Gene

KWMTBOMO01694  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006032

Annotation

PREDICTED:_adenylate_kinase_isoenzyme_1_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr4(-):1677683-1690458      View in EpiBrowser

Full name

Adenylate kinase isoenzyme 1      

Alternative Name

ATP-AMP transphosphorylase 1
ATP:AMP phosphotransferase
Adenylate monophosphate kinase
Myokinase

Location in the cell

Nuclear   Reliability : 4.258

CDS

ATGGCACCCATAGATACATCGAAAAAGTCAATCGTGTGGGTCCTGGGAGGTCCCGGATCAGGAAAGGGAACACAATGCGACAAGATCGTCGCCAAATACGGGTTCACTCACCTCTCGACTGGAGACCTGCTCAGGGCTGAAGTCAAAAGCGGCTCGGAGAGGGCGAAATGCCTTACCGCTATTATGGAAAGAGGCGAGCTTGTCCCTAATGAAATCGTCCTGGATCTGCTAAAAGAAGCGATCCTGGCCCGCGCTGAAGAATCCAAAGGCTTCCTCATCGACGGCTACCCTCGCGAGAAGTCACAGGGTATCGCTTTTGAAGAGAACATCGCTCCTGTTTCGGTAATAATATACTTCGAGGCCTCCTCGGAGACGCTGACGCAGCGCCTGCTGGGCCGCGCCGCCAGCTCCGGCCGTGCCGATGACAACGAGGAGACCATCAAGCTCAGGCTGAAGACCTTCCTGGACAACAACGACCTCGTACTGGCTCAATACCCGGACAAACTCAGGAGGATAAACGCGGAACGTCCTGTGGATGAGATCTTCGCGGAGGTACAGTCGATCCTGGACCCGCTGGTCGCGTGA

Protein

MAPIDTSKKSIVWVLGGPGSGKGTQCDKIVAKYGFTHLSTGDLLRAEVKSGSERAKCLTAIMERGELVPNEIVLDLLKEAILARAEESKGFLIDGYPREKSQGIAFEENIAPVSVIIYFEASSETLTQRLLGRAASSGRADDNEETIKLRLKTFLDNNDLVLAQYPDKLRRINAERPVDEIFAEVQSILDPLVA

Description

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also possesses broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). May provide a mechanism to buffer the adenylate energy charge for sperm motility.

Catalytic Activity

AMP + ATP = 2 ADP
a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP

Subunit

Monomer.

Similarity

Belongs to the adenylate kinase family.
Belongs to the adenylate kinase family. AK1 subfamily.

Keywords

ATP-binding   Complete proteome   Cytoplasm   Kinase   Nucleotide-binding   Reference proteome   Transferase   Acetylation   Alternative splicing   Direct protein sequencing   Phosphoprotein  

Feature

chain  Adenylate kinase isoenzyme 1
splice variant  In isoform 2.

Uniprot

H9J940   A0A220K8L6   A0A194R5Y6   A0A194PYW9   A0A2W1BNE1   A0A2A4KB60   + More
A0A2A4KAT5   A0A2H1VQ92   D6WJX7   J3JVF3   U4U9W1   A0A0T6B682   A0A1A9W548   A0A1Y1N9H6   A0A0P4WDJ8   A0A034WMG6   A0A034WQY9   A0A0K8UAD9   A0A0K8V9S7   W8CAY2   C3Y327   W8BWF8   A0A0A1WER3   A0A0A1WKU5   C1BPN7   C3YAN3   A0A212EJ57   A0A0D3L709   H3BB97   H3BB96   A0A2H8TET5   Q6GQF9   Q6DFN0   F7CEM0   C1BTY0   K4FYQ8   P05081   T1FNK1   A0A1B6MUT7   A0A2S2P5H6   A0A2W1BM84   A0A1B6LHM9   R4WDG3   A0A336MQY4   A0A310TQK3   Q66J33   A0A2D4Q353   A0A067REE0   A0A1B6M5G1   J9JQL8   Q9R0Y5   A0A182K5K4   V4ANU9   A0A0V0G4J5   C1BZW4   A0A2D4JGP1   A0A2H6NA96   A0A226NXC1   A0A023EKD2   E2B248   E9H0V7   A0A1U7RV51   A0A023EKE5   A0A1B6HEU2   Q9R0Y5-2   A0A2P4SF41   T1HFU1   Q16W51   F6PLC0   Q16W53   A0A1U7S5Y0   W5M844   F4WX98   A0A182J6U4   A0A1U7RHU6   A0A1S4H0P8   Q7QGG2   A0A084VM63   A0A0P5EI24   A0A224XKK9   G1QBS7   A0A0A9Y5Y3   A0A0K8SFI8   A0A069DX59   A0A151WNH3   P39069   A0A3Q0CFS5   A0A287D6D9   A0A3M7RII3   A0A0P4VJV2   A0A1S4H0S9   S7Q8G6   A0A1A6GV92   A0A1I8NPD1   T1E2E3   I3N0J3   K7FSU9   A0A1I8NPD9   G1PN10   A0A026WP83  

