Gene

KWMTBOMO01751

Pre Gene Modal

BGIBMGA006136

Annotation

PREDICTED:_tribbles_homolog_2-like_[Papilio_machaon]

Location

Bomo_Chr4(+):3649044-3682804      View in EpiBrowser

Full name

Tribbles homolog 2      

Location in the cell

Mitochondrial   Reliability : 1.512 Nuclear   Reliability : 1.928

CDS

ATGGATCCCGGATCACCCTCGTTGTTATGGCCGTTGCGGCTGAGCAAGCCGGCGGTGACGATGCCGGTGCCCAGTACAGGAGAGAGCAGTAAAGCTGAAGACCGAGCGCAGTCCCCAGGGCTGCAGGAGCGGCTGTCCGCGGCGCCACCGAGCCCGGCGCCACCCAGTCCCGCACCAACCCAACATCAATTCCAAGCAGCTCTCGTTGCCGAGAAGTACCTCCTGCTGGAACAAGTCGAAGGTTCCTCGTTATGTCGGTGTGTAGACGTGCGTACCCAAGAGGAATATGTATGCAAGGTTGTGTCCCGAGACTGCAGCAGTTTACTACAAGCACATTACCGTCTCGACGGGCATCCGCACGTCAATCCTATTCACGAAGTCCTAGTCGGCGATAAGAGGGTGTACCTGATCTTCCCTCGGTCGCATTCAGATCTACATTCATACGTTCGGGCGAGGAAAAGGCTAAGAGAGCACGAAGCCCGAAGACTCTTCAGACAAATGGCCGAAACGGTAGCGGCGTGCCACGAACAGGGCATCGTATTAAGAGATCTCAAATTAAGGAAGTTCGTCTTCGCAGACCCACAACGGACGACTCTAAAATTAGAATCATTAGAAGACGCGGTCGTCCTCGACGATCCGGAGGAAGATTTACTTCAAGATAAGCGAGGGTGTCCCGCCTACGTGTCGCCCGAGATCCTCAAAGCGCACAGAACGTATTCGGGCAAGGCCGCCGATATGTGGTCGCTCGGCGTCATACTCTACACCATGCTCGTCGGAAGGTATCCGTTCAACGACTCCGAGCACGCGTCGCTGTTCGCGAAGATATCGCGGGGCTTCTTCGTGGTGCCGGAGTGTTTGTCGTCGCGCGGCAAGTGCCTGATCAGGTCGTTGCTCCGTCGGGAGGCGGGCGAGCGGCTGAGCGCGGCGGCGGTGCTGCGACACCCCTGGCTGGCGCGGGACCCCCGCAACGAGCTGCCGCCGCGCGCCGCCGCCGCGCTCGACCGCCTCGTGCCCGACTGTCTCTAG

Protein

MDPGSPSLLWPLRLSKPAVTMPVPSTGESSKAEDRAQSPGLQERLSAAPPSPAPPSPAPTQHQFQAALVAEKYLLLEQVEGSSLCRCVDVRTQEEYVCKVVSRDCSSLLQAHYRLDGHPHVNPIHEVLVGDKRVYLIFPRSHSDLHSYVRARKRLREHEARRLFRQMAETVAACHEQGIVLRDLKLRKFVFADPQRTTLKLESLEDAVVLDDPEEDLLQDKRGCPAYVSPEILKAHRTYSGKAADMWSLGVILYTMLVGRYPFNDSEHASLFAKISRGFFVVPECLSSRGKCLIRSLLRREAGERLSAAAVLRHPWLARDPRNELPPRAAAALDRLVPDCL

Description

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).

Similarity

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.

