Gene

KWMTBOMO01756

Pre Gene Modal

BGIBMGA006009

Annotation

PREDICTED:_alsin_[Bombyx_mori]

Location

Bomo_Chr4(-):3736115-3746153      View in EpiBrowser

Full name

Alsin      

Alternative Name

Amyotrophic lateral sclerosis 2 protein homolog

Location in the cell

Cytoplasmic   Reliability : 3.148

CDS

ATGCCCCAAATATCACTAGATTCTAATAGTATTAAGAAGATACCGTTCTTTGAAGGAAGAACTGTATACAGTGCCTCCATTGGTCAAAACTTTGCTGCTGTGATAGCAAGGAAAAATGTTAAACAGTCTGATAACTGCGATACAGACAGTGAAAATGATGAAGAAGAAGTGTTCGCAACTAATTGTTCACAGTGCCAGACTATCATAGGCCTTGCATCTCCTGCATCTGTGCCGTCCTTTTCTGAAACCTGTCCATTAGGTGTTCATATAAGTAAATCAAGTGAAGACTCAAGTAGTACTACTGCTCCACCTACAGATTTTCATATTGATGCTTACAGTTATACTGAAGATTCTAGTCCCTCTTCGGAGGAATCAAAAATAGCACAAAACATTATACAAACTACTGAAACATTAACTGAAAGAAAATGTGATGAATTAATTAATACAGAAAATGGTGATGGCTCAGATAAAGATAGTGATACAACTGAAGCCGATGCAGAAAAGATTAATAATATATTCATGAATGCTGATGCGGCAAGACAGTTTTTAAGTCGACAATTATCATGGGTGTCAGCTGGTGAAGATTATTTAGTGGAATATACAGAAAAACCTACAAGAATCATAAAAGAGAATGTTTCAAATCTCACTAATTTTGTCTATGAAGGTGTTAAAACTGTAGGTGATAAAGTTGCAACACTTTCGAGGCATGTCAGTGGTAGTAGCGAAAACAATGAGACAGTAGAACAACTATCAAGAAATCAGAACGAAGAAACCAAGTCCCTCATGTACAGCTGCACTTCAAACTGTAATGTAGATGATCTGCAGTTTTCCACCAGCACTATTAGTAGTGAAAAAGAGTTTGAAGAAGCCAGAAAAAAAGAGACTATTAAGAACATGTCTAAACTAGGAAGGAATATTTTAGCTACAGAATTATGGACTTGGGGTGACATAAGTTATGGACAGTTAGGAATTGGTGACACAGTCAAAAGGGTTAAACCAATGATTGTCATGAGTTTATCGGGGTTTGGGCTACAAAAAGTTTCTTGTGGGAGTTTGCATTGTTCTACGCTCACGCTCGATGGACGAATGTTTGCTTGGGGATACAATCATTACCATCAATTAAGCTTCGGTTCAAGAGAAGATAAAAGTGGACCACAACAATTTACAGAAAACTCAGAGAGCGATAGAATTAGGGATGTCATTGCTGCTGATCATCATACTCTAGTCTACACGCACAATGAGAATATATTATACATGGGCAAACACACAGATGGTTTCACAGAATCTGTTGTGAATTTAAATCCTAGTTTGTTAGAGGAAGATAGTGAGAAATCTCCAAGCATGGTGACTATAAAAATTACAGAGCCACAACACCATACAAGTAAACCCCAAAATCTGTGTTATCACTGGAGAATCTTATCTTCAGGTAATATTAGTTATTGCTCAGTAGAAAACTCAAAGAAAAATCCACAGTTCCAAGACTTATCTATTGCTCAAAGATATCTAGAAGAAATGTTACTGATTTATCAAAATCTTATTAAGGTTTTTTTGAAGAAAAGTAAAGCAATTACTGCACATTCCAATGTTTATGAAACAGTATGTGATATTTTTGGTGACATATTGAATGTCACAGCTTTAAATGTATTATCAGTTTGGCAGTATGCAGAAAAACATATAAATGAATGTGATATATCATTGATTAAAAATTTAGAAGAGTTTATTTTTTTGTATAGAAAGTATTATGTAGCTGTAAGCAATTTAATTGTTATTGGTGGTTTCACCCAAATCAATAGTGTTATTGATGTCCCAACGAGTATTTATAATTTATTTAGTGATCAACTTCCTTCGAACAAACAGAAAAATAGTAAAAAGACATCAGAAGCCATAATAGGTCTTGCCTTTGTGCAACCATTAACAAGATTAAGTTCATACAAATGTATAACTCAATCTATATTGAGACATAAAACCAAGAGAAAAAAAGGCGAAATTGTATTAAAGATTGAAGAAAGATTAAATAAAGTTGTTTCATCATTTGATTCATTAATAGAAGAGCAAGAAAAAAAACGTAAAGAAGCGGAAGTTACGAAATTATTTTGGGAAACAATTGGTAAAAGTTTGGAGCAATATAGAGCTCCAGAACGACGATTAATAAGAGAATCAAAATCTCGACCTATATATCTAGTCAATCCTGGAAGATTTTCATCACATTGGTTCATTTTATTTAATGACATATTTGTTCATGTTAGTGGTAGCTCACCTAGTGTGCACCCCCTTCAAACCCTGTGGGTCGAGTCTGTCATACATTCTGATCCATCACAATACATAATCCAACTTACTACTCCAGAAGAAGTTATATCAGTGTCAACAGTTACCGAGCAAGAGAAAACTGAATGGATACAAGCTCTGAATAATTCCATAAGAATAATTTTGAACAAAGAATCTGTATTTAAACTACCCTCAATAAGATCAGCAAGTTATACATTCTCAAGTAAAAGCACATTTTTTAAAGATTCGAAATACATTGGTAGATGGTTAGATGGTAAAGTACATGGAAACGGTAAAGTAGAATGGTCAGATGGCAAGCAGTACATTGGACAATTTCAACTAAATACTCTATGTGGCCATGGAAAAATGGAAATACCTGGTGTAGGGATTTATGAAGGCCAGTGGAAAGATAACTTACAGAATGGCTACGGTAAAATGAAGTATTGCTCGGGTGACATATATGAGGGATATTTCAAAGACGGTCAGCCTCATGGACATGGTATTAAAAAGCAAGGAGATTTCACATCTTCATCTGCAACTATTTACACTGGAGAATGGGTTAACGGGGCAAGACAAGGCTACGGTGTCATGGACGACATTGGAAAAGGAGAAAAATATTTAGGAAATTGGAGTGACAACAAGAAACACGGATGTGGGTTGATCGTGACTTTGGACGGAATATATTACGAAGGTTTATTTACGCAAGATGTGTTGACGGGTCATGGGGTTATGGTGTTTGAAGACGGTACACATTACGAAGGCGAATTCAGATCTGCTGGTGTATTTTCTGGTAAAGGAGTTCTCACATTTTCTAGTGGGGATAAGATAGAAGGTTCATTGAGCGGGGCTTGGACTGAGGGAGTTAAAATATCGAATGCCACCATGCATATGAACGTATCGAATCCTGTGTTGCCAGCTAATCCCAAACCTAATTCATTCGGAAAATTAAGCGTAGCACCAAACCAGAAATGGAACGCTCTATTCCGCCAGTGCTTCCAATGCTTGGGTATATCAGACGCGGTGCTAACACCCACCGGTAATCATTTTGCCCACGGACCATCGGGTCCAACGGTGGACAACGTGAAGATATGGCAAAACGTTGCGGTAGCGATATCCTCTTCCCATAAAGAGGGAATGAAAACGAGCCTTAAAAGGAATAAAAGCACTGATCTTGAAAAATCTGTGGATTGTTTGGAAGTCATACCAAAGTTTGGACAAGATACTTTGAATTTAGACGAATATACGGAATTGAAGCAGTATTTGTACAATGCTTGCGAGTCCTCTCACCATCCGCTGGGGCAGCTGGTTCTGGGCTTGACGAACGCATTCAACACGACGTACGGAGGCGTCCGTGTACATCCGCTACTTCTCAGTCATGCGGTCAAAGAACTCAAAAGTATAACCGCGAGGCTCTACCAAGTGGTGAGGCTTCTGTTCCCAGCCCTACCCTCAGAGAATGCCGATCTAGTCTTGCCGTATAAGACCCAAGAGAACGACGATGAAGTTGAAAACGATAGCAATCCTATTCACGGTGAAGTGGTATCGGCAGCTGCATTGCTTCAGCCAACGTTGTTGCCTCGTGTGCACCCGGCTCTATTCGTGCTGTATGCGTTACACAACAAGAGAGAAGACGACATGTACTGGAGGAGGCTGCTGAAATGGAACAAACAGCCGGATATCACTCTGATGGCCTTCCTCGGGATCGATCAGAAATTCTGGGTGAGTTACTCGTCGCAAAACAATCAGTCACCTCCTTACTCTCCGATGAAGGATCAACACTTTCAAGAGGCAGTAGAAACGCTTCAGCAATTGAAGACCACTTTCTCGCCGATCGAGAAACTCCTCGTCATAAGGAATACATTTCAGAAGATGACCAGCGCCGTCCAACAAGAATTAGGTCAAAACTACCTATGGACCATGGACGAGCTGTTCCCGGTCTTCCATTTCGTGGTGGTCCGCTCCAGGATCCTGCAGCTCGGCTCCGAAATACATTTCGTTGAGGACTTCCTCGAGCCGGGCATGCAGCATGGGGAACTCGGCCTTATGTTCACCACTTTAAAGGCCTGCTACTTCCAGATACTTCAAGAGAAGATGTCGATGAATTAG