EC Number

2.7.4.3
2.7.4.6

Pubmed

19121390    28630352    26354079    28756777    18362917    19820115    + More
22516182    23537049    28004739    25348373    24495485    18563158    25830018    22118469    9215903    12454917    12477932    17495919    23056606    2419325    2844738    2161682    23254933    23691247    24845553    10557075    16790685    16141072    19468303    15489334    16452087    21183079    24621616    24945155    20798317    21292972    17510324    20431018    21719571    12364791    24438588    21993624    25401762    26334808    8468325    22673903    30375419    27129103    24330624    17381049    24508170    30249741   

EMBL

BABH01004466    MF319716    ASJ26430.1    KQ460644    KPJ13233.1    KQ459584    + More
KPI98521.1    KZ150052    PZC74386.1    NWSH01000011    PCG80902.1    PCG80903.1    ODYU01003780    SOQ42967.1    KQ971342    EFA03917.1    APGK01043872    BT127221    KB741018    AEE62183.1    ENN75232.1    KB632152    ERL89138.1    LJIG01009533    KRT82889.1    GEZM01009463    JAV94572.1    GDRN01071336    GDRN01071334    JAI63707.1    GAKP01002236    JAC56716.1    GAKP01002235    JAC56717.1    GDHF01028672    JAI23642.1    GDHF01016605    JAI35709.1    GAMC01005306    JAC01250.1    GG666482    EEN65439.1    GAMC01005307    JAC01249.1    GBXI01016793    JAC97498.1    GBXI01014633    JAC99658.1    BT076566    ACO10990.1    GG666494    EEN62781.1    AGBW02014536    OWR41498.1    KC822758    AHJ80786.1    AFYH01046138    GFXV01000812    MBW12617.1    BC072785    AAH72785.1    BC076704    CR855821    AAH76704.1    CAJ83224.1    BT078059    BT120860    BT121139    HACA01028991    ACO12483.1    ADD24500.1    ADD38069.1    CDW46352.1    JX053354    AFK11582.1    M12153    D00251    AMQM01007061    KB097558    ESN94879.1    GEBQ01000273    JAT39704.1    GGMR01011983    MBY24602.1    PZC74387.1    GEBQ01026828    GEBQ01016755    GEBQ01009572    JAT13149.1    JAT23222.1    JAT30405.1    AK417663    BAN20878.1    UFQS01000997    UFQT01000997    SSX08345.1    SSX28368.1    KV467239    OCT57008.1    BC081078    AAH81078.1    IACN01117612    LAB63899.1    KK852514    KDR22221.1    GEBQ01008825    JAT31152.1    ABLF02039069    AJ010108    AJ010109    DQ486026    AK046613    AK089270    AL772271    BC014802    BC054366    KB201205    ESO98837.1    GECL01003520    JAP02604.1    BT080143    ACO14567.1    IACK01186307    LAA95676.1    IACI01077941    LAA28108.1    AWGT02000307    OXB72144.1    GAPW01003990    JAC09608.1    GL445059    EFN60223.1    GL732582    EFX74525.1    GAPW01003991    JAC09607.1    GECU01034520    GECU01031332    GECU01025307    GECU01022044    GECU01020516    GECU01014224    GECU01012683    JAS73186.1    JAS76374.1    JAS82399.1    JAS85662.1    JAS87190.1    JAS93482.1    JAS95023.1    PPHD01055425    POI22721.1    ACPB03001435    CH477575    EAT38802.2    AAMC01047190    AAMC01047191    AAMC01047192    AAMC01047193    AAMC01047194    AAMC01047195    EAT38800.1    EAT38801.1    AHAT01025332    GL888423    EGI61147.1    AAAB01008835    EAA05792.3    ATLV01014580    KE524975    KFB39057.1    GDIP01146162    JAJ77240.1    GFTR01003419    JAW13007.1    AAPE02044248    GBHO01016030    GBHO01016029    JAG27574.1    JAG27575.1    GBRD01013779    GBRD01013778    GBRD01013777    JAG52047.1    GBGD01002970    JAC85919.1    KQ982926    KYQ49235.1    AB022701    BC089797    D13376    AGTP01020068    REGN01003329    RNA23200.1    GDKW01002078    JAI54517.1    KE164341    EPQ17187.1    LZPO01073204    OBS69257.1    GALA01000799    JAA94053.1    AGCU01057997    AGCU01057998    AGCU01057999    AGCU01058000    AGCU01058001    AGCU01058002    AGCU01058003    AGCU01058004    AGCU01058005    AGCU01058006    KK107154    QOIP01000001    EZA56909.1    RLU27201.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007266    UP000019118    + More
UP000030742    UP000091820    UP000001554    UP000007151    UP000008672    UP000002280    UP000000539    UP000015101    UP000027135    UP000007819    UP000000589    UP000075881    UP000030746    UP000198419    UP000000311    UP000000305    UP000189705    UP000015103    UP000008820    UP000008143    UP000018468    UP000007755    UP000075880    UP000189706    UP000007062    UP000030765    UP000001074    UP000075809    UP000002494    UP000005215    UP000276133    UP000092124    UP000095300    UP000007267    UP000053097    UP000279307   

