Gene

KWMTBOMO01723  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006020

Annotation

PREDICTED:_RNA_pseudouridylate_synthase_domain-containing_protein_2-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr4(-):2452186-2483332      View in EpiBrowser

Full name

Pseudouridine synthase      

Location in the cell

Mitochondrial   Reliability : 2.076

CDS

ATGCCAATCGTGATCGTCTTAGGTAAGGGAGAAAAAGACAACGGCAAGAATATAATCTTATCTTGCGAGAAGAGGAAAGCAGATGATAGCGAAATCAACAAAGACTTAAAAAAGGCTAAATTAGAAACGAAGGCTTTAAAAGCAAAGAGGCCCGGCTTCACGGACGACAGATACAACGAGACATCATATTACATGGAAAACGGTCTTAGAAAAGTCTACCCGTACTATTTCACGTTCACGACCTTCACGAAAGGGAGATGGGTCGGGGAGAAGATCCTGGATGTCTTCGCGAGAGAGTTCAGAGCGCACCCTGCAGCGGAGTACGAAAGGTGCATCAGGGCCGGTACCCTCACGGTCAACTACGAGAGGGTTGACCCTGATTACAGACTCAAACACAACGACCTTCTAGCGAACGTAGTGCACAGGCACGAAGTACCGGTCACCAGCCAACCCATCACCCTCGTTCATATCGACGAGGACATTGTGGTTGTCAACAAACCGGCCTCTATCCCCGTGCATCCATGCGGTCGCTACAGACACAATACCGTTGTTTTTATCCTCGCGAAGGAATACAACTTGAAGAACCTGAGGACCATCCACAGACTGGACAGGCTCACGTCAGGACTTCTTCTGTTCGGGAGGAGTCCGAAGAAAGCTAGACAGATGGAGCACCAGATTAGGAACCGACAAGTCCAGAAGGAATACGTCTGCAGGGTCGACGGAGAATTTCCTGACGAGGAAATAGAATGTCAAGAGCCGATAGAAGTGGTCAGCTACAAAATAGGCGTGTGCAAGGTGTCTCCGAAAGGCAAGGACTGCTCGACTGTGTTCAAGCGACTTGGCTTCAACCAGGCGAACAACACTAGCGTGGTGCTCTGCCGCCCGAAGACCGGTAGAATGCACCAGATCAGAGTTCACCTGCAGTACCTTGGTTACCCGGTAGTAAACGATCCCCTGTACAACCACCCTGTGTTCGGTCCACTGCGCGGTAAGGGCGGCGACACCGGCGGCAAAACTGACGAGCAACTAGTCCGGGATCTGATCGCCATCCACAACGCCGAGAACTGGCTCGGTGTTGATGCTGCTGATGACGATTTGCTGTTCTCAAAGCCGGCGCCTGATGATAAAGTTGGCGAAGACGACTGCGACACAGGACCCGCTTCCAGGGAGTCTTCACCGAGATTAGATTCGCCAGCGCCCGGAGTGACAGCCTCTACCGTCATGACTCCAACTCTAGCGAGTCCGTCGAGCGGCGCTGAGGCCCCGGCGGAGGAGTCACCTCGCGCGCCACCCTCTCCCACCCCCCTCGCGACGCTCCCTATCAATGAAGACTCTAACGATGCCAAGTCAGACAAGGTGACGGTGGCGACGCAGACGGGCTGCGCGGAGACCGCAACGAGCGCGGCGGGCGCGGCTGAGGTCATCGACCCGCACTGCTACGAGTGCCGCGTGCGGTACCGCGACCCGCGCCCGCGCGACCTCGTCATGTACCTACACGCCTGGAAGTACAAGGGCCCGGGCTGGGAATACGAGACGGAGCTGCCGCAGTGGGCGAGCCTAGACTGGGACGAGCCAGAGAACTCATAG

Protein

MPIVIVLGKGEKDNGKNIILSCEKRKADDSEINKDLKKAKLETKALKAKRPGFTDDRYNETSYYMENGLRKVYPYYFTFTTFTKGRWVGEKILDVFAREFRAHPAAEYERCIRAGTLTVNYERVDPDYRLKHNDLLANVVHRHEVPVTSQPITLVHIDEDIVVVNKPASIPVHPCGRYRHNTVVFILAKEYNLKNLRTIHRLDRLTSGLLLFGRSPKKARQMEHQIRNRQVQKEYVCRVDGEFPDEEIECQEPIEVVSYKIGVCKVSPKGKDCSTVFKRLGFNQANNTSVVLCRPKTGRMHQIRVHLQYLGYPVVNDPLYNHPVFGPLRGKGGDTGGKTDEQLVRDLIAIHNAENWLGVDAADDDLLFSKPAPDDKVGEDDCDTGPASRESSPRLDSPAPGVTASTVMTPTLASPSSGAEAPAEESPRAPPSPTPLATLPINEDSNDAKSDKVTVATQTGCAETATSAAGAAEVIDPHCYECRVRYRDPRPRDLVMYLHAWKYKGPGWEYETELPQWASLDWDEPENS

Description

Responsible for synthesis of pseudouridine from uracil.