Keywords

Complete proteome   Cytoplasm   Cytoskeleton   Protein kinase inhibitor   Reference proteome  

Feature

chain  Tribbles homolog 2

Uniprot

A0A2A4JQB8   A0A1Y1KLV6   A0A1B6DSY4   A0A139WI05   V5GQU8   A0A1B6H5K9   + More
A0A023EUZ0   A0A1S4G7P6   A0A1B6GLZ5   A0A1Q3FXU2   A0A1Q3FXN3   A0A023EZF0   A0A069DSH6   A0A1L8DKA6   A0A1L8DK86   A0A224XFT1   A0A0N7Z8H9   A0A0P6GQ41   A0A0A9X162   A0A1I8JT69   A0A0V0GF27   A0A2M4AGK8   A0A2M4ABC3   A0A2M3ZGR9   A0A2M4BPI1   A0A2M4BR55   A0A2M4CGS0   A0A2M4A6S5   A0A182Y655   A0A2M4A656   A0A2M4BLU9   A0A2M4CGT5   A0A2M4CGQ3   A0A2M4CHY5   A0A2M4BGP3   A0A0N8EQC5   A0A336LPA0   A0A293MX02   A0A1Z5KXK8   A0A2R5LAD9   B7PAN3   V5HDJ0   A0A1E1XKY1   A0A087UE82   A0A1E1XAM1   G3MIY1   A0A131YPY1   A0A224Z488   A0A131XC18   L7M1C6   L7LRV4   A0A1W7R9C6   A0A154NYQ2   A0A2A3EGS1   A0A195E5M7   A0A151IKT0   A0A310S6C1   A0A158NG97   A0A0C9Q9L5   A0A0M9A3K2   F4WP51   A0A026WQ26   A0A0J7L1E3   E2A3K4   A0A210Q7I2   A0A0L7RJZ6   K7INF4   T1JD19   C3YMQ1   A0A151WMA4   A0A3M6U337   V9K983   A0A091E7V4   A0A2B4S343   A0A1S3EXK5   W5NI83   A0A1S3MBQ9   A0A286XZB7   A0A060XNY0   A0A250YFY7   A7S0A1   G5AST4   A0A1U7R0L9   A0A287BA06   I3M0W8   H0WKU6   H3AA74   Q8K4K3   A0A2I2V3C7   L8I375   Q5GLH2  

Pubmed

28004739    18362917    19820115    24945155    25474469    26334808    + More
27129103    25401762    26823975    25244985    28528879    25765539    29209593    28503490    22216098    26830274    28797301    28049606    25576852    21347285    21719571    24508170    30249741    20798317    28812685    20075255    18563158    30382153    24402279    21993624    24755649    28087693    17615350    21993625    30723633    9215903    16141072    15489334    17975172    22751099    15829623   

