Gene

KWMTBOMO01697

Pre Gene Modal

BGIBMGA006117

Annotation

PREDICTED:_tripartite_motif-containing_protein_45_[Bombyx_mori]

Location

Bomo_Chr4(+):1743189-1763443      View in EpiBrowser

Full name

Tripartite motif-containing protein 45      

Alternative Name

RING finger protein 99

Location in the cell

Nuclear   Reliability : 2.8

CDS

ATGAATAATTTATGCTTCACCCGCAAGAAGGACAAGCGGAAGTCACTGGAGCCCTCATCAATAAGTGCCGGTAATAGTCCTTTAAGGACCCGACCGGCTAGCCAAAGCCTGTCTATAGCGCCAAGGACCTCAGCTTACGACAAAAAAGATGTAATGAAGGAGTGGATCTGCGGGATATGTAGGAAAGAATTGGTGGAACCGAGGCTGCTGGGCTGCCTCCACAGCTTCTGCACCAGCTGTCTTCAGGGTCTGCATCAGGAGGGTGCTTGTGAATTGTGGAGCGAAGTCGATAGAGAGTCAATCCAACAAGATCCTGCCGAATCAGGATCAGGCTTGGGTTCCGCCGGATCCGGATACGAGAGTGACTTGAGACATTCAGACTCTGAGGGCAGTTGGGAGCACAAAAACAAGAAATACGGTATTCTGACAAGAAAGATTTCCGGTAAAAGCGTGCAATTCGTAGTATGCCCAACATGCGGTCAAGAGAGCGCGCTCCCTCTGGGAGGTATAGCGGCGTTGCCCCTCAACTACGTGCTGCTTCGGAAGATGAACTCACATGAGAACGGTGTGGCGGTACTCTGCGACCTTTGCGACAGTGACCATAAGGCTGTGAGTCGTTGCGGGAAATGCCTGATCAGCATATGCTCATCGTGCGGCGACGCCCACGAGAGGCAGCCGACCACGGCGAGACACGTACTGGAGCCGCTACACCCTCCCGTCAGATACTGCTCGCAACATCCCAAGGCTGAACTGTGCATCTACTGCGCTACTTGTCAACAGGTTGTGTGCCGAGAGTGCTGCGTGGTGTCGCACGGCGGGCACGCGCTGGCGGCGGCGTCCCGCGCGGCTGCCGAGCGCGCCCGCGTGCTGCGTGCCGCCTGCGATCGCGCCGCGCACGTGCCGGGCAACGTGCAGCGGGCGGCCAGGGCGCTGCAAGTGCATGCCGCTCAAGTTGATGCTCAGGCTTCCAAAGTGGAATCGGAAGTGGAGACGTGGGCGGCGGAGTACAGTCGCGCGGTGGAGGCGCACGGGCGCGCGCTGCTGCGGGCCGCGGGGCGGGCGCGCTGCGGGTTCCGTCGCGGCGTGCGGCGCCACGAGCAGCGCCTCGACGAGCGCGTGCGGGACGCGCACGAAGCCGTCGCCTTCGCCCAGGAGTTGCTCTCGGGAGCCAGAGACGATGAGTTGCTATCCCTGAGCGGGCCCGTCCTCCGGCGGTTAGAGAGGGTGACGGAGGTAGAGGGGCTGGGGCAGGCTCCCCAGTGCGAGGTCAGGTTCGCGCCGCTGGCCCCCGCCGCGCCGCACTCCACGCTGTACGGGCGGCTGCTCACTCAGGCGCCGGACCCCGACAAATGCGTTCTGGATACTGAAGGTCTCCAAGACCTGATGGTGAATTGTCAACACGAGACAGTTTTAGAGCTGAGGGACTGTAACGGTGAGCGCATTTGGTGCGGAGGCGAACAGGTGTCGGGCTACCTGCGGCGCCGCGACTCGAGCGCGCGGCCGGCCGGCGCCGCGGTTACGGACCGCGCCGACGGTCGCTACACGCTCGCCTTCACGCCCGCCGCGCCCGGCGCATACCTGCTGGCCGTCACCGTCGCCAACAAGCCTATTAAGGTAACACCGACACCGGTCCGGTCCGGTCACCACTCTCGTCGAGCCCGTCGCTTGCGACATAGGGCTCGGTGA

