSNEPMKTYESIVAGRYRCPSSFSTDLRDLIRNTLQVDITKRYGVMKNSVLDFKNHKWFKGIEWDAILNCKVTPPFVPKCKSLHDTSNFDKYNEEPVVPGSYCRFESEFVDF

Description

Serine/threonine-protein kinase involved in memory formation (PubMed:29473541). Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity (PubMed:29473541). As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane (PubMed:29444420).

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Subunit

Composed of two regulatory chains and two catalytic chains.

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

Keywords

ATP-binding   cAMP   Complete proteome   Kinase   Lipoprotein   Myristate   Nucleotide-binding   Phosphoprotein   Reference proteome   Transferase  

Feature

chain  cAMP-dependent protein kinase catalytic subunit 1

Uniprot

A0A0L7LQB0   A0A212EWD5   A0A194PZ30   A0A194R2E1   H9IV83   A0A0N1IPW6   + More
A0A194Q915   A0A0L7LC89   A0A0C9RV13   E0VEQ2   A0A0L7R855   A0A1S3JGB8   A0A1Y1N4Z4   A0A1S3JH22   A0A2R2MJH3   A0A1S3JGA5   A0A2R2MJ26   A0A1D1VT87   A0A210R3N9   A0A369RZW3   A0A170RC44   A0A3M6V447   A0A1X7UBF8   A0A076FKS1   R7UPG8   K7J5F3   T1KSF6   J9JK31   A0A2S2NEM0   A0A2H8TN08   A0A2S2PZY9   F6UP78   N6UW64   B7S901   A0A2R7VYK8   A0A0S2VHW6   A0A2A4K291   A0A194RME0   A0A212FLD3   H9GAL8   A0A0A9WIZ8   A0A0A1X7C9   A0A094KSF4   A5JNM1   F6T0T9   A0A0K8TSM1   V9KQ53   A0A0C9RJF4   W8C0H4   A0A1W4W8R0   B4M9H6   B4KH13   Q29NB1   B4NY66   B4MVA0   B4JCE3   B3N8G6   B4Q7V0   B3MUX5   P12370   A0A218VET5   Q7ZWV0   A0A1D5P6I8   C3YT92   A0A087V9U4   A0A091NAU9   E9GNI4   A0A091TYR0   A0A091T8G2   A0A1D5NW04   A0A1D5PLV3   A0A0Q3LUM3   T1PGE9   A0A1I8NM79   A0A1Y1MUE8   A0A1W4WWQ6   G3W5L7   A0A151NJ10   A0A0G4AJS6   A0A091HTZ5   U3JU00   B7S8R5   A0A151NJ57   A0A1U7SDV1   A0A2I4AJ56   A0A2I0MEC8   R4GCW7   A0A1U7SGF3   A0A0K0JSZ6   A0A151NJ28   A0A3Q0HA31   A0A194PMX1   D6WC07   A0A093CTL8   A0A068XIH9   A0A2I4AJ99   A0A091VJW1   G1N3V9   A0A091JZS9   A0A094L3Q4  

EC Number

2.7.11.11

Pubmed

26227816    22118469    26354079    19121390    20566863    28004739    + More
27649274    28812685    30042472    30382153    23254933    20075255    20431018    23537049    21881562    25401762    25830018    26369729    24402279    24495485    17994087    15632085    17550304    22936249    18057021    2828348    3215511    10731132    12537572    12537569    29444420    29473541    18563158    21292972    15592404    25315136    21709235    22293439    26252388    23371554    17885136    18362917    19820115    20838655   

EMBL

JTDY01000340    KOB77630.1    AGBW02012010    OWR45805.1    KQ459584    KPI98576.1    + More
KQ460855    KPJ11867.1    BABH01000681    KQ460202    KPJ17176.1    KQ459299    KPJ01909.1    JTDY01001711    KOB73103.1    GBYB01011506    JAG81273.1    AAZO01001585    DS235093    EEB11858.1    KQ414637    KOC66936.1    GEZM01015981    JAV91396.1    BDGG01000011    GAV04740.1    NEDP02000628    OWF55534.1    NOWV01000108    RDD40225.1    KU193794    ANB82449.1    RCHS01000136    RMX60647.1    KF516617    AII16521.1    AMQN01007889    KB301649    ELU05311.1    CAEY01000425    ABLF02039909    GGMR01002966    MBY15585.1    GFXV01003710    MBW15515.1    GGMS01001883    MBY71086.1    AAMC01003225    AAMC01003226    AAMC01003227    AAMC01003228    AAMC01003229    AAMC01003230    APGK01006540    APGK01007788    APGK01021688    KB740353    KB737454    KB736818    KB632345    ENN80824.1    ENN83018.1    ENN83127.1    ERL93117.1    EF710656    ACE75376.1    KK854174    PTY12587.1    KT207930    ALP86605.1    NWSH01000246    PCG78048.1    KQ460205    KPJ17156.1    AGBW02007798    OWR54554.1    AAWZ02004438    GBHO01035197    JAG08407.1    GBXI01012766    GBXI01007088    JAD01526.1    JAD07204.1    KL262375    KFZ60277.1    BABH01015550    EF551340    ABQ41111.1    GDAI01000658    JAI16945.1    JW867900    AFP00418.1    GBYB01008335    JAG78102.1    GAMC01004015    GAMC01004014    GAMC01004013    GAMC01004012    JAC02544.1    CH940654    EDW57852.2    CH933807    EDW12224.2    CH379060    EAL33431.3    CM000157    EDW88668.2    CH963857    EDW76445.2    CH916368    EDW03097.1    CH954177    EDV58389.2    CM000361    CM002910    EDX04382.1    KMY89299.1    CH902624    EDV33040.2    KPU74269.1    M18655    X16969    AE014134    AY069425    MUZQ01000002    OWK64503.1    BC046697    AAH46697.1    GG666551    EEN56459.1    KL485232    KFO09386.1    KL380329    KFP86838.1    GL732555    EFX78769.1    KK408331    KFQ83376.1    KK945962    KFQ54356.1    AADN05000647    LMAW01003072    KQK74224.1    KA647769    AFP62398.1    GEZM01025015    JAV87646.1    AEFK01069289    AKHW03002907    KYO36791.1    KR133400    AKM70870.1    KL217788    KFO98612.1    AGTO01021089    EF710650    ACE75288.1    KYO36790.1    AKCR02000018    PKK28038.1    KYO36792.1    KQ459601    KPI94079.1    KQ971309    EEZ99369.1    KL248304    KFV16254.1    KK734081    KFR03712.1    KK540411    KFP30707.1    KL350738    KFZ58739.1   

Proteomes

UP000037510    UP000007151    UP000053268    UP000053240    UP000005204    UP000009046    + More
UP000053825    UP000085678    UP000186922    UP000242188    UP000253843    UP000275408    UP000007879    UP000014760    UP000002358    UP000015104    UP000007819    UP000008143    UP000019118    UP000030742    UP000218220    UP000001646    UP000192221    UP000008792    UP000009192    UP000001819    UP000002282    UP000007798    UP000001070    UP000008711    UP000000304    UP000007801    UP000000803    UP000197619    UP000001554    UP000000305    UP000000539    UP000051836    UP000095301    UP000095300    UP000192223    UP000007648    UP000050525    UP000054308    UP000016665    UP000189705    UP000192220    UP000053872    UP000006672    UP000007266    UP000053605    UP000001645   

PRIDE

H9IV83    A5JNM1    P12370   

Pfam

PF00069   Pkinase

Interpro

IPR017441   Protein_kinase_ATP_BS        + More
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR000961   AGC-kinase_C       
IPR000719   Prot_kinase_dom       
IPR039083   PKA_C-beta       
IPR039035   PKA_C-alpha       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

A0A0L7LQB0   A0A212EWD5   A0A194PZ30   A0A194R2E1   H9IV83   A0A0N1IPW6   + More
A0A194Q915   A0A0L7LC89   A0A0C9RV13   E0VEQ2   A0A0L7R855   A0A1S3JGB8   A0A1Y1N4Z4   A0A1S3JH22   A0A2R2MJH3   A0A1S3JGA5   A0A2R2MJ26   A0A1D1VT87   A0A210R3N9   A0A369RZW3   A0A170RC44   A0A3M6V447   A0A1X7UBF8   A0A076FKS1   R7UPG8   K7J5F3   T1KSF6   J9JK31   A0A2S2NEM0   A0A2H8TN08   A0A2S2PZY9   F6UP78   N6UW64   B7S901   A0A2R7VYK8   A0A0S2VHW6   A0A2A4K291   A0A194RME0   A0A212FLD3   H9GAL8   A0A0A9WIZ8   A0A0A1X7C9   A0A094KSF4   A5JNM1   F6T0T9   A0A0K8TSM1   V9KQ53   A0A0C9RJF4   W8C0H4   A0A1W4W8R0   B4M9H6   B4KH13   Q29NB1   B4NY66   B4MVA0   B4JCE3   B3N8G6   B4Q7V0   B3MUX5   P12370   A0A218VET5   Q7ZWV0   A0A1D5P6I8   C3YT92   A0A087V9U4   A0A091NAU9   E9GNI4   A0A091TYR0   A0A091T8G2   A0A1D5NW04   A0A1D5PLV3   A0A0Q3LUM3   T1PGE9   A0A1I8NM79   A0A1Y1MUE8   A0A1W4WWQ6   G3W5L7   A0A151NJ10   A0A0G4AJS6   A0A091HTZ5   U3JU00   B7S8R5   A0A151NJ57   A0A1U7SDV1   A0A2I4AJ56   A0A2I0MEC8   R4GCW7   A0A1U7SGF3   A0A0K0JSZ6   A0A151NJ28   A0A3Q0HA31   A0A194PMX1   D6WC07   A0A093CTL8   A0A068XIH9   A0A2I4AJ99   A0A091VJW1   G1N3V9   A0A091JZS9   A0A094L3Q4  

PDB

3MVJ     E-value=6.75957e-118,     Score=1084

KEGG

101740078    no KO assigned | (RefSeq) cAMP-dependent protein kinase catalytic subunit alpha pseudogene

GO

GO:0004674   GO:0005524   GO:0034237   GO:0004691   GO:0007186   GO:0016021   GO:0045187   GO:0032436   GO:0044297   GO:0007615   GO:0050804   GO:0008355   GO:0008359   GO:0030425   GO:0010628   GO:0045879   GO:0045880   GO:0005829   GO:2000249   GO:0007476   GO:0042981   GO:0046823   GO:0048682   GO:0007622   GO:0007448   GO:0005886   GO:0007317   GO:0008103   GO:0040040   GO:0071361   GO:0007314   GO:0048477   GO:0006468   GO:0048749   GO:0019933   GO:0048149   GO:0004672   GO:0006470   GO:0008138   GO:0006370   GO:0006397   GO:0004651   GO:0005634  

PANTHER

PTHR24353:SF116   PTHR24353:SF82  

Length:

372

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.14931

Exp number, first 60 AAs:

1e-05

Total prob of N-in:

0.17226

outside

1  -  372

 

 

Pi

133.012324

Theta

172.333136

Tajima's D

-0.635567

CLR

0.808126

CSRT

0.213889305534723

Interpretation

Uncertain