Gene

KWMTBOMO01742  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006016

Annotation

PREDICTED:_lysosomal_thioesterase_PPT2_homolog_[Bombyx_mori]

Location

Bomo_Chr4(-):3267111-3271494      View in EpiBrowser

Full name

Lysosomal thioesterase PPT2 homolog      

Location in the cell

Nuclear   Reliability : 2.743

CDS

ATGAATCTTGTTAAAGCTTTATTGTTTAATGTATTAAGTTTAAGTATAGGATTTGCGTATAAGCCTGTGGTTTTAATGCATGGAATTATGACTGGGAGTGGTAGTATGGAAATAATAAAGCATAGAATAGAAGAGAAACATCCCGGAACAGTTGTGTACAATGTGAACAGGTTCGAGAGCTGGTCCAGCTTGGAAAGTATGTGGCACCAAGTTTTGGAAATTGGTTTGGACGTGGCTAACATATCTGCGTCACATCCTGAAGGAATCAATTTAATAGGATATTCTCAAGGAGGTCTGGTAGCAAGAGGGATCGTCGAGACATTCTCTAATGTATCTGTTAGTACATTCATATCACTTAGTTCACCACAAGCTGGTCAATATGGAGCTGGTTTCCTGCACTTGGTGTTTCCGGGCTTGGTCAAAGAAACTGTCTATGAGTTGTTCTACTCGAAAGTTGGTCAGCACACATCCGTTGGCAATTACTGGAACGACCCATACCATCAGCCGCTGTACGAGACCTACTGCATGTTTTTGCCTTACCTAAATAATCATAAACAGTCGAAGAAGTCTGAAGAATTCAAAGCCAACATGCTGAGACTGAAGCGGCTGGTGCTGATCGGGGGACCGGACGACGACGTCATCACACCCTGGCAGAGCAGTCAATTCGGCTACTACAACGCCAACGAAACGGTCATCGAGCTTCGCAATCAGGAAATCTACAAGGACGACAAAATAGGACTGAAGAGTCTAGACGAGTCGGGCAGGCTACACGTCCTCAGCGTTCCAGGTGTGAACCATTTCAATTGGCACATGAACGTCAGCGTAGTCGACGACTATCTGTTGCCATATTTAGATTAG

Protein

MNLVKALLFNVLSLSIGFAYKPVVLMHGIMTGSGSMEIIKHRIEEKHPGTVVYNVNRFESWSSLESMWHQVLEIGLDVANISASHPEGINLIGYSQGGLVARGIVETFSNVSVSTFISLSSPQAGQYGAGFLHLVFPGLVKETVYELFYSKVGQHTSVGNYWNDPYHQPLYETYCMFLPYLNNHKQSKKSEEFKANMLRLKRLVLIGGPDDDVITPWQSSQFGYYNANETVIELRNQEIYKDDKIGLKSLDESGRLHVLSVPGVNHFNWHMNVSVVDDYLLPYLD

Description

Probable thioesterase removing fatty acyl groups from various substrates such as S-palmitoyl-CoA. Because of structural constraints, may be unable to remove palmitate from peptides or proteins (By similarity).

Similarity

Belongs to the palmitoyl-protein thioesterase family.

Keywords

Complete proteome   Glycoprotein   Hydrolase   Lysosome   Reference proteome   Signal  

Feature

chain  Lysosomal thioesterase PPT2 homolog

Uniprot

H9J924   A0A291P128   A0A291P156   A0A2A4JXH6   A0A1V0M893   A0A2H1VF96   + More
A0A2H1VHY7   A0A194PZU0   A0A212F6T0   A0A088M9J3   A0A2A3EID9   A0A1Y1MSQ9   A0A087ZMY7   V5GM39   A0A194R7J9   J3JUM0   D7ELF0   A0A026WH65   A0A1W4XE11   A0A0N0BCW2   A0A232F5I2   E9IJU4   A0A151WYL2   A0A1W7R7K7   Q17LU4   A0A1S4EYA3   A0A195F8J3   U5ES24   B0W633   A0A158ND04   A0A1Q3FPC1   A0A067RNM5   A0A0K8TH02   A0A0A9XD97   A0A0P6IZL3   A0A2P8YZ28   E2AXZ9   A0A182F259   A0A2M4BW37   A0A2M4BW29   A0A195D0E2   A0A2M4AXL1   A0A2M4BW96   W5JHN8   A0A069DYE8   A0A182PTV0   A0A2J7QU23   A0A182YFT9   A0A1L8DPT1   A0A1L8DPP2   A0A1L8DQ35   A0A182IMY8   E2BR36   A0A182VU04   F4X0L5   A0A182QW16   A0A0L7R6C1   A0A182KFK0   A0A1B6C2B5   A0A182GKK7   A0A3B0K1N0   A0A195D8L2   A0A1B6MNE8   A0A336MGD0   A0A336L6E1   A0A146M7A1   A0A1W4VM03   B4KH97   B4N7B1   A0A182HI70   A0A182TR60   A0A1B0DKY8   A0A182UPE0   Q29M27   B4G6M7   E0VFQ7   A0A195B824   A0A182XN25   A0A1B0CR03   Q7Q1P3   Q9VKH6   A0A0M5IYF9   B4LQF9   A0A224XWU3   A0A0V0GB72   B4QAD3   B3N4J1   A0A0K8W5F9   A0A1B6HTE7   B4HX37   A0A1B6IIK6   A0A1B6K4L0   A0A182MNI9   A0A1B6I5T9   A0A1B6I7R3   B3MMV1   A0A1I8PK54   B4P1F9   A0A0C9RNF9   A0A0T6B8F2  

