Gene

KWMTBOMO01752  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006013

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_uncharacterized_protein_LOC101740551_[Bombyx_mori]

Location

Bomo_Chr4(-):3685285-3691353      View in EpiBrowser

Full name

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial      

Alternative Name

Complex I-51kD
NADH-ubiquinone oxidoreductase 51 kDa subunit

Location in the cell

Nuclear   Reliability : 4.319

CDS

ATGGCTGGTGCACTGACAAGAGTGATTCAGGGCACAAAACCACATTTGGGCATTATTGGGCCTTTGGCAATTAATGTCAACAATGTACCGGTGCGCTTCCAGCAGACCCAGGCGCCTTCAAAAGACAAGTATGGACCGCTGGCCGATAGCGATCGGGTTTTCACAAACTTGTATGGTCGACATGAATGGAGGTTGAAGGGTGCTCTCGCCCGAGGGGACTGGTATTTGACGAAGGAGATTTTACTGAAAGGAACCGACTGGATCGTTAATGAAATGAAAACATCTGGCCTTCGAGGCAGGGGAGGAGCAGGTTTTCCAACAGGAATGAAGTGGTCATTCATGAACAAGCCATCAGATGGCCGTCCAAAATATCTCGTGGTGAATGCTGATGAGGGTGAACCTGGTACTTGTAAAGACAGGGAGATTATGCGTCACGACCCCCACAAACTGGTGGAAGGATGTCTAATTGCTGGCCGAGCCATGGGTGCACAAGCAGCATACATTTACATCAGAGGTGAATTCTACAATGAAGCAAGCAATTTGCAAGTTGCTATTGCTGAGGCTTACCAAGCCGGTCTCATTGGTAAGAACTCTTGTGGTTCTGGTTATGACTTTGATATATTCGTACACCGCGGTGCCGGCGCATACATCTGTGGTGAGGAGACAGCTCTCATTGAGTCCATTGAGGGCAAACAAGGCAAGCCGAGGCTCAAACCTCCTTTCCCCGCTGACGTGGGTTTGTTCGGTTGTCCCACCACTGTCAACAATGTAGAAACAATCGCGGTAGCGCCCACGATCTGTAGGCGTGGCGGCAAGTGGTTCGCATCGTTCGGGCGCCAACGTAACTCTGGCACGAAGCTGTTCAATATATCGGGTCACGTGAACACGCCGTGCACCGTGGAGGAGGAGATGAGCATCCCGCTCAAGGAGCTCATTGAGAGGCACGCGGGCGGAGTCACCGGCGGCTGGGACAACCTGCTCGCCATCATACCAGGAGGCTCCTCGACCCCGCTCATACCCAAGAACGTCTGCGAGACAGTGTTGATGGACTTCGACGGTCTAGTAGCCGCGCAGACCTCCCTGGGCACGGCGGCCATCATTGTCATGGACAAGTCAACTGACATCGTGAAGGCGATCGCTCGACTCATCATGTTCTACAAGCACGAGTCCTGCGGCCAGTGCACTCCTTGCCGCGAAGGTGTCTCCTGGATGAACAAGATTATATACAGATTCGTCGATGGTAATGCTTCACCGAAAGAAATCGACATGCTGTGGGAAATTTCGAAACAAATCGAAGGGCACACGATCTGCGCTCTGGGCGACGGAGCCGCGTGGCCGGTGCAGGGACTCATACGTCACTTCCGGCCCGAGCTCGAGCGACGCATGCAGGAGTACTCGGCCGCGCACGGGCCGAGCAAAGCCGAGCGCCTGTACTAG

Protein

MAGALTRVIQGTKPHLGIIGPLAINVNNVPVRFQQTQAPSKDKYGPLADSDRVFTNLYGRHEWRLKGALARGDWYLTKEILLKGTDWIVNEMKTSGLRGRGGAGFPTGMKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIMRHDPHKLVEGCLIAGRAMGAQAAYIYIRGEFYNEASNLQVAIAEAYQAGLIGKNSCGSGYDFDIFVHRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGLFGCPTTVNNVETIAVAPTICRRGGKWFASFGRQRNSGTKLFNISGHVNTPCTVEEEMSIPLKELIERHAGGVTGGWDNLLAIIPGGSSTPLIPKNVCETVLMDFDGLVAAQTSLGTAAIIVMDKSTDIVKAIARLIMFYKHESCGQCTPCREGVSWMNKIIYRFVDGNASPKEIDMLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELERRMQEYSAAHGPSKAERLY

Description

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Catalytic Activity

A + H(+) + NADH = AH2 + NAD(+)
a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)

Cofactor

FMN
[4Fe-4S] cluster

Subunit

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (By similarity).

Similarity

Belongs to the complex I 51 kDa subunit family.

Keywords

3D-structure   4Fe-4S   Acetylation   Complete proteome   Direct protein sequencing   Electron transport   Flavoprotein   FMN   Iron   Iron-sulfur   Membrane   Metal-binding   Methylation   Mitochondrion   Mitochondrion inner membrane   NAD   Oxidoreductase   Reference proteome   Respiratory chain   Transit peptide   Translocase   Transport   Ubiquinone  

Feature

chain  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

Uniprot

H9J921   A0A194R3P0   A0A194PZ05   A0A212EVS8   A0A2A4JP06   A0A2H1VYJ4   + More
A0A182F331   T1DN18   A0A2P8YPW5   A0A2M4BLF0   A0A1B6CWN4   A0A2M4A273   W5JVR1   A0A1W4UXW4   A0A2J7RAB5   A0A0K8TSY0   A0A2M3ZG33   A0A2M3Z095   V5GR67   D6WKB4   A0A182PDX6   A0A182JNE4   A0A182XHC5   A0A182UQQ2   A0A1S4H2T5   A0A182L7X1   A0A182HR46   A0A182R1T4   A0A1A9YLI0   A0A1B6GR77   D3TS33   J3JUS2   A0A067RGT2   A0A182ULL1   A0A182W8L8   A0A182Y655   Q9VMI3   Q7PMH3   A0A1B6GZ57   A0A2S2R2E1   A0A0J9QXJ4   A0A1B0BQ20   A0A1A9ZWA1   J9JIY5   A0A2H8TE50   B4NZQ8   B3MKI8   H9J919   B0WGB3   A0A0M4E3M9   A0A1I8PBI8   B3N9R3   A0A182LXF2   A0A1A9V1J3   T1P7Z7   A0A1A9W856   A0A2K5QWR4   E2R514   A0A182NNV7   U3BG69   A0A1L8EEP0   A0A182QA74   A0A034WMT4   A0A2K5DQ22   A0A2U3YIV9   M3VX83   B4LRL7   A0A034WIS7   B4KL74   A0A2Y9GU77   U3DH76   M3XY56   A0A383Z7F0   B4MUX4   A0A1A6H3E3   F1RVN1   A0A1S2ZFY1   A0A2U3VGJ4   A0A2F0AUY4   Q91YT0   A0A1S3FKS0   A0A1Y1M4Z9   A0A384DJY0   A0A2Y9JN07   A0A3P4QN48   G1L2L0   A0A1U7T3J7   A0A2Y9PMH0   A0A250YIQ0   A0A2Y9DZW7   A0A1B0FE00   A0A2K6A345   A0A2K5L8V7   W5PUX0   A0A1S2ZFW6   B4JB10   A0A2K6DJ47   A0A2K6M2W1   A0A0D9R8L3   A0A2K6QG60  

EC Number

1.6.99.3
7.1.1.2

Pubmed

19121390    26354079    22118469    29403074    20920257    23761445    + More
26369729    18362917    19820115    12364791    20966253    20353571    22516182    23537049    24845553    25244985    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    22936249    17994087    17550304    25315136    16341006    25243066    25348373    17975172    27912063    27654917    16141072    15489334    10870971    21183079    23806337    23576753    24129315    28004739    24813606    20010809    28087693    20809919    27595392    25362486   