Protein

MPQISLDSNSIKKIPFFEGRTVYSASIGQNFAAVIARKNVKQSDNCDTDSENDEEEVFATNCSQCQTIIGLASPASVPSFSETCPLGVHISKSSEDSSSTTAPPTDFHIDAYSYTEDSSPSSEESKIAQNIIQTTETLTERKCDELINTENGDGSDKDSDTTEADAEKINNIFMNADAARQFLSRQLSWVSAGEDYLVEYTEKPTRIIKENVSNLTNFVYEGVKTVGDKVATLSRHVSGSSENNETVEQLSRNQNEETKSLMYSCTSNCNVDDLQFSTSTISSEKEFEEARKKETIKNMSKLGRNILATELWTWGDISYGQLGIGDTVKRVKPMIVMSLSGFGLQKVSCGSLHCSTLTLDGRMFAWGYNHYHQLSFGSREDKSGPQQFTENSESDRIRDVIAADHHTLVYTHNENILYMGKHTDGFTESVVNLNPSLLEEDSEKSPSMVTIKITEPQHHTSKPQNLCYHWRILSSGNISYCSVENSKKNPQFQDLSIAQRYLEEMLLIYQNLIKVFLKKSKAITAHSNVYETVCDIFGDILNVTALNVLSVWQYAEKHINECDISLIKNLEEFIFLYRKYYVAVSNLIVIGGFTQINSVIDVPTSIYNLFSDQLPSNKQKNSKKTSEAIIGLAFVQPLTRLSSYKCITQSILRHKTKRKKGEIVLKIEERLNKVVSSFDSLIEEQEKKRKEAEVTKLFWETIGKSLEQYRAPERRLIRESKSRPIYLVNPGRFSSHWFILFNDIFVHVSGSSPSVHPLQTLWVESVIHSDPSQYIIQLTTPEEVISVSTVTEQEKTEWIQALNNSIRIILNKESVFKLPSIRSASYTFSSKSTFFKDSKYIGRWLDGKVHGNGKVEWSDGKQYIGQFQLNTLCGHGKMEIPGVGIYEGQWKDNLQNGYGKMKYCSGDIYEGYFKDGQPHGHGIKKQGDFTSSSATIYTGEWVNGARQGYGVMDDIGKGEKYLGNWSDNKKHGCGLIVTLDGIYYEGLFTQDVLTGHGVMVFEDGTHYEGEFRSAGVFSGKGVLTFSSGDKIEGSLSGAWTEGVKISNATMHMNVSNPVLPANPKPNSFGKLSVAPNQKWNALFRQCFQCLGISDAVLTPTGNHFAHGPSGPTVDNVKIWQNVAVAISSSHKEGMKTSLKRNKSTDLEKSVDCLEVIPKFGQDTLNLDEYTELKQYLYNACESSHHPLGQLVLGLTNAFNTTYGGVRVHPLLLSHAVKELKSITARLYQVVRLLFPALPSENADLVLPYKTQENDDEVENDSNPIHGEVVSAAALLQPTLLPRVHPALFVLYALHNKREDDMYWRRLLKWNKQPDITLMAFLGIDQKFWVSYSSQNNQSPPYSPMKDQHFQEAVETLQQLKTTFSPIEKLLVIRNTFQKMTSAVQQELGQNYLWTMDELFPVFHFVVVRSRILQLGSEIHFVEDFLEPGMQHGELGLMFTTLKACYFQILQEKMSMN

Description

May act as a GTPase regulator. Controls survival and growth of spinal motoneurons.
May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons.