Catalytic Activity

a uridine in RNA = a psi-uridine in RNA

Similarity

Belongs to the pseudouridine synthase RluA family.

Uniprot

H9J928   A0A2A4K912   A0A2A4K7Z7   A0A182YFU0   A0A2M4CIS4   Q17LU3   + More
Q5TP89   A0A1B6C5M5   A0A023F451   A0A1J1HFZ9   A0A146L739   D6WKG9   A0A146LH65   A0A336LNY1   A0A146M822   A0A1B0GBA4   A0A1A9UNR2   A0A1A9ZXG1   A0A336LK45   A0A1A9XTY7   A0A1B0C242   A0A1Y1LYV3   A0A146LHY8   A0A067RFR0   T1P9G1   T1HVH2   A0A1I8M359   T1PJY5   A0A3L8DHA1   B4MUA8   A0A088A1C1   B4JQ06   K7IM46   A0A026WTE9   B4LVB5   A0A182VCQ2   B4KHQ8   A0A0J9QZQ3   A0A158NNB8   A0A1L8DGS6   A0A1W4UG01   B4HWQ5   A0A2H1VEV7   B3MJJ0   B4P0P9   A0A154P6F0   B4Q9B3   A0A0R1DJT1   B3N5F0   Q9VKV0   A0A3B0JLH9   A0A0Q5WP40   Q86P70   A0A0M4E5C8   A0A194R3L9   A0A1A9W0P6   A0A1B6FQB4   A0A1B6F8K1   N6U6B2   W8BTC2   A0A034W376   A0A2S2PYJ6   A0A182NBG5   A0A0Q9W8C8   A0A0Q9W8B4   B4LVB6   A0A0A1X7N9   A0A1Q3G0D2   J9JTE7   A0A2H8TV31   A0A1B6D791   Q9VKU8   A0A0R1DR12   A0A0R1DLZ8   M9MRH0   A0A182LSB0   A0A1B6KRK1   B4HWQ6   B4MUA7   A0A1W4UST0   A0A1W4UFB8   B4G757   A0A1B6MUR0   A0A0L0CFL4   A0A0Q9W8E7   J9K377   B3N5E9   T1ISV6  

EC Number

5.4.99.-

Pubmed

19121390    25244985    17510324    12364791    25474469    26823975    + More
18362917    19820115    28004739    24845553    25315136    30249741    17994087    20075255    24508170    18057021    22936249    21347285    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    26354079    23537049    24495485    25348373    25830018    26108605   

EMBL

BABH01004531    BABH01004532    BABH01004533    BABH01004534    BABH01004535    NWSH01000036    + More
PCG80394.1    PCG80395.1    GGFL01001082    MBW65260.1    CH477212    EAT47670.1    AAAB01008980    EAL39149.3    GEDC01028495    GEDC01028378    JAS08803.1    JAS08920.1    GBBI01002456    JAC16256.1    CVRI01000001    CRK86474.1    GDHC01015647    JAQ02982.1    KQ971342    EFA03993.2    GDHC01011076    JAQ07553.1    UFQT01000037    SSX18383.1    GDHC01003723    JAQ14906.1    CCAG010011565    CCAG010011566    CCAG010011567    SSX18382.1    JXJN01024339    GEZM01043843    GEZM01043841    GEZM01043840    JAV78733.1    GDHC01011500    JAQ07129.1    KK852498    KDR22592.1    KA644548    AFP59177.1    ACPB03012938    ACPB03012939    ACPB03012940    ACPB03012941    ACPB03012942    KA649076    KA649152    AFP63705.1    QOIP01000008    RLU19696.1    CH963857    EDW76034.1    CH916372    EDV98986.1    KK107109    EZA59228.1    CH940649    EDW63294.1    KRF81019.1    CH933807    EDW13345.2    CM002910    KMY89557.1    ADTU01021209    ADTU01021210    ADTU01021211    ADTU01021212    ADTU01021213    ADTU01021214    ADTU01021215    ADTU01021216    ADTU01021217    ADTU01021218    GFDF01008519    JAV05565.1    CH480818    EDW52450.1    ODYU01002192    SOQ39365.1    CH902620    EDV32358.1    KPU73917.1    KPU73918.1    KPU73919.1    CM000157    EDW87944.1    KRJ97499.1    KQ434819    KZC06924.1    CM000361    EDX04555.1    KRJ97500.1    CH954177    EDV59029.1    KQS70601.1    AE014134    BT044578    AAF52959.2    AAF52960.2    AAN10755.1    ACI16540.1    OUUW01000006    SPP81713.1    KQS70600.1    BT003451    AAO39454.1    CP012523    ALC39284.1    KQ460855    KPJ11835.1    GECZ01023012    GECZ01017428    JAS46757.1    JAS52341.1    GECZ01023269    GECZ01012248    JAS46500.1    JAS57521.1    APGK01037835    APGK01037836    KB740949    ENN77170.1    GAMC01006327    GAMC01006325    JAC00229.1    GAKP01010759    JAC48193.1    GGMS01001237    MBY70440.1    KRF81018.1    KRF81021.1    EDW63295.2    GBXI01007542    JAD06750.1    GFDL01001777    JAV33268.1    ABLF02028880    ABLF02028881    GFXV01005995    MBW17800.1    GEDC01015768    GEDC01014515    JAS21530.1    JAS22783.1    AY058686    AAF52961.2    AAL13915.1    ADV37032.2    KRJ97504.1    KRJ97501.1    ADV37033.1    AXCM01001775    GEBQ01025926    JAT14051.1    EDW52451.1    EDW76033.1    CH479180    EDW28311.1    GEBQ01000319    JAT39658.1    JRES01000469    KNC30992.1    KRF81020.1    ABLF02015120    EDV59028.2    JH431448   