EMBL

BABH01004638    BABH01004639    BABH01004640    BABH01004641    KQ460855    KPJ11855.1    + More
KQ459584    KPI98562.1    AGBW02012119    OWR45608.1    NWSH01000867    PCG73795.1    ODYU01005241    SOQ45905.1    GAMD01003250    JAA98340.1    PYGN01000442    PSN46298.1    GGFJ01004746    MBW53887.1    GEDC01019494    JAS17804.1    GGFK01001427    MBW34748.1    ADMH02000277    ETN67150.1    NEVH01006574    PNF37779.1    GDAI01000136    JAI17467.1    GGFM01006649    MBW27400.1    GGFM01001194    MBW21945.1    GALX01004379    JAB64087.1    KQ971342    EFA04664.1    AAAB01008980    APCN01001643    GECZ01004827    JAS64942.1    EZ424235    ADD20511.1    APGK01053537    BT126987    KB741224    KB631749    AEE61949.1    ENN72318.1    ERL85747.1    KK852692    KDR18342.1    AE014134    AY051642    AAF52334.1    AAK93066.1    AHN54172.1    EAA13847.5    GECZ01002075    JAS67694.1    GGMS01014900    MBY84103.1    CM002910    KMY88454.1    JXJN01018356    ABLF02030142    GFXV01000571    MBW12376.1    CM000157    EDW88842.1    CH902620    EDV31541.1    BABH01004644    BABH01004645    DS231924    EDS26851.1    CP012523    ALC38258.1    CH954177    EDV58558.1    AXCM01000658    KA644682    AFP59311.1    AAEX03011611    GAMT01000068    GAMS01002084    GAMP01005499    JAB11793.1    JAB21052.1    JAB47256.1    GFDG01001628    JAV17171.1    AXCN02001989    GAKP01003467    JAC55485.1    AANG04000779    CH940649    EDW63612.1    GAKP01003466    JAC55486.1    CH933807    EDW11735.1    GAMR01002340    JAB31592.1    AEYP01049320    CH963857    EDW76319.1    LZPO01055072    OBS72871.1    AEMK02000006    NTJE010004745    MBV94564.1    AK075692    BC014818    BC041682    GEZM01043063    JAV79345.1    CYRY02037493    VCX24049.1    ACTA01122041    GFFW01001362    JAV43426.1    CCAG010016923    AMGL01061994    CH916368    EDW02880.1    AQIB01078333   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000218220    UP000069272    + More
UP000245037    UP000000673    UP000192221    UP000235965    UP000007266    UP000075885    UP000075881    UP000076407    UP000075903    UP000075882    UP000075840    UP000075900    UP000092443    UP000019118    UP000030742    UP000027135    UP000075902    UP000075920    UP000076408    UP000000803    UP000007062    UP000092460    UP000092445    UP000007819    UP000002282    UP000007801    UP000002320    UP000092553    UP000095300    UP000008711    UP000075883    UP000078200    UP000095301    UP000091820    UP000233040    UP000002254    UP000075884    UP000008225    UP000075886    UP000233020    UP000245341    UP000011712    UP000008792    UP000009192    UP000248481    UP000000715    UP000261681    UP000007798    UP000092124    UP000008227    UP000079721    UP000245340    UP000000589    UP000081671    UP000261680    UP000291021    UP000248482    UP000008912    UP000189704    UP000248483    UP000248480    UP000092444    UP000233140    UP000233060    UP000002356    UP000001070    UP000233120    UP000233180    UP000029965    UP000233200   

PRIDE

H9J921    Q9VMI3    H9J919    E2R514    F1RVN1    Q91YT0    + More

Pfam

PF10531   SLBB        + More
PF10589   NADH_4Fe-4S
PF01512   Complex1_51K
PF00069   Pkinase
PF01331   mRNA_cap_enzyme
PF00782   DSPc