EMBL

NWSH01000867    PCG73794.1    GEZM01086038    JAV59827.1    GEDC01008533    JAS28765.1    + More
KQ971342    KYB27630.1    GALX01004514    JAB63952.1    GECU01037717    JAS69989.1    GAPW01001299    JAC12299.1    GECZ01006304    JAS63465.1    GFDL01002664    JAV32381.1    GFDL01002704    JAV32341.1    GBBI01004566    JAC14146.1    GBGD01002262    JAC86627.1    GFDF01007195    JAV06889.1    GFDF01007196    JAV06888.1    GFTR01005090    JAW11336.1    GDKW01003299    JAI53296.1    GDIQ01040653    JAN54084.1    GBHO01032764    GBHO01020613    GBRD01010322    GDHC01020797    GDHC01018650    GDHC01018486    JAG10840.1    JAG22991.1    JAG55502.1    JAP97831.1    JAP99978.1    JAQ00143.1    APCN01001643    GECL01000221    JAP05903.1    GGFK01006447    MBW39768.1    GGFK01004770    MBW38091.1    GGFM01006958    MBW27709.1    GGFJ01005773    MBW54914.1    GGFJ01006322    MBW55463.1    GGFL01000358    MBW64536.1    GGFK01003176    MBW36497.1    GGFK01002881    MBW36202.1    GGFJ01004915    MBW54056.1    GGFL01000355    MBW64533.1    GGFL01000354    MBW64532.1    GGFL01000350    MBW64528.1    GGFJ01003084    MBW52225.1    GDIQ01004268    JAN90469.1    UFQT01000030    SSX18197.1    GFWV01019152    MAA43880.1    GFJQ02007097    JAV99872.1    GGLE01002314    MBY06440.1    ABJB010057699    ABJB010608531    DS672165    EEC03655.1    GANP01011241    JAB73227.1    GFAA01003432    JAU00003.1    KK119418    KFM75671.1    GFAC01002888    JAT96300.1    JO841832    AEO33449.1    GEDV01007965    JAP80592.1    GFPF01012849    MAA23995.1    GEFH01004082    JAP64499.1    GACK01008091    JAA56943.1    GACK01010293    JAA54741.1    GFAH01000641    JAV47748.1    KQ434777    KZC04204.1    KZ288253    PBC30965.1    KQ979608    KYN20391.1    KQ977164    KYN05212.1    KQ797156    OAD46995.1    ADTU01015083    ADTU01015084    GBYB01011068    JAG80835.1    KQ435771    KOX75149.1    GL888243    EGI63982.1    KK107139    QOIP01000003    EZA57796.1    RLU24700.1    LBMM01001289    KMQ96572.1    GL436444    EFN71986.1    NEDP02004701    OWF44684.1    KQ414578    KOC71154.1    JH432094    GG666531    EEN58392.1    KQ982944    KYQ48931.1    RCHS01002311    RMX48095.1    JW862171    AFO94688.1    KN122310    KFO31191.1    LSMT01000225    PFX22905.1    AHAT01009048    AAKN02053135    FR905679    CDQ80932.1    GFFW01002245    JAV42543.1    DS469560    EDO42841.1    JH166813    GEBF01005553    EHB00096.1    JAN98079.1    AEMK02000021    DQIR01239618    HDB95095.1    AGTP01047896    AGTP01047897    AAQR03048269    AFYH01219898    AFYH01219899    AFYH01219900    AF358867    AK044747    AK080064    AK082329    AK144192    BC027159    BC034338    BC037387    AAH27159.1    AAH34338.1    AAH37387.1    AAM45477.1    BAC32063.1    BAC37820.1    BAC38467.1    BAE25758.1    AANG04003329    JH882087    ELR50955.1    AY360147    AY247741    BC123595    AAP04410.1    AAR12274.1   

Proteomes

UP000218220    UP000007266    UP000075840    UP000076408    UP000001555    UP000054359    + More
UP000076502    UP000242457    UP000078492    UP000078542    UP000005205    UP000053105    UP000007755    UP000053097    UP000279307    UP000036403    UP000000311    UP000242188    UP000053825    UP000002358    UP000001554    UP000075809    UP000275408    UP000028990    UP000225706    UP000081671    UP000018468    UP000087266    UP000005447    UP000193380    UP000001593    UP000006813    UP000189706    UP000008227    UP000005215    UP000005225    UP000008672    UP000000589    UP000011712    UP000009136   

PRIDE

Q8K4K3    Q5GLH2   

Pfam

PF00069   Pkinase        + More
PF01512   Complex1_51K
PF10589   NADH_4Fe-4S
PF10531   SLBB
PF00018   SH3_1

Interpro

IPR000719   Prot_kinase_dom        + More
IPR011009   Kinase-like_dom_sf       
IPR024104   Tribbles/Ser_Thr_kinase_40       
IPR011538   Nuo51_FMN-bd       
IPR011537   NADH-UbQ_OxRdtase_suF       
IPR019554   Soluble_ligand-bd       
IPR037225   Nuo51_FMN-bd_sf       
IPR037207   Nuop51_4Fe4S-bd_sf       
IPR001949   NADH-UbQ_OxRdtase_51kDa_CS       
IPR019575   Nuop51_4Fe4S-bd       
IPR001452   SH3_domain       
IPR036028   SH3-like_dom_sf       
IPR024106   Tribbles_TRB3       