PRIDE

H9J940    P05081    Q9R0Y5    P39069   

Interpro

IPR033690   Adenylat_kinase_CS        + More
IPR027417   P-loop_NTPase       
IPR000850   Adenylat/UMP-CMP_kin       
IPR006267   AK1/5       
IPR028582   AK1       
IPR006266   UMP_CMP_kinase       

SUPFAM

SSF52540   SSF52540       

CDD

cd01428  ADK

ProteinModelPortal

H9J940   A0A220K8L6   A0A194R5Y6   A0A194PYW9   A0A2W1BNE1   A0A2A4KB60   + More
A0A2A4KAT5   A0A2H1VQ92   D6WJX7   J3JVF3   U4U9W1   A0A0T6B682   A0A1A9W548   A0A1Y1N9H6   A0A0P4WDJ8   A0A034WMG6   A0A034WQY9   A0A0K8UAD9   A0A0K8V9S7   W8CAY2   C3Y327   W8BWF8   A0A0A1WER3   A0A0A1WKU5   C1BPN7   C3YAN3   A0A212EJ57   A0A0D3L709   H3BB97   H3BB96   A0A2H8TET5   Q6GQF9   Q6DFN0   F7CEM0   C1BTY0   K4FYQ8   P05081   T1FNK1   A0A1B6MUT7   A0A2S2P5H6   A0A2W1BM84   A0A1B6LHM9   R4WDG3   A0A336MQY4   A0A310TQK3   Q66J33   A0A2D4Q353   A0A067REE0   A0A1B6M5G1   J9JQL8   Q9R0Y5   A0A182K5K4   V4ANU9   A0A0V0G4J5   C1BZW4   A0A2D4JGP1   A0A2H6NA96   A0A226NXC1   A0A023EKD2   E2B248   E9H0V7   A0A1U7RV51   A0A023EKE5   A0A1B6HEU2   Q9R0Y5-2   A0A2P4SF41   T1HFU1   Q16W51   F6PLC0   Q16W53   A0A1U7S5Y0   W5M844   F4WX98   A0A182J6U4   A0A1U7RHU6   A0A1S4H0P8   Q7QGG2   A0A084VM63   A0A0P5EI24   A0A224XKK9   G1QBS7   A0A0A9Y5Y3   A0A0K8SFI8   A0A069DX59   A0A151WNH3   P39069   A0A3Q0CFS5   A0A287D6D9   A0A3M7RII3   A0A0P4VJV2   A0A1S4H0S9   S7Q8G6   A0A1A6GV92   A0A1I8NPD1   T1E2E3   I3N0J3   K7FSU9   A0A1I8NPD9   G1PN10   A0A026WP83  

PDB

5XZ2     E-value=6.33619e-55,     Score=537

KEGG

101736367    K00939 adenylate kinase [EC:2.7.4.3] | (RefSeq) adenylate kinase isoenzyme 1

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00730    Thiamine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0019205   GO:0006139   GO:0005524   GO:0004017   GO:0005737   GO:0046034   GO:0046033   GO:0004550   GO:0009142   GO:0006172   GO:0001520   GO:0005829   GO:0007050   GO:0005886   GO:0006165   GO:0043005   GO:0036126   GO:0048471   GO:0010828   GO:0030017   GO:0046103   GO:0009041   GO:0006207   GO:0004127   GO:0006221   GO:0033574   GO:0021772   GO:0030182   GO:0014042   GO:0032355   GO:0021549   GO:0007517   GO:0042493   GO:0014823   GO:0046083   GO:0016301   GO:0006355   GO:0006508   GO:0006811   GO:0016020   GO:0005515   GO:0003779   GO:0016021  

PANTHER

PTHR23359  

Subcellular location

Cytoplasm  

Length:

194

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00391

Exp number, first 60 AAs:

0.00052

Total prob of N-in:

0.15837

outside

1  -  194

 

 

Pi

244.757614

Theta

179.35336

Tajima's D

1.657573

CLR

0.032589

CSRT

0.817159142042898

Interpretation

Uncertain