Subunit

Forms a heteromeric complex with ALS2CL. Interacts with ALS2CL (By similarity).

Keywords

Acetylation   Alternative splicing   Complete proteome   Guanine-nucleotide releasing factor   Phosphoprotein   Reference proteome   Repeat  

Feature

chain  Alsin
splice variant  In isoform 2.

Uniprot

H9J917   A0A2A4IY45   A0A2H1V1E2   A0A194PZ10   A0A194R2W2   A0A0L7LEA1   + More
E2C623   A0A2A3E6X6   A0A0M8ZRB8   A0A088AJN0   A0A0J7KIQ8   A0A151JZ26   A0A0L7R100   E2AZ33   A0A195BL05   A0A195C4S6   F4WKS2   A0A2J7RB13   A0A026WMF1   A0A151JM59   A0A067RC20   A0A154PSR8   A0A0C9PNX5   A0A232EYP7   A0A1Y1M7V7   D6WJR6   A0A1B6C7L6   A0A1B6BY78   A0A310SV45   A0A023EXX4   T1HUQ5   A0A146M3M8   A0A146LD36   U4U904   N6TET4   N6T7S3   A0A0A9Y1N6   A0A0A9Y655   T1J5J3   A0A1E1X3Y6   A0A1E1XL39   A0A131XRF8   A0A162NJ55   A0A0P5RAZ1   A0A0P5FPW2   A0A2R2MTE0   A0A0P6CN23   A0A210PZY2   A0A2T7PW61   A0A3B4ECD7   A0A3B1IG64   A0A3B4ECG7   Q920R0   H2L2T4   A0A3B5A1S2   A0A146ZQE8   A0A3P9KVA0   A0A3B1JU77   A0A250Y7U7   A0A2D0S6E2   A0A2D0S4V0   A0A1U7QBY6   W5MW38   G1T3G9   W5KC30   A0A1A7WPQ9   A0A3B3UA36   A0A3P9CLZ1   H9G4L6   A0A2I4BGQ4   A0A1A8ECJ3   A0A1A8HZ63   P0C5Y8   W5MW31   A0A1S3MV00   A0A087XQA5   A0A1S3MUT1   A0A146ZR45   A0A3B3VHX5   A0A1A7YZX6   A0A1A8V695   A0A2K6BYF3   A0A2K6A9A2   A0A096MS36   H9FXQ9   A0A2Y9SSC3   G7N8N5   G7PL71   A0A2K6MGE7   A0A2K5M3Z4   A0A2K5REB1   A0A2J8N5A8   A0A2J8WUW9  

Pubmed

19121390    26354079    26227816    20798317    21719571    24508170    + More
30249741    24845553    28648823    28004739    18362917    19820115    25474469    26823975    23537049    25401762    28503490    29209593    29652888    28812685    25329095    11586298    19468303    15489334    16141072    15345747    17242355    21183079    23806337    17554307    28087693    21993624    25186727    21881562    15057822    16802292    15686953    22673903    25319552    22002653   