EC Number

3.1.2.-

Pubmed

19121390    28986331    28349297    26354079    22118469    26385554    + More
28004739    22516182    23537049    18362917    19820115    24508170    30249741    28648823    21282665    17510324    21347285    24845553    25401762    26999592    29403074    20798317    20920257    23761445    26334808    25244985    21719571    26483478    26823975    17994087    15632085    20566863    12364791    18719403    10731132    12537572    12537569    22936249    17550304   

EMBL

BABH01004596    MF687649    ATJ44575.1    MF706178    ATJ44605.1    NWSH01000468    + More
PCG76203.1    KU755493    ARD71203.1    ODYU01001984    SOQ38934.1    ODYU01002656    SOQ40443.1    KQ459584    KPI98553.1    AGBW02009976    OWR49437.1    KJ579208    AIN34684.1    KZ288242    PBC31234.1    GEZM01023912    JAV88138.1    GALX01005789    JAB62677.1    KQ460855    KPJ11846.1    APGK01021327    BT126935    KB740314    KB631743    AEE61897.1    ENN80889.1    ERL85730.1    DS497846    EFA12062.1    KK107213    QOIP01000007    EZA55298.1    RLU20575.1    KQ435896    KOX69241.1    NNAY01000988    OXU25597.1    GL763883    EFZ19122.1    KQ982650    KYQ52876.1    GEHC01000528    JAV47117.1    CH477212    EAT47669.1    KQ981744    KYN36374.1    GANO01002557    JAB57314.1    DS231846    EDS36181.1    ADTU01012128    GFDL01005595    JAV29450.1    KK852514    KDR22190.1    GBRD01008672    GBRD01001042    JAG64779.1    GBHO01024914    GBHO01024912    JAG18690.1    JAG18692.1    GDUN01000656    JAN95263.1    PYGN01000277    PSN49504.1    GL443740    EFN61702.1    GGFJ01008071    MBW57212.1    GGFJ01008073    MBW57214.1    KQ977012    KYN06385.1    GGFK01012212    MBW45533.1    GGFJ01008070    MBW57211.1    ADMH02001369    ETN62823.1    GBGD01002435    JAC86454.1    NEVH01011191    PNF32079.1    GFDF01005635    JAV08449.1    GFDF01005636    JAV08448.1    GFDF01005634    JAV08450.1    GL449898    EFN81842.1    GL888498    EGI60007.1    AXCN02000619    KQ414646    KOC66388.1    GEDC01029636    JAS07662.1    JXUM01070038    KQ562585    KXJ75544.1    OUUW01000004    SPP79506.1    KQ981135    KYN09230.1    GEBQ01002507    JAT37470.1    UFQT01001120    SSX29000.1    UFQS01002029    UFQT01002029    SSX13004.1    SSX32444.1    GDHC01008281    GDHC01002978    JAQ10348.1    JAQ15651.1    CH933807    EDW13314.1    CH964182    EDW80252.1    APCN01005638    AJVK01006563    CH379060    EAL33868.1    CH479180    EDW29141.1    DS235123    EEB12213.1    KQ976558    KYM80683.1    AJWK01024273    AAAB01008980    EAA14558.2    AE014134    BT021446    AY060722    CP012523    ALC39311.1    CH940649    EDW63409.1    GFTR01003975    JAW12451.1    GECL01000872    JAP05252.1    CM000361    CM002910    EDX04688.1    KMY89748.1    CH954177    EDV58903.1    GDHF01006027    JAI46287.1    GECU01029749    JAS77957.1    CH480818    EDW52582.1    GECU01020961    JAS86745.1    GECU01027529    GECU01021627    GECU01019621    GECU01018918    GECU01016736    GECU01004621    GECU01001317    JAS80177.1    JAS86079.1    JAS88085.1    JAS88788.1    JAS90970.1    JAT03086.1    JAT06390.1    AXCM01002101    GECU01025410    JAS82296.1    GECU01024728    JAS82978.1    CH902620    EDV30976.2    CM000157    EDW88066.2    GBYB01015037    JAG84804.1    LJIG01009170    KRT83616.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000242457    UP000005203    + More
UP000053240    UP000019118    UP000030742    UP000007266    UP000053097    UP000279307    UP000192223    UP000053105    UP000215335    UP000075809    UP000008820    UP000078541    UP000002320    UP000005205    UP000027135    UP000245037    UP000000311    UP000069272    UP000078542    UP000000673    UP000075885    UP000235965    UP000076408    UP000075880    UP000008237    UP000075920    UP000007755    UP000075886    UP000053825    UP000075881    UP000069940    UP000249989    UP000268350    UP000078492    UP000192221    UP000009192    UP000007798    UP000075840    UP000075902    UP000092462    UP000075903    UP000001819    UP000008744    UP000009046    UP000078540    UP000076407    UP000092461    UP000007062    UP000000803    UP000092553    UP000008792    UP000000304    UP000008711    UP000001292    UP000075883    UP000007801    UP000095300    UP000002282   