Proteomes

UP000005204    UP000218220    UP000076408    UP000008820    UP000007062    UP000183832    + More
UP000007266    UP000092444    UP000078200    UP000092445    UP000092443    UP000092460    UP000027135    UP000015103    UP000095301    UP000279307    UP000007798    UP000005203    UP000001070    UP000002358    UP000053097    UP000008792    UP000075903    UP000009192    UP000005205    UP000192221    UP000001292    UP000007801    UP000002282    UP000076502    UP000000304    UP000008711    UP000000803    UP000268350    UP000092553    UP000053240    UP000091820    UP000019118    UP000075884    UP000007819    UP000075883    UP000008744    UP000037069   

PRIDE

H9J928    Q9VKV0    Q86P70    Q9VKU8   

Pfam

PF00849   PseudoU_synth_2

Interpro

IPR006145   PsdUridine_synth_RsuA/RluA        + More
IPR020103   PsdUridine_synth_cat_dom_sf       
IPR002942   S4_RNA-bd       
IPR006225   PsdUridine_synth_RluC/D       
IPR006224   PsdUridine_synth_RluC/D_CS       

SUPFAM

SSF55120   SSF55120       

CDD

cd00165  S4

ProteinModelPortal

H9J928   A0A2A4K912   A0A2A4K7Z7   A0A182YFU0   A0A2M4CIS4   Q17LU3   + More
Q5TP89   A0A1B6C5M5   A0A023F451   A0A1J1HFZ9   A0A146L739   D6WKG9   A0A146LH65   A0A336LNY1   A0A146M822   A0A1B0GBA4   A0A1A9UNR2   A0A1A9ZXG1   A0A336LK45   A0A1A9XTY7   A0A1B0C242   A0A1Y1LYV3   A0A146LHY8   A0A067RFR0   T1P9G1   T1HVH2   A0A1I8M359   T1PJY5   A0A3L8DHA1   B4MUA8   A0A088A1C1   B4JQ06   K7IM46   A0A026WTE9   B4LVB5   A0A182VCQ2   B4KHQ8   A0A0J9QZQ3   A0A158NNB8   A0A1L8DGS6   A0A1W4UG01   B4HWQ5   A0A2H1VEV7   B3MJJ0   B4P0P9   A0A154P6F0   B4Q9B3   A0A0R1DJT1   B3N5F0   Q9VKV0   A0A3B0JLH9   A0A0Q5WP40   Q86P70   A0A0M4E5C8   A0A194R3L9   A0A1A9W0P6   A0A1B6FQB4   A0A1B6F8K1   N6U6B2   W8BTC2   A0A034W376   A0A2S2PYJ6   A0A182NBG5   A0A0Q9W8C8   A0A0Q9W8B4   B4LVB6   A0A0A1X7N9   A0A1Q3G0D2   J9JTE7   A0A2H8TV31   A0A1B6D791   Q9VKU8   A0A0R1DR12   A0A0R1DLZ8   M9MRH0   A0A182LSB0   A0A1B6KRK1   B4HWQ6   B4MUA7   A0A1W4UST0   A0A1W4UFB8   B4G757   A0A1B6MUR0   A0A0L0CFL4   A0A0Q9W8E7   J9K377   B3N5E9   T1ISV6  

PDB

1XPI     E-value=3.13693e-19,     Score=235

KEGG

101737404    no KO assigned | (RefSeq) RNA pseudouridylate synthase domain-containing protein 2-like

GO

GO:0003723   GO:0009982   GO:0001522   GO:0000455   GO:0106029   GO:0016021   GO:0050829   GO:0045089   GO:0009451   GO:0006396   GO:0030529   GO:0016020   GO:0005515   GO:0003779  

Length:

528

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0072

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00073

outside

1  -  528

 

 

Pi

206.252109

Theta

160.845449

Tajima's D

0.940319

CLR

0.436734

CSRT

0.638818059097045

Interpretation

Uncertain