EMBL

BABH01004646    NWSH01004947    PCG64569.1    ODYU01000050    SOQ34162.1    KQ459584    + More
KPI98567.1    KQ460855    KPJ11859.1    JTDY01001500    KOB73720.1    GL452895    EFN76628.1    KZ288349    PBC27450.1    KQ435964    KOX67949.1    LBMM01006796    KMQ90323.1    KQ981427    KYN41758.1    KQ414668    KOC64530.1    GL444078    EFN61307.1    KQ976453    KYM85362.1    KQ978317    KYM95163.1    GL888206    EGI65164.1    NEVH01006564    PNF38027.1    KK107167    QOIP01000010    EZA56294.1    RLU17499.1    KQ978949    KYN27375.1    KK852804    KDR16248.1    KQ435178    KZC14951.1    GBYB01001400    GBYB01002833    JAG71167.1    JAG72600.1    NNAY01001596    OXU23475.1    GEZM01040965    JAV80680.1    KQ971343    EFA04485.1    GEDC01027979    JAS09319.1    GEDC01031077    JAS06221.1    KQ760158    OAD61694.1    GBBI01004557    JAC14155.1    ACPB03002623    GDHC01005007    JAQ13622.1    GDHC01013573    JAQ05056.1    KB631904    ERL87101.1    APGK01040756    KB740984    ENN76273.1    ENN76274.1    GBHO01018581    GBHO01018577    JAG25023.1    JAG25027.1    GBHO01018583    GBHO01018579    JAG25021.1    JAG25025.1    JH431865    GFAC01005213    JAT93975.1    GFAA01003510    JAT99924.1    GEFM01005923    GEGO01005350    JAP69873.1    JAR90054.1    LRGB01000568    KZS18031.1    GDIQ01122860    JAL28866.1    GDIP01145376    JAJ78026.1    GDIP01012169    JAM91546.1    NEDP02005321    OWF42064.1    PZQS01000001    PVD37648.1    AB053307    AC153652    CH466548    BC031479    BC046828    AK014320    AAH31479.1    AAH46828.1    BAB69016.1    GCES01017773    JAR68550.1    GFFV01000238    JAV39707.1    AHAT01034650    AHAT01034651    AAGW02042203    AAGW02042204    AAGW02042205    HADW01006119    SBP07519.1    AAWZ02028705    AAWZ02028706    HAEA01014846    SBQ43326.1    HAED01003547    SBQ89530.1    AABR03068212    BK005190    AYCK01006857    GCES01017512    JAR68811.1    HADX01013444    SBP35676.1    HAEJ01014301    SBS54758.1    AHZZ02004391    JU335664    JU335665    JU335666    JU473719    JU473720    AFE79418.1    AFH30523.1    CM001264    EHH21585.1    AQIA01015563    AQIA01015564    AQIA01015565    CM001287    EHH55080.1    NBAG03000236    PNI66951.1    NDHI03003377    PNJ73577.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000037510    UP000008237    + More
UP000242457    UP000053105    UP000005203    UP000036403    UP000078541    UP000053825    UP000000311    UP000078540    UP000078542    UP000007755    UP000235965    UP000053097    UP000279307    UP000078492    UP000027135    UP000076502    UP000215335    UP000007266    UP000015103    UP000030742    UP000019118    UP000076858    UP000085678    UP000242188    UP000245119    UP000261440    UP000018467    UP000000589    UP000001038    UP000261400    UP000265180    UP000221080    UP000189706    UP000018468    UP000001811    UP000261500    UP000265160    UP000001646    UP000192220    UP000002494    UP000087266    UP000028760    UP000233120    UP000233140    UP000028761    UP000248484    UP000009130    UP000233100    UP000233180    UP000233060    UP000233040   

PRIDE

H9J917    Q920R0    P0C5Y8   

Pfam

PF02493   MORN        + More
PF00415   RCC1
PF02204   VPS9
PF03942   DTW
PF01923   Cob_adeno_trans
PF11838   ERAP1_C
PF00169   PH
PF08718   GLTP
PF01433   Peptidase_M1
PF00621   RhoGEF

Interpro

IPR003123   VPS9        + More
IPR003409   MORN       
IPR037191   VPS9_dom_sf       
IPR000408   Reg_chr_condens       
IPR011993   PH-like_dom_sf       
IPR009091   RCC1/BLIP-II       
IPR001849   PH_domain       
IPR035899   DBL_dom_sf       
IPR011047   Quinoprotein_ADH-like_supfam       
IPR005636   DTW       
IPR000219   DH-domain       
IPR036451   CblAdoTrfase-like_sf       
IPR016030   CblAdoTrfase-like       
IPR029499   PduO-typ       
IPR001930   Peptidase_M1       
IPR014830   Glycolipid_transfer_prot_dom       
IPR034016   M1_APN-typ       
IPR024571   ERAP1-like_C_dom       
IPR014782   Peptidase_M1_dom       
IPR042097   Aminopeptidase_N-like_N       
IPR036497   GLTP_sf       