PRIDE

H9J924    Q9VKH6   

Pfam

PF02089   Palm_thioest

Interpro

IPR030295   PPT2        + More
IPR002472   Palm_thioest       
IPR029058   AB_hydrolase       

SUPFAM

SSF53474   SSF53474       

Gene 3D

3.40.50.1820    

ProteinModelPortal

H9J924   A0A291P128   A0A291P156   A0A2A4JXH6   A0A1V0M893   A0A2H1VF96   + More
A0A2H1VHY7   A0A194PZU0   A0A212F6T0   A0A088M9J3   A0A2A3EID9   A0A1Y1MSQ9   A0A087ZMY7   V5GM39   A0A194R7J9   J3JUM0   D7ELF0   A0A026WH65   A0A1W4XE11   A0A0N0BCW2   A0A232F5I2   E9IJU4   A0A151WYL2   A0A1W7R7K7   Q17LU4   A0A1S4EYA3   A0A195F8J3   U5ES24   B0W633   A0A158ND04   A0A1Q3FPC1   A0A067RNM5   A0A0K8TH02   A0A0A9XD97   A0A0P6IZL3   A0A2P8YZ28   E2AXZ9   A0A182F259   A0A2M4BW37   A0A2M4BW29   A0A195D0E2   A0A2M4AXL1   A0A2M4BW96   W5JHN8   A0A069DYE8   A0A182PTV0   A0A2J7QU23   A0A182YFT9   A0A1L8DPT1   A0A1L8DPP2   A0A1L8DQ35   A0A182IMY8   E2BR36   A0A182VU04   F4X0L5   A0A182QW16   A0A0L7R6C1   A0A182KFK0   A0A1B6C2B5   A0A182GKK7   A0A3B0K1N0   A0A195D8L2   A0A1B6MNE8   A0A336MGD0   A0A336L6E1   A0A146M7A1   A0A1W4VM03   B4KH97   B4N7B1   A0A182HI70   A0A182TR60   A0A1B0DKY8   A0A182UPE0   Q29M27   B4G6M7   E0VFQ7   A0A195B824   A0A182XN25   A0A1B0CR03   Q7Q1P3   Q9VKH6   A0A0M5IYF9   B4LQF9   A0A224XWU3   A0A0V0GB72   B4QAD3   B3N4J1   A0A0K8W5F9   A0A1B6HTE7   B4HX37   A0A1B6IIK6   A0A1B6K4L0   A0A182MNI9   A0A1B6I5T9   A0A1B6I7R3   B3MMV1   A0A1I8PK54   B4P1F9   A0A0C9RNF9   A0A0T6B8F2  

PDB

1PJA     E-value=1.39974e-58,     Score=571

KEGG

101739036    K01074 palmitoyl-protein thioesterase [EC:3.1.2.22] | (RefSeq) lysosomal thioesterase PPT2 homolog

PATHWAY

00062    Fatty acid elongation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01212    Fatty acid metabolism - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0008474   GO:0016740   GO:0005764   GO:0016021   GO:0098734   GO:0098599  

PANTHER

PTHR11247:SF27  

Subcellular location

Lysosome  

SignalP

Position:   1 - 19,         Likelihood:  0.628333

 

 

Length:

285

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

20.93684

Exp number, first 60 AAs:

20.88955

Total prob of N-in:

0.92511

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  29

outside

30  -  285

 

 

Pi

188.145105

Theta

170.484268

Tajima's D

-0.458964

CLR

283.703168

CSRT

0.248587570621469

Interpretation

Uncertain