SUPFAM

SSF56112   SSF56112        + More
SSF142019   SSF142019       
SSF140490   SSF140490       
SSF50044   SSF50044       

Gene 3D

1.20.1440.230     3.40.50.11540    

ProteinModelPortal

A0A2A4JQB8   A0A1Y1KLV6   A0A1B6DSY4   A0A139WI05   V5GQU8   A0A1B6H5K9   + More
A0A023EUZ0   A0A1S4G7P6   A0A1B6GLZ5   A0A1Q3FXU2   A0A1Q3FXN3   A0A023EZF0   A0A069DSH6   A0A1L8DKA6   A0A1L8DK86   A0A224XFT1   A0A0N7Z8H9   A0A0P6GQ41   A0A0A9X162   A0A1I8JT69   A0A0V0GF27   A0A2M4AGK8   A0A2M4ABC3   A0A2M3ZGR9   A0A2M4BPI1   A0A2M4BR55   A0A2M4CGS0   A0A2M4A6S5   A0A182Y655   A0A2M4A656   A0A2M4BLU9   A0A2M4CGT5   A0A2M4CGQ3   A0A2M4CHY5   A0A2M4BGP3   A0A0N8EQC5   A0A336LPA0   A0A293MX02   A0A1Z5KXK8   A0A2R5LAD9   B7PAN3   V5HDJ0   A0A1E1XKY1   A0A087UE82   A0A1E1XAM1   G3MIY1   A0A131YPY1   A0A224Z488   A0A131XC18   L7M1C6   L7LRV4   A0A1W7R9C6   A0A154NYQ2   A0A2A3EGS1   A0A195E5M7   A0A151IKT0   A0A310S6C1   A0A158NG97   A0A0C9Q9L5   A0A0M9A3K2   F4WP51   A0A026WQ26   A0A0J7L1E3   E2A3K4   A0A210Q7I2   A0A0L7RJZ6   K7INF4   T1JD19   C3YMQ1   A0A151WMA4   A0A3M6U337   V9K983   A0A091E7V4   A0A2B4S343   A0A1S3EXK5   W5NI83   A0A1S3MBQ9   A0A286XZB7   A0A060XNY0   A0A250YFY7   A7S0A1   G5AST4   A0A1U7R0L9   A0A287BA06   I3M0W8   H0WKU6   H3AA74   Q8K4K3   A0A2I2V3C7   L8I375   Q5GLH2  

PDB

5CEM     E-value=6.48383e-68,     Score=653

KEGG

101739790    K08814 tribbles homolog 1/2 | (RefSeq) tribbles homolog 2-like

GO

GO:0005524   GO:0004672   GO:0003714   GO:0031434   GO:0043405   GO:0005634   GO:0032436   GO:0004674   GO:0008137   GO:0051539   GO:0010181   GO:0051287   GO:0004579   GO:0031625   GO:0045599   GO:0055106   GO:0008134   GO:0045081   GO:0001947   GO:0005737   GO:0006468   GO:0004860   GO:0043433   GO:0005856   GO:0051443   GO:0008270   GO:0006396   GO:0030529   GO:0016020   GO:0005515   GO:0003779   GO:0016021  

PANTHER

PTHR22961   PTHR11780   PTHR22961:SF14  

Subcellular location

Cytoplasm   May associate with the cytoskeleton.   With evidence from 1 publications.
Cytoskeleton   May associate with the cytoskeleton.   With evidence from 1 publications.

Length:

341

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.15612

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00229

outside

1  -  341

 

 

Pi

166.674819

Theta

179.72692

Tajima's D

-0.671636

CLR

148.978192

CSRT

0.206789660516974

Interpretation

Uncertain