SUPFAM

SSF109993   SSF109993        + More
SSF50985   SSF50985       
SSF48065   SSF48065       
SSF50998   SSF50998       
SSF89028   SSF89028       
SSF110004   SSF110004       

Gene 3D

1.20.1050.80     2.130.10.30     2.30.29.30     1.20.900.10     1.20.1200.10     1.10.3520.10     2.60.40.1730    

CDD

cd09601  M1_APN_2

ProteinModelPortal

H9J917   A0A2A4IY45   A0A2H1V1E2   A0A194PZ10   A0A194R2W2   A0A0L7LEA1   + More
E2C623   A0A2A3E6X6   A0A0M8ZRB8   A0A088AJN0   A0A0J7KIQ8   A0A151JZ26   A0A0L7R100   E2AZ33   A0A195BL05   A0A195C4S6   F4WKS2   A0A2J7RB13   A0A026WMF1   A0A151JM59   A0A067RC20   A0A154PSR8   A0A0C9PNX5   A0A232EYP7   A0A1Y1M7V7   D6WJR6   A0A1B6C7L6   A0A1B6BY78   A0A310SV45   A0A023EXX4   T1HUQ5   A0A146M3M8   A0A146LD36   U4U904   N6TET4   N6T7S3   A0A0A9Y1N6   A0A0A9Y655   T1J5J3   A0A1E1X3Y6   A0A1E1XL39   A0A131XRF8   A0A162NJ55   A0A0P5RAZ1   A0A0P5FPW2   A0A2R2MTE0   A0A0P6CN23   A0A210PZY2   A0A2T7PW61   A0A3B4ECD7   A0A3B1IG64   A0A3B4ECG7   Q920R0   H2L2T4   A0A3B5A1S2   A0A146ZQE8   A0A3P9KVA0   A0A3B1JU77   A0A250Y7U7   A0A2D0S6E2   A0A2D0S4V0   A0A1U7QBY6   W5MW38   G1T3G9   W5KC30   A0A1A7WPQ9   A0A3B3UA36   A0A3P9CLZ1   H9G4L6   A0A2I4BGQ4   A0A1A8ECJ3   A0A1A8HZ63   P0C5Y8   W5MW31   A0A1S3MV00   A0A087XQA5   A0A1S3MUT1   A0A146ZR45   A0A3B3VHX5   A0A1A7YZX6   A0A1A8V695   A0A2K6BYF3   A0A2K6A9A2   A0A096MS36   H9FXQ9   A0A2Y9SSC3   G7N8N5   G7PL71   A0A2K6MGE7   A0A2K5M3Z4   A0A2K5REB1   A0A2J8N5A8   A0A2J8WUW9  

PDB

4DNV     E-value=6.82304e-12,     Score=176

KEGG

101740931    K04575 amyotrophic lateral sclerosis 2 protein | (RefSeq) alsin

GO

GO:0005089   GO:0035023   GO:0005737   GO:0008237   GO:0120013   GO:0008270   GO:0043005   GO:0016197   GO:0030424   GO:0030425   GO:0030676   GO:0031982   GO:0030426   GO:0045860   GO:0001662   GO:0007409   GO:0014069   GO:0043547   GO:0005813   GO:0051036   GO:0030027   GO:0042803   GO:0043231   GO:0007032   GO:0006979   GO:0016020   GO:0042802   GO:0017137   GO:0035249   GO:0001881   GO:0043539   GO:0005634   GO:0043087   GO:0016601   GO:0007626   GO:0016050   GO:0008219   GO:0043025   GO:0005829   GO:0048365   GO:0048812   GO:0001726   GO:0051260   GO:0005096   GO:0001701   GO:0043197   GO:0007528   GO:0032991   GO:0005769   GO:0008104   GO:0017112   GO:0007041  

Length:

1456

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.13812

Exp number, first 60 AAs:

0.00415

Total prob of N-in:

0.00042

outside

1  -  1456

 

 

Pi

199.796803

Theta

167.585102

Tajima's D

0.492938

CLR

0.393216

CSRT

0.507524623768812

Interpretation

Uncertain