Protein

MNNLCFTRKKDKRKSLEPSSISAGNSPLRTRPASQSLSIAPRTSAYDKKDVMKEWICGICRKELVEPRLLGCLHSFCTSCLQGLHQEGACELWSEVDRESIQQDPAESGSGLGSAGSGYESDLRHSDSEGSWEHKNKKYGILTRKISGKSVQFVVCPTCGQESALPLGGIAALPLNYVLLRKMNSHENGVAVLCDLCDSDHKAVSRCGKCLISICSSCGDAHERQPTTARHVLEPLHPPVRYCSQHPKAELCIYCATCQQVVCRECCVVSHGGHALAAASRAAAERARVLRAACDRAAHVPGNVQRAARALQVHAAQVDAQASKVESEVETWAAEYSRAVEAHGRALLRAAGRARCGFRRGVRRHEQRLDERVRDAHEAVAFAQELLSGARDDELLSLSGPVLRRLERVTEVEGLGQAPQCEVRFAPLAPAAPHSTLYGRLLTQAPDPDKCVLDTEGLQDLMVNCQHETVLELRDCNGERIWCGGEQVSGYLRRRDSSARPAGAAVTDRADGRYTLAFTPAAPGAYLLAVTVANKPIKVTPTPVRSGHHSRRARRLRHRAR

Description

May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.

Similarity

Belongs to the peptidase S1 family.
Belongs to the TRIM/RBCC family.

Keywords

Coiled coil   Complete proteome   Cytoplasm   Metal-binding   Nucleus   Reference proteome   Repeat   Zinc   Zinc-finger   3D-structure   Alternative splicing   Polymorphism  

Feature

chain  Tripartite motif-containing protein 45
splice variant  In isoform 2.
sequence variant  In dbSNP:rs34863850.

Uniprot

H9J9C5   A0A2W1BH59   A0A2H1W5L3   A0A212EUM6   A0A194Q0K3   A0A194R7L5   + More
A0A2A4JDV3   A0A0L7LI21   A0A067QS44   A0A1Y1NGD9   A0A2J7PUX6   A0A139WGX8   A0A1W4XKZ8   N6U9I2   U4UGS1   A0A146LE64   A0A336M470   A0A0A1WSU3   A0A0L0BV24   A0A034WHX8   K7GAL8   A0A0K8TZ76   A0A0K8WL26   W8BND0   B4G921   Q29ML5   B3N718   E0VVI1   B4NWF1   Q3ZAM2   Q9VLR7   B4Q6B4   B3MPI3   B4HYG2   A0A1W4UV96   T1GU90   A0A1I8PK99   B4MVX4   W5JIX1   A0A250YJX4   D2HMJ2   U3E940   A0A2Y9IV36   A0A2K5PDD8   G1QZH5   A0A2K6PGQ7   U6CTY3   G9KV41   G5BFJ1   I3L6F2   G3SJ16   A0A2K5KHR7   H0WUL0   A0A2K5YZ01   E2RGD5   K7GR26   A0A2K6CHA8   A0A0D9S639   G7NX54   G7MFZ7   C3Z575   A0A384DNI2   I3M9K9   M3W3N1   K7GLN7   L8YCK3   W5QGE2   K9IMF5   A0A1B0ANZ9   G3H907   A0A3L7IFW3   F7E8F4   A0A2K5IF96   B4KGW7   S7MIH9   D4A7S9   A0A2U3Z157   A0A2I3TLJ8   K7BMQ7   A0A1U7QX26   A0A383Z2R1   L8I6N5   Q5BIM1   A0A2J8SQM0   A0A2Y9P0D6   A0A2U3V5L6   H2N678   K7D444   K7AS39   A0A2K5C9J5   Q9H8W5   W5MZ37   A0A096NE79   A0A212CHA0   A0A2Y9H995   A0A341D0N3   F6RUP9   L5LXM3   A0A182H059   G3X1J0  

Pubmed

19121390    28756777    22118469    26354079    26227816    24845553    + More
28004739    18362917    19820115    23537049    26823975    25830018    26108605    25348373    17381049    24495485    17994087    15632085    20566863    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    22936249    20920257    23761445    28087693    20010809    25243066    25362486    23236062    21993625    30723633    22398555    16341006    22002653    25319552    18563158    24813606    17975172    23385571    20809919    21804562    29704459    17495919    15057822    15632090    16136131    22751099    16305752    15351693    14702039    16710414    15489334    19892987    26483478    21709235   