Interpro

IPR037225   Nuo51_FMN-bd_sf        + More
IPR019554   Soluble_ligand-bd       
IPR011537   NADH-UbQ_OxRdtase_suF       
IPR011538   Nuo51_FMN-bd       
IPR019575   Nuop51_4Fe4S-bd       
IPR001949   NADH-UbQ_OxRdtase_51kDa_CS       
IPR037207   Nuop51_4Fe4S-bd_sf       
IPR000719   Prot_kinase_dom       
IPR011009   Kinase-like_dom_sf       
IPR029021   Prot-tyrosine_phosphatase-like       
IPR016130   Tyr_Pase_AS       
IPR000387   TYR_PHOSPHATASE_dom       
IPR001339   mRNA_cap_enzyme       
IPR000340   Dual-sp_phosphatase_cat-dom       

SUPFAM

SSF142019   SSF142019        + More
SSF140490   SSF140490       
SSF56112   SSF56112       
SSF52799   SSF52799       

Gene 3D

1.20.1440.230     3.40.50.11540     3.90.190.10    

ProteinModelPortal

H9J921   A0A194R3P0   A0A194PZ05   A0A212EVS8   A0A2A4JP06   A0A2H1VYJ4   + More
A0A182F331   T1DN18   A0A2P8YPW5   A0A2M4BLF0   A0A1B6CWN4   A0A2M4A273   W5JVR1   A0A1W4UXW4   A0A2J7RAB5   A0A0K8TSY0   A0A2M3ZG33   A0A2M3Z095   V5GR67   D6WKB4   A0A182PDX6   A0A182JNE4   A0A182XHC5   A0A182UQQ2   A0A1S4H2T5   A0A182L7X1   A0A182HR46   A0A182R1T4   A0A1A9YLI0   A0A1B6GR77   D3TS33   J3JUS2   A0A067RGT2   A0A182ULL1   A0A182W8L8   A0A182Y655   Q9VMI3   Q7PMH3   A0A1B6GZ57   A0A2S2R2E1   A0A0J9QXJ4   A0A1B0BQ20   A0A1A9ZWA1   J9JIY5   A0A2H8TE50   B4NZQ8   B3MKI8   H9J919   B0WGB3   A0A0M4E3M9   A0A1I8PBI8   B3N9R3   A0A182LXF2   A0A1A9V1J3   T1P7Z7   A0A1A9W856   A0A2K5QWR4   E2R514   A0A182NNV7   U3BG69   A0A1L8EEP0   A0A182QA74   A0A034WMT4   A0A2K5DQ22   A0A2U3YIV9   M3VX83   B4LRL7   A0A034WIS7   B4KL74   A0A2Y9GU77   U3DH76   M3XY56   A0A383Z7F0   B4MUX4   A0A1A6H3E3   F1RVN1   A0A1S2ZFY1   A0A2U3VGJ4   A0A2F0AUY4   Q91YT0   A0A1S3FKS0   A0A1Y1M4Z9   A0A384DJY0   A0A2Y9JN07   A0A3P4QN48   G1L2L0   A0A1U7T3J7   A0A2Y9PMH0   A0A250YIQ0   A0A2Y9DZW7   A0A1B0FE00   A0A2K6A345   A0A2K5L8V7   W5PUX0   A0A1S2ZFW6   B4JB10   A0A2K6DJ47   A0A2K6M2W1   A0A0D9R8L3   A0A2K6QG60  

PDB

6G72     E-value=0,     Score=2104

KEGG

101739646    K03942 NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:7.1.1.2 1.6.99.3] | (RefSeq) NADH dehydrog

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005743   GO:0010181   GO:0046872   GO:0070469   GO:0051287   GO:0008137   GO:0051539   GO:0005524   GO:0004672   GO:0045333   GO:0006120   GO:0005739   GO:0005747   GO:0016021   GO:0003954   GO:0008138   GO:0006370   GO:0004725   GO:0004484   GO:0042775   GO:0005829   GO:0016651   GO:0030529   GO:0016020   GO:0005515   GO:0003779  

PANTHER

PTHR11780  

Subcellular location

Mitochondrion inner membrane  

Length:

478

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05829

Exp number, first 60 AAs:

0.00724

Total prob of N-in:

0.00518

outside

1  -  478

 

 

Pi

175.973597

Theta

155.151778

Tajima's D

0.385289

CLR

0.637044

CSRT

0.47777611119444

Interpretation

Uncertain