EMBL

BABH01004468    BABH01004469    BABH01004470    KZ150052    PZC74382.1    ODYU01006354    + More
SOQ48132.1    AGBW02012334    OWR45195.1    KQ459584    KPI98524.1    KQ460644    KPJ13230.1    NWSH01001783    PCG70151.1    JTDY01001103    KOB74876.1    KK853366    KDR08100.1    GEZM01003004    GEZM01003003    JAV96994.1    NEVH01021189    PNF20133.1    KQ971343    KYB27222.1    APGK01037333    APGK01037334    KB740948    ENN77306.1    KB632288    ERL91548.1    GDHC01012710    JAQ05919.1    UFQS01000320    UFQT01000320    SSX02829.1    SSX23197.1    GBXI01012717    JAD01575.1    JRES01001418    KNC23094.1    GAKP01005227    JAC53725.1    AGCU01152279    GDHF01032723    JAI19591.1    GDHF01000542    JAI51772.1    GAMC01006228    JAC00328.1    CH479180    EDW28851.1    CH379060    EAL33678.2    CH954177    EDV59314.1    AAZO01005641    DS235812    EEB17387.1    CM000157    EDW88468.1    BT023847    AAZ86768.1    AE014134    BT081973    AAF52617.1    ACO53088.1    CM000361    CM002910    EDX04190.1    KMY88975.1    CH902620    EDV31279.1    CH480818    EDW52092.1    CAQQ02017106    CAQQ02017107    CH963857    EDW75844.2    ADMH02001111    ETN64076.1    GFFW01000865    JAV43923.1    ACTA01130516    GL193045    EFB13582.1    GAMT01006772    GAMS01004671    JAB05089.1    JAB18465.1    ADFV01041685    ADFV01041686    HAAF01002339    CCP74165.1    JP020172    AES08770.1    JH170044    GEBF01005209    EHB08052.1    JAN98423.1    AEMK02000024    DQIR01187376    HDB42853.1    CABD030005566    AAQR03105779    AAQR03105780    AAQR03105781    AAEX03011013    DQIR01100779    DQIR01256175    DQIR01259368    DQIR01259369    DQIR01264626    DQIR01273752    DQIR01318016    HDA56255.1    HDC11653.1    AQIB01086232    AQIA01002779    CM001276    EHH50207.1    JU336496    JV045067    CM001253    AFE80249.1    AFI35138.1    EHH15100.1    GG666582    EEN52432.1    AGTP01080053    AANG04003279    DQIR01306602    HDC62080.1    KB359359    ELV14148.1    AMGL01004359    GABZ01005218    JAA48307.1    JXJN01001093    JXJN01001094    JXJN01001095    JH000221    EGW05805.1    RAZU01000058    RLQ76985.1    CH933807    EDW11167.1    KE161437    EPQ03771.1    AABR07012715    CH474015    EDL85532.1    AACZ04034370    GABC01003802    JAA07536.1    GABD01001549    NBAG03000423    JAA31551.1    PNI26405.1    JH881870    ELR51863.1    BT021203    NDHI03003555    PNJ23052.1    ABGA01029953    GABE01010220    JAA34519.1    GABF01001389    JAA20756.1    AY669488    AK023243    AK222901    AL391476    BC034943    AHAT01003684    AHAT01003685    AHZZ02016712    AHZZ02016713    MKHE01000020    OWK05423.1    KB106585    ELK30851.1    JXUM01100705    JXUM01100706    KQ564591    KXJ72048.1    AEFK01176495   

Proteomes

UP000005204    UP000007151    UP000053268    UP000053240    UP000218220    UP000037510    + More
UP000027135    UP000235965    UP000007266    UP000192223    UP000019118    UP000030742    UP000037069    UP000007267    UP000008744    UP000001819    UP000008711    UP000009046    UP000002282    UP000000803    UP000000304    UP000007801    UP000001292    UP000192221    UP000015102    UP000095300    UP000007798    UP000000673    UP000008912    UP000008225    UP000248482    UP000233040    UP000001073    UP000233200    UP000006813    UP000008227    UP000001519    UP000233060    UP000005225    UP000233140    UP000002254    UP000233120    UP000029965    UP000009130    UP000233100    UP000001554    UP000261680    UP000291021    UP000005215    UP000011712    UP000011518    UP000002356    UP000092460    UP000001075    UP000273346    UP000002280    UP000233080    UP000009192    UP000002494    UP000245341    UP000002277    UP000189706    UP000261681    UP000009136    UP000248483    UP000245320    UP000001595    UP000233020    UP000005640    UP000018468    UP000028761    UP000248481    UP000252040    UP000002281    UP000069940    UP000249989    UP000007648   

PRIDE

H9J9C5    Q3ZAM2    Q9VLR7    I3L6F2    E2RGD5    K7GR26    + More
K7GLN7    G3H907    D4A7S9    Q5BIM1    Q9H8W5   

Pfam

PF13445   zf-RING_UBOX        + More
PF00630   Filamin
PF00643   zf-B_box
PF00097   zf-C3HC4
PF00089   Trypsin

Interpro

IPR001841   Znf_RING        + More
IPR027370   Znf-RING_LisH       
IPR017907   Znf_RING_CS       
IPR013783   Ig-like_fold       
IPR001298   Filamin/ABP280_rpt       
IPR014756   Ig_E-set       
IPR000315   Znf_B-box       
IPR017868   Filamin/ABP280_repeat-like       
IPR018957   Znf_C3HC4_RING-type       
IPR001314   Peptidase_S1A       
IPR009003   Peptidase_S1_PA       
IPR001254   Trypsin_dom       
IPR018114   TRYPSIN_HIS       
IPR022700   CLIP       
IPR033116   TRYPSIN_SER       
IPR013083   Znf_RING/FYVE/PHD       
IPR003649   Bbox_C       

SUPFAM

SSF81296   SSF81296        + More
SSF50494   SSF50494       

Gene 3D

2.60.40.10     3.30.40.10    

CDD

cd00021  BBOX
cd00190  Tryp_SPc

ProteinModelPortal

H9J9C5   A0A2W1BH59   A0A2H1W5L3   A0A212EUM6   A0A194Q0K3   A0A194R7L5   + More
A0A2A4JDV3   A0A0L7LI21   A0A067QS44   A0A1Y1NGD9   A0A2J7PUX6   A0A139WGX8   A0A1W4XKZ8   N6U9I2   U4UGS1   A0A146LE64   A0A336M470   A0A0A1WSU3   A0A0L0BV24   A0A034WHX8   K7GAL8   A0A0K8TZ76   A0A0K8WL26   W8BND0   B4G921   Q29ML5   B3N718   E0VVI1   B4NWF1   Q3ZAM2   Q9VLR7   B4Q6B4   B3MPI3   B4HYG2   A0A1W4UV96   T1GU90   A0A1I8PK99   B4MVX4   W5JIX1   A0A250YJX4   D2HMJ2   U3E940   A0A2Y9IV36   A0A2K5PDD8   G1QZH5   A0A2K6PGQ7   U6CTY3   G9KV41   G5BFJ1   I3L6F2   G3SJ16   A0A2K5KHR7   H0WUL0   A0A2K5YZ01   E2RGD5   K7GR26   A0A2K6CHA8   A0A0D9S639   G7NX54   G7MFZ7   C3Z575   A0A384DNI2   I3M9K9   M3W3N1   K7GLN7   L8YCK3   W5QGE2   K9IMF5   A0A1B0ANZ9   G3H907   A0A3L7IFW3   F7E8F4   A0A2K5IF96   B4KGW7   S7MIH9   D4A7S9   A0A2U3Z157   A0A2I3TLJ8   K7BMQ7   A0A1U7QX26   A0A383Z2R1   L8I6N5   Q5BIM1   A0A2J8SQM0   A0A2Y9P0D6   A0A2U3V5L6   H2N678   K7D444   K7AS39   A0A2K5C9J5   Q9H8W5   W5MZ37   A0A096NE79   A0A212CHA0   A0A2Y9H995   A0A341D0N3   F6RUP9   L5LXM3   A0A182H059   G3X1J0  

PDB

2DS4     E-value=6.40868e-06,     Score=121

KEGG

101736579    K12021 tripartite motif-containing protein 45 | (RefSeq) tripartite motif-containing protein 45

GO

GO:0046872   GO:0008270   GO:0004252   GO:0005829   GO:0005654   GO:0045171   GO:0004842   GO:0051865   GO:0060348   GO:0005622   GO:0005515   GO:0006355   GO:0006508   GO:0006811   GO:0016020   GO:0003779   GO:0016021  

Subcellular location

Cytoplasm  
Nucleus  

Length:

561

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.01146

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02809

outside

1  -  561

 

 

Pi

156.495806

Theta

146.039187

Tajima's D

0.385543

CLR

0.461393

CSRT

0.482125893705315

Interpretation